|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK4 203
TK ABL1 261
Other AURKA 133
TK FGFR2 481
AGC PDPK1 82
Other PLK1 53
TK PTK2 422
-F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKKA-MYKAG--MV-QRVQNEVKIHCQL-KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVK-----------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQL---KMPHEKHYT---LCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLI-GRPPFDTD---TVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM-----------
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV--EE-FL-K-EAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR--EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EH-QLRR-EVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
--LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSD-LV-S-EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLR--ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-N-N--IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
-F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRH-IIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLKPH--QR-EKMSMEISIHRSL-AHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHK-RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF-----------
--IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVREK-FL-Q-EALTMRQF-DHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQ--VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM---E--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
|