Protein Surface  Ribbon
Inhibitor SB6
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 46 kinases in KIF 1BL6A_SB6 (MAPK14, PDB code: 1BL6, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
AGC        PRKG2        203 
CAMK       BRSK1         50 
CAMK       BRSK2         19 
CMGC       CDK2           4 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
TK         FGFR2        481 
TK         FYN          271 
AGC        GRK6         186 
CMGC       GSK3B         56 
TK         HCK          241 
CMGC       MAPK10        64 
CMGC       MAPK11        24 
CMGC       MAPK12        27 
CMGC       MAPK14        24 
CMGC       MAPK8         26 
CMGC       MAPK9         26 
CAMK       MARK1         60 
CAMK       MARK2         53 
CAMK       MARK4         59 
Other      NEK1           4 
CMGC       NLK          126 
CAMK       NUAK1         55 
AGC        PDPK1         82 
CAMK       PHKG1         20 
Other      PLK1          53 
Other      PLK3          62 
AGC        PRKACA        44 
AGC        PRKACB        44 
CAMK       PRKD1        583 
CAMK       PRKD2        551 
CAMK       PRKD3        576 
AGC        PRKG1        375 
TK         PTK6         191 
AGC        RPS6KA1       62 
AGC        RPS6KA2       59 
AGC        RPS6KA3       68 
AGC        RPS6KA6       73 
STE        SLK           34 
CAMK       STK17A        61 
AGC        STK32B        23 
Other      STK36          4 
CAMK       TSSK1B        12 


----L-EIIATLGVGGFGRV---ELVKVK-------NENV---AFAMKCIRKKHIVDTK--QQ-EHVY------SEKRILEEL--CSPFIVKLYRTFKD------NKYVY--MLLEACLGG--ELWSILR----DRG-----------------SFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILD-AEGYL----KLVDFGFAKK------IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPPFSGV---DQMMTYNLILKGIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
-----YRLEKTLGKGQTGLV---KLGVHC-------ITGQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--EHPHVLKLHDVYEN------KKYLY--LVLEHVSGG--ELFDYLV----KKG-----------------RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLV---KLGVHC-------VTCQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--EHPHVLKLHDVYEN------KKYLY--LVLEHVSGG--ELFDYLV----KKG-----------------RLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----FQKVEKIGEGTYGVV---YKARNK-------LTGE---VVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
----W-DLVQTLGEGAYGEV---QLAVNR-------VTEE---AVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEV---KLAFER-------KTCK---KVAIKIISKRKFAIGS--AR-EADPALN-VETEIEILKKL--NHPCIIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
-----YDTGEELGSGQFAVV---KKCREK-------STGL---QYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--QHPNVITLHEVYEN------KTDVI--LILELVAGG--ELFDFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-----YDIGEELGSGQFAIV---KKCREK-------STGL---EYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--LHHNVITLHDVYEN------RTDVV--LILELVSGG--ELFDFLA----QKE-----------------SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANITAVSYDFDEEFFSQTS-----------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI-----------
-----YEMGEELGSGQFAIV---RKCRQK-------GTGK---EYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--RHPNIITLHDIFEN------KTDVV--LILELVSGG--ELFDFLA----EKE-----------------SLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
-----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAV---TVAVKMLK-DDAT-EKDLSD-LV-S-------EMEMMKMIG-KHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLR-----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVM----KIADFGLARDI--N--N--IDYYKKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LQLIKRLGNGQFGEV---WMGTWN--------GNT---KVAIKTLK-PGTM-SP--ES-FL-E-------EAQIMKKL--KHDKLVQLYAVVS-------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC----KIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-------------
----F-RQYRVLGKGGFGEV---CACQVR-------ATGK---MYACKKLEKKRIKKRK--GE-AMAL------NEKQILEKV--NSRFVVSLAYAYET------KDALC--LVLTLMNGG--DLKFHIYH--MGQA-----------------GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH------VPEGQTIKG---RVGTVGYMAPEVVK------NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
-----YTDTKVIGNGSFGVV---YQAKLC-------DSGE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LKLEKKLGAGQFGEV---WMATYN--------KHT---KVAVKTMK-PGSM-SV--EA-FL-A-------EANVMKTL--QHDKLVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC----KIADFGLARVI-----E--DNEYTAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
--LQG---LRPVGSGAYGSV---CSAYDA-------RLRQ---KVAVKKLSRPFQSLIH--AR-RTYR-------ELRLLKHL--KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL----RILDFGLAR--------QADEEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF-----------
-----YRDLQPVGSGAYGAV---CSAVDG-------RTGA---KVAIKKLYRPFQSELF--AK-RAYR-------ELRLLKHM--RHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE-----------------KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCEL----KILDFGLAR--------QADSEMTG---YVVTRWYRAPEVIL-----NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF-----------
-----YQNLSPVGSGAYGSV---CAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AK-RTYR-------ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL----KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------ILER---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI-----------
-----YQQLKPIGSGAQGIV---CAAFDT-------VLGI---NVAVKKLSRPFQNQTH--AK-RAYR-------ELVLLKCV--NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART------ACTNFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
-----YRLQKTIGKGNFAKV---KLARHV-------LTGR---EVAVKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--NHPNIVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV----AHG-----------------RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD-GDMNI----KIADFGFSNE------FTVGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKLLVLNPIKRGS-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------LTGK---EVAVKIIDKTQLNSSS--LQ-KLFR-------EVRIMKVL--NHPNIVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV----AHG-----------------RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNI----KIADFGFSNE------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLRTIGKGNFAKV---KLARHI-------LTGR---EVAIKIIDKTQLNPSS--LQ-KLFR-------EVRIMKGL--NHPNIVKLFEVIET------EKTLY--LVMEYASAG--EVFDYLV----SHG-----------------RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-AEANI----KIADFGFSNE------FTLGSKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GSLPFDGH---NLKELRERVLRGKYRVPFYMS---------------------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
----Y-VRLQKIGEGSFGKA---ILVKST-------EDGR---QYVIKEINISRMSSKE--RE-ESRR-------EVAVLANM--KHPNIVQYRESFEE------NGSLY--IVMDYCEGG--DLFKRINA--QKGV-----------------LFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLT-KDGTV----QLGDFGIARVL-----NSTVELART---CIGTPYYLSPEICE------NKPYNNKSDIWALGCVLYELCT-LKHAFEAG---SMKNLVLKIISGSFPPVSLHYS--------------------------------------YDLRSLVSQLFKRNPRDRPS-----VNSILEKGF-I----------
--IEP---DRPIGYGAFGVV---WSVTDP-------RDGK---RVALKKMPNVFQNLVS--CK-RVFR-------ELKMLCFF--KHDNVLSALDILQPPH-IDYFEEIY--VVTELMQS---DLHKIIV----SPQ-----------------PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVL----KICDFGLARVE----ELDESRHMTQ---EVVTQYYRAPEILM-----GSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL-----------
-----YELQETLGKGTYGKV---KRATER-------FSGR---VVAIKSIRKDKIKDEQ--DM-VHIR------REIEIMSSL--NHPHIISIYEVFEN------KDKIV--IIMEYASKG--ELYDYIS----ERR-----------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI----KIADFGLSNL------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP----------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
----F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIHK-------PTSQ---EYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SGHPNIIQLKDTYET------NTFFF--LVFDLMKRG--ELFDYLT----EKV-----------------TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
---YV--RGRFLGKGGFAKC---FEISDA-------DTKE---VFAGKIVPKSLLLKPH--QR-EKMS------MEISIHRSL--AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS------KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
---YL--KGRLLGKGGFARC---YEATDT-------ETGS---AYAVKVIPQSRVAKPH--QR-EKIL------NEIELHRDL--QHRHIVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL------RQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
----F-ERIKTLGTGSFGRV---MLVKHK-------ETGN---HYAMKILDKQKVVKLK--QI-EHTL------NEKRILQAV--NFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG-----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI----QVTDFGFAK--------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF-----------
----F-ERKKTLGTGSFGRV---MLVKHK-------ATEQ---YYAMKILDKQKVVKLK--QI-EHTL------NEKRILQAV--NFPFLVRLEYAFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG-----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-HQGYI----QVTDFGFAK--------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWF-----------
---PD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKIIDKLRFPTKQ--ES-QLRN-------EVAILQNL--HHPGVVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKG-----------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVV---YGGKHR-------KTGR---DVAVKVIDKLRFPTKQ--ES-QLRN-------EVAILQSL--RHPGIVNLECMFET------PEKVF--VVMEKLHGD--MLEMILS---SEKG-----------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKVIDKMRFPTKQ--ES-QLRN-------EVAILQNL--HHPGIVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
----F-NIIDTLGVGGFGRV---ELVQLKS------EESK---TFAMKILKKRHIVDTR--QQ-EHIR------SEKQIMQGA--HSDFIVRLYRTFKD------SKYLY--MLMEACLGG--ELWTILR----DRG-----------------SFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD-HRGYA----KLVDFGFAKK------IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPPFSGP---DPMKTYNIILRGIDMIEFPKKIA-------------------------------------KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF-----------
----F-TLCRKLGSGYFGEV---FEGLWK--------DRV---QVAIKVIS-RDNL-LH-QQM-LQ-S-------EIQAMKKL--RHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DS--------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC----KVGDFGLARLI--------KEDVYLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL-------------
-----FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKATLKVRD--RV-RTKM-------ERDILADV--NHPFVVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA-----IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKATLKVRD--RV-RSKM-------ERDILAEV--NHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI----KITDFGLSKEA-----IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS---------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FELLKVLGQGSFGKV---FLVKKI-------SGSDARQLYAMKVLKKATLKVRD--RV-RTKM-------ERDILVEV--NHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI----KLTDFGLSKES-----IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS---------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKASLKVRD--RV-RTKM-------ERDILVEV--NHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS----KEV-----------------LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHI----KLTDFGLSKES-----VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS---------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
-----WEIIGELGDGAFGKV---YKAQNK-------ETSV---LAAAKVIDTKSEEELE--DY-M--V-------EIDILASC--DHPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN-----TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV-----------
--LCP---GRELGRGKFAVV---RKCIKK-------DSGK---EFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QDNPWVINLHEVYET------ASEMI--LVLEYAAGG--EIFDQCVA--DREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISPFLGN---DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL-----------
-----FQILRAIGKGSFGKV---CIVQKR-------DTKK---MYAMKYMNKQKCIERD--EV-RNVF------RELQIMQGL--EHPFLVNLWYSFQD------EEDMF--MVVDLLLGG--DLRYHLQ----QNV-----------------HFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLD-EHGHV----HITDFNIATV------VKGAERASS---MAGTKPYMAPEVFQVY-MDRGPGYSYPVDWWSLGITAYELLR-GWRPYEIHSVTPIDEILNMFKVERVHYSSTWC---------------------------------------KGMVALLRKLLTKDPESRVS----SLHDIQS----VPYL-------
-----YHVLEMIGEGSFGRV---YKGRRK-------YSAQ---VVALKFIPKLGRSEKE--LR-NLQR-------EIEIMRGL--RHPNIVHMLDSFET------DKEVV--VVTDYAEG---ELFQILE----DDG-----------------KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA-KGGGI----KLCDFGFARAM-----STNTMVLTS---IKGTPLYMSPELVE------ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI-----------
YLLGI-----NLGEGSYAKV---KSAYSE-------RLKF---NVAIKIIDRKKAPADF--LE-KFLP------REIEILAML--NHCSIIKTYEIFET-----SHGKVY--IVMELAVQG--DLLELIK----TRG-----------------ALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLD-KDFNI----KLSDFSFSKRCLR-DDSGRMALSKT---FCGSPAYAAPEVLQ-----GIPYQPKVYDIWSLGVILYIMVC-GSMPYDDS---NIKKMLRIQKEHRVNFPRSKHLT-------------------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM-----------