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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKACA 203
AGC AKT1 150
AGC AKT3 148
CAMK CAMK2A 13
CAMK MAPKAPK2 64
AGC ROCK1 76
--F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEFSFKD----NSNLYMVMEYVPGGEMFSHLR--RIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYI---QVTDFGFAK----RVKGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFAD----QPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF
--F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-RHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF
-FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-RHPFLTSLKYSFQT----KDRLCFVMEYVNGGELFFHLS--RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHI---KITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLS----SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF
---YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLER-EARICRLL-KHPNIVRLHDSISE----EGHHYLIFDLVTGGELFEDIV--AREYYSEADASHCIQQILEAVLHCHQ-MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR----KDPYGKPVDLWACGVILYILLVGYPPFWDE----DQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSK--RIT-----AAEALKHPWI
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R-EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMT-----ITEFMNHPWI
---YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-NSPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLMS---NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHL---KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD----SLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF
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