Protein Surface  Ribbon
Inhibitor UCM
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 97 kinases in KIF 1NVSA_UCM (CHEK1, PDB code: 1NVS, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
AGC        PRKG2        203 
AGC        AKT3         148 
Other      AURKA        133 
Other      AURKB         77 
Other      AURKC         43 
TK         BLK          241 
CAMK       BRSK1         50 
CAMK       BRSK2         19 
CAMK       CAMK2A        13 
CAMK       CAMK2B        14 
CAMK       CAMK2D        14 
CAMK       CAMK2G        14 
Other      CAMKK1       128 
Other      CAMKK2       165 
CMGC       CDC2           4 
CMGC       CDK2           4 
CMGC       CDK4           6 
CMGC       CDK5           4 
CMGC       CDK6          13 
CMGC       CDK9       2.7.11.23 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
CMGC       CSNK2A1       39 
CMGC       CSNK2A2       40 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
CMGC       GSK3A        119 
CMGC       GSK3B         56 
TK         HCK          241 
Other      IKBKE          9 
TKL        IRAK4        186 
TK         JAK1         875 
TKL        LIMK1        339 
TK         LYN          247 
STE        MAP3K2       356 
STE        MAP3K3       362 
CAMK       MAPKAPK2      64 
CAMK       MARK1         60 
CAMK       MARK2         53 
CAMK       MARK3         56 
CAMK       MARK4         59 
CAMK       MKNK2         84 
Other      NEK4           6 
Other      NEK8           4 
TK         NTRK1        510 
TK         NTRK2        538 
TK         NTRK3        538 
CAMK       NUAK1         55 
STE        PAK1         270 
STE        PAK2         249 
STE        PAK3         268 
CAMK       PASK         999 
AGC        PDPK1         82 
CAMK       PHKG1         20 
CAMK       PIM1          38 
CAMK       PIM2         132 
CAMK       PIM3          40 
AGC        PKN1         615 
AGC        PKN2         657 
AGC        PRKACA        44 
AGC        PRKACG        44 
AGC        PRKCA        339 
AGC        PRKCB        342 
AGC        PRKCD        349 
AGC        PRKCE        408 
AGC        PRKCH        355 
AGC        PRKCQ        380 
CAMK       PRKD1        583 
CAMK       PRKD2        551 
CAMK       PRKD3        576 
AGC        PRKG1        375 
AGC        PRKX          49 
AGC        RPS6KA1       62 
AGC        RPS6KA2       59 
AGC        RPS6KA3       68 
AGC        RPS6KA4       33 
AGC        RPS6KA5       49 
AGC        RPS6KA6       73 
AGC        RPS6KB1       91 
AGC        RPS6KB2       67 
AGC        SGK1          98 
AGC        SGK2          35 
CAMK       SIK2          20 
STE        SLK           34 
STE        STK10         36 
CAMK       STK17A        61 
STE        STK24         24 
STE        STK25         20 
CAMK       STK33        116 
AGC        STK38         89 
Other      TBK1           9 
Other      TLK2         440 
CAMK       TSSK1B        12 
Other      ULK3          14 


----L-EIIATLGVGGFGRV---ELVKV---K-----NENV---AFAMKCIRKKH-IVD---TK--Q-Q-EHVY------------------------SEKRI-L-EEL-C----SPF--IVKLYRTFK-D--------NKY--VY--MLLEA-CLGG--ELWSILR-----------------------DRG-----------------SFDEPTSKFCVACVTEAFDYLHR-L--GIIYRDLKPENLI--LD--AEGYL---------KLVDFGFAKK------------------------------------IGSGQKT--------------WT---FCGTPEYVAPEVIL--------NKG--HDFSVDFWSLGILVYELLT-GNPP--------------FS-GV---------------DQMMTYNLILKGIEKMDFPRKIT--------------------------------RRPED-LIRRLCRQNPTERLGNL--KNGIN-DIKKHRWL-------------------------------------------------------
---FD--YLKLLGKGTFGKV---ILVRE---K-----ASGK---YYAMKILKKEV-IIA---KD--E-V-AHTL------------------------TESRV-L-KNT-R----HPF--LTSLKYSFQ-T--------KDR--LC--FVMEY-VNGG--ELFFHLS-----------------------RER-----------------VFSEDRTRFYGAEIVSALDYLHS-G--KIVYRDLKLENLM--LD--KDGHI---------KITDFGLCKEG-----------------------------------ITDAATM--------------KT---FCGTPEYLAPEVLE--------DND--YGRAVDWWGLGVVMYEMMC-GRLP--------------FY-NQ---------------DHEKLFELILMEDIKFPRTLS----------------------------------SDAKS-LLSGLLIKDPNKRLGGG--PDDAK-EIMRHSFF-------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLARE---K-----QSKF---ILALKVLFKAQLEKA---GV--E-H-QLRR-------------------------EVEI-Q-SHL-R----HPN--ILRLYGYFH-D--------ATR--VY--LILEY-APLG--TVYRELQ-----------------------KLS-----------------KFDEQRTATYITELANALSYCHS-K--RVIHRDIKPENLL--LG--SAGEL---------KIADFGWSV-------------------------------------HAPSSRR--------------TT---LCGTLDYLPPEMIE--------GRM--HDEKVDLWSLGVLCYEFLV-GKPP--------------FE-AN---------------TYQETYKRISRVEFTFPDFVT----------------------------------EGARD-LISRLLKHNPSQRPM-------LR-EVLEHPWI-------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLARE---K-----KSHF---IVALKVLFKSQ-IEK---EG--V-E-HQLR------------------------REIEI-Q-AHL-H----HPN--ILRLYNYFY-D--------RRR--IY--LILEY-APRG--ELYKELQ-----------------------KSC-----------------TFDEQRTATIMEELADALMYCHG-K--KVIHRDIKPENLL--LG--LKGEL---------KIADFGWSV-------------------------------------HAPSLRR--------------KT---MCGTLDYLPPEMIE--------GRM--HNEKVDLWCIGVLCYELLV-GNPP--------------FE-SA---------------SHNETYRRIVKVDLKFPASVP----------------------------------MGAQD-LISKLLRHNPSERLP-------LA-QVSAHPWV-------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLARL---K-----ESHF---IVALKVLFKSQ-IEK---EG--L-E-HQLR------------------------REIEI-Q-AHL-Q----HPN--ILRLYNYFH-D--------ARR--VY--LILEY-APRG--ELYKELQ-----------------------KSE-----------------KLDEQRTATIIEELADALTYCHD-K--KVIHRDIKPENLL--LG--FRGEV---------KIADFGWSV-------------------------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE--------GRT--YDEKVDLWCIGVLCYELLV-GYPP--------------FE-SA---------------SHSETYRRILKVDVRFPLSMP----------------------------------LGARD-LISRLLRYQPLERLP-------LA-QILKHPWV-------------------------------------------------------
----L-RLVRKLGSGQFGEV---WMGYY---K------NNM---KVAIKTLK-EG-TM----SP--E-A-FL-G-------------------------EANV-M-KAL-Q----HER--LVRLYAVVT----------KEP--IY--IVTEY-MARG--CLLDFLK------------------------TD--------------EGSRLSLPRLIDMSAQIAEGMAYIER-M--NSIHRDLRAANIL--VS--EALCC---------KIADFGLARII--------------------------------------DSEY--------------TAQEGAKFPIKWTAPEAIH--------FGV--FTIKADVWSFGVLLMEVVTYGRVP--------------YP-GM------------SNPEVIRNLERGYRMPRPDTCP------------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L-------------------------------------------------------
-----YRLEKTLGKGQTGLV---KLGVH---C-----ITGQ---KVAIKIVNREK-LSE---SV--L-M-KVER-------------------------EIAI-L-KLI-E----HPH--VLKLHDVYE-N--------KKY--LY--LVLEH-VSGG--ELFDYLV-----------------------KKG-----------------RLTPKEARKFFRQIVSALDFCHS-Y--SICHRDLKPENLL--LD--EKNNI---------RIADFGMASL------------------------------------QVGDSLL--------------ET---SCGSPHYACPEVIK-------GEKY--DGRRADMWSCGVILFALLV-GALP--------------FD-DD---------------NLRQLLEKVKRGVFHMPHFIP----------------------------------PDCQS-LLRGMIEVEPEKRLS-------LE-QIQKHPW-Y------------------------------------------------------
-----YRLEKTLGKGQTGLV---KLGVH---C-----VTCQ---KVAIKIVNREK-LSE---SV--L-M-KVER-------------------------EIAI-L-KLI-E----HPH--VLKLHDVYE-N--------KKY--LY--LVLEH-VSGG--ELFDYLV-----------------------KKG-----------------RLTPKEARKFFRQIISALDFCHS-H--SICHRDLKPENLL--LD--EKNNI---------RIADFGMASL------------------------------------QVGDSLL--------------ET---SCGSPHYACPEVIR-------GEKY--DGRKADVWSCGVILFALLV-GALP--------------FD-DD---------------NLRQLLEKVKRGVFHMPHFIP----------------------------------PDCQS-LLRGMIEVDAARRLT-------LE-HIQKHIW-Y------------------------------------------------------
-----YQLFEELGKGAFSVV---RRCVK---V-----LAGQ---EYAAKIINTKK-LSA---RD--H-Q-KLER-------------------------EARI-C-RLL-K----HPN--IVRLHDSIS-E--------EGH--HY--LIFDL-VTGG--ELFEDIV-----------------------ARE-----------------YYSEADASHCIQQILEAVLHCHQ-M--GVVHRDLKPENLL--LA--SKLKGA------AVKLADFGLAIEV-----------------------------------EGEQQAW--------------FG---FAGTPGYLSPEVLR--------KDP--YGKPVDLWACGVILYILLV-GYPP--------------FW-DE---------------DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKD-LINKMLTINPSKRIT-------AA-EALKHPWI-------------------------------------------------------
-----YQLYEDIGKGAFSVV---RRCVK---L-----CTGH---EYAAKIINTKK-LSA---RD--H-Q-KLER-------------------------EARI-C-RLL-K----HSN--IVRLHDSIS-E--------EGF--HY--LVFDL-VTGG--ELFEDIV-----------------------ARE-----------------YYSEADASHCIQQILEAVLHCHQ-M--GVVHRDLKPENLL--LA--SKCKGA------AVKLADFGLAIEV-----------------------------------QGDQQAW--------------FG---FAGTPGYLSPEVLR--------KEA--YGKPVDIWACGVILYILLV-GYPP--------------FW-DE---------------DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKN-LINQMLTINPAKRIT-------AH-EALKHPWV-------------------------------------------------------
-----YQLFEELGKGAFSVV---RRCMK---I-----PTGQ---EYAAKIINTKK-LSA---RD--H-Q-KLER-------------------------EARI-C-RLL-K----HPN--IVRLHDSIS-E--------EGF--HY--LVFDL-VTGG--ELFEDIV-----------------------ARE-----------------YYSEADASHCIQQILESVNHCHL-N--GIVHRDLKPENLL--LA--SKSKGA------AVKLADFGLAIEV-----------------------------------QGDQQAW--------------FG---FAGTPGYLSPEVLR--------KDP--YGKPVDMWACGVILYILLV-GYPP--------------FW-DE---------------DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKD-LINKMLTINPAKRIT-------AS-EALKHPWI-------------------------------------------------------
-----YQLFEELGKGAFSVV---RRCVK---K-----TSTQ---EYAAKIINTKK-LSA---RD--H-Q-KLER-------------------------EARI-C-RLL-K----HPN--IVRLHDSIS-E--------EGF--HY--LVFDL-VTGG--ELFEDIV-----------------------ARE-----------------YYSEADASHCIHQILESVNHIHQ-H--DIVHRDLKPENLL--LA--SKCKGA------AVKLADFGLAIEV-----------------------------------QGEQQAW--------------FG---FAGTPGYLSPEVLR--------KDP--YGKPVDIWACGVILYILLV-GYPP--------------FW-DE---------------DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKN-LINQMLTINPAKRIT-------AD-QALKHPWV-------------------------------------------------------
-----YKLQSEIGKGAYGVV---RLAYN---E-----SEDR---HYAMKVLSKKK-LLK---QY--G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAI-L-KKL-D----HVN--VVKLIEVLD-DP------AEDN--LY--LVFDL-LRKG--PVMEVPC------------------------DK-----------------PFSEEQARLYLRDVILGLEYLHC-Q--KIVHRDIKPSNLL--LG--DDGHV---------KIADFGVSNQF-----------------------------------EGNDAQL--------------SS---TAGTPAFMAPEAISD-----SGQSF--SGKALDVWATGVTLYCFVY-GKCP--------------FI-DD---------------FILALHRKIKNEPVVFPEEPEIS--------------------------------EELKD-LILKMLDKNPETRIG-------VP-DIKLHPWV-------------------------------------------------------
-----YTLKDEIGKGSYGVV---KLAYN---E-----NDNT---YYAMKVLSKKK-LIR---QA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAI-L-KKL-D----HPN--VVKLVEVLD-DP------NEDH--LY--MVFEL-VNQG--PVMEVPT------------------------LK-----------------PLSEDQARFYFQDLIKGIEYLHY-Q--KIIHRDIKPSNLL--VG--EDGHI---------KIADFGVSNEF-----------------------------------KGSDALL--------------SN---TVGTPAFMAPESLS-------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP--------------FM-DE---------------RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKD-LITRMLDKNPESRIV-------VP-EIKLHPWV-------------------------------------------------------
-----YTKIEKIGEGTYGVV---YKGRH---K-----TTGQ---VVAMKKIRLES-EEE---GV--P-S-TAIR-------------------------EISL-L-KEL-R----HPN--IVSLQDVLM-Q--------DSR--LY--LIFEF-LSM---DLKKYLDS--------------------IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHS-R--RVLHRDLKPQNLL--ID--DKGTI---------KLADFGLARAF-----------------------------------GIPIRVY--------------TH---EVVTLWYRSPEVLL-------GSAR--YSTPVDIWSIGTIFAELAT-KKPL--------------FH-GD------------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GK-MALNHPYF-------------------------------------------------------
-----FQKVEKIGEGTYGVV---YKARN---K-----LTGE---VVALKKIRLDT-ETE---GV--P-S-TAIR-------------------------EISL-L-KEL-N----HPN--IVKLLDVIH-T--------ENK--LY--LVFEF-LHQ---DLKKFMDA---------------------SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-H--RVLHRDLKPQNLL--IN--TEGAI---------KLADFGLARAF-----------------------------------GVPVRTY--------------TH---EVVTLWYRAPEILL-------GCKY--YSTAVDIWSLGCIFAEMVT-RRAL--------------FP-GD------------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF-------------------------------------------------------
----Y-EPVAEIGVGAYGTV---YKARD---P-----HSGH---FVALKSVRVPN-GGGGGGGL--P-I-STVR-------------------------EVAL-L-RRL-EA-FEHPN--VVRLMDVCA-TSR---TDREIK--VT--LVFEH-VDQ---DLRTYLDK---------------------APPP-----------------GLPAETIKDLMRQFLRGLDFLHA-N--CIVHRDLKPENIL--VT--SGGTV---------KLADFGLARI------------------------------------YSYQMAL--------------TP---VVVTLWYRAPEVLL--------QST--YATPVDMWSVGCIFAEMFR-RKPL--------------FC-GN------------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-------AF-RALQHSYL-------------------------------------------------------
-----YEKLEKIGEGTYGTV---FKAKN---R-----ETHE---IVALKRVRLDD-DDE---GV--P-S-SALR-------------------------EICL-L-KEL-K----HKN--IVRLHDVLH-S--------DKK--LT--LVFEF-CDQ---DLKKYFD----------------------SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHS-R--NVLHRDLKPQNLL--IN--RNGEL---------KLADFGLARAF-----------------------------------GIPVRCY--------------SA---EVVTLWYRPPDVLF-------GAKL--YSTSIDMWSAGCIFAELANAGRPL--------------FP-GN------------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-------AE-EALQHPYF-------------------------------------------------------
-----YECVAEIGEGAYGKV---FKARD---L-----KNGG--RFVALKRVRVQT-GEE---GM--P-L-STIR-------------------------EVAV-L-RHL-ET-FEHPN--VVRLFDVCT-VSR---TDRETK--LT--LVFEH-VDQ---DLTTYLDK---------------------VPEP-----------------GVPTETIKDMMFQLLRGLDFLHS-H--RVVHRDLKPQNIL--VT--SSGQI---------KLADFGLARI------------------------------------YSFQMAL--------------TS---VVVTLWYRAPEVLL--------QSS--YATPVDLWSVGCIFAEMFR-RKPL--------------FR-GS------------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-------AY-SALSHPYF-------------------------------------------------------
-----YEKLAKIGQGTFGEV---FKARH---R-----KTGQ---KVALKKVLMEN-EKE---GF--P-I-TALR-------------------------EIKI-L-QLL-K----HEN--VVNLIEICR-TKASPYNRCKGS--IY--LVFDF-CEH---DLAGLLS----------------------NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHR-N--KILHRDMKAANVL--IT--RDGVL---------KLADFGLARAFSL-------------------------------AKNSQPNRY--------------TN---RVVTLWYRPPELLL-------GERD--YGPPIDLWGAGCIMAEMWT-RSPI--------------MQ-GN------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK-----RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-------SD-DALNHDFF-------------------------------------------------------
----W-DLVQTLGEGAYGEV---QLAVN---R-----VTEE---AVAVKIVDMKR-AVD---CP--E-N-I-KK-------------------------EICI-N-KML-N----HEN--VVKFYGHRR-E--------GNI--QY--LFLEY-CSGG--ELFDRIE-----------------------PDI-----------------GMPEPDAQRFFHQLMAGVVYLHG-I--GITHRDIKPENLL--LD--ERDNL---------KISDFGLATVFR---------------------------------YNNRERLL--------------NK---MCGTLPYVAPELLK-------RREF--HAEPVDVWSCGIVLTAMLA-GELP--------------WD-QP--------------SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLA-LLHKILVENPSARIT-------IP-DIKKDRW-Y------------------------------------------------------
---YI--MSKTLGSGACGEV---KLAFE---R-----KTCK---KVAIKIISKRK-FAI---GS--A-R-EADPALN-------------------VETEIEI-L-KKL-N----HPC--IIKIKNFF--D--------AED--YY--IVLEL-MEGG--ELFDKVV-----------------------GNK-----------------RLKEATCKLYFYQMLLAVQYLHE-N--GIIHRDLKPENVL--LS--SQEEDC------LIKITDFGHSKI------------------------------------LGETSLM--------------RT---LCGTPTYLAPEVLVS-----VGTAG--YNRAVDCWSLGVILFICLS-GYPP--------------FS-EH--------------RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALD-LVKKLLVVDPKARFT-------TE-EALRHPWL-------------------------------------------------------
-----YQLVRKLGRGKYSEV---FEAIN---I-----TNNE---KVVVKILKPVK-KKK---IK--R--------------------------------EIKI-L-ENLRG----GPN--IITLADIVK-DP------VSRT--PA--LVFEH-VNNT--DFKQLY--------------------------Q-----------------TLTDYDIRFYMYEILKALDYCHS-M--GIMHRDVKPHNVM--ID-HEHRKL---------RLIDWGLAEF------------------------------------YHPGQEY--------------NV---RVASRYFKGPELLV-------DYQM--YDYSLDMWSLGCMLASMIF-RKEP--------------FFHGH------------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT-------AR-EAMEHPYF-------------------------------------------------------
-----YQLVRKLGRGKYSEV---FEAIN---I-----TNNE---RVVVKILKPVK-KKK---IK--R--------------------------------EVKI-L-ENLRG----GTN--IIKLIDTVK-DP------VSKT--PA--LVFEY-INNT--DFKQLY--------------------------Q-----------------ILTDFDIRFYMYELLKALDYCHS-K--GIMHRDVKPHNVM--ID-HQQKKL---------RLIDWGLAEF------------------------------------YHPAQEY--------------NV---RVASRYFKGPELLV-------DYQM--YDYSLDMWSLGCMLASMIF-RREP--------------FFHGQ------------DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-------AK-EAMEHPYF-------------------------------------------------------
-----YDTGEELGSGQFAVV---KKCRE---K-----STGL---QYAAKFIKKRR-TKS---SR--R-G-VSREDI---------------------EREVSI-L-KEI-Q----HPN--VITLHEVYE-N--------KTD--VI--LILEL-VAGG--ELFDFLA-----------------------EKE-----------------SLTEEEATEFLKQILNGVYYLHS-L--QIAHFDLKPENIM--LL--DRNVPKP-----RIKIIDFGLAHK------------------------------------IDFGNEF--------------KN---IFGTPEFVAPEIVN--------YEP--LGLEADMWSIGVITYILLS-GASP--------------FL-GD---------------TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKD-FIRRLLVKDPKKRMT-------IQ-DSLQHPWI-------------------------------------------------------
-----YDIGEELGSGQFAIV---KKCRE---K-----STGL---EYAAKFIKKRQ-SRA---SR--R-G-VSREEI---------------------EREVSI-L-RQV-L----HHN--VITLHDVYE-N--------RTD--VV--LILEL-VSGG--ELFDFLA-----------------------QKE-----------------SLSEEEATSFIKQILDGVNYLHT-K--KIAHFDLKPENIM--LL--DKNIPIP-----HIKLIDFGLAHE------------------------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN--------YEP--LGLEADMWSIGVITYILLS-GASP--------------FL-GD---------------TKQETLANITAVSYDFDEEFFSQTS------------------------------ELAKD-FIRKLLVKETRKRLT-------IQ-EALRHPWI-------------------------------------------------------
-----YEMGEELGSGQFAIV---RKCRQ---K-----GTGK---EYAAKFIKKRR-LSS---SR--R-G-VSREEI---------------------EREVNI-L-REI-R----HPN--IITLHDIFE-N--------KTD--VV--LILEL-VSGG--ELFDFLA-----------------------EKE-----------------SLTEDEATQFLKQILDGVHYLHS-K--RIAHFDLKPENIM--LL--DKNVPNP-----RIKLIDFGIAHK------------------------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN--------YEP--LGLEADMWSIGVITYILLS-GASP--------------FL-GE---------------TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKD-FIRRLLVKDPKRRMT-------IA-QSLEHSWI-------------------------------------------------------
-----YTDIKVIGNGSFGVV---YQARL---A-----ETRE---LVAIKKVLQDK-RFK---NR-----------------------------------ELQI-M-RKL-D----HCN--IVRLRYFFY-SSG----EKKDE--LYLNLVLEY-VPETVYRVARHFT----------------------KAKL-----------------TIPILYVKVYMYQLFRSLAYIHS-Q--GVCHRDIKPQNLL--VD-PDTAVL---------KLCDFGSAKQ------------------------------------LVRGEPN--------------VS---YICSRYYRAPELIF-------GATD--YTSSIDVWSAGCVLAELLL-GQPI--------------FP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-------PL-EACAHSFF-------------------------------------------------------
-----YTDTKVIGNGSFGVV---YQAKL---C-----DSGE---LVAIKKVLQDK-RFK---NR-----------------------------------ELQI-M-RKL-D----HCN--IVRLRYFFY-SSG----EKKDE--VYLNLVLDY-VPETVYRVA---RHY-------------------SRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHS-F--GICHRDIKPQNLL--LD-PDTAVL---------KLCDFGSAKQ------------------------------------LVRGEPN--------------VS---YICSRYYRAPELIF-------GATD--YTSSIDVWSAGCVLAELLL-GQPI--------------FP-GD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-------PL-EACAHSFF-------------------------------------------------------
-----LKLEKKLGAGQFGEV---WMATY---N------KHT---KVAVKTMK-PG-SM----SV--E-A-FL-A-------------------------EANV-M-KTL-Q----HDK--LVKLHAVVT----------KEP--IY--IITEF-MAKG--SLLDFLK------------------------SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-R--NYIHRDLRAANIL--VS--ASLVC---------KIADFGLARVI-----------------------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN--------FGS--FTIKSDVWSFGILLMEIVTYGRIP--------------YP-GM------------SNPEVIRALERGYRMPRPENCP------------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L-------------------------------------------------------
----W-HTDDLLGQGATASV---YKARN---K-----KSGE---LVAVKVFNTTS-YLR---PR--E-V--QVR-------------------------EFEV-L-RKL-N----HQN--IVKLFAVEE-TG------GSRQ--KV--LVMEY-CSSG--SLLSVLES--------------------PENAF-----------------GLPEDEFLVVLRCVVAGMNHLRE-N--GIVHRDIKPGNIMRLVG--EEGQSI-------YKLTDFGAARE------------------------------------LDDDEKF--------------VS---VYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT-GSLP--------------FI-PF-----------GGPRRNKEIMYRITTEKPAGAIA---------------------------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
--VGG----NKMGEGGFGVV---YKGYV---N-----NTT-----VAVKKLAAMV-DIT---TE--ELK-QQFD------------------------QEIKV-M-AKC-Q----HEN--LVELLGFSS-D--------GDD--LC--LVYVY-MPNG--SLLDRLSC--------------------LDGTP-----------------PLSWHMRCKIAQGAANGINFLHE-N--HHIHRDIKSANIL--LD--EAFTA---------KISDFGLARASE---------------------------------KFAQTVMT--------------SR---IVGTTAYMAPEALR---------GE--ITPKSDIYSFGVVLLEIIT-GLPA--------------VD-EH------------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------------STSVEAMYS-VASQCLHEKKNKRPD-------IK-KVQQ----LLQ----------------------------------------------------
----L-KRIRDLGEGHFGKV---ELCRY---DP-EGDNTGE---QVAVKSLK-PE-SG----GNHIA-D-LK-K-------------------------EIEI-L-RNL-Y----HEN--IVKYKGICTED---------GGNGIK--LIMEF-LPSG--SLKEYLP------------------------KN---------------KNKINLKQQLKYAVQICKGMDYLGS-R--QYVHRDLAARNVL--VE--SEHQV---------KIGDFGLTKAI------------ET---------------------D--KEYY--------------TVKDDRDSPVFWYAPECLM--------QSK--FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHG-QM------------TVTRLVNTLKEGKRLPCPPNCP------------------------------------DEVYQ-LMRKCWEFQPSNRTS-------FQ-NLIE---GF------------------------------------------------------
---LI--HGEVLGKGCFGQA---IKVTH---R-----ETGE---VMVMKELI--R-FD----EETQR-T-FL-K-------------------------EVKV-M-RCL-E----HPN--VLKFIGVLY-K--------DKR--LN--FITEY-IKGG--TLRGIIK------------------------SM---------------DSQYPWSQRVSFAKDIASGMAYLHS-M--NIIHRDLNSHNCL--VR--ENKNV---------VVADFGLARLM-------------V---------------------D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN--------GRS--YDEKVDVFSFGIVLCEIIGRVNAD--------------PD-YL-P----------RTMDFGLNVRGFLDRYCPPNCP------------------------------------PSFFP-ITVRCCDLDPEKRPS-------FV-KLEH---WL------------------------------------------------------
-----IKLVKRLGAGQFGEV---WMGYY---N------NST---KVAVKTLK-PG-TM----SV--Q-A-FL-E-------------------------EANL-M-KTL-Q----HDK--LVRLYAVVT-R--------EEP--IY--IITEY-MAKG--SLLDFLK------------------------SD--------------EGGKVLLPKLIDFSAQIAEGMAYIER-K--NYIHRDLRAANVL--VS--ESLMC---------KIADFGLARVI-----------------------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN--------FGC--FTIKSDVWSFGILLYEIVTYGKIP--------------YP-GR------------TNADVMTALSQGYRMPRVENCP------------------------------------DELYD-IMKMCWKEKAEERPT-------FD-YLQSV--L-------------------------------------------------------
-----WRLGKLLGQGAFGRV---YLCYD---V-----DTGR---ELAVKQVQFDP-DSP---ET--S-K-EVNAL----------------------ECEIQL-L-KNL-L----HER--IVQYYGCLR-DP------QEKT--LS--IFMEY-MPGG--SIKDQLK-----------------------AYG-----------------ALTENVTRKYTRQILEGVHYLHS-N--MIVHRDIKGANIL--RD--STGNV---------KLGDFGASKRLQ--------------------------------TICLSGTGM--------------KS---VTGTPYWMSPEVIS--------GEG--YGRKADIWSVACTVVEMLT-EKPP--------------WA-EF---------------EAMAAIFKIATQPTNPKLPPHVS--------------------------------DYTRD-FLKRIFV-EAKLRPS-------AD-ELLRHMF-V------------------------------------------------------
----W-RRGKLLGQGAFGRV---YLCYD---V-----DTGR---ELASKQVQFDP-DSP---ET--S-K-EVSAL----------------------ECEIQL-L-KNL-Q----HER--IVQYYGCLR-DR------AEKT--LT--IFMEY-MPGG--SVKDQLK-----------------------AYG-----------------ALTESVTRKYTRQILEGMSYLHS-N--MIVHRDIKGANIL--RD--SAGNV---------KLGDFGASKRLQ--------------------------------TICMSGTGM--------------RS---VTGTPYWMSPEVIS--------GEG--YGRKADVWSLGCTVVEMLT-EKPP--------------WA-EY---------------EAMAAIFKIATQPTNPQLPSHIS--------------------------------EHGRD-FLRRIFV-EARQRPS-------AE-ELLTHHF-A------------------------------------------------------
--KVT---SQVLGLGINGKV---LQIFN---K-----RTQE---KFALKMLQDCP-KAR--------------R-------------------------EVEL-H-WRASQ----CPH--IVRIVDVYE-NLY----AGRKC--LL--IVMEC-LDGG--ELFSRIQD---------------------RGDQ-----------------AFTEREASEIMKSIGEAIQYLHS-I--NIAHRDVKPENLL--YT--SKRPNA------ILKLTDFGFAKE------------------------------------TTSHNSL--------------TT---PCYTPYYVAPEVLG--------PEK--YDKSCDMWSLGVIMYILLC-GYPP--------------FY-SN-----------HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKM-LIRNLLKTEPTQRMT-------IT-EFMNHPWI-------------------------------------------------------
-----YRLQKTIGKGNFAKV---KLARH---V-----LTGR---EVAVKIIDKTQ-LNP---TS--L-Q-KLFR-------------------------EVRI-M-KIL-N----HPN--IVKLFEVIE-T--------EKT--LY--LVMEY-ASGG--EVFDYLV-----------------------AHG-----------------RMKEKEARAKFRQIVSAVQYCHQ-K--YIVHRDLKAENLL--LD--GDMNI---------KIADFGFSNE------------------------------------FTVGNKL--------------DT---FCGSPPYAAPELFQ-------GKKY--DGPEVDVWSLGVILYTLVS-GSLP--------------FD-GQ---------------NLKELRERVLRGKYRIPFYMS----------------------------------TDCEN-LLKKLLVLNPIKRGS-------LE-QIMKDRWM-------------------------------------------------------
-----YRLLKTIGKGNFAKV---KLARH---I-----LTGK---EVAVKIIDKTQ-LNS---SS--L-Q-KLFR-------------------------EVRI-M-KVL-N----HPN--IVKLFEVIE-T--------EKT--LY--LVMEY-ASGG--EVFDYLV-----------------------AHG-----------------RMKEKEARAKFRQIVSAVQYCHQ-K--FIVHRDLKAENLL--LD--ADMNI---------KIADFGFSNE------------------------------------FTFGNKL--------------DT---FCGSPPYAAPELFQ-------GKKY--DGPEVDVWSLGVILYTLVS-GSLP--------------FD-GQ---------------NLKELRERVLRGKYRIPFYMS----------------------------------TDCEN-LLKKFLILNPSKRGT-------LE-QIMKDRWM-------------------------------------------------------
-----YRLLKTIGKGNFAKV---KLARH---I-----LTGR---EVAIKIIDKTQ-LNP---TS--L-Q-KLFR-------------------------EVRI-M-KIL-N----HPN--IVKLFEVIE-T--------EKT--LY--LIMEY-ASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QVSFDLLSLMFTFIVSAVQYCHQ-K--RIVHRDLKAENLL--LD--ADMNI---------KIADFGFSNE------------------------------------FTVGGKL--------------DT---FCGSPPYAAPELFQ-------GKKY--DGPEVDVWSLGVILYTLVS-GSLP--------------FD-GQ---------------NLKELRERVLRGKYRIPFYMS----------------------------------TDCEN-LLKRFLVLNPIKRGT-------LE-QIMKDRWI-------------------------------------------------------
-----YRLLRTIGKGNFAKV---KLARH---I-----LTGR---EVAIKIIDKTQ-LNP---SS--L-Q-KLFR-------------------------EVRI-M-KGL-N----HPN--IVKLFEVIE-T--------EKT--LY--LVMEY-ASAG--EVFDYLV-----------------------SHG-----------------RMKEKEARAKFRQIVSAVHYCHQ-K--NIVHRDLKAENLL--LD--AEANI---------KIADFGFSNE------------------------------------FTLGSKL--------------DT---FCGSPPYAAPELFQ-------GKKY--DGPEVDIWSLGVILYTLVS-GSLP--------------FD-GH---------------NLKELRERVLRGKYRVPFYMS----------------------------------TDCES-ILRRFLVLNPAKRCT-------LE-QIMKDKWI-------------------------------------------------------
-QLQE----DVLGEGAHARV---QTCIN---L-----ITSQ---EYAVKIIEKQP-GHI---RS--R----VFR-------------------------EVEM-L-YQCQG----HRN--VLELIEFFE-E--------EDR--FY--LVFEK-MRGG--SILSHIH-----------------------KRR-----------------HFNELEASVVVQDVASALDFLHN-K--GIAHRDLKPENIL--CE--HPNQVS------PVKICDFDLGSGIKLN----------------------------GDCSPISTPEL--------------LT---PCGSAEYMAPEVVEAF---SEEASI--YDKRCDLWSLGVILYILLS-GYPP--------------FV-GRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS------------------------------CAAKD-LISKLLVRDAKQRLS-------AA-QVLQHPWV-------------------------------------------------------
----Y-CYLRVVGKGSYGEV---TLVKH---R-----RDGK---QYVIKKLNLRN-ASS---RE--R-R-AAEQ-------------------------EAQL-L-SQL-K----HPN--IVTYKESWE-G-------GDGL--LY--IVMGF-CEGG--DLYRKLKE---------------------QKGQ-----------------LLPENQVVEWFVQIAMALQYLHE-K--HILHRDLKTQNVF--LT--RTNII---------KVGDLGIARVL-----------------------------------ENHCDMA--------------ST---LIGTPYYMSPELFS--------NKP--YNYKSDVWALGCCVYEMAT-LKHA--------------FN-AK---------------DMNSLVYRIIEGKLPPMPRDY---S------------------------------PELAE-LIRTMLSKRPEERPS-------VR-SILRQPYI-------------------------------------------------------
-----YERIRVVGRGAFGIV---HLCLR---K-----ADQK---LVIIKQIPVEQ-MTK---EE--R-Q-AAQN-------------------------ECQV-L-KLL-N----HPN--VIEYYENFL-E--------DKA--LM--IAMEY-APGG--TLAEFIQK---------------------RCNS-----------------LLEEETILHFFVQILLALHHVHT-H--LILHRDLKTQNIL--LD-KHRMVV---------KIGDFGISKI------------------------------------LSSKSKA--------------YT---VVGTPCYISPELCE--------GKP--YNQKSDIWALGCVLYELAS-LKRA--------------FE-AA---------------NLPALVLKIMSGTFAPISDRY---S------------------------------PELRQ-LVLSLLSLEPAQRPP-------LS-HIMAQP--LC-----------------------------------------------------
---IV--LKWELGEGAFGKV---FLAEC---HNLLPEQDKM---LVAVKALK-EA-SE----SA-RQ-D-FQ-R-------------------------EAEL-L-TML-Q----HQH--IVRFFGVCT-E--------GRP--LL--MVFEY-MRHG--DLNRFLR------------------------SHGPDAKL-LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG-L--HFVHRDLATRNCL--VG--QGLVV---------KIGDFGMSRDI-------------Y---------------------S--TDYY--------------RVGGRTMLPIRWMPPESIL--------YRK--FTTESDVWSFGVVLWEIFTYGKQP--------------WY-QL------------SNTEAIDCITQGRELERPRACP------------------------------------PEVYA-IMRGCWQREPQQRHS-------IK-DVHARL---------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAEC---YNLCPEQDKI---LVAVKTLK-DA-SD----NA-RK-D-FH-R-------------------------EAEL-L-TNL-Q----HEH--IVKFYGVCV-E--------GDP--LI--MVFEY-MKHG--DLNKFLR------------------------AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS-Q--HFVHRDLATRNCL--VG--ENLLV---------KIGDFGMSRDV-------------Y---------------------S--TDYY--------------RVGGHTMLPIRWMPPESIM--------YRK--FTTESDVWSLGVVLWEIFTYGKQP--------------WY-QL------------SNNEVIECITQGRVLQRPRTCP------------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L-------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAEC---YNLSPTKDKM---LVAVKALK-DP-TL----AA-RK-D-FQ-R-------------------------EAEL-L-TNL-Q----HEH--IVKFYGVCG-D--------GDP--LI--MVFEY-MKHG--DLNKFLR------------------------AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS-Q--HFVHRDLATRNCL--VG--ANLLV---------KIGDFGMSRDV-------------Y---------------------S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM--------YRK--FTTESDVWSFGVILWEIFTYGKQP--------------WF-QL------------SNTEVIECITQGRVLERPRVCP------------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL---------------------------------------------------------
-----YELQETLGKGTYGKV---KRATE---R-----FSGR---VVAIKSIRKDK-IKD---EQ--D-M-VHIR------------------------REIEI-M-SSL-N----HPH--IISIYEVFE-N--------KDK--IV--IIMEY-ASKG--ELYDYIS-----------------------ERR-----------------RLSERETRHFFRQIVSAVHYCHK-N--GVVHRDLKLENIL--LD--DNCNI---------KIADFGLSNL------------------------------------YQKDKFL--------------QT---FCGSPLYASPEIVN-------GRPY--RGPEVDSWALGVLLYTLVY-GTMP--------------FD-GF---------------DHKNLIRQISSGEYREPTQP-----------------------------------SDARG-LIRWMLMVNPDRRAT-------IE-DIANHWW-V------------------------------------------------------
-----YTRFEKIGQGASGTV---YTAMD---V-----ATGQ---EVAIKQMNLQQ-QPK---KE--L-I-I--N-------------------------EILV-M-REN-K----NPN--IVNYLDSYL-V--------GDE--LW--VVMEY-LAGG--SLTDVVT------------------------ET-----------------CMDEGQIAAVCRECLQALEFLHS-N--QVIHRDIKSDNIL--LG--MDGSV---------KLTDFGFCAQI-----------------------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT--------RKA--YGPKVDIWSLGIMAIEMIE-GEPP--------------YL-NE------------NPLRALYLIATNGTPELQNPEKLS----------------------------------AIFRD-FLNRCLEMDVEKRGS-------AK-ELLQHQFL-------------------------------------------------------
-----YTRYEKIGQGASGTV---FTATD---V-----ALGQ---EVAIKQINLQK-QPK---KE--L-I-I--N-------------------------EILV-M-KEL-K----NPN--IVNFLDSYL-V--------GDE--LF--VVMEY-LAGG--SLTDVVT------------------------ET-----------------CMDEAQIAAVCRECLQALEFLHA-N--QVIHRDIKSDNVL--LG--MEGSV---------KLTDFGFCAQI-----------------------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT--------RKA--YGPKVDIWSLGIMAIEMVE-GEPP--------------YL-NE------------NPLRALYLIATNGTPELQNPEKLS----------------------------------PIFRD-FLNRCLEMDVEKRGS-------AK-ELLQHPFL-------------------------------------------------------
-----YTRFEKIGQGASGTV---YTALD---I-----ATGQ---EVAIKQMNLQQ-QPK---KE--L-I-I--N-------------------------EILV-M-REN-K----NPN--IVNYLDSYL-V--------GDE--LW--VVMEY-LAGG--SLTDVVT------------------------ET-----------------CMDEGQIAAVCRECLQALDFLHS-N--QVIHRDIKSDNIL--LG--MDGSV---------KLTDFGFCAQI-----------------------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT--------RKA--YGPKVDIWSLGIMAIEMVE-GEPP--------------YL-NE------------NPLRALYLIATNGTPELQNPERLS----------------------------------AVFRD-FLNRCLEMDVDRRGS-------AK-ELLQHPFL-------------------------------------------------------
-----YSTMSPLGSGAFGFV---WTAVD---K-----EKNK---EVVVKFIKKEK-VLE---DC--W-I-EDPKLGK-------------------VTLEIAI-L-SRV-E----HAN--IIKVLDIFE-N--------QGF--FQ--LVMEK-HGSG-LDLFAFID-----------------------RHP-----------------RLDEPLASYIFRQLVSAVGYLRL-K--DIIHRDIKDENIV--IA--EDFTI---------KLIDFGSAAY------------------------------------LERGKLF--------------YT---FCGTIEYCAPEVLM-------GNPY--RGPELEMWSLGVTLYTLVF-EENP--------------FC-EL-----------------EETVEAAIHPPYLVS--------------------------------------KELMS-LVSGLLQPVPERRTT-------LE-KLVTDPWV-------------------------------------------------------
----F-KFGKILGEGSFSTV---VLARE---L-----ATSR---EYAIKILEKRH-IIK---EN--K-VPYVTR-------------------------ERDV-M-SRL-D----HPF--FVKLYFTFQ-D--------DEK--LY--FGLSY-AKNG--ELLKYIR-----------------------KIG-----------------SFDETCTRFYTAEIVSALEYLHG-K--GIIHRDLKPENIL--LN--EDMHI---------QITDFGTAKVLS---------------------------------PESKQARA--------------NS---FVGTAQYVSPELLT--------EKS--ACKSSDLWALGCIIYQLVA-GLPP--------------FR-AG---------------NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARD-LVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF--------------------------------------------
-----YEPKEILGRGVSSVV---RRCIH---K-----PTSQ---EYAVKVIDVTG-GGS---FS--P-E-EVRELRE------------------ATLKEVDI-L-RKVSG----HPN--IIQLKDTYE-T--------NTF--FF--LVFDL-MKRG--ELFDYLT-----------------------EKV-----------------TLSEKETRKIMRALLEVICTLHK-L--NIVHRDLKPENIL--LD--DNMNI---------KLTDFGFSCQ------------------------------------LEPGERL--------------RE---VCGTPSYLAPEIIECS--MNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP--------------FW-HR---------------KQMLMLRMIMSGNYQFGSPEWDDYS------------------------------DTVKD-LVSRFLVVQPQNRYT-------AE-EALAHPFF-------------------------------------------------------
-----YQVGPLLGSGGFGSV---YSGIR---V-----SDNL---PVAIKHVEKDR-ISD---WG--E-L-PNGTRV---------------------PMEVVL-L-KKV-S----SGFSGVIRLLDWFE-R--------PDS--FV--LILER-PEPV-QDLFDFIT-----------------------ERG-----------------ALQEELARSFFWQVLEAVRHCHN-C--GVLHRDIKDENIL--ID-LNRGEL---------KLIDFGSGA-------------------------------------LLKDTVY--------------TD---FDGTRVYSPPEWIR-------YHRY--HGRSAAVWSLGILLYDMVC-GDIP--------------FE-HD---------------------EEIIRGQVFFRQRVS----------------------------------SECQH-LIRWCLALRPSDRPT-------FE-EIQNHPWM-------------------------------------------------------
-----YRLGPLLGKGGFGTV---FAGHR---L-----TDRL---QVAIKVIPRNR-VLG---WS--P-L-SDSVTC---------------------PLEVAL-L-WKV-GAGGGHPG--VIRLLDWFE-T--------QEG--FM--LVLERPLPAQ--DLFDYIT-----------------------EKG-----------------PLGEGPSRCFFGQVVAAIQHCHS-R--GVVHRDIKDENIL--ID-LRRGCA---------KLIDFGSGA-------------------------------------LLHDEPY--------------TD---FDGTRVYSPPEWIS-------RHQY--HALPATVWSLGILLYDMVC-GDIP--------------FE-RD---------------------QEILEAELHFPAHVS----------------------------------PDCCA-LIRRCLAPKPSSRPS-------LE-EILLDPWM-------------------------------------------------------
-----YQVGAVLGSGGFGTV---YAGSR---I-----ADGL---PVAVKHVVKER-VTE---WG--S-L-GGATV----------------------PLEVVL-L-RKV-GAAGGARG--VIRLLDWFE-R--------PDG--FL--LVLER-PEPA-QDLFDFIT-----------------------ERG-----------------ALDEPLARRFFAQVLAAVRHCHS-C--GVVHRDIKDENLL--VD-LRSGEL---------KLIDFGSGA-------------------------------------LLKDTVY--------------TD---FDGTRVYSPPEWIR-------YHRY--HGRSATVWSLGVLLYDMVC-GDIP--------------FE-QD---------------------EEILRGRLLFRRRVS----------------------------------PECQQ-LIRWCLSLRPSERPS-------LD-QIAAHPWM-------------------------------------------------------
----F-KFLAVLGRGHFGKV---LLSEF---R-----PSGE---LFAIKALKKGD-IVA---RD--E-V-ESLM------------------------CEKRI-L-AAV-TS-AGHPF--LVNLFGCFQ-T--------PEH--VC--FVMEY-SAGG--DLMLHIH------------------------SD-----------------VFSEPRAIFYSACVVLGLQFLHE-H--KIVYRDLKLDNLL--LD--TEGYV---------KIADFGLCKEG-----------------------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT--------DTS--YTRAVDWWGLGVLLYEMLV-GESP--------------FP-GD---------------DEEEVFDSIVNDEVRYPRFLS----------------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF-------------------------------------------------------
---FR--CCAVLGRGHFGKV---LLAEY---K-----NTNE---MFAIKALKKGD-IVA---RD--E-V-DSLM------------------------CEKRI-F-ETV-NS-VRHPF--LVNLFACFQ-T--------KEH--VC--FVMEY-AAGG--DLMMHIH------------------------TD-----------------VFSEPRAVFYAACVVLGLQYLHE-H--KIVYRDLKLDNLL--LD--TEGFV---------KIADFGLCKEG-----------------------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT--------ETS--YTRAVDWWGLGVLIYEMLV-GESP--------------FP-GD---------------DEEEVFDSIVNDEVRYPRFLS----------------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF-------------------------------------------------------
----F-ERIKTLGTGSFGRV---MLVKH---K-----ETGN---HYAMKILDKQK-VVK---LK--Q-I-EHTL------------------------NEKRI-L-QAV-N----FPF--LVKLEFSFK-D--------NSN--LY--MVMEY-VPGG--EMFSHLR-----------------------RIG-----------------RFSEPHARFYAAQIVLTFEYLHS-L--DLIYRDLKPENLL--ID--QQGYI---------QVTDFGFAK--------------------------------------RVKGRT--------------WT---LCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA-GYPP--------------FF-AD---------------QPIQIYEKIVSGKVRFPSHFS----------------------------------SDLKD-LLRNLLQVDLTKRFGNL--KNGVN-DIKNHKWF-------------------------------------------------------
-----FERLRTLGMGSFGRV---MLVRH---Q-----ETGG---HYAMKILNKQK-VVK---MK--Q-V-EHIL------------------------NEKRI-L-QAI-D----FPF--LVKLQFSFK-D--------NSY--LY--LVMEY-VPGG--EMFSRLQ-----------------------RVG-----------------RFSEPHACFYAAQVVLAVQYLHS-L--DLIHRDLKPENLL--ID--QQGYL---------QVTDFGFAK--------------------------------------RVKGRT--------------WT---LCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAV-GFPP--------------FY-AD---------------QPIQIYEKIVSGRVRFPSKLS----------------------------------SDLKH-LLRSLLQVDLTKRFGNL--RNGVG-DIKNHKWF-------------------------------------------------------
----F-NFLMVLGKGSFGKV---MLADR---K-----GTEE---LYAIKILKKDV-VIQ---DD--D-V-ECTM------------------------VEKRV-L-ALLDK----PPF--LTQLHSCFQ-T--------VDR--LY--FVMEY-VNGG--DLMYHIQ-----------------------QVG-----------------KFKEPQAVFYAAEISIGLFFLHK-R--GIIYRDLKLDNVM--LD--SEGHI---------KIADFGMCKEH-----------------------------------MMDGVTT--------------RT---FCGTPDYIAPEIIA--------YQP--YGKSVDWWAYGVLLYEMLA-GQPP--------------FD-GE---------------DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF-----------------------------------------
----F-NFLMVLGKGSFGKV---MLSER---K-----GTDE---LYAVKILKKDV-VIQ---DD--D-V-ECTM------------------------VEKRV-L-ALPGK----PPF--LTQLHSCFQ-T--------MDR--LY--FVMEY-VNGG--DLMYHIQ-----------------------QVG-----------------RFKEPHAVFYAAEIAIGLFFLQS-K--GIIYRDLKLDNVM--LD--SEGHI---------KIADFGMCKEN-----------------------------------IWDGVTT--------------KT---FCGTPDYIAPEIIA--------YQP--YGKSVDWWAFGVLLYEMLA-GQAP--------------FE-GE---------------DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVA-ICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF-----------------------------------------
---FI--FHKVLGKGSFGKV---LLGEL---K-----GRGE---YFAIKALKKDV-VLI---DD--D-V-ECTM------------------------VEKRV-L-TLAAE----NPF--LTHLICTFQ-T--------KDH--LF--FVMEF-LNGG--DLMYHIQ-----------------------DKG-----------------RFELYRATFYAAEIMCGLQFLHS-K--GIIYRDLKLDNVL--LD--RDGHI---------KIADFGMCKEN-----------------------------------IFGESRA--------------ST---FCGTPDYIAPEILQ--------GLK--YTFSVDWWSFGVLLYEMLI-GQSP--------------FH-GD---------------DEDELFESIRVDTPHYPRWIT----------------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF-------------------------------------------------------
----F-NFIKVLGKGSFGKV---MLAEL---K-----GKDE---VYAVKVLKKDV-ILQ---DD--D-V-DCTM------------------------TEKRI-L-ALARK----HPY--LTQLYCCFQ-T--------KDR--LF--FVMEY-VNGG--DLMFQIQ-----------------------RSR-----------------KFDEPRSRFYAAEVTSALMFLHQ-H--GVIYRDLKLDNIL--LD--AEGHC---------KLADFGMCKEG-----------------------------------ILNGVTT--------------TT---FCGTPDYIAPEILQ--------ELE--YGPSVDWWALGVLMYEMMA-GQPP--------------FE-AD---------------NEDDLFESILHDDVLYPVWLS----------------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF-----------------------------------------------------
-----FEFIRVLGKGSFGKV---MLARV---K-----ETGD---LYAVKVLKKDV-ILQ---DD--D-V-ECTM------------------------TEKRI-L-SLARN----HPF--LTQLFCCFQ-T--------PDR--LF--FVMEF-VNGG--DLMFHIQ-----------------------KSR-----------------RFDEARARFYAAEIISALMFLHD-K--GIIYRDLKLDNVL--LD--HEGHC---------KLADFGMCKEG-----------------------------------ICNGVTT--------------AT---FCGTPDYIAPEILQ--------EML--YGPAVDWWAMGVLLYEMLC-GHAP--------------FE-AE---------------NEDDLFEAILNDEVVYPTWLH----------------------------------EDATG-ILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F------------------------------------------------------
---FI--LHKMLGKGSFGKV---FLAEF---K-----KTNQ---FFAIKALKKDV-VLM---DD--D-V-ECTM------------------------VEKRV-L-SLAWE----HPF--LTHMFCTFQ-T--------KEN--LF--FVMEY-LNGG--DLMYHIQ-----------------------SCH-----------------KFDLSRATFYAAEIILGLQFLHS-K--GIVYRDLKLDNIL--LD--KDGHI---------KIADFGMCKEN-----------------------------------MLGDAKT--------------NT---FCGTPDYIAPEILL--------GQK--YNHSVDWWSFGVLLYEMLI-GQSP--------------FH-GQ---------------DEEELFHSIRMDNPFYPRWLE----------------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF-------------------------------------------------------
---PD----EVLGSGQFGIV---YGGKH---R-----KTGR---DVAIKIIDKLR-FPT---KQ--E-S-QLRN-------------------------EVAI-L-QNL-H----HPG--VVNLECMFE-T--------PER--VF--VVMEK-LHGD--MLEMILS----------------------SEKG-----------------RLPEHITKFLITQILVALRHLHF-K--NIVHCDLKPENVL--LA--SADPFP------QVKLCDFGFARI------------------------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR--------NKG--YNRSLDMWSVGVIIYVSLS-GTFP--------------FN-ED-----------------EDIHDQIQNAAFMYPPNPWKEIS------------------------------HEAID-LINNLLQVKMRKRYS-------VD-KTLSHPWL-------------------------------------------------------
---PD----EVLGSGQFGVV---YGGKH---R-----KTGR---DVAVKVIDKLR-FPT---KQ--E-S-QLRN-------------------------EVAI-L-QSL-R----HPG--IVNLECMFE-T--------PEK--VF--VVMEK-LHGD--MLEMILS----------------------SEKG-----------------RLPERLTKFLITQILVALRHLHF-K--NIVHCDLKPENVL--LA--SADPFP------QVKLCDFGFARI------------------------------------IGEKSFR--------------RS---VVGTPAYLAPEVLL--------NQG--YNRSLDMWSVGVIMYVSLS-GTFP--------------FN-ED-----------------EDINDQIQNAAFMYPASPWSHIS------------------------------AGAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL-------------------------------------------------------
--FAD----EVLGSGQFGIV---YGGKH---R-----KTGR---DVAIKVIDKMR-FPT---KQ--E-S-QLRN-------------------------EVAI-L-QNL-H----HPG--IVNLECMFE-T--------PER--VF--VVMEK-LHGD--MLEMILS----------------------SEKS-----------------RLPERITKFMVTQILVALRNLHF-K--NIVHCDLKPENVL--LA--SAEPFP------QVKLCDFGFARI------------------------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR--------SKG--YNRSLDMWSVGVIIYVSLS-GTFP--------------FN-ED-----------------EDINDQIQNAAFMYPPNPWREIS------------------------------GEAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL-------------------------------------------------------
----F-NIIDTLGVGGFGRV---ELVQL---KS----EESK---TFAMKILKKRH-IVD---TR--Q-Q-EHIR------------------------SEKQI-M-QGA-H----SDF--IVRLYRTFK-D--------SKY--LY--MLMEA-CLGG--ELWTILR-----------------------DRG-----------------SFEDSTTRFYTACVVEAFAYLHS-K--GIIYRDLKPENLI--LD--HRGYA---------KLVDFGFAKK------------------------------------IGFGKKT--------------WT---FCGTPEYVAPEIIL--------NKG--HDISADYWSLGILMYELLT-GSPP--------------FS-GP---------------DPMKTYNIILRGIDMIEFPKKIA--------------------------------KNAAN-LIKKLCRDNPSERLGNL--KNGVK-DIQKHKWF-------------------------------------------------------
---FD--TLATVGTGTFGRV---HLVKE---K-----TAKH---FFALKVMSIPD-VIR---LK--Q-E-QHVH------------------------NEKSV-L-KEV-S----HPF--LIRLFWTWH-D--------ERF--LY--MLMEY-VPGG--ELFSYLR-----------------------NRG-----------------RFSSTTGLFYSAEIICAIEYLHS-K--EIVYRDLKPENIL--LD--RDGHI---------KLTDFGFAKK--------------------------------------LVDRT--------------WT---LCGTPEYLAPEVIQ--------SKG--HGRAVDWWALGILIFEMLS-GFPP--------------FF-DD---------------NPFGIYQKILAGKIDFPRHLD----------------------------------FHVKD-LIKKLLVVDRTRRLGNM--KNGAN-DVKHHRWF-------------------------------------------------------
-----FELLKVLGQGSFGKVFLVRKVTR---P-----DSGH---LYAMKVLKKAT-LKV---RD--R-V-RTKM-------------------------ERDI-L-ADV-N----HPF--VVKLHYAFQ-T--------EGK--LY--LILDF-LRGG--DLFTRLS-----------------------KEV-----------------MFTEEDVKFYLAELALGLDHLHS-L--GIIYRDLKPENIL--LD--EEGHI---------KLTDFGLSKEA-----------------------------------IDHEKKA--------------YS---FCGTVEYMAPEVVN--------RQG--HSHSADWWSYGVLMFEMLT-GSLP--------------FQ-GK---------------DRKETMTLILKAKLGMPQFLS----------------------------------TEAQS-LLRALFKRNPANRLGSG--PDGAE-EIKRHV--FY-----------------------------------------------------
-----FELLKVLGQGSYGKV---FLVRK---V-----KGSDAGQLYAMKVLKKAT-LKV---RD--R-V-RSKM-------------------------ERDI-L-AEV-N----HPF--IVKLHYAFQ-T--------EGK--LY--LILDF-LRGG--DLFTRLS-----------------------KEV-----------------MFTEEDVKFYLAELALALDHLHS-L--GIIYRDLKPENIL--LD--EEGHI---------KITDFGLSKEA-----------------------------------IDHDKRA--------------YS---FCGTIEYMAPEVVN--------RRG--HTQSADWWSFGVLMFEMLT-GSLP--------------FQ-GK---------------DRKETMALILKAKLGMPQFLS----------------------------------GEAQS-LLRALFKRNPCNRLGAG--IDGVE-EIKRHPFF-------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVKK---I-----SGSDARQLYAMKVLKKAT-LKV---RD--R-V-RTKM-------------------------ERDI-L-VEV-N----HPF--IVKLHYAFQ-T--------EGK--LY--LILDF-LRGG--DLFTRLS-----------------------KEV-----------------MFTEEDVKFYLAELALALDHLHS-L--GIIYRDLKPENIL--LD--EEGHI---------KLTDFGLSKES-----------------------------------IDHEKKA--------------YS---FCGTVEYMAPEVVN--------RRG--HTQSADWWSFGVLMFEMLT-GTLP--------------FQ-GK---------------DRKETMTMILKAKLGMPQFLS----------------------------------PEAQS-LLRMLFKRNPANRLGAG--PDGVE-EIKRHSFF-------------------------------------------------------
--REP-----ALGQGSFSVC---RRCRQ---R-----QSGQ---EFAVKILSRRL-EAN---TQ--R--------------------------------EVAA-L-RLCQS----HPN--VVNLHEVHH-D--------QLH--TY--LVLEL-LRGG--ELLEHIR-----------------------KKR-----------------HFSESEASQILRSLVSAVSFMHEEA--GVVHRDLKPENIL--YA--DDT-PGA-----PVKIIDFGFARLR----------------------------------PQSPGVPM--------------QT---PCFTLQYAAPELLA--------QQG--YDESCDLWSLGVILYMMLS-GQVP--------------FQ-GASG--------QGGQSQAAEIMCKIREGRFSLDGEAWQGVS------------------------------EEAKE-LVRGLLTVDPAKRLK-------LE-GLRGSSW-L------------------------------------------------------
-----FELLKVLGTGAYGKV---FLVRKISGH-----DTGK---LYAMKVLKKAT-IVQ---KA--K-T-TEHTR-----------------------TERQV-L-EHIRQ----SPF--LVTLHYAFQ-T--------ETK--LH--LILDY-INGG--ELFTHLS-----------------------QRE-----------------RFTEHEVQIYVGEIVLALEHLHK-L--GIIYRDIKLENIL--LD--SNGHV---------VLTDFGLSKEF----------------------------------VADETERA--------------YS---FCGTIEYMAPDIVR------GGDSG--HDKAVDWWSLGVLMYELLT-GASP--------------FT-VD-----------GEKNSQAEISRRILKSEPPYPQEMS----------------------------------ALAKD-LIQRLLMKDPKKRLGCG--PRDAD-EIKEHLFF-------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVRK---K-----TGPDAGQLYAMKVLKKAS-LKV---RD--R-V-RTKM-------------------------ERDI-L-VEV-N----HPF--IVKLHYAFQ-T--------EGK--LY--LILDF-LRGG--DVFTRLS-----------------------KEV-----------------LFTEEDVKFYLAELALALDHLHQ-L--GIVYRDLKPENIL--LD--EIGHI---------KLTDFGLSKES-----------------------------------VDQEKKA--------------YS---FCGTVEYMAPEVVN--------RRG--HSQSADWWSYGVLMFEMLT-GTLP--------------FQ-GK---------------DRNETMNMILKAKLGMPQFLS----------------------------------AEAQS-LLRMLFKRNPANRLGS----EGVE-EIKRHLFF-------------------------------------------------------
-----FELLRVLGKGGYGKV---FQVRKVTGA-----NTGK---IFAMKVLKKAM-IVR---NA--K-D-TAHTK-----------------------AERNI-L-EEV-K----HPF--IVDLIYAFQ-T--------GGK--LY--LILEY-LSGG--ELFMQLE-----------------------REG-----------------IFMEDTACFYLAEISMALGHLHQ-K--GIIYRDLKPENIM--LN--HQGHV---------KLTDFGLCKES-----------------------------------IHDGTVT--------------HT---FCGTIEYMAPEILM--------RSG--HNRAVDWWSLGALMYDMLT-GAPP--------------FT-GE---------------NRKKTIDKILKCKLNLPPYLT----------------------------------QEARD-LLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF-------------------------------------------------------
-----FELLRVLGKGGYGKV---FQVRK---V-----QGTNLGKIYAMKVLRKAK-IVR---NA--K-D-TAHTR-----------------------AERNI-L-ESV-K----HPF--IVELAYAFQ-T--------GGK--LY--LILEC-LSGG--ELFTHLE-----------------------REG-----------------IFLEDTACFYLAEITLALGHLHS-Q--GIIYRDLKPENIM--LS--SQGHI---------KLTDFGLCKES-----------------------------------IHEGAVT--------------HT---FCGTIEYMAPEILV--------RSG--HNRAVDWWSLGALMYDMLT-GSPP--------------FT-AE---------------NRKKTMDKIIRGKLALPPYLT----------------------------------PDARD-LVKKFLKRNPSQRIGGG--PGDAA-DVQRHPFF-------------------------------------------------------
-----FHFLKVIGKGSFGKV---LLARH---K-----AEEV---FYAVKVLQKKA-ILK---KK--E-E-KHIM------------------------SERNV-LLKNV-K----HPF--LVGLHFSFQ-T--------ADK--LY--FVLDY-INGG--ELFYHLQ-----------------------RER-----------------CFLEPRARFYAAEIASALGYLHS-L--NIVYRDLKPENIL--LD--SQGHI---------VLTDFGLCKEN-----------------------------------IEHNSTT--------------ST---FCGTPEYLAPEVLH--------KQP--YDRTVDWWCLGAVLYEMLY-GLPP--------------FY-SR---------------NTAEMYDNILNKPLQLKPNIT----------------------------------NSARH-LLEGLLQKDRTKRLGAK---DDFM-EIKSHV--FF-----------------------------------------------------
----F-DFLKVIGKGNYGKV---LLAKR---K-----SDGA---FYAVKVLQKKS-ILK---KK--E-Q-SHIM------------------------AERSVLL-KNV-R----HPF--LVGLRYSFQ-T--------PEK--LY--FVLDY-VNGG--ELFFHLQ-----------------------RER-----------------RFLEPRARFYAAEVASAIGYLHS-L--NIIYRDLKPENIL--LD--CQGHV---------VLTDFGLCKEG-----------------------------------VEPEDTT--------------ST---FCGTPEYLAPEVLR--------KEP--YDRAVDWWCLGAVLYEMLH-GLPP--------------FY-SQ---------------DVSQMYENILHQPLQIPGGRT----------------------------------VAACD-LLQSLLHKDQRQRLGSK---ADFL-EIKNHVFF-------------------------------------------------------
-----YDIEGTLGKGNFAVV---KLGRH---R-----ITKT---EVAIKIIDKSQ-LDA---VN--L-E-KIYR-------------------------EVQI-M-KML-D----HPH--IIKLYQVME-T--------KSM--LY--LVTEY-AKNG--EIFDYLA-----------------------NHG-----------------RLNESEARRKFWQILSAVDYCHG-R--KIVHRDLKAENLL--LD--NNMNI---------KIADFGFGNF------------------------------------FKSGELL--------------AT---WCGSPPYAAPEVFE-------GQQY--EGPQLDIWSMGVVLYVLVC-GALP--------------FD-GP---------------TLPILRQRVLEGRFRIPYFMS----------------------------------EDCEH-LIRRMLVLDPSKRLT-------IA-QIKEHKWM-------------------------------------------------------
-----WEIIGELGDGAFGKV---YKAQN---K-----ETSV---LAAAKVIDTKS-EEE---LE--D-Y-M--V-------------------------EIDI-L-ASC-D----HPN--IVKLLDAFY-Y--------ENN--LW--ILIEF-CAGG--AVDAVML----------------------ELER-----------------PLTESQIQVVCKQTLDALNYLHD-N--KIIHRDLKAGNIL--FT--LDGDI---------KLADFGVSAKN-----------------------------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE---TSKDRP--YDYKADVWSLGITLIEMAE-IEPP--------------HH-EL------------NPMRVLLKIAKSEPPTLAQPSRWS----------------------------------SNFKD-FLKKCLEKNVDARWT-------TS-QLLQHPFV-------------------------------------------------------
-----WEIVGELGDGAFGKV---YKAKN---K-----ETGA---LAAAKVIETKS-EEE---LE--D-Y-I--V-------------------------EIEI-L-ATC-D----HPY--IVKLLGAYY-H--------DGK--LW--IMIEF-CPGG--AVDAIML----------------------ELDR-----------------GLTEPQIQVVCRQMLEALNFLHS-K--RIIHRDLKAGNVL--MT--LEGDI---------RLADFGVSAKN-----------------------------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE---TMKDTP--YDYKADIWSLGITLIEMAQ-IEPP--------------HH-EL------------NPMRVLLKIAKSDPPTLLTPSKWS----------------------------------VEFRD-FLKIALDKNPETRPS-------AA-QLLEHPFV-------------------------------------------------------
--LCP---GRELGRGKFAVV---RKCIK---K-----DSGK---EFAAKFMRKRR-KGQ---DC--R-M-EIIH-------------------------EIAV-L-ELAQD----NPW--VINLHEVYE-T--------ASE--MI--LVLEY-AAGG--EIFDQCVA---------------------DREE-----------------AFKEKDVQRLMRQILEGVHFLHT-R--DVVHLDLKPQNIL--LT--SESPLG------DIKIVDFGLSRI------------------------------------LKNSEEL--------------RE---IMGTPEYVAPEILS--------YDP--ISMATDMWSIGVLTYVMLT-GISP--------------FL-GN---------------DKQETFLNISQMNLSYSEEEFDVLS------------------------------ESAVD-FIRTLLVKKPEDRAT-------AE-ECLKHPWL-------------------------------------------------------
-----FTKLEKIGKGSFGEV---FKGID---N-----RTQK---VVAIKIIDLEE-AED---EI--E-D-IQ-Q-------------------------EITV-L-SQC-D----SPY--VTKYYGSYL-K--------DTK--LW--IIMEY-LGGG--SALDLLE------------------------PG-----------------PLDETQIATILREILKGLDYLHS-E--KKIHRDIKAANVL--LS--EHGEV---------KLADFGVAGQL-----------------------------------TDTQIKR--------------NT---FVGTPFWMAPEVIK--------QSA--YDSKADIWSLGITAIELAR-GEPP--------------HS-EL------------HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI-------------------------------------------------------
----F-TKLDRIGKGSFGEV---YKGID---N-----HTKE---VVAIKIIDLEE-AED---EI--E-D-IQ-Q-------------------------EITV-L-SQC-D----SPY--ITRYFGSYL-K--------STK--LW--IIMEY-LGGG--SALDLLK------------------------PG-----------------PLEETYIATILREILKGLDYLHS-E--RKIHRDIKAANVL--LS--EQGDV---------KLADFGVAGQL-----------------------------------TDTQIKR--------------NT---FVGTPFWMAPEVIK--------QSA--YDFKADIWSLGITAIELAK-GEPP--------------NS-DL------------HPMRVLFLIPKNSPPTLEGQHS------------------------------------KPFKE-FVEACLNKDPRFRPT-------AK-ELLKHKFI-------------------------------------------------------
-----YTFGRILGKGSFGIV---IEATD---K-----ETET---KWAIKKVNKEK-AGS---SA--V-K-LLER-------------------------EVNI-L-KSV-K----HEH--IIHLEQVFE-T--------PKK--MY--LVMEL-CEDG--ELKEILD-----------------------RKG-----------------HFSENETRWIIQSLASAIAYLHN-N--DIVHRDLKLENIM--VK--SSLIDDNNEINLNIKVTDFGLAVKK----------------------------------QSRSEAML--------------QA---TCGTPIYMAPEVIS--------AHD--YSQQCDIWSIGVVMYMLLR-GEPP--------------FL-AS---------------SEEKLFELIRKGELHFENAVWNSIS------------------------------DCAKS-VLKQLMKVDPAHRIT-------AK-ELLDNQWL-------------------------------------------------------
----F-ESLKVIGRGAFGEV---RLVQK---K-----DTGH---VYAMKILRKAD-MLE---KE--Q-V-GHIR------------------------AERDI-L-VEA-D----SLW--VVKMFYSFQ-D--------KLN--LY--LIMEF-LPGG--DMMTLLM-----------------------KKD-----------------TLTEEETQFYIAETVLAIDSIHQ-L--GFIHRDIKPDNLL--LD--SKGHV---------KLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA--------------FS---TVGTPDYIAPEVFM--------QTG--YNKLCDWWSLGVIMYEMLI-GYPP--------------FC-SE---------------TPQETYKKVMNWKETLTFPPEVPIS------------------------------EKAKD-LILRFCCEW------------------------EHRIGAPGVEEIKSNSFF-------------------------------------
--WLL---SDILGQGATANV---FRGRH---K-----KTGD---LFAIKVFNNIS-FLR---PV--D-V-Q-MR-------------------------EFEV-L-KKL-N----HKN--IVKLFAIEE-ET------TTRH--KV--LIMEF-CPCG--SLYTVLEE--------------------PSNAY-----------------GLPESEFLIVLRDVVGGMNHLRE-N--GIVHRDIKPGNIMRVIG--EDGQSV-------YKLTDFGAARE------------------------------------LEDDEQF--------------VS---LYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT-GSLP--------------FR-PF-----------EGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDM---------PVSCSLSRGLQV--------------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY-
---YL--LLHLLGRGGFSEV---YKAFD---L-----TEQR---YVAVKIHQLNK-NWR---DE--K-K-ENYHKH--------------------ACREYRI-H-KEL-D----HPR--IVKLYDYFS-L-------DTDS--FC--TVLEY-CEGN--DLDFYLK-----------------------QHK-----------------LMSEKEARSIIMQIVNALKYLNE-IKPPIIHYDLKPGNIL--LV--NGTACG------EIKITDFGLSKIMDDD----------------------------SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVV----GKEPPK--ISNKVDVWSVGVIFYQCLY-GRKP--------------FG-HN-------------QSQQDILQENTILKATEVQFPPKPVVT------------------------------PEAKA-FIRRCLAYRKEDRID-------VQ-QLACDPYL-------------------------------------------------------
YLLGI-----NLGEGSYAKV---KSAYS---E-----RLKF---NVAIKIIDRKK-APA---DF--L-E-KFLP------------------------REIEI-L-AML-N----HCS--IIKTYEIFE-T-------SHGK--VY--IVMEL-AVQG--DLLELIK-----------------------TRG-----------------ALHEDEARKKFHQLSLAIKYCHD-L--DVVHRDLKCDNLL--LD--KDFNI---------KLSDFSFSKRCLR-------------------------------DDSGRMALS--------------KT---FCGSPAYAAPEVLQ-------GIPY--QPKVYDIWSLGVILYIMVC-GSMP--------------YD-DS---------------NIKKMLRIQKEHRVNFPRSKHLT--------------------------------GECKD-LIYHMLQPDVNRRLH-------ID-EILSHCWM-------------------------------------------------------
---FI--LTERLGSGTYATV---YKAYA---KK----DTRE---VVAIKCVAKKS-LNK---AS--V-E-NLLT-------------------------EIEI-L-KGI-R----HPH--IVQLKDFQW-D--------SDN--IY--LIMEF-CAGG--DLSRFIH-----------------------TRR-----------------ILPEKVARVFMQQLASALQFLHE-R--NISHLDLKPQNIL--LSSLEKPHL---------KLADFGFAQH------------------------------------MSPWDEK--------------HV---LRGSPLYMAPEMVC--------QRQ--YDARVDLWSMGVILYEALF-GQPP--------------FA-SR------------SFSELEEKIRSNRVIELPLRPLLS----------------------------------RDCRD-LLQRLLERDPSRRIS-------FQ-DFFAHPWV-------------------------------------------------------