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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK1 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC DMPK 81
Other EIF2AK2 267
TK FGFR1 478
AGC GRK7 191
CMGC GSK3B 56
TK HCK 241
CAMK HUNK 61
TK INSR 1023
TKL IRAK4 186
CMGC MAPK14 24
CAMK MGC42105 74
Other NEK2 8
Other NEK3 4
CAMK PHKG2 24
AGC PKN2 657
Other PLK2 82
Other PLK3 62
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
STE SLK 34
STE STK10 36
TK TNK1 116
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIV---PKSL-LLKPH--Q-REKMS------------------------MEISIHRSL--A---HQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-------KKG--HSFEVDVWSIGCIMYTLLV-GK-PPFETS----CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKAQLEKAGV--E-HQLRR-------------------------EVEIQSHL--R---HPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-------GRM--HDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI------
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVL---FKSQ-IEKEG--V-EHQLR------------------------REIEIQAHL--H---HPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG-LKGEL----KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-------GRM--HNEKVDLWCIGVLCYELLV-GN-PPFESA----SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV------
---YQLYEDIGKGAFSVVRRCVKL-------CTGHEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL--K---HSNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------YYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KEA--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT-----AHEALKHPWV------
---YQLFEELGKGAFSVVRRCMKI-------PTGQEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL--K---HPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------YYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDMWACGVILYILLV-GY-PPFWDE----DQHRLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKDLINKMLTINPAKRIT-----ASEALKHPWI------
---YQLFEELGKGAFSVVRRCVKK-------TSTQEYAAKII---NTKK-LSARD--H-QKLER-------------------------EARICRLL--K---HPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------YYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV----QGEQQAWFG---FAGTPGYLSPEVLR-------KDP--YGKPVDIWACGVILYILLV-GY-PPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT------------------------PEAKNLINQMLTINPAKRIT-----ADQALKHPWV------
---YKLQSEIGKGAYGVVRLAYNE-------SEDRHYAMKVL---SKKK-LLKQY--G-FPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D---HVNVVKLIEVLDDP---------------------------AEDNLY--LVFDLLRKG--PVMEVPC-----DK-----------------PFSEEQARLYLRDVILGLEYLHCQ-----KIVHRDIKPSNLLLG-DDGHV----KIADFGVSNQF----EGNDAQLSS---TAGTPAFMAPEAISD----SGQSF--SGKALDVWATGVTLYCFVY-GK-CPFIDD----FILALHRKIKNEPVVFPEEPEIS---------------------------EELKDLILKMLDKNPETRIG-----VPDIKLHPWV------
---YTLKDEIGKGSYGVVKLAYNE-------NDNTYYAMKVL---SKKK-LIRQA--G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D---HPNVVKLVEVLDDP---------------------------NEDHLY--MVFELVNQG--PVMEVPT-----LK-----------------PLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEF----KGSDALLSN---TVGTPAFMAPESLS------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CPFMDE----RIMCLHSKIKSQALEFPDQPDIA---------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLDT-ETEGV--P-STAIR-------------------------EISLLKEL--N---HPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL------GCKY--YSTAVDIWSLGCIFAEMVT-RR-ALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTS-MPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------
---YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRV---RLDD-DDEGV--P-SSALR-------------------------EICLLKEL--K---HKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF------GAKL--YSTSIDMWSAGCIFAELANAGR-PLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTK-LPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKII---SKRK-FAIGS--A-READPALN-------------------VETEIEILKKL--N---HPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS----VGTAG--YNRAVDCWSLGVILFICLS-GY-PPFSEH---RTQVSLKDQITSGKYNFIPEVWAE-VS------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL------
---YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFI---KKRR-TKSSR--R-GVSREDI---------------------EREVSILKEI--Q---HPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANVSAVNYEFEDEYFSN-TS------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------
---YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFI---KKRQ-SRASR--R-GVSREEI---------------------EREVSILRQV--L---HHNVITLHDVYEN-----------------------------RTDVV--LILELVSGG--ELFDFLA----QKE-----------------SLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANITAVSYDFDEEFFSQ-TS------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI------
---YEMGEELGSGQFAIVRKCRQK-------GTGKEYAAKFI---KKRR-LSSSR--R-GVSREEI---------------------EREVNILREI--R---HPNIITLHDIFEN-----------------------------KTDVV--LILELVSGG--ELFDFLA----EKE-----------------SLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SPFLGE----TKQETLTNISAVNYDFDEEYFSN-TS------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI------
---FEILKVIGRGAFSEVAVVKMK-------QTGQVYAMKIM---NKWD-MLKRG--E-VSCFR------------------------EERDVLVNG--D---RRWITQLHFAFQD-----------------------------ENYLY--LVMEYYVGG--DLLTLLS---KFGE-----------------RIPAEMARFYLAEIVMAIDSVHRL-----GYVHRDIKPDNILLD-RCGHI----RLADFGSCLKL---RADGTVRSLV---AVGTPDYLSPEILQAVGGGPGTGS--YGPECDWWALGVFAYEMFY-GQ-TPFYAD-STAETYGKIVHYKE---HLSLPLVDEGVP------------------------EEARDFIQRLLCPP-ETRLGR--GGAGDFRTHPFF------
--F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRV---KYNN-EKAER----------------------------------EVKALAKL--D---HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-----LKNDGKRTR---SKGTLRYMSPEQIS-------SQD--YGKEVDLYALGLILAELLH-VCDTAFET--------SKFFTDLRDGIISDIFDK------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT---
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-SD-AT-EKDLS-DLI-S-------------------------EMEMMKMIG-K---HKNIINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVT-EDNVM----KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF-------DRI--YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLLKEGHRMDKPSNCT-------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--------
--F-TEFRVLGKGGFGEVCAVQVK-------NTGKMYACKKL---DKKR-LKKKG--G-EKMAL------------------------LEKEILEKV--S---SPFIVSLAYAFES-----------------------------KTHLC--LVMSLMNGG--DLKFHIYN--VGTR-----------------GLDMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF----T------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKV---LQDK-RFKNR----------------------------------ELQIMRKL--D---HCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF------GATD--YTSSIDVWSAGCVLAELLL-GQ-PIFPGD-SGVDQLVEIIKVLGTPTREQIREMNP-NYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTM---K-PG-SM-SV--E-AFL-A-------------------------EANVMKTL--Q---HDKLVKLHAVVT------------------------------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVS-ASLVC----KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-------FGS--FTIKSDVWSFGILLMEIVTYGR-IPYPGM-SNPEVIRALERGYRMPRPENCP-------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L------
IGS----RKLGEGSFAKVREGLHV-------LTGEKVAIKVI---DKKR-AKKDT--Y-VTKNLR-----------------------REGQIQQMI--R---HPNITQLLDILET-----------------------------ENSYY--LVMELCPGG--NLMHKIY----EKK-----------------RLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD-EDNNI----KLIDFGLSNCAG--ILGYSDPFST---QCGSPAYAAPELLA-------RKK--YGPKIDVWSIGVNMYAMLT-GT-LPFTVE--PFSLRALYQKMVD-KEMNPLPTQ---LS------------------------TGAISFLRSLLEPDPVKRPN-----IQQALANRWL------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTV---N-ES-AS-LRERI-EFL-N-------------------------EASVMKGF--T---CHHVVRLLGVVSK-----------------------------GQPTL--VVMELMAHG--DLKSYLR-----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVA-HDFTV----KIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMAPESLK-------DGV--FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFVMDGGYLDQPDNCP-------------------------------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL--------
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKL---AAMV-DITTE--ELKQQFD------------------------QEIKVMAKC--Q---HENLVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--------GE--ITPKSDIYSFGVVLLEIIT-GL-PAVDEH-REPQLLLDIKEEIEDEEKTIEDYIDK-KMNDAD----------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ---
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKL---SRPF-QSIIH--A-KRTYR-------------------------ELRLLKHM--K---HENVIGLLDVFTPARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVN-EDCEL----KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML------NWMH--YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLILRLVGTPGAELLKKISS-ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF------
---YRIRGEIGSGNFSQVKLGIHS-------LTKEKVAIKIL---DKTK-LDQKT--Q-RLLSR-------------------------EISSMEKL--H---HPNIIRLYEVVET-----------------------------LSKLH--LVMEYAGGG--ELFGKIS----TEG-----------------KLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT-SNTCV----KVGDFGFSTV-----SKKGEMLNT---FCGSPPYAAPELFR------DEHY--IGIYVDIWALGVLLYFMVT-GT-MPFRAE----TVAKLKKSILEGTYSVPPHV-----S------------------------EPCHRLIRGVLQQIPTERYG-----IDCIMNDEWM------
---YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKEL---DYGS-MTEAE--K-QMLVS-------------------------EVNLLREL--K---HPNIVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLASVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL----NHDTSFAKT---FVGTPYYMSPEQMN-------RMS--YNEKSDIWSLGCLLYELCA-LM-PPFTAF----SQKELAGKIREGKFRRIPYRY----S------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I-----
--Y-MVLRMIGEGSFGRALLVQHE-------SSNQMFAMKEI---RLPK-SFSNT--Q-N-SRK-------------------------EAVLLAKM--K---HPNIVAFKESFEA-----------------------------EGHLY--IVMEYCDGG--DLMQKIKQ--QKGK-----------------LFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLT-QNGKV----KLGDFGSARLL----SNPMAFACT---YVGTPYYVPPEIWE-------NLP--YNNKSDIWSLGCILYELCT-LK-HPFQAN-SWKNLILKVCQGCISPLPSHYS-------------------------------YELQFLVKQMFKRNPSHRPS-----ATTLLS----RGIV--
YDP---KDVIGRGVSSVVRRCVHR-------ATGHEFAVKIM---EVTA-ERLSP--E-QLEEVREA-------------------TRRETHILRQV-AG---HPHIITLIDSYES-----------------------------SSFMF--LVFDLMRKG--ELFDYLT----EKV-----------------ALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD-DNMQI----RLSDFGFSCH-----LEPGEKLRE---LCGTPGYLAPEILKCS-MDETHPG--YGKEVDLWACGVILFTLLA-GS-PPFWHR----RQILMLRMIMEGQYQFSSPEWDD-RS------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF------
-FR--CCAVLGRGHFGKVLLAEYK-------NTNEMFAIKAL---KKGD-IVARD--E-VDSLM------------------------CEKRIFETV--NSVRHPFLVNLFACFQT-----------------------------KEHVC--FVMEYAAGG--DLMMHIH-----TD-----------------VFSEPRAVFYAACVVLGLQYLHEH-----KIVYRDLKLDNLLLD-TEGFV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEVLT-------ETS--YTRAVDWWGLGVLIYEMLV-GE-SPFPGD----DEEEVFDSIVNDEVRYPRFLS-----------------------------TEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFF------
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKII---PHSR-VAKPH--Q-REKID------------------------KEIELHRIL--H---HKHVVQFYHYFED-----------------------------KENIY--ILLEYCSRR--SMAHILK----ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN-EAMEL----KVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-------KQG--HGCESDIWALGCVMYTMLL-GR-PPFETT----NLKETYRCIREARYTMPSSLL-----------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF------
-YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVI---PQSR-VAKPH--Q-REKIL------------------------NEIELHRDL--Q---HRHIVRFSHHFED-----------------------------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-------RQG--HGPEADVWSLGCVMYTLLC-GS-PPFETA----DLKETYRCIKQVHYTLPASLS-----------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF------
-PD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKII---DKLR-FPTKQ--E-SQLRN-------------------------EVAILQNL--H---HPGVVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKG-----------------RLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------NKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDIHDQIQNAAFMYPPNPWKE-IS------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------
-PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVI---DKLR-FPTKQ--E-SQLRN-------------------------EVAILQSL--R---HPGIVNLECMFET-----------------------------PEKVF--VVMEKLHGD--MLEMILS---SEKG-----------------RLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLL-------NQG--YNRSLDMWSVGVIMYVSLS-GT-FPFNED------EDINDQIQNAAFMYPASPWSH-IS------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------
FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVI---DKMR-FPTKQ--E-SQLRN-------------------------EVAILQNL--H---HPGIVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-------SKG--YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDINDQIQNAAFMYPPNPWRE-IS------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTC---K-NC-TS-DSVRE-KFL-Q-------------------------EALTMRQF--D---HPHIVKLIGVIT------------------------------ENPVW--IIMELCTLG--ELRSFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVS-SNDCV----KLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-------FRR--FTSASDVWMFGVCMWEILMHGV-KPFQGV-KNNDVIGRIENGERLPMPPNCP-------------------------------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL--------
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVI---DTKS-EEELE--D-YM--V-------------------------EIDILASC--D---HPNIVKLLDAFYY-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCE--TSKDRP--YDYKADVWSLGITLIEMAE-IE-PPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS-----------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV------
---WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVI---ETKS-EEELE--D-YI--V-------------------------EIEILATC--D---HPYIVKLLGAYYH-----------------------------DGKLW--IMIEFCPGG--AVDAIML---ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMT-LEGDI----RLADFGVSAKN----LKTLQKRDS---FIGTPYWMAPEVVMCE--TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PPHHEL-NPMRVLLKIAKSDPPTLLTPSKWS-----------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV------
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-EG-PM-GTELG-DFL-R-------------------------EVSVMMNL--E---HPHVLRLHGLVL------------------------------GQPLQ--MVMELAPLG--SLHARLT-----AP-------------APTPPLLVALLCLFLRQLAGAMAYLGAR-----GLVHRDLATRNLLLA-SPRTI----KVADFGLVRPL-GG-A--RGRYVMGGPRPIPYAWCAPESLR-------HGA--FSSASDVWMFGVTLWEMFSGGE-EPWAGV-PPYLILQRLEDRARLPRPPLCS-------------------------------RALYSLALRCWAPHPADRPS-----FSHLE----GLL----
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