|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK1 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
TK INSR 1023
Other PLK2 82
Other PLK3 62
YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKSL-LLKPH--QREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHK--RRK-----------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV-EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
--FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ--KLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
--FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ--KSC-----------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
--FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT-----------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ES-AS-LRERIEFL-N-EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLR---SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL--
-Y-CRGKVLGKGGFAKCYEMTDL-----TNNKVYAAKIIPHSR-VAKPH--QREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK--ARK-----------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL-EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFETT---NLKETYRCIREARYTMPSSLL--------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF
YL--KGRLLGKGGFARCYEATDT-----ETGSAYAVKVIPQSR-VAKPH--QREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWK--ARH-----------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL-EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLS--------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF
|