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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCQ 203
TK ABL1 261
TK ABL2 288
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
CAMK CAMK2A 13
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDKL2 4
CAMK CHEK1 9
CMGC CSNK2A2 40
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1B 111
TK FER 563
TK FES 561
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC ICK 4
TK ITK 363
TK JAK2 849
TK JAK3 822
CMGC MAPK10 64
CMGC MAPK8 26
AGC MAST1 374
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
AGC PKN2 657
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK RET 724
Other SBK1 53
STE SLK 34
TK SRC 270
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
TK TEK 824
TK TIE1 839
TK TNK2 150
TK TXK 271
TK TYRO3 518
TK YES1 277
TK ZAP70 338
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKALKKD--VVL-MDD--DV-ECTM------------------------VEKRVLSLA-WE---HPF-----LTHMFCTFQ--T------KEN------LF--FVMEYLNGG--DLMYHIQ----SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN-----------------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ-----DE-EELF-HSIRMDNPFYPRWLE-------------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--DTM--EV--EE-FL-K-------------------------EAAVMKEI--K---HPN-----LVQLLGVCT--R------EPP------FY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI--DLSQV-YELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------
----ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTLK-E--DTM--EV--EE-FL-K-------------------------EAAVMKEI--K---HPN-----LVQLLGVCT--L------EPP------FY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHVV----KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT--FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI--DLSQV-YDLL-EKGYRMEQPEGCP---------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-------FA-ETHQA--F--------------
----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKS--QIE-KEG--VE-HQLR------------------------REIEIQAHL--H---HPN-----ILRLYNYFY--D------RRR------IY--LILEYAPRG--ELYKELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL----KIADFGWSV-------------------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA-----SH-NETY-RRIVKVDLKFPASVP-------------------------------------------------------------MGAQD-LISKLLRHNPSERLP-------LA-QVSAHPWV--------------
----FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKS--QIE-KEG--LE-HQLR------------------------REIEIQAHL--Q---HPN-----ILRLYNYFH--D------ARR------VY--LILEYAPRG--ELYKELQ----KSE-------------------------KL---DEQRTATIIEELADALTYCHD--KKVIHRDIKPENLLLG--FRGEV----KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA-----SH-SETY-RRILKVDVRFPLSMP-------------------------------------------------------------LGARD-LISRLLRYQPLERLP-------LA-QILKHPWV--------------
---V-ALGKTLGEGEFGAVMEGQLN-----QDDSILKVAVKTMK-I-AICT--RSELED-FL-S-------------------------EAVCMKEF--D---HPN-----VMRLIGVCF--Q------GSERESFPAPV--VILPFMKHG--DLHSFLL-----YSRL------------------GDQPVYL---PTQMLVKFMADIASGMEYLST--KRFIHRDLAARNCMLN--ENMSV----CVADFGLSKKI--------Y--------N--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV--YTSKSDVWSFGVTMWEIATRGQTP---------------YP-GV--ENSEI-YDYL-RQGNRLKQPADCL---------------------------------------------------------------DGLYA-LMSRCWELNPQDRPS-------FT-ELREDL----------------
---L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTLK-E--GTM--SP--EA-FL-G-------------------------EANVMKAL--Q---HER-----LVRLYAVVT---------KEP------IY--IVTEYMARG--CLLDFLK-----TD----------------------EGSRL---SLPRLIDMSAQIAEGMAYIER--MNSIHRDLRAANILVS--EALCC----KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV--FTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM--SNPEV-IRNL-ERGYRMPRPDTCP---------------------------------------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------
----YQLFEELGKGAFSVVRRCVKV-------LAGQEYAAKIINTK--KLS-ARD--HQ-KLER-------------------------EARICRLL--K---HPN-----IVRLHDSIS--E------EGH------HY--LIFDLVTGG--ELFEDIV----ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--MGVVHRDLKPENLLLA--SKLKGA-AVKLADFGLAIEV-----------------EGEQQAW--------------FG---FAGTPGYLSPEVLR------KDP--YGKPVDLWACGVILYILLV-GYPP---------------FW-DE-----DQ-HRLY-QQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKD-LINKMLTINPSKRIT-------AA-EALKHPWI--------------
----YKLQSEIGKGAYGVVRLAYNE-------SEDRHYAMKVLSKK--KLL-KQY--GF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D---HVN-----VVKLIEVLD--DP----AEDN------LY--LVFDLLRKG--PVMEVPC-----DK-------------------------PF---SEEQARLYLRDVILGLEYLHC--QKIVHRDIKPSNLLLG--DDGHV----KIADFGVSNQF-----------------EGNDAQL--------------SS---TAGTPAFMAPEAISD---SGQSF--SGKALDVWATGVTLYCFVY-GKCP---------------FI-DD-----FI-LALH-RKIKNEPVVFPEEPEIS-----------------------------------------------------------EELKD-LILKMLDKNPETRIG-------VP-DIKLHPWV--------------
----YTLKDEIGKGSYGVVKLAYNE-------NDNTYYAMKVLSKK--KLI-RQA--GF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D---HPN-----VVKLVEVLD--DP----NEDH------LY--MVFELVNQG--PVMEVPT-----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--QKIIHRDIKPSNLLVG--EDGHI----KIADFGVSNEF-----------------KGSDALL--------------SN---TVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVF-GQCP---------------FM-DE-----RI-MCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKD-LITRMLDKNPESRIV-------VP-EIKLHPWV--------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE--SEE-EGV--PS-TAIR-------------------------EISLLKEL--R---HPN-----IVSLQDVLM--Q------DSR------LY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI----KLADFGLARAF-----------------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD--SEIDQ-LFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--TET-EGV--PS-TAIR-------------------------EISLLKEL--N---HPN-----IVKLLDVIH--T------ENK------LY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF-----------------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD--SEIDQ-LFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
----YENLGLVGEGSYGMVMKCRNK-------DTGRIVAIKKFLES--DDD-KMV--KK-IAMR-------------------------EIKLLKQL--R---HEN-----LVNLLEVCK--K------KKR------WY--LVFEFVDHT--ILDDLEL----FPN-------------------------GL---DYQVVQKYLFQIINGIGFCHS--HNIIHRDIKPENILVS--QSGVV----KLCDFGFARTL-----------------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFM-GEPL---------------FP-GD--SDIDQ-LYHI-MMCLGNLIPRHQELFNKNPVFAGVRLPEIKE---------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMK--RAV-DCP--EN-I-KK-------------------------EICINKML--N---HEN-----VVKFYGHRR--E------GNI------QY--LFLEYCSGG--ELFDRIE----PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL----KISDFGLATVFR---------------YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP----SDS-CQEY-SDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLA-LLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
----YQLVRKLGRGKYSEVFEAINI-------TNNERVVVKILKPV--KKK-KIK--R-------------------------------EVKILENL-RG---GTN-----IIKLIDTVK--DP----VSKT------PA--LVFEYINNT--DFKQLY-------Q-------------------------IL---TDFDIRFYMYELLKALDYCHS--KGIMHRDVKPHNVMID-HQQKKL----RLIDWGLAEF------------------YHPAQEY--------------NV---RVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ--DNYDQ-LVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK---------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-------AK-EAMEHPYF--------------
----YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFIKKR--QSR-ASR--RG-VSREEI---------------------EREVSILRQV--L---HHN-----VITLHDVYE--N------RTD------VV--LILELVSGG--ELFDFLA----QKE-------------------------SL---SEEEATSFIKQILDGVNYLHT--KKIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GASP---------------FL-GD-----TK-QETL-ANITAVSYDFDEEFFSQTS---------------------------------------------------------ELAKD-FIRKLLVKETRKRLT-------IQ-EALRHPWI--------------
----YEMGEELGSGQFAIVRKCRQK-------GTGKEYAAKFIKKR--RLS-SSR--RG-VSREEI---------------------EREVNILREI--R---HPN-----IITLHDIFE--N------KTD------VV--LILELVSGG--ELFDFLA----EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--KRIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GASP---------------FL-GE-----TK-QETL-TNISAVNYDFDEEYFSNTS---------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------
----YEIDSLIGKGSFGQVVKAYDH-------QTQELVAIKIIKNK--KAF-LNQ--AQ-I----------------------------ELRLLELM-NQ---HDTEMKYYIVHLKRHFM--F------RNH------LC--LVFELLSY---NLYDLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ--------------------LGQRI--------------YQ---YIQSRFYRSPEVLL------GTP--YDLAIDMWSLGCILVEMHT-GEPL---------------FS-GS--NEVDQ-MNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-------PL-GALQHGFF--------------
--VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTCK-E--DLP--QELKIK-FL-Q-------------------------EAKILKQY--D---HPN-----IVKLIGVCT--Q------RQP------VY--IIMELVSGG--DFLTFLR-----RK-----------------------KDEL---KLKQLVKFSLDAAAGMLYLES--KNCIHRDLAARNCLVG--ENNVL----KISDFGMSRQE-----------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGR--YSSESDVWSFGILLWETFSLGVCP---------------YP-GM--TNQQA-REQV-ERGYRMSAPQHCP---------------------------------------------------------------EDISK-IMMKCWDYKPENRPK-------FS-ELQKEL----------------
---L-VLGEQIGRGNFGEVFSGRLR-------ADNTLVAVKSCR-E--TLP--PDLKAK-FL-Q-------------------------EARILKQY--S---HPN-----IVRLIGVCT--Q------KQP------IY--IVMELVQGG--DFLTFLR-----TE-----------------------GARL---RVKTLLQMVGDAAAGMEYLES--KCCIHRDLAARNCLVT--EKNVL----KISDFGMSREE--------A--------D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGR--YSSESDVWSFGILLWETFSLGASP---------------YP-NL--SNQQT-REFV-EKGGRLPCPELCP---------------------------------------------------------------DAVFR-LMEQCWAYEPGQRPS-------FS-TIYQEL----------------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT--EKDLSD-LV-S-------------------------EMEMMKMIG-K---HKN-----IINLLGACT--Q------DGP------LY--VIVEYASKG--NLREYLR-----ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--QKCIHRDLAARNVLVT--ENNVM----KIADFGLARDI--------N--------N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLMWEIFTLGGSP---------------YP-GI--PVEEL-FKLL-KEGHRMDKPANCT---------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-D--DAT--DKDLSD-LV-S-------------------------EMEMMKMIG-K---HKN-----IINLLGACT--Q------GGP------LY--VLVEYAAKG--NLREFLR-----ARRPPGLDY--------SFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--QKCIHRDLAARNVLVT--EDNVM----KIADFGLARDV--------H--------N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GI--PVEEL-FKLL-KEGHRMDKPANCT---------------------------------------------------------------HDLYM-IMRECWHAAPSQRPT-------FK-QLVEDL----------------
---L-VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-D--NAS--DKDLAD-LV-S-------------------------EMEVMKLIG-R---HKN-----IINLLGVCT--Q------EGP------LY--VIVECAAKG--NLREFLR-----ARRPPGPDL--------SPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--RKCIHRDLAARNVLVT--EDNVM----KIADFGLARGV--------H--------H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGILLWEIFTLGGSP---------------YP-GI--PVEEL-FSLL-REGHRMDRPPHCP---------------------------------------------------------------PELYG-LMRECWHAAPSQRPT-------FK-QLVEAL----------------
----ITLERRLGTGCFGDVWLGTWN--------GSTKVAVKTLK-P--GTM--SP--KA-FL-E-------------------------EAQVMKLL--R---HDK-----LVQLYAVVS---------EEP------IY--IVTEFMCHG--SLLDFLK-----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG--ERLAC----KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR--FTIKSDVWSFGILLTELITKGRIP---------------YP-GM--NKREV-LEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------
----LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--GTM--SP--ES-FL-E-------------------------EAQIMKKL--K---HDK-----LVQLYAVVS---------EEP------IY--IVTEYMNKG--SLLDFLK-----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--MNYIHRDLRSANILVG--NGLIC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELVTKGRVP---------------YP-GM--NNREV-LEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------
FLDF----RVLGKGGFGEVSACQMK-------ATGKLYACKKLNKK--RLK-KRK--GY-QGAM------------------------VEKKILMKV--H---SRF-----IVSLAYAFE--T------KAD------LC--LVMTIMNGG--DIRYHIYNVNEENP-------------------------GF---PEPRALFYTAQIICGLEHLHQ--RRIVYRDLKPENVLLD--NDGNV----RISDLGLAVEL-----------------LDGQSKT--------------KG---YAGTPGFMAPELLQ------GEE--YDFSVDYFALGVTLYEMIA-ARGP---------------FR-AR-GEKVEN-KELK-HRIISEPVKYPDKFS-------------------------------------------------------------QASKD-FCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEVCACQVR-------ATGKMYACKKLQKK--RIK-KRK--GE-AMAL------------------------NEKRILEKV--Q---SRF-----VVSLAYAYE--T------KDA------LC--LVLTIMNGG--DLKFHIYN--LGNP-------------------------GF---DEQRAVFYAAELCCGLEDLQR--ERIVYRDLKPENILLD--DRGHI----RISDLGLATE------------------IPEGQRV--------------RG---RVGTVGYMAPEVVN------NEK--YTFSPDWWGLGCLIYEMIQ-GHSP---------------FK-KY--KEKVK-WEEV-DQRIKNDTEEYSE---KFS---------------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCR--GEGAA-GVKQHPV-F-------------
---F-TEFRVLGKGGFGEVCAVQVK-------NTGKMYACKKLDKK--RLK-KKG--GE-KMAL------------------------LEKEILEKV--S---SPF-----IVSLAYAFE--S------KTH------LC--LVMSLMNGG--DLKFHIYN--VGTR-------------------------GL---DMSRVIFYSAQIACGMLHLHE--LGIVYRDMKPENVLLD--DLGNC----RLSDLGLAVE------------------MKGGKPI--------------TQ---RAGTNGYMAPEILM-----EKVS--YSYPVDWFAMGCSIYEMVA-GRTP---------------FK-DY-KEKVSK-EDLK-QRTLQDEVKFQHDNF---T---------------------------------------------------------EEAKD-ICRLFLAKKPEQRLG-------SR-E-------KSDDPR--------
----YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQD--KRF-KNR----------------------------------ELQIMRKL--D---HCN-----IVRLRYFFY--SSG--EKKDE------LYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVL----KLCDFGSAKQ------------------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD--SGVDQ-LVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQD--KRF-KNR----------------------------------ELQIMRKL--D---HCN-----IVRLRYFFY--SSG--EKKDE------VYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ------------------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD--SGVDQ-LVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-------PL-EACAHSFF--------------
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--GSM--SV--EA-FL-A-------------------------EANVMKTL--Q---HDK-----LVKLHAVVT---------KEP------IY--IITEFMAKG--SLLDFLK-----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS--ASLVC----KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS--FTIKSDVWSFGILLMEIVTYGRIP---------------YP-GM--SNPEV-IRAL-ERGYRMPRPENCP---------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L--------------
----YTTIRQLGDGTYGSVLLGRSI-------ESGELIAIKKMKRK--FYS-WEE--C--MNLR-------------------------EVKSLKKL--N---HAN-----VVKLKEVIR--E------NDH------LY--FIFEYMKE---NLYQLIK---ERNK-------------------------LF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLLCM--GPELV----KIADFGLARE------------------IRSKPPY--------------TD---YVSTRWYRAPEVLL-----RSTN--YSSPIDVWAVGCIMAEVYT-LRPL---------------FP-GA--SEIDT-IFKI-CQVLGTPKKTDWPEGYQLSSAMNFRWPQCV----------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--GAM--SE--ED-FI-E-------------------------EAEVMMKL--S---HPK-----LVQLYGVCL--E------QAP------IC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLF---AAETLLGMCLDVCEGMAYLEE--ACVIHRDLAARNCLVG--ENQVI----KVSDFGMTRFV-----------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR--YSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR--SNSEV-VEDI-STGFRLYKPRLAS---------------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-------FS-RLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--STE---EHLRD-FE-R-------------------------EIEILKSL--Q---HDN-----IVKYKGVCYSAG------RRN------LK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV----KIGDFGLTKVL-------PQ--------D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM--IVFHL-IELL-KNNGRLPRPDGCP---------------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-------FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--SGP--DQ-QRD-FQ-R-------------------------EIQILKAL--H---SDF-----IVKYRGVSYGPG------RQS------LR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV----KIADFGLAKLL-------PL--------D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DVP-ALCRL-LELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP--FQN-QTH--AK-RAYR-------------------------ELVLMKCV--N---HKN-----IISLLNVFT--PQKTLEEFQD------VY--LVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART------------------AGTSFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR--DYIDQ-WNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-------VD-DALQHPYI--------------
----YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRP--FQN-QTH--AK-RAYR-------------------------ELVLMKCV--N---HKN-----IIGLLNVFT--PQKSLEEFQD------VY--IVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART------------------AGTSFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR--DYIDQ-WNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-------VD-EALQHPYI--------------
--FD--TIKLISNGAYGAVYLVRHR-------DTRQRFAMKKINKQ--NLILRNQ--IQ-QAFV-------------------------ERDILTFA--E---NPF-----VVGMFCSFE--T------RRH------LC--MVMEYVEGG--DCATLLK----NIG-------------------------AL---PVEMARMYFAETVLALEYLHN--YGIVHRDLKPDNLLIT--SMGHI----KLTDFGLSKMGLMSLTTN--LYEGHIEKDAREFLD--------------KQ---VCGTPEYIAPEVIL------RQG--YGKPVDWWAMGIILYEFLV-GCVP---------------FF-GD-----TP-EELF-GQVISDDILWPEGDE-ALP---------------------------------------------------------TEAQL-LISSLLQTNPLVRLGA----GGAF-EVKQHSFF--------------
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--ASE--SA-RQD-FQ-R-------------------------EAELLTML--Q---HQH-----IVRFFGVCT--E------GRP------LL--MVFEYMRHG--DLNRFLR-----SHGPDAKL---------LAGGEDVAPGPL---GLGQLLAVASQVAAGMVYLAG--LHFVHRDLATRNCLVG--QGLVV----KIGDFGMSRDI--------Y--------S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK--FTTESDVWSFGVVLWEIFTYGKQP---------------WY-QL--SNTEA-IDCI-TQGRELERPRACP---------------------------------------------------------------PEVYA-IMRGCWQREPQQRHS-------IK-DVHARL----------------
---I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-D--ASD--NA-RKD-FH-R-------------------------EAELLTNL--Q---HEH-----IVKFYGVCV--E------GDP------LI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVG--ENLLV----KIGDFGMSRDV--------Y--------S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSLGVVLWEIFTYGKQP---------------WY-QL--SNNEV-IECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L--------------
---I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D--PTL--AA-RKD-FQ-R-------------------------EAELLTNL--Q---HEH-----IVKFYGVCG--D------GDP------LI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--QHFVHRDLATRNCLVG--ANLLV----KIGDFGMSRDV--------Y--------S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSFGVILWEIFTYGKQP---------------WF-QL--SNTEV-IECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL----------------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--HII-KEN--KVPYVTR-------------------------ERDVMSRL--D---HPF-----FVKLYFTFQ--D------DEK------LY--FGLSYAKNG--ELLKYIR----KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS---------------PESKQARA--------------NS---FVGTAQYVSPELLT------EKS--ACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG-----NE-YLIF-QKIIKLEYDFPEKFF-------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
----YEPKEILGRGVSSVVRRCIHK-------PTSQEYAVKVIDVT--GGG-SFS--PE-EVRELRE------------------ATLKEVDILRKV-SG---HPN-----IIQLKDTYE--T------NTF------FF--LVFDLMKRG--ELFDYLT----EKV-------------------------TL---SEKETRKIMRALLEVICTLHK--LNIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ------------------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP---------------FW-HR-----KQ-MLML-RMIMSGNYQFGSPEWDDYS---------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
-YDP---KDVIGRGVSSVVRRCVHR-------ATGHEFAVKIMEVT--AER-LSP--EQ-LEEVREA-------------------TRRETHILRQV-AG---HPH-----IITLIDSYE--S------SSF------MF--LVFDLMRKG--ELFDYLT----EKV-------------------------AL---SEKETRSIMRSLLEAVSFLHA--NNIVHRDLKPENILLD--DNMQI----RLSDFGFSCH------------------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GSPP---------------FW-HR-----RQ-ILML-RMIMEGQYQFSSPEWDDRS---------------------------------------------------------STVKD-LISRLLQVDPEARLT-------AE-QALQHPFF--------------
---F-KFLAVLGRGHFGKVLLSEFR-------PSGELFAIKALKKG--DIV-ARD--EV-ESLM------------------------CEKRILAAV--TSAGHPF-----LVNLFGCFQ--T------PEH------VC--FVMEYSAGG--DLMLHIH-----SD-------------------------VF---SEPRAIFYSACVVLGLQFLHE--HKIVYRDLKLDNLLLD--TEGYV----KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS--YTRAVDWWGLGVLLYEMLV-GESP---------------FP-GD-----DE-EEVF-DSIVNDEVRYPRFLS-------------------------------------------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEYK-------NTNEMFAIKALKKG--DIV-ARD--EV-DSLM------------------------CEKRIFETV--NSVRHPF-----LVNLFACFQ--T------KEH------VC--FVMEYAAGG--DLMMHIH-----TD-------------------------VF---SEPRAVFYAACVVLGLQYLHE--HKIVYRDLKLDNLLLD--TEGFV----KIADFGLCKEG-----------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------ETS--YTRAVDWWGLGVLIYEMLV-GESP---------------FP-GD-----DE-EEVF-DSIVNDEVRYPRFLS-------------------------------------------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLSERK-------GTDELYAVKILKKD--VVI-QDD--DV-ECTM------------------------VEKRVLALP-GK---PPF-----LTQLHSCFQ--T------MDR------LY--FVMEYVNGG--DLMYHIQ----QVG-------------------------RF---KEPHAVFYAAEIAIGLFFLQS--KGIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEN-----------------IWDGVTT--------------KT---FCGTPDYIAPEIIA------YQP--YGKSVDWWAFGVLLYEMLA-GQAP---------------FE-GE-----DE-DELF-QSIMEHNVAYPKSMS-------------------------------------------------------------KEAVA-ICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKALKKD--VVL-IDD--DV-ECTM------------------------VEKRVLTLA-AE---NPF-----LTHLICTFQ--T------KDH------LF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVLLD--RDGHI----KIADFGMCKEN-----------------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK--YTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD-----DE-DELF-ESIRVDTPHYPRWIT-------------------------------------------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKVMLAELK-------GKDEVYAVKVLKKD--VIL-QDD--DV-DCTM------------------------TEKRILALA-RK---HPY-----LTQLYCCFQ--T------KDR------LF--FVMEYVNGG--DLMFQIQ----RSR-------------------------KF---DEPRSRFYAAEVTSALMFLHQ--HGVIYRDLKLDNILLD--AEGHC----KLADFGMCKEG-----------------ILNGVTT--------------TT---FCGTPDYIAPEILQ------ELE--YGPSVDWWALGVLMYEMMA-GQPP---------------FE-AD-----NE-DDLF-ESILHDDVLYPVWLS-------------------------------------------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
----FEFIRVLGKGSFGKVMLARVK-------ETGDLYAVKVLKKD--VIL-QDD--DV-ECTM------------------------TEKRILSLA-RN---HPF-----LTQLFCCFQ--T------PDR------LF--FVMEFVNGG--DLMFHIQ----KSR-------------------------RF---DEARARFYAAEIISALMFLHD--KGIIYRDLKLDNVLLD--HEGHC----KLADFGMCKEG-----------------ICNGVTT--------------AT---FCGTPDYIAPEILQ------EML--YGPAVDWWAMGVLLYEMLC-GHAP---------------FE-AE-----NE-DDLF-EAILNDEVVYPTWLH-------------------------------------------------------------EDATG-ILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F-------------
--PD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKIIDKL--RFP-TKQ--ES-QLRN-------------------------EVAILQNL--H---HPG-----VVNLECMFE--T------PER------VF--VVMEKLHGD--MLEMILS---SEKG-------------------------RL---PEHITKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------NKG--YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED--------EDIH-DQIQNAAFMYPPNPWKEIS---------------------------------------------------------HEAID-LINNLLQVKMRKRYS-------VD-KTLSHPWL--------------
--PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVIDKL--RFP-TKQ--ES-QLRN-------------------------EVAILQSL--R---HPG-----IVNLECMFE--T------PEK------VF--VVMEKLHGD--MLEMILS---SEKG-------------------------RL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLL------NQG--YNRSLDMWSVGVIMYVSLS-GTFP---------------FN-ED--------EDIN-DQIQNAAFMYPASPWSHIS---------------------------------------------------------AGAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
-FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVIDKM--RFP-TKQ--ES-QLRN-------------------------EVAILQNL--H---HPG-----IVNLECMFE--T------PER------VF--VVMEKLHGD--MLEMILS---SEKS-------------------------RL---PERITKFMVTQILVALRNLHF--KNIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKG--YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED--------EDIN-DQIQNAAFMYPPNPWREIS---------------------------------------------------------GEAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--NAS--PSELRD-LL-S-------------------------EFNVLKQV--N---HPH-----VIKLYGACS--Q------DGP------LL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--MKLVHRDLAARNILVA--EGRKM----KISDFGLSRDV--------Y--------E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI--YTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI--PPERL-FNLL-KTGHRMERPDNCS---------------------------------------------------------------EEMYR-LMLQCWKQEPDKRPV-------FA-DISKDL----------------
----YELVRELGKGTYGKVDLVVYK-------GTGTKMALKFVNKS--KTK-LKN--F----LR-------------------------EVSITNSL-SS---SPF-----IIKVFDVVF--E-----TEDC------YV--FAQEYAPAG--DLFDIIP----PQV-------------------------GL---PEDTVKRCVQQLGLALDFMHG--RQLVHRDIKPENVLLFDRECRRV----KLADFGMTR--------------------RVGCRV--------------KR---VSGTIPYTAPEVCQAG-RADGLA--VDTGVDVWAFGVLIFCVLT-GNFP---------------WE-AA--SGADAFFEEF-VRWQRGRLPGLPSQWRRFT---------------------------------------------------------EPALR-MFQRLLALEPERRGP-------AK-EVF-----RFLKH---------
----WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK--SEE-ELE--DY-M--V-------------------------EIDILASC--D---HPN-----IVKLLDAFY--Y------ENN------LW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE-TSKDRP--YDYKADVWSLGITLIEMAE-IEPP---------------HH-EL--NPMRV-LLKI-AKSEPPTLAQPSRWS-------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-------TS-QLLQHPFV--------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--GTM--SP--EA-FL-Q-------------------------EAQVMKKL--R---HEK-----LVQLYAVVS---------EEP------IY--IVTEYMSKG--SLLDFLK-----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC----KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELTTKGRVP---------------YP-GM--VNREV-LDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------
-LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFMRKR--RKG-QDC--RM-EIIH-------------------------EIAVLELA-QD---NPW-----VINLHEVYE--T------ASE------MI--LVLEYAAGG--EIFDQCVA--DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT--RDVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI------------------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN-----DK-QETF-LNISQMNLSYSEEEFDVLS---------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------
-ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFLKKR--RRG-QDC--RA-EILH-------------------------EIAVLELA-KS---CPR-----VINLHEVYE--N------TSE------II--LILEYAAGG--EIFSLCLP--ELAE-------------------------MV---SENDVIRLIKQILEGVYYLHQ--NNIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK------------------IGHACEL--------------RE---IMGTPEYLAPEILN------YDP--ITTATDMWNIGIIAYMLLT-HTSP---------------FV-GE-----DN-QETY-LNISQVNVDYSEETFSSVS---------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-------AE-ICLSHSWL--------------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--EAE-DEI--ED-IQ-Q-------------------------EITVLSQC--D---SPY-----VTKYYGSYL--K------DTK------LW--IIMEYLGGG--SALDLLE-----PG-------------------------PL---DETQIATILREILKGLDYLHS--EKKIHRDIKAANVLLS--EHGEV----KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELAR-GEPP---------------HS-EL--HPMKV-LFLI-PKNNPPTLEGNYS---------------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
----IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E--YAS--KDDHRD-FA-G-------------------------ELEVLCKLG-H---HPN-----IINLLGACE--H------RGY------LY--LAIEYAPHG--NLLDFLR-----KSRVLETDP--------AFAIANSTASTL---SSQQLLHFAADVARGMDYLSQ--KQFIHRDLAARNILVG--ENYVA----KIADFGLSRGQ---------------------EVY--------------VKKTMGRLPVRWMAIESLN------YSV--YTTNSDVWSYGVLLWEIVSLGGTP---------------YC-GM--TCAEL-YEKL-PQGYRLEKPLNCD---------------------------------------------------------------DEVYD-LMRQCWREKPYERPS-------FA-QILV---SL-------------
----ITFEDLIGEGNFGQVIRAMIK-----KDGLKMNAAIKMLK-E--YAS--ENDHRD-FA-G-------------------------ELEVLCKLG-H---HPN-----IINLLGACK--N------RGY------LY--IAIEYAPYG--NLLDFLR-----KSRVLETDP--------AFAREHGTASTL---SSRQLLRFASDAANGMQYLSE--KQFIHRDLAARNVLVG--ENLAS----KIADFGLSRGE---------------------EVY--------------VKKTMGRLPVRWMAIESLN------YSV--YTTKSDVWSFGVLLWEIVSLGGTP---------------YC-GM--TCAEL-YEKL-PQGYRMEQPRNCD---------------------------------------------------------------DEVYE-LMRQCWRDRPYERPP-------FA-QIALQ--L--------------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVLSQ--PEAMDD-FI-R-------------------------EVNAMHSL--D---HRN-----LIRLYGVVL---------TPP------MK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHF---LLGTLSRYAVQVAEGMGYLES--KRFIHRDLAARNLLLA--TRDLV----KIGDFGLMRAL-------PQ--------N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL--NGSQI-LHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------
---L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--GSM--SE--ED-FI-E-------------------------EAKVMMKL--S---HSK-----LVQLYGVCI--Q------RKP------LY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER--NGYIHRDLAARNCLVS--STCIV----KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNK--YSSKSDVWSFGVLMWEVFTEGKMP---------------FE-NK--SNLQV-VEAI-SEGFRLYRPHLAP---------------------------------------------------------------MSIYE-VMYSCWHEKPEGRPT-------FA-ELLR---AV-------------
---F-TLGRMLGKGEFGSVREAQLK----QEDGSFVKVAVKMLK-A-DIIA--SSDIEE-FL-R-------------------------EAACMKEF--D---HPH-----VAKLVGVSL--R------SRAKGRLPIPM--VILPFMKHG--DLHAFLL-----ASRI------------------GENPFNL---PLQTLIRFMVDIACGMEYLSS--RNFIHRDLAARNCMLA--EDMTV----CVADFGLSRKI--------Y--------S--GDYY--------------RQGCASKLPVKWLALESLA------DNL--YTVQSDVWAFGVTMWEIMTRGQTP---------------YA-GI--ENAEI-YNYL-IGGNRLKQPPECM---------------------------------------------------------------EDVYD-LMYQCWSADPKQRPS-------FT-CLRME--L--------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-P--GTM--MP--EA-FL-Q-------------------------EAQIMKKL--R---HDK-----LVPLYAVVS---------EEP------IY--IVTEFMSKG--SLLDFLK-----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC----KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILQTELVTKGRVP---------------YP-GM--VNREV-LEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--GTE--KADTEE-MM-R-------------------------EAQIMHQL--D---NPY-----IVRLIGVCQ---------AEA------LM--LVMEMAGGG--PLHKFLV-----GK-----------------------REEI---PVSNVAELLHQVSMGMKYLEE--KNFVHRDLAARNVLLV--NRHYA----KISDFGLSKAL-------GA--------D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK--FSSRSDVWSYGVTMWEALSYGQKP---------------YK-KM--KGPEV-MAFI-EQGKRMECPPECP---------------------------------------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------
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