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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCI 203
Other AURKA 133
CMGC CDK2 4
CAMK CHEK2 220
CAMK DAPK1 13
AGC GRK6 186
CAMK MAPKAPK2 64
Other NEK2 8
Other NEK7 34
STE OXSR1 17
AGC PDPK1 82
Other PLK1 53
AGC ROCK1 76
AGC RPS6KA1 62
CAMK STK11 49
STE STK24 24
Other TTK 525
--F-DLLRVIGRGSYAKV---LLVRLKKTDRIYAMKVVKKEL-VNDDEDI-DWVQ-----TEKHVFEQASN-HPFLVGLHSCFQT----ESRLFFVIEYVNGG--DLMFHMQ--------RQRKLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLDSEGHI----KLTDYGMCKEG-----LRPGDTTSTFCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKE--RLGCHPQTGFADIQGHPF-F----------
---FEIGRPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-R-HPNILRLYGYFHD----ATRVYLILEYAPLG--TVYRELQ--------KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGEL----KIADFGWSV-------HAPSSRRTTLCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQ--RPM------LREVLEHPWI-----------
---FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-N-HPNIVKLLDVIHT----ENKLYLVFEFLHQ---DLKKFMDA------SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI----KLADFGLARAF-----GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVTRRALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS------AKAALAHPFF-----------
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-N-HPCIIKIKNFF-D----AEDYYIVLELMEGG--ELFDKVV--------GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI------LGETSLMRTLCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLSGYPPFSEH--------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKA--RFT------TEEALRHPWL-----------
---YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSILKEI-Q-HPNVITLHEVYEN----KTDVILILELVAGG--ELFDFLA--------EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK------IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFLGD---------TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKK--RMT------IQDSLQHPWI-----------
--F-RQYRVLGKGGFGEV---CACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-N-SRFVVSLAYAYET----KDALCLVLTLMNGG--DLKFHIYH------MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLDDHGHI----RISDLGLAVH------VPEGQTIKGRVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF-----------
KVT---SQVLGLGINGKV---LQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELHWRASQ-CPHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQD------RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYTSKRPNA-ILKLTDFGFAKE------TTSHNSLTTPCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLCGYPPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQ--RMT------ITEFMNHPWI-----------
---YEVLYTIGTGSYGRC---QKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLLREL-K-HPNIVRYYDRIIDR--TNTTLYIVMEYCEGG--DLASVITKG----TKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV----KLGDFGLARIL-----NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCALMPPFTAF---------SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYH--RPS------VEEILENPL-I----------
---FRIEKKIGRGQFSEV---YRAACLLDGVPVALKKVQIFD-LMDAKAR-ADCI-----KEIDLLKQL-N-HPNVIKYYASFIE----DNELNIVLELADAG--DLSRMIKHF----KKQKRLIPERTVWKYFVQLCSALEHMHSR-----RVMHRDIKPANVFITATGVV----KLGDLGLGRFF-----SSKTTAAHSLVGTPYYMSPERIH-----------ENGYNFKSDIWSLGCLLYEMAALQSPFYGD-------KMNLYSLCKKIEQCDYPPLPSDHYS------------------------EELRQLVNMCINPDPEK--RPD------VTYV------YDVA-------
---YELQEVIGSGATAVV---QAAYCAPKKEKVAIKRINLEK-CQTSMDE--LLK------EIQAMSQC-H-HPNIVSYYTSFVV----KDELWLVMKLLSGG--SVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLGEDGSV----QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME----------QVRGYDFKADIWSFGITAIELATGAAPYHKY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK-----------------KYGKSFRKMISLCLQKDPEK--RPT------AAELLRHKFF-----------
--F-KFGKILGEGSFSTV---VLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-D-HPFFVKLYFTFQD----DEKLYFGLSYAKNG--ELLKYIR--------KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLNEDMHI----QITDFGTAKVLS---PESKQARANSFVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVAGLPPFRAG---------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATK--RLG------CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKC---FEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIHRSL-A-HQHVVGFHGFFED----NDFVFVVLELCRRR--SLLELHK--------RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNEDLEV----KIGDFGLATKV-----EYDGERKKTLCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLVGKPPFETS---------CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTA--RPT------INELLNDEFF-----------
---YEVVKVIGRGAFGEV---QLVRHKSTRKVYAMKLLSKFE-MIKRSDS-AFFW-----EERDIMAFA-N-SPWVVQLFYAFQD----DRYLYMVMEYMPGG--DLVNLMS---------NYDVPEKWARFYTAEVVLALDAIHSM-----GFIHRDVKPDNMLLDKSGHL----KLADFGTCMKM----NKEGMVRCDTAVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD---------SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG------VEEIKRHLFF-----------
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRV-RTKM------ERDILADV-N-HPFVVKLHYAFQT----EGKLYLILDFLRGG--DLFTRLS--------KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLDEEGHI----KLTDFGLSKEA-----IDHEKKAYSFCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLTGSLPFQGK---------DRKETMTLILKAKLGMPQFLS--------------------------TEAQSLLRALFKRNPAN--RLGSG-PDGAEEIKRHV--FY---------
YLM---GDLLGEGSYGKV---KEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLLRRL-R-HKNVIQLVDVLYNE--EKQKMYMVMEYCVCGMQEMLDSVP---------EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLTTGGTL----KISDLGVAEALH---PFAADDTCRTSQGSPAFQPPEIAN---------GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGD---------NIYKLFENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAK--RFS------IRQIRQHSWF-----------
---FTKLEKIGKGSFGEV---FKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVLSQC-D-SPYVTKYYGSYLK----DTKLWIIMEYLGGG--SALDLLE---------PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLSEHGEV----KLADFGVAGQL-----TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELARGEPPHSEL------HPMKVLFLIPKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSF--RPT------AKELLKHKFI-----------
---YSILKQIGSGGSSKV---FQVLNEKKQ-IYAIKYVNLEE-ADNQTLD-SYRN------EIAYLNKLQQHSDKIIRLYDYEIT----DQYIYMVMECGNI---DLNSWLK--------KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV-DGML----KLIDFGIANQMQ---PDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--------INQISKLHAIIDPNHEIEFPDIPE------------------------KDLQDVLKCCLKRDPKQ--RIS------IPELLAHPYV-----------
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