Protein Surface  Ribbon
Inhibitor UCN
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 179 kinases in KIF 1OKZA_UCN (PDPK1, PDB code: 1OKZ, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
AGC        PRKG2        203 
TK         ABL1         261 
TK         ABL2         288 
AGC        AKT1         150 
AGC        AKT3         148 
Other      AURKA        133 
Other      AURKB         77 
Other      AURKC         43 
TK         BMX          422 
CAMK       BRSK1         50 
CAMK       BRSK2         19 
TK         BTK          402 
CAMK       CAMK1G        23 
CAMK       CAMK2A        13 
CAMK       CAMK2B        14 
CAMK       CAMK2D        14 
CMGC       CDC2           4 
CMGC       CDC2L5       705 
CMGC       CDC2L6        20 
CMGC       CDK15        103 
CMGC       CDK2           4 
CMGC       CDK3           4 
CMGC       CDK4           6 
CMGC       CDK5           4 
CMGC       CDK6          13 
CMGC       CDK7       2.7.11.23 
CMGC       CDK8       2.7.11.23 
CMGC       CDKL1          5 
CMGC       CDKL2          4 
CMGC       CDKL3          4 
CMGC       CDKL5         13 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
TK         CSK          195 
CMGC       CSNK2A1       39 
CMGC       CSNK2A2       40 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
CMGC       DYRK1A       150 
CMGC       DYRK1B       111 
CMGC       DYRK2        222 
TK         EGFR         712 
Other      EIF2AK2      267 
Other      EIF2AK4      590 
TK         EPHA3        621 
TK         EPHA4        621 
TK         EPHA5        675 
TK         EPHB1        619 
TK         ERBB4        718 
TK         FGFR2        481 
Other      GAK           40 
AGC        GRK1         190 
AGC        GRK4         187 
AGC        GRK5         186 
AGC        GRK6         186 
AGC        GRK7         191 
CMGC       GSK3A        119 
CMGC       GSK3B         56 
CMGC       HIPK1        190 
CMGC       HIPK2        199 
CMGC       HIPK3        197 
CMGC       HIPK4         -1 
CAMK       HUNK          61 
CMGC       ICK            4 
TKL        IRAK4        186 
TK         JAK2         849 
TK         JAK3         822 
CAMK       KIAA0999      66 
TKL        LIMK1        339 
TKL        LIMK2        331 
TK         LYN          247 
CMGC       MAK            4 
STE        MAP3K1      1242 
STE        MAP3K15      649 
STE        MAP3K2       356 
STE        MAP3K3       362 
STE        MAP3K4      1342 
STE        MAP3K5       677 
STE        MAP3K6       645 
CMGC       MAPK1         13 
CMGC       MAPK10        64 
CMGC       MAPK12        27 
CMGC       MAPK13        25 
CMGC       MAPK14        24 
CMGC       MAPK15        13 
CMGC       MAPK3         42 
CMGC       MAPK7         55 
CMGC       MAPK8         26 
CMGC       MAPK9         26 
CAMK       MAPKAPK2      64 
CAMK       MAPKAPK5      22 
CAMK       MARK2         53 
CAMK       MARK4         59 
TK         MATK         235 
CAMK       MELK          11 
CAMK       MGC42105      74 
Other      NEK1           4 
Other      NEK2           8 
Other      NEK4           6 
Other      NEK5           4 
Other      NEK8           4 
Other      NEK9          52 
CAMK       NUAK1         55 
CAMK       NUAK2         97 
STE        OXSR1         17 
STE        PAK1         270 
STE        PAK2         249 
STE        PAK3         268 
STE        PAK4         321 
STE        PAK6         407 
STE        PAK7         449 
CMGC       PCTK1        165 
CMGC       PCTK2        192 
CMGC       PCTK3        172 
AGC        PDPK1         82 
CMGC       PFTK1        117 
CAMK       PHKG1         20 
CAMK       PHKG2         24 
CAMK       PIM1          38 
CAMK       PIM2         132 
CAMK       PIM3          40 
AGC        PKN2         657 
Other      PLK1          53 
Other      PLK2          82 
Other      PLK3          62 
Other      PLK4          12 
CAMK       PRKAA1        18 
CAMK       PRKAA2        16 
AGC        PRKACA        44 
AGC        PRKACB        44 
AGC        PRKACG        44 
AGC        PRKCB        342 
AGC        PRKCD        349 
AGC        PRKCH        355 
AGC        PRKCI        245 
AGC        PRKCQ        380 
AGC        PRKCZ        252 
CAMK       PRKD1        583 
CAMK       PRKD2        551 
CAMK       PRKD3        576 
AGC        PRKG1        375 
AGC        PRKX          49 
CMGC       PRPF4B       687 
TK         RET          724 
AGC        RPS6KA1       62 
AGC        RPS6KA2       59 
AGC        RPS6KA3       68 
AGC        RPS6KA6       73 
AGC        RPS6KB1       91 
AGC        RPS6KB2       67 
Other      SBK1          53 
CAMK       SIK1          27 
CAMK       SIK2          20 
STE        SLK           34 
CAMK       SNRK          16 
CAMK       STK11         49 
CAMK       STK17A        61 
CAMK       STK17B        33 
STE        STK24         24 
AGC        STK32A        23 
AGC        STK32B        23 
AGC        STK32C        93 
CAMK       STK33        116 
Other      STK36          4 
STE        STK39         63 
TK         TEC          370 
Other      TLK1         477 
Other      TLK2         440 
CAMK       TSSK1B        12 
CAMK       TSSK2         12 
Other      TTK          525 
TK         TXK          271 
Other      ULK1          16 
Other      ULK2           9 
Other      ULK3          14 
STE        YSK4        1162 


-------------------------------L-EIIATLGVGGFGRV---ELVKV---K-------N-ENV---AFAM-KCIRKKH-IVD---TK--Q-Q-EHVY------SEKRILEEL--C------SPF-----IVKLYRTFK--D-----------------------------NKYVY--MLLEA-CLGG--ELWSILR---------DRG-------------------------SF---DEPTSKFCVACVTEAFDYLHR--L-----GIIYRDLKPENLILD----AEGYL---------KLVDFGFAKK------------------------IGSGQKT------------WT---FCGTPEYVAPEV----IL------------------NKGHDFSVDFWSLGILVYELLT-GN-PP---------------FS-GV------------DQ-MMTYNLILKGIEKMDFPRKIT-------------------------------------------------------------------------RRPEDLIRRLCRQNPTERLGNL-KNGIN-DIKKHRWL--------------
--------------------------------ITMKHKLGGGQYGEV---YEGVW---K-------K-YSL---TVAV-KTLK-ED-TM----EV--E-E-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCT--R-----------------------------EPPFY--IITEF-MTYG--NLLDYLR----------EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG----ENHLV---------KVADFGLSRLM-----------------------T--GDTY------------TAHAGAKFPIKWTAPES----LA------------------YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI---------DLSQV-YELLEKDYRMERPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS------FA-EIHQA--F--------------
--------------------------------ITMKHKLGGGQYGEV---YVGVW---K-------K-YSL---TVAV-KTLK-ED-TM----EV--E-E-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCT--L-----------------------------EPPFY--IVTEY-MPYG--NLLDYLR----------EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK--K-----NFIHRDLAARNCLVG----ENHVV---------KVADFGLSRLM-----------------------T--GDTY------------TAHAGAKFPIKWTAPES----LA------------------YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI---------DLSQV-YDLLEKGYRMEQPEGCP-----------------------------------------------------------------------------PKVYELMRACWKWSPADRPS------FA-ETHQA--F--------------
-------------------------------F-EYLKLLGKGTFGKV---ILVKE---K-------A-TGR---YYAM-KILKKEV-IVA---KD--E-V-AHTL------TENRVLQNS--R------HPF-----LTALKYSFQ--T-----------------------------HDRLC--FVMEY-ANGG--ELFFHLS---------RER-------------------------VF---SEDRARFYGAEIVSALDYLHS-EK-----NVVYRDLKLENLMLD----KDGHI---------KITDFGLCKEG-----------------------IKDGATM------------KT---FCGTPEYLAPEV----LE------------------DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FY-NQ------------DH-EKLFELILMEEIRFPRTLG---------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLGGG-SEDAK-EIMQHRFF--------------
------------------------------FD--YLKLLGKGTFGKV---ILVRE---K-------A-SGK---YYAM-KILKKEV-IIA---KD--E-V-AHTL------TESRVLKNT--R------HPF-----LTSLKYSFQ--T-----------------------------KDRLC--FVMEY-VNGG--ELFFHLS---------RER-------------------------VF---SEDRTRFYGAEIVSALDYLHS--G-----KIVYRDLKLENLMLD----KDGHI---------KITDFGLCKEG-----------------------ITDAATM------------KT---FCGTPEYLAPEV----LE------------------DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FY-NQ------------DH-EKLFELILMEDIKFPRTLS---------------------------------------------------------------------------SDAKSLLSGLLIKDPNKRLGGG-PDDAK-EIMRHSFF--------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-------Q-SKF---ILAL-KVLFKAQLEKA---GV--E-H-QLRR-------EVEIQSHL--R------HPN-----ILRLYGYFH--D-----------------------------ATRVY--LILEY-APLG--TVYRELQ---------KLS-------------------------KF---DEQRTATYITELANALSYCHS--K-----RVIHRDIKPENLLLG----SAGEL---------KIADFGWSV-------------------------HAPSSRR------------TT---LCGTLDYLPPEM----IE------------------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN------------TY-QETYKRISRVEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI--------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-------K-SHF---IVAL-KVLFKSQ-IEK---EG--V-E-HQLR------REIEIQAHL--H------HPN-----ILRLYNYFY--D-----------------------------RRRIY--LILEY-APRG--ELYKELQ---------KSC-------------------------TF---DEQRTATIMEELADALMYCHG--K-----KVIHRDIKPENLLLG----LKGEL---------KIADFGWSV-------------------------HAPSLRR------------KT---MCGTLDYLPPEM----IE------------------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA------------SH-NETYRRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV--------------
--------------------------------FEIGRPLGKGKFGNV---YLARL---K-------E-SHF---IVAL-KVLFKSQ-IEK---EG--L-E-HQLR------REIEIQAHL--Q------HPN-----ILRLYNYFH--D-----------------------------ARRVY--LILEY-APRG--ELYKELQ---------KSE-------------------------KL---DEQRTATIIEELADALTYCHD--K-----KVIHRDIKPENLLLG----FRGEV---------KIADFGWSV-------------------------HTPSLRR------------KT---MCGTLDYLPPEM----IE------------------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FE-SA------------SH-SETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV--------------
--------------------------------ITLLKELGSGQFGVV---QLGKW---K---------GQY---DVAV-KMIK-EG-SM----SE--D-E-FF-Q-------EAQTMMKL--S------HPK-----LVKFYGVCS--K-----------------------------EYPIY--IVTEY-ISNG--CLLNYLR----------SH-----------------------GKGL---EPSQLLEMCYDVCEGMAFLES--H-----QFIHRDLAARNCLVD----RDLCV---------KVSDFGMTRYV-----------------------L--DDQY------------VSSVGTKFPVKWSAPEV----FH------------------YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YD-LY---------DNSQV-VLKVSQGHRLYRPHLAS-----------------------------------------------------------------------------DTIYQIMYSCWHELPEKRPT------FQ-QLLSS--I--------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-------I-TGQ---KVAI-KIVNREK-LSE---SV--L-M-KVER-------EIAILKLI--E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV---------KKG-------------------------RL---TPKEARKFFRQIVSALDFCHS--Y-----SICHRDLKPENLLLD----EKNNI---------RIADFGMASL------------------------QVGDSLL------------ET---SCGSPHYACPEV----IK-----------------GEKYDGRRADMWSCGVILFALLV-GA-LP---------------FD-DD------------NL-RQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVEPEKRLS------LE-QIQKHPW-Y-------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-------V-TCQ---KVAI-KIVNREK-LSE---SV--L-M-KVER-------EIAILKLI--E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEH-VSGG--ELFDYLV---------KKG-------------------------RL---TPKEARKFFRQIISALDFCHS--H-----SICHRDLKPENLLLD----EKNNI---------RIADFGMASL------------------------QVGDSLL------------ET---SCGSPHYACPEV----IR-----------------GEKYDGRKADVWSCGVILFALLV-GA-LP---------------FD-DD------------NL-RQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT------LE-HIQKHIW-Y-------------
--------------------------------LTFLKELGTGQFGVV---KYGKW---R---------GQY---DVAI-KMIK-EG-SM----SE--D-E-FI-E-------EAKVMMNL--S------HEK-----LVQLYGVCT--K-----------------------------QRPIF--IITEY-MANG--CLLNYLR----------EM-----------------------RHRF---QTQQLLEMCKDVCEAMEYLES--K-----QFLHRDLAARNCLVN----DQGVV---------KVSDFGLSRYV-----------------------L--DDEY------------TSSVGSKFPVRWSPPEV----LM------------------YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YE-RF---------TNSET-AEHIAQGLRLYRPHLAS-----------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT------FK-ILLSN--I--------------
------------------------------FI--FMEVLGSGAFSEV---FLVKQ---R-------L-TGK---LFAL-KCIKKSP-AFR---DS--S-L-E--N-------EIAVLKKI--K------HEN-----IVTLEDIYE--S-----------------------------TTHYY--LVMQL-VSGG--ELFDRIL---------ERG-------------------------VY---TEKDASLVIQQVLSAVKYLHE--N-----GIVHRDLKPENLLYLT-PEENSKI---------MITDFGLSK-------------------------MEQNGIM------------ST---ACGTPGYVAPEV----LA------------------QKPYSKAVDCWSIGVITYILLC-GY-PP---------------FY-EE------------TE-SKLFEKIKEGYYEFESPFWDDIS-----------------------------------------------------------------------ESAKDFICHLLEKDPNERYT------CE-KALSHPWI--------------
--------------------------------YQLFEELGKGAFSVV---RRCVK---V-------L-AGQ---EYAA-KIINTKK-LSA---RD--H-Q-KLER-------EARICRLL--K------HPN-----IVRLHDSIS--E-----------------------------EGHHY--LIFDL-VTGG--ELFEDIV---------ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----GVVHRDLKPENLLLA----SKLKGA------AVKLADFGLAIEV-----------------------EGEQQAW------------FG---FAGTPGYLSPEV----LR------------------KDPYGKPVDLWACGVILYILLV-GY-PP---------------FW-DE------------DQ-HRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPSKRIT------AA-EALKHPWI--------------
--------------------------------YQLYEDIGKGAFSVV---RRCVK---L-------C-TGH---EYAA-KIINTKK-LSA---RD--H-Q-KLER-------EARICRLL--K------HSN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDL-VTGG--ELFEDIV---------ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----GVVHRDLKPENLLLA----SKCKGA------AVKLADFGLAIEV-----------------------QGDQQAW------------FG---FAGTPGYLSPEV----LR------------------KEAYGKPVDIWACGVILYILLV-GY-PP---------------FW-DE------------DQ-HKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT------AH-EALKHPWV--------------
--------------------------------YQLFEELGKGAFSVV---RRCMK---I-------P-TGQ---EYAA-KIINTKK-LSA---RD--H-Q-KLER-------EARICRLL--K------HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDL-VTGG--ELFEDIV---------ARE-------------------------YY---SEADASHCIQQILESVNHCHL--N-----GIVHRDLKPENLLLA----SKSKGA------AVKLADFGLAIEV-----------------------QGDQQAW------------FG---FAGTPGYLSPEV----LR------------------KDPYGKPVDMWACGVILYILLV-GY-PP---------------FW-DE------------DQ-HRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT------AS-EALKHPWI--------------
--------------------------------YTKIEKIGEGTYGVV---YKGRH---K-------T-TGQ---VVAM-KKIRLES-EEE---GV--P-S-TAIR-------EISLLKEL--R------HPN-----IVSLQDVLM--Q-----------------------------DSRLY--LIFEF-LSM---DLKKYLDS------IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--R-----RVLHRDLKPQNLLID----DKGTI---------KLADFGLARAF-----------------------GIPIRVY------------TH---EVVTLWYRSPEV----LL-----------------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD---------SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
-------------------------------F-DIIGIIGEGTYGQV---YKARD---K-------D-TGE---MVAL-KKVRLDN-EKE---GF--P-I-TAIR-------EIKILRQL--T------HQS-----IINMKEIVT--DKEDAL-------------------DFKKDKGAFY--LVFEY-MDH---DLMGLLE--------SGLV-------------------------HF---NENHIKSFMRQLMEGLDYCHK--K-----NFLHRDIKCSNILLN----NRGQI---------KLADFGLARLY----------------------SSEESRPY------------TN---KVITLWYRPPEL----LL-----------------GEERYTPAIDVWSCGCILGELFT-KK-PI---------------FQ-AN---------QELAQ-LELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------------------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSKRCT------AE-QALQCEF-L-------------
-----------------------------EGC-----KVGRGTYGHV---YKARR---K-------D-GKDE-KEYAL-KQIEGTG-ISM---SA--C------R-------EIALLREL--K------HPN-----VIALQKVFL--SH---------------------------SDRKVW--LLFDY-AEH---DLWHIIKFHR--ASKANKK-------------------------PMQ-LPRSMVKSLLYQILDGIHYLHA--N-----WVLHRDLKPANILVMGEGPERGRV---------KIADMGFARLFN--------------------SPLKPLADL------------DP---VVVTFWYRAPEL----LL-----------------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPFHHDQ-LDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT------SE-QALQDPYF--------------
------------------------------YL--NLEKLGEGSYATV---YKGIS---R-------I-NGQ---LVAL-KVISMNA-EEG---VP----F-TAIR-------EASLLKGL--K------HAN-----IVLLHDIIH--T-----------------------------KETLT--FVFEY-MHT---DLAQYMS--------QHPG-------------------------GL---HPHNVRLFMFQLLRGLAYIHH--Q-----HVLHRDLKPQNLLIS----HLGEL---------KLADFGLARAK-----------------------SIPSQTY------------SS---EVVTLWYRPPDA----LL-----------------GATEYSSELDIWGAGCIFIEMFQ-GQ-PL---------------FP-GV--------SNILEQ-LEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS------AQ-EALVHDYF--------------
--------------------------------FQKVEKIGEGTYGVV---YKARN---K-------L-TGE---VVAL-KKIRLDT-ETE---GV--P-S-TAIR-------EISLLKEL--N------HPN-----IVKLLDVIH--T-----------------------------ENKLY--LVFEF-LHQ---DLKKFMDA-------SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----RVLHRDLKPQNLLIN----TEGAI---------KLADFGLARAF-----------------------GVPVRTY------------TH---EVVTLWYRAPEI----LL-----------------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD---------SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
--------------------------------FQKVEKIGEGTYGVV---YKAKN---R-------E-TGQ---LVAL-KKIRLDL-EME---GV--P-S-TAIR-------EISLLKEL--K------HPN-----IVRLLDVVH--N-----------------------------ERKLY--LVFEF-LSQ---DLKKYMDS-------TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H-----RVIHRDLKPQNLLIN----ELGAI---------KLADFGLARAF-----------------------GVPLRTY------------TH---EVVTLWYRAPEI----LL-----------------GSKFYTTAVDIWSIGCIFAEMVT-RK-AL---------------FP-GD---------SEIDQ-LFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT------AK-TALAHPYF--------------
-------------------------------Y-EPVAEIGVGAYGTV---YKARD---P-------H-SGH---FVAL-KSVRVPN-GGGGGGGL--P-I-STVR-------EVALLRRL--EA---FEHPN-----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEH-VDQ---DLRTYLDK-------APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--N-----CIVHRDLKPENILVT----SGGTV---------KLADFGLARI------------------------YSYQMAL------------TP---VVVTLWYRAPEV----LL------------------QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN---------SEADQ-LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
--------------------------------YEKLEKIGEGTYGTV---FKAKN---R-------E-THE---IVAL-KRVRLDD-DDE---GV--P-S-SALR-------EICLLKEL--K------HKN-----IVRLHDVLH--S-----------------------------DKKLT--LVFEF-CDQ---DLKKYFD--------SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R-----NVLHRDLKPQNLLIN----RNGEL---------KLADFGLARAF-----------------------GIPVRCY------------SA---EVVTLWYRPPDV----LF-----------------GAKLYSTSIDMWSAGCIFAELANAGR-PL---------------FP-GN---------DVDDQ-LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS------AE-EALQHPYF--------------
--------------------------------YECVAEIGEGAYGKV---FKARD---L-------K-NGG--RFVAL-KRVRVQT-GEE---GM--P-L-STIR-------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSR------------------------TDRETKLT--LVFEH-VDQ---DLTTYLDK-------VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--H-----RVVHRDLKPQNILVT----SSGQI---------KLADFGLARI------------------------YSFQMAL------------TS---VVVTLWYRAPEV----LL------------------QSSYATPVDLWSVGCIFAEMFR-RK-PL---------------FR-GS---------SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AY-SALSHPYF--------------
--------------------------------YEKLDFLGEGQFATV---YKARD---K-------N-TNQ---IVAI-KKIKLGH-RSE---AK--D-G-INRTA----LREIKLLQEL--S------HPN-----IIGLLDAFG--H-----------------------------KSNIS--LVFDF-MET---DLEVIIK--------DNSL-------------------------VL---TPSHIKAYMLMTLQGLEYLHQ--H-----WILHRDLKPNNLLLD----ENGVL---------KLADFGLAKSF-----------------------GSPNRAY------------TH---QVVTRWYRAPEL----LF-----------------GARMYGVGVDMWAVGCILAELLL-RV-PF---------------LP-GD---------SDLDQ-LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------AT-QALKMKYF--------------
-----------------------------EGC-----KVGRGTYGHV---YKAKR---K-------D-GKDD-KDYAL-KQIEGTG-ISM---SA--C------R-------EIALLREL--K------HPN-----VISLQKVFL--SH---------------------------ADRKVW--LLFDY-AEH---DLWHIIKFHRASKANKKPV-------------------------QL---PRGMVKSLLYQILDGIHYLHA--N-----WVLHRDLKPANILVMGEGPERGRV---------KIADMGFARLFN--------------------SPLKPLADL------------DP---VVVTFWYRAPEL----LL-----------------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPYHHDQ-LDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----------------------------------------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT------SE-QAMQDPYF--------------
--------------------------------YEKIGKIGEGSYGVV---FKCRN---R-------D-TGQ---IVAI-KKFLESE-DDP---VI--K-K-IALR-------EIRMLKQL--K------HPN-----LVNLLEVFR--R-----------------------------KRRLH--LVFEY-CDHT--VLHELDR---------YQR-------------------------GV---PEHLVKSITWQTLQAVNFCHK--H-----NCIHRDVKPENILIT----KHSVI---------KLCDFGFARLL-----------------------AGPSDYY------------TD---YVATRWYRSPEL----LV-----------------GDTQYGPPVDVWAIGCVFAELLS-GV-PL---------------WP-GK---------SDVDQ-LYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-----------------------------------------------MEPLELKFPNISYPALGLLKGCLHMDPTQRLT------CE-QLLHHPYF--------------
--------------------------------YENLGLVGEGSYGMV---MKCRN---K-------D-TGR---IVAI-KKFLESD-DDK---MV--K-K-IAMR-------EIKLLKQL--R------HEN-----LVNLLEVCK--K-----------------------------KKRWY--LVFEF-VDHT--ILDDLEL---------FPN-------------------------GL---DYQVVQKYLFQIINGIGFCHS--H-----NIIHRDIKPENILVS----QSGVV---------KLCDFGFARTL-----------------------AAPGEVY------------TD---YVATRWYRAPEL----LV-----------------GDVKYGKAVDVWAIGCLVTEMFM-GE-PL---------------FP-GD---------SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF------CA-ELLHHDFF--------------
--------------------------------YETLGKVGEGSYGTV---MKCKH---K-------N-TGQ---IVAI-KIFYERP-EQS---VN--K---IAMR-------EIKFLKQF--H------HEN-----LVNLIEVFR--Q-----------------------------KKKIH--LVFEF-IDHT--VLDELQH---------YCH-------------------------GL---ESKRLRKYLFQILRAIDYLHS--N-----NIIHRDIKPENILVS----QSGIT---------KLCDFGFARTL-----------------------AAPGDIY------------TD---YVATRWYRAPEL----VL-----------------KDTSYGKPVDIWALGCMIIEMAT-GN-PY---------------LP-SS---------SDLDL-LHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQ----------------------------------------------HPKNARKKYPKLNGLLADIVHACLQIDPADRIS------SS-DLLHHEYF--------------
--------------------------------FEILGVVGEGAYGVV---LKCRH---K-------E-THE---IVAI-KKFKDSE-ENE---EV--K-E-TTLR-------ELKMLRTL--K------QEN-----IVELKEAFR--R-----------------------------RGKLY--LVFEY-VEK---NMLELLE--------EMPN-------------------------GV---PPEKVKSYIYQLIKAIHWCHK--N-----DIVHRDIKPENLLIS----HNDVL---------KLCDFGFARNL----------------------SEGNNANY------------TE---YVATRWYRSPEL----LL------------------GAPYGKSVDMWSVGCILGELSD-GQ-PL---------------FP-GE---------SEIDQ-LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL------TE-QCLNHPTF--------------
-------------------------------W-DLVQTLGEGAYGEV---QLAVN---R-------V-TEE---AVAV-KIVDMKR-AVD---CP--E-N-I-KK-------EICINKML--N------HEN-----VVKFYGHRR--E-----------------------------GNIQY--LFLEY-CSGG--ELFDRIE---------PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I-----GITHRDIKPENLLLD----ERDNL---------KISDFGLATVFR---------------------YNNRERLL------------NK---MCGTLPYVAPEL----LK-----------------RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-----------SDS-CQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
------------------------------YI--MSKTLGSGACGEV---KLAFE---R-------K-TCK---KVAI-KIISKRK-FAI---GS--A-R-EADPALN-VETEIEILKKL--N------HPC-----IIKIKNFF---D-----------------------------AEDYY--IVLEL-MEGG--ELFDKVV---------GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--N-----GIIHRDLKPENVLLS----SQEEDC------LIKITDFGHSKI------------------------LGETSLM------------RT---LCGTPTYLAPEV----LVS---------------VGTAGYNRAVDCWSLGVILFICLS-GY-PP---------------FS-EH-----------RTQ-VSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT------TE-EALRHPWL--------------
--------------------------------LKLLQTIGKGEFGDV---MLGDY---R----------GN---KVAV-KCIK-ND-AT----AQ----A-FL-A-------EASVMTQL--R------HSN-----LVQLLGVIV-EE-----------------------------KGGLY--IVTEY-MAKG--SLVDYLR----------SR----------------------GRSVL---GGDCLLKFSLDVCEAMEYLEG--N-----NFVHRDLAARNVLVS----EDNVA---------KVSDFGLTKEA-----------------------------S------------STQDTGKLPVKWTAPEA----LR------------------EKKFSTKSDVWSFGILLWEIYSFGR-VP---------------YP-RI---------PLKDV-VPRVEKGYKMDAPDGCP-----------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS------FL-QLREQL----------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---KVVV-KILKPVK-KKK---IK--R--------------EIKILENL-RG------GPN-----IITLADIVK--DP---------------------------VSRTPA--LVFEH-VNNT--DFKQLY------------Q-------------------------TL---TDYDIRFYMYEILKALDYCHS--M-----GIMHRDVKPHNVMID---HEHRKL---------RLIDWGLAEF------------------------YHPGQEY------------NV---RVASRYFKGPEL----LV-----------------DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH---------DNYDQ-LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-------T-NNE---RVVV-KILKPVK-KKK---IK--R--------------EVKILENL-RG------GTN-----IIKLIDTVK--DP---------------------------VSKTPA--LVFEY-INNT--DFKQLY------------Q-------------------------IL---TDFDIRFYMYELLKALDYCHS--K-----GIMHRDVKPHNVMID---HQQKKL---------RLIDWGLAEF------------------------YHPAQEY------------NV---RVASRYFKGPEL----LV-----------------DYQMYDYSLDMWSLGCMLASMIF-RR-EP---------------FFHGQ---------DNYDQ-LVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT------AK-EAMEHPYF--------------
--------------------------------YDTGEELGSGQFAVV---KKCRE---K-------S-TGL---QYAA-KFIKKRR-TKS---SR--R-G-VSREDI---EREVSILKEI--Q------HPN-----VITLHEVYE--N-----------------------------KTDVI--LILEL-VAGG--ELFDFLA---------EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--L-----QIAHFDLKPENIMLL----DRNVPKP-----RIKIIDFGLAHK------------------------IDFGNEF------------KN---IFGTPEFVAPEI----VN------------------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GD------------TK-QETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT------IQ-DSLQHPWI--------------
--------------------------------YDIGEELGSGQFAIV---KKCRE---K-------S-TGL---EYAA-KFIKKRQ-SRA---SR--R-G-VSREEI---EREVSILRQV--L------HHN-----VITLHDVYE--N-----------------------------RTDVV--LILEL-VSGG--ELFDFLA---------QKE-------------------------SL---SEEEATSFIKQILDGVNYLHT--K-----KIAHFDLKPENIMLL----DKNIPIP-----HIKLIDFGLAHE------------------------IEDGVEF------------KN---IFGTPEFVAPEI----VN------------------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GD------------TK-QETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT------IQ-EALRHPWI--------------
--------------------------------YEMGEELGSGQFAIV---RKCRQ---K-------G-TGK---EYAA-KFIKKRR-LSS---SR--R-G-VSREEI---EREVNILREI--R------HPN-----IITLHDIFE--N-----------------------------KTDVV--LILEL-VSGG--ELFDFLA---------EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--K-----RIAHFDLKPENIMLL----DKNVPNP-----RIKLIDFGIAHK------------------------IEAGNEF------------KN---IFGTPEFVAPEI----VN------------------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GE------------TK-QETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT------IA-QSLEHSWI--------------
--------------------------------YEIDSLIGKGSFGQV---VKAYD---R-------V-EQE---WVAI-KIIKNKK-AFL---NQ--A-Q-I----------EVRLLELM-NK------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFEM-LSY---NLYDLLR----------NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL-----SIIHCDLKPENILLCN--PKRSAI---------KIVDFGSSCQ--------------------------LGQRI------------YQ---YIQSRFYRSPEV----LL------------------GMPYDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GA---------NEVDQ-MNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ------PY-YALQHSFF--------------
--------------------------------YEIDSLIGKGSFGQV---VKAYD---H-------Q-TQE---LVAI-KIIKNKK-AFL---NQ--A-Q-I----------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFEL-LSY---NLYDLLR----------NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL-----SIIHCDLKPENILLCN--PKRSAI---------KIVDFGSSCQ--------------------------LGQRI------------YQ---YIQSRFYRSPEV----LL------------------GTPYDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GS---------NEVDQ-MNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS------PL-GALQHGFF--------------
--------------------------------YEVLKVIGKGSFGQV---VKAYD---H-------K-VHQ---HVAL-KMVRNEK-RFH---RQ--A-A-E----------EIRILEHL--RKQDKDNTMN-----VIHMLENFT--F-----------------------------RNHIC--MTFEL-LSM---NLYELIKK-------NKFQ-------------------------GF---SLPLVRKFAHSILQCLDALHK--N-----RIIHCDLKPENILLK----QQGRSG-------IKVIDFGSSC--------------------------YEHQRV------------YT---YIQSRFYRAPEV----IL------------------GARYGMPIDMWSLGCILAELLT-GY-PL---------------LP-GE---------DEGDQ-LACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT------PG-QALRHPWL--------------
-------------------------------F-KKIKVLGSGAFGTV---YKGLW---IP---EGEK-VKI---PVAI-KELR-EA-TS----PKANK-E-IL-D-------EAYVMASV--D------NPH-----VCRLLGICL--------------------------------TSTVQ--LITQL-MPFG--CLLDYVR----------EH-----------------------KDNI---GSQYLLNWCVQIAKGMNYLED--R-----RLVHRDLAARNVLVK----TPQHV---------KITDFGLAKLL-------------G---------A--EEKE------------YHAEGGKVPIKWMALES----IL------------------HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YD-GI---------PASEI-SSILEKGERLPQPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF------------
-------------------------------F-KEIELIGSGGFGQV---FKAKH---R-------I-DGK---TYVI-KRVKYNN-EKA---ER-----------------EVKALAKL--D------HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEF-CDKG--TLEQWIEK-------RRGE-------------------------KL---DKVLALELFEQITKGVDYIHS--K-----KLIHRDLKPSNIFLV----DTKQV---------KIGDFGLVTS------------------------LKNDGKR------------TR---SKGTLRYMSPEQ----IS------------------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FE-T-----------------SKFFTDLRDGIISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN------TS-EILR----TLT-----------
EDENSKSQNQDEDCNEKNGCHESEPSVTTEAV---------------------------------------------------------------------------------------------------------------------------------------------------HYLY--IQMEY-CEKS--TLRDTID---------QGL-------------------------YR---DTVRLWRLFREILDGLAYIHE--K-----GMIHRDLKPVNIFLD----SDDHV---------KIGDFGLATDHLAFSADSKQ-----DDQTGDLIKSDPSGHL------------TG---MVGTALYVSPEV---QGS-----------------TKSAYNQKVDLFSLGIIFFEMSY-HP-MV---------------TA-SE------------RI-FVLNQLRDPTSPKFPEDFDDGEH-----------------------------------------------------------------------AKQKSVISWLLNHDPAKRPT------AT-ELLKSEL-L-------------
-------------------------------I-SIDKVVGAGEFGEV---CSGRL---K----LPSK-KEI---SVAI-KTLK-VG-YT----EKQRR-D-FL-G-------EASIMGQF--D------HPN-----IIRLEGVVT--K-----------------------------SKPVM--IVTEY-MENG--SLDSFLR----------KH-----------------------DAQF---TVIQLVGMLRGIASGMKYLSD--M-----GYVHRDLAARNILIN----SNLVC---------KVSDFGLSRVL-------------E---------D--DPEA-----------AYTTRGGKIPIRWTSPEA----IA------------------YRKFTSASDVWSYGIVLWEVMSYGE-RP---------------YW-EM---------SNQDV-IKAVDEGYRLPPPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK------FE-QIVSIL----------------
--------------------------------IKIEKVIGVGEFGEV---CSGRL---K----VPGK-REI---CVAI-KTLK-AG-YT----DKQRR-D-FL-S-------EASIMGQF--D------HPN-----IIHLEGVVT--K-----------------------------CKPVM--IITEY-MENG--SLDAFLR----------KN-----------------------DGRF---TVIQLVGMLRGIGSGMKYLSD--M-----SYVHRDLAARNILVN----SNLVC---------KVSDFGMSRVL-------------E---------D--DPEA-----------AYTTRGGKIPIRWTAPEA----IA------------------YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YW-DM---------SNQDV-IKAIEEGYRLPPPMDCP-----------------------------------------------------------------------------IALHQLMLDCWQKERSDRPK------FG-QIVNML----------------
--------------------------------ITIERVIGAGEFGEV---CSGRL---K----LPGK-REL---PVAI-KTLK-VG-YT----EKQRR-D-FL-G-------EASIMGQF--D------HPN-----IIHLEGVVT--K-----------------------------SKPVM--IVTEY-MENG--SLDTFLK----------KN-----------------------DGQF---TVIQLVGMLRGISAGMKYLSD--M-----GYVHRDLAARNILIN----SNLVC---------KVSDFGLSRVL-------------E---------D--DPEA-----------AYTTRGGKIPIRWTAPEA----IA------------------FRKFTSASDVWSYGIVMWEVVSYGE-RP---------------YW-EM---------TNQDV-IKAVEEGYRLPSPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKERNSRPK------FD-EIVNML----------------
-------------------------------V-KIEEVIGAGEFGEV---YKGRL---K----LPGK-REI---YVAI-KTLK-AG-YS----EKQRR-D-FL-S-------EASIMGQF--D------HPN-----IIRLEGVVT--K-----------------------------SRPVM--IITEF-MENG--ALDSFLR----------QN-----------------------DGQF---TVIQLVGMLRGIAAGMKYLAE--M-----NYVHRDLAARNILVN----SNLVC---------KVSDFGLSRYLQ----------DDT---------S--DPTY------------TSSLGGKIPVRWTAPEA----IA------------------YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YW-DM---------SNQDV-INAIEQDYRLPPPMDCP-----------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR------FA-EIVNTL----------------
-------------------------------L-KRVKVLGSGAFGTV---YKGIW---VP---EGET-VKI---PVAI-KILN-ET-TG----PKANV-E-FM-D-------EALIMASM--D------HPH-----LVRLLGVCL--------------------------------SPTIQ--LVTQL-MPHG--CLLEYVH----------EH-----------------------KDNI---GSQLLLNWCVQIAKGMMYLEE--R-----RLVHRDLAARNVLVK----SPNHV---------KITDFGLARLL-------------E---------G--DEKE------------YNADGGKMPIKWMALEC----IH------------------YRKFTHQSDVWSYGVTIWELMTFGG-KP---------------YD-GI---------PTREI-PDLLEKGERLPQPPICT-----------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK------FK-ELAAE--F--------------
--------------------------------LTLGKPLGEGCFGQV---VMAEA---VGIDKDKPK-EAV---TVAV-KMLK-DD-AT----EKDLS-D-LV-S-------EMEMMKMIG-K------HKN-----IINLLGACT--Q-----------------------------DGPLY--VIVEY-ASKG--NLREYLR----------ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q-----KCIHRDLAARNVLVT----ENNVM---------KIADFGLARDI-------------N---------N--IDYY------------KKTTNGRLPVKWMAPEA----LF------------------DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YP-GI---------PVEEL-FKLLKEGHRMDKPANCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT------FK-QLVEDL----------------
------------------------------LR--VRRVLAEGGFAFV---YEAQD---V-------G-SGR---EYAL-KRLLSNE-EEK---NR--A-I---IQ-------EVCFMKKL-SG------HPN-----IVQFCSAAS--IGKEE---------------------SDTGQAEFL--LLTEL-CKG---QLVEFLKK------MESRG-------------------------PL---SCDTVLKIFYQTCRAVQHMHR--QK---PPIIHRDLKVENLLLS----NQGTI---------KLCDFGSATTISHYPDY-----------SWSAQRRALVEEE------------IT---RNTTPMYRTPEI----IDL---------------YSNFPIGEKQDIWALGCILYLLCF-RQ-HP---------------FE-DG------------AK-LRIVNGKYS-IPPHDTQY----------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS------IA-EVVHQ---L-------------
----------------------------FLDF----RVLGKGGFGEV---SACQM---K-------A-TGK---LYAC-KKLNKKR-LKK---RK--G-Y-QGAM------VEKKILMKV--H------SRF-----IVSLAYAFE--T-----------------------------KADLC--LVMTI-MNGG--DIRYHIYNV-----NEENP-------------------------GF---PEPRALFYTAQIICGLEHLHQ--R-----RIVYRDLKPENVLLD----NDGNV---------RISDLGLAVEL-----------------------LDGQSKT------------KG---YAGTPGFMAPEL----LQ------------------GEEYDFSVDYFALGVTLYEMIA-AR-GP---------------FR-AR--------GEKVEN-KELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF--
------------------------------FR--HYRVLGKGGFGEV---CACQV---R-------A-TGK---MYAC-KKLQKKR-IKK---RK--G-E-AMAL------NEKRILEKV--Q------SRF-----VVSLAYAYE--T-----------------------------KDALC--LVLTI-MNGG--DLKFHIYN-------LGNP-------------------------GF---DEQRAVFYAAELCCGLEDLQR--E-----RIVYRDLKPENILLD----DRGHI---------RISDLGLATE------------------------IPEGQRV------------RG---RVGTVGYMAPEV----VN------------------NEKYTFSPDWWGLGCLIYEMIQ-GH-SP---------------FK-KY---------KEKVK-WEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-------------
-------------------------------F-RQYRVLGKGGFGEV---CACQV---R-------A-TGK---MYAC-KRLEKKR-IKK---RK--G-E-SMAL------NEKQILEKV--N------SQF-----VVNLAYAYE--T-----------------------------KDALC--LVLTI-MNGG--DLKFHIYN-------MGNP-------------------------GF---EEERALFYAAEILCGLEDLHR--E-----NTVYRDLKPENILLD----DYGHI---------RISDLGLAVK------------------------IPEGDLI------------RG---RVGTVGYMAPEV----LN------------------NQRYGLSPDYWGLGCLIYEMIE-GQ-SP---------------FR-GR------------KE-KVKREEVDRRVLETEEVYSHKFS-----------------------------------------------------------------------EEAKSICKMLLTKDAKQRLGCQ-EEGAA-EVKRHPFF--------------
-------------------------------F-RQYRVLGKGGFGEV---CACQV---R-------A-TGK---MYAC-KKLEKKR-IKK---RK--G-E-AMAL------NEKQILEKV--N------SRF-----VVSLAYAYE--T-----------------------------KDALC--LVLTL-MNGG--DLKFHIYH-------MGQA-------------------------GF---PEARAVFYAAEICCGLEDLHR--E-----RIVYRDLKPENILLD----DHGHI---------RISDLGLAVH------------------------VPEGQTI------------KG---RVGTVGYMAPEV----VK------------------NERYTFSPDWWALGCLLYEMIA-GQ-SP---------------FQ-QR---------KKKIK-REEVERLVK-EVPEEYSER--FS-----------------------------------------------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAR-EVKEHPLF--------------
-------------------------------F-TEFRVLGKGGFGEV---CAVQV---K-------N-TGK---MYAC-KKLDKKR-LKK---KG--G-E-KMAL------LEKEILEKV--S------SPF-----IVSLAYAFE--S-----------------------------KTHLC--LVMSL-MNGG--DLKFHIYN-------VGTR-------------------------GL---DMSRVIFYSAQIACGMLHLHE--L-----GIVYRDMKPENVLLD----DLGNC---------RLSDLGLAVE------------------------MKGGKPI------------TQ---RAGTNGYMAPEI----LM-----------------EKVSYSYPVDWFAMGCSIYEMVA-GR-TP---------------FK-DY--------KEKVSK-EDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG------SR-E-------KSDDPR--------
--------------------------------YTDIKVIGNGSFGVV---YQARL---A-------E-TRE---LVAI-KKVLQDK-RFK---NR-----------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEY-VPETVYRVARHFT--------KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q-----GVCHRDIKPQNLLVD---PDTAVL---------KLCDFGSAKQ------------------------LVRGEPN------------VS---YICSRYYRAPEL----IF-----------------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD---------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF--------------
--------------------------------YTDTKVIGNGSFGVV---YQAKL---C-------D-SGE---LVAI-KKVLQDK-RFK---NR-----------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDY-VPETVYRVA---RHY-----SRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F-----GICHRDIKPQNLLLD---PDTAVL---------KLCDFGSAKQ------------------------LVRGEPN------------VS---YICSRYYRAPEL----IF-----------------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD---------SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
--------------------------------YEVLEFLGRGTFGQV---AKCWK---R-------S-TKE---IVAI-KILKNHP-SYA---RQ--G-Q-I----------EVSILSRL--S------SENADEYNFVRSYECFQ--H-----------------------------KNHTC--LVFEM-LEQ---NLYDFLKQ-------NKFS-------------------------PL---PLKYIRPILQQVATALMKLKS--L-----GLIHADLKPENIMLV----DPVRQPY-----RVKVIDFGSAS-------------------------HVSKAVC------------ST---YLQSRYYRAPEI----IL------------------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT------PL-KTLNHQFV--------------
--------------------------------YEVLEFLGRGTFGQV---VKCWK---R-------G-TNE---IVAI-KILKNHP-SYA---RQ--G-Q-I----------EVSILARL--STE-SADDYN-----FVRAYECFQ--H-----------------------------KNHTC--LVFEM-LEQ---NLYDFLKQ-------NKFS-------------------------PL---PLKYIRPVLQQVATALMKLKS--L-----GLIHADLKPENIMLV----DPSRQPY-----RVKVIDFGSAS-------------------------HVSKAVC------------ST---YLQSRYYRAPEI----IL------------------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT------PI-ETLNHPFV--------------
--------------------------------YEVLDFLGRGTFGQV---VKCWK---R-------G-TNE---IVAI-KILKNHP-SYA---RQ--G-Q-I----------EVSILARL--S------TENADEYNFVRAYECFQ--H-----------------------------RNHTC--LVFEM-LEQ---NLYDFLKQ-------NKFS-------------------------PL---PLKVIRPILQQVATALKKLKS--L-----GLIHADLKPENIMLV----DPVRQPY-----RVKVIDFGSAS-------------------------HVSKTVC------------ST---YLQSRYYRAPEI----IL------------------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------LEYDQ-IRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT------PA-ETLNHPFV--------------
--------------------------------YDIIEVLGKGTFGEV---AKGWR---R-------S-TGE---MVAI-KILKNDA-YRN---RI--I-K-N----------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFH--D-----------------------------ALKFY--LVFEL-LEQ---NLFEFQK----------EN-------------------------NFAPLPARHIRTVTLQVLTALARLKE--L-----AIIHADLKPENIMLV----DQTRCPF-----RVKVIDFGSASIF-----------------------SEVRYVK------------EP---YIQSRFYRAPEI----LL------------------GLPFCEKVDVWSLGCVMAELHL-GW-PL---------------YP-GN---------NEYDQ-VRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS------PS-AALRHPFV--------------
-----------------------------IGS----RKLGEGSFAKV---REGLH---V-------L-TGE---KVAI-KVIDKKR-AKK---DT--Y-V-TKNLR-----REGQIQQMI--R------HPN-----ITQLLDILE--T-----------------------------ENSYY--LVMEL-CPGG--NLMHKIY---------EKK-------------------------RL---EESEARRYIRQLISAVEHLHR--A-----GVVHRDLKIENLLLD----EDNNI---------KLIDFGLSNCAG---------------------ILGYSDPF------------ST---QCGSPAYAAPEL----LA------------------RKKYGPKIDVWSIGVNMYAMLT-GT-LP---------------FT-VE----------PFSL-RALYQKMVD-KEMNPLPTQ--LS-----------------------------------------------------------------------TGAISFLRSLLEPDPVKRPN------IQ-QALANRWL--------------
--------------------------------YTTIRQLGDGTYGSV---LLGRS---I-------E-SGE---LIAI-KKMKRKF-YSW---EE--C---MNLR-------EVKSLKKL--N------HAN-----VVKLKEVIR--E-----------------------------NDHLY--FIFEY-MKE---NLYQLIK--------ERNK-------------------------LF---PESAIRNIMYQILQGLAFIHK--H-----GFFHRDLKPENLLCM----GPELV---------KIADFGLARE------------------------IRSKPPY------------TD---YVSTRWYRAPEV----LL-----------------RSTNYSSPIDVWAVGCIMAEVYT-LR-PL---------------FP-GA---------SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT------AS-QALRYPYF--------------
-----------------------------VGG----NKMGEGGFGVV---YKGYV---N-------N-TT-----VAV-KKLAAMV-DIT---TE--ELK-QQFD------QEIKVMAKC--Q------HEN-----LVELLGFSS--D-----------------------------GDDLC--LVYVY-MPNG--SLLDRLSC------LDGTP-------------------------PL---SWHMRCKIAQGAANGINFLHE--N-----HHIHRDIKSANILLD----EAFTA---------KISDFGLARASE---------------------KFAQTVMT------------SR---IVGTTAYMAPEA----LR-------------------GEITPKSDIYSFGVVLLEIIT-GL-PA---------------VD-EH---------REPQL-LLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD------IK-KVQQ----LLQ-----------
--------------------------------LKFLQQLGKGNFGSV---EMCRY---DP---LQDN-TGE---VVAV-KKLQ-HS-TE-----EHLR-D-FE-R-------EIEILKSL--Q------HDN-----IVKYKGVCYSAG-----------------------------RRNLK--LIMEY-LPYG--SLRDYLQ----------KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--K-----RYIHRDLATRNILVE----NENRV---------KIGDFGLTKVL------------PQ---------D--KEYY------------KVKEPGESPIFWYAPES----LT------------------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM---------IVFHL-IELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV------------
-------------------------------L-KYISQLGKGNFGSV---ELCRY---DP---LGDN-TGA---LVAV-KQLQ-HS-GP----DQ-QR-D-FQ-R-------EIQILKAL--H------SDF-----IVKYRGVSYGPG-----------------------------RQSLR--LVMEY-LPSG--CLRDFLQ----------RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--R-----RCVHRDLAARNILVE----SEAHV---------KIADFGLAKLL------------PL---------D--KDYY------------VVREPGQSPIFWYAPES----LS------------------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P-------ALCRL-LELLEEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
--------------------------------YEIDRTIGKGNFAVV---KRATH---L-------V-TKA---KVAI-KIIDKTQ-LDE---EN--L-K-KIFR-------EVQIMKML--C------HPH-----IIRLYQVME--T-----------------------------ERMIY--LVTEY-ASGG--EIFDHLV---------AHG-------------------------RM---AEKEARRKFKQIVTAVYFCHC--R-----NIVHRDLKAENLLLD----ANLNI---------KIADFGFSNL------------------------FTPGQLL------------KT---WCGSPPYAAPEL----FE-----------------GKEYDGPKVDIWSLGVVLYVLVC-GA-LP---------------FD-GS------------TL-QNLRARVLSGKFRIPFFMS---------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS------ME-QICKHKWM--------------
------------------------------LI--HGEVLGKGCFGQA---IKVTH---R-------E-TGE---VMVM-KELI--R-FD----EETQR-T-FL-K-------EVKVMRCL--E------HPN-----VLKFIGVLY--K-----------------------------DKRLN--FITEY-IKGG--TLRGIIK----------SM-----------------------DSQY---PWSQRVSFAKDIASGMAYLHS--M-----NIIHRDLNSHNCLVR----ENKNV---------VVADFGLARLM-------------V---------D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEM----IN------------------GRSYDEKVDVFSFGIVLCEIIGRVN-AD---------------PD-YL-P-------RTMDF-GLNVRGFLDRYCPPNCP-----------------------------------------------------------------------------PSFFPITVRCCDLDPEKRPS------FV-KLEH---WL-------------
------------------------------LI--HGEVLGKGFFGQA---IKVTH---K---------ATG---KVMVMKEL--IR-CD----EETQK-T-FL-T-------EVKVMRSL--D------HPN-----VLKFIGVLY--K-----------------------------DKKLN--LLTEY-IEGG--TLKDFLR----------SM------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M-----CIIHRDLNSHNCLIK----LDKTV---------VVADFGLSRLIVEERKRAPMEKATT---------------KKRTL---RKNDRKKRYTVVGNPYWMAPEM----LN------------------GKSYDETVDIFSFGIVLCEIIGQVY-AD---------------PD-CL-P-------RTLDF-GLNVKLFWEKFVPTDCP-----------------------------------------------------------------------------PAFFPLAAICCRLEPESRPA------FS-KLED---SF-------------
--------------------------------IKLVKRLGAGQFGEV---WMGYY---N---------NST---KVAV-KTLK-PG-TM----SV--Q-A-FL-E-------EANLMKTL--Q------HDK-----LVRLYAVVT--R-----------------------------EEPIY--IITEY-MAKG--SLLDFLK----------SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K-----NYIHRDLRAANVLVS----ESLMC---------KIADFGLARVI-----------------------E--DNEY------------TAREGAKFPIKWTAPEA----IN------------------FGCFTIKSDVWSFGILLYEIVTYGK-IP---------------YP-GR---------TNADV-MTALSQGYRMPRVENCP-----------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT------FD-YLQSV--L--------------
--------------------------------YTTMRQLGDGTYGSV---LMGKS---N-------E-SGE---LVAI-KRMKRKF-YSW---DE--C-M--NLR-------EVKSLKKL--N------HAN-----VIKLKEVIR--E-----------------------------NDHLY--FIFEY-MKE---NLYQLMK--------DRNK-------------------------LF---PESVIRNIMYQILQGLAFIHK--H-----GFFHRDMKPENLLCM----GPELV---------KIADFGLARE------------------------LRSQPPY------------TD---YVSTRWYRAPEV----LL-----------------RSSVYSSPIDVWAVGSIMAELYM-LR-PL---------------FP-GT---------SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT------AS-QALKHPYF--------------
------------------------------WL--KGQQIGLGAFSSC---YQAQD---V-------G-TGT---LMAV-KQVTYVR-NTS---SE--Q-E-EVVEAL---REEIRMMSHL--N------HPN-----IIRMLGATC--E-----------------------------KSNYN--LFIEW-MAGG--SVAHLLS---------KYG-------------------------AF---KESVVINYTEQLLRGLSYLHE--N-----QIIHRDVKGANLLID----STGQR--------LRIADFGAAARLAS-------------------KGTGAGEFQ------------GQ---LLGTIAFMAPEV----LR------------------GQQYGRSCDVWSVGCAIIEMAC-AK-PP---------------WN-AE---------KHSNH-LALIFKIASATTAPSIPSHLS-------------------------------------------------------------------------PGLRDVALRCLELQPQDRPP------SR-ELLKHPVF--------------
-----------------------------ERV-----VLGKGTYGIV---YAGRD---L-------S-NQV---RIAI-KEIPERD-SRY---SQ--P-L-H--E-------EIALHKYL--K------HRN-----IVQYLGSVS--E-----------------------------NGYIK--IFMEQ-VPGG--SLSALLR--------SKWG-------------------------PM---KEPTIKFYTKQILEGLKYLHE--N-----QIVHRDIKGDNVLVN---TYSGVV---------KISDFGTSKRL-----------------------AGVNPCT------------ET---FTGTLQYMAPEI----ID----------------QGPRGYGAPADIWSLGCTIIEMAT-SK-PP---------------FH-EL-----------GEP-QAAMFKVGMFKIHPEIPEALS-------------------------------------------------------------------------AEARAFILSCFEPDPHKRAT------TA-ELLREGF-L-------------
--------------------------------WRLGKLLGQGAFGRV---YLCYD---V-------D-TGR---ELAV-KQVQFDP-DSP---ET--S-K-EVNAL----ECEIQLLKNL--L------HER-----IVQYYGCLR--DP---------------------------QEKTLS--IFMEY-MPGG--SIKDQLK---------AYG-------------------------AL---TENVTRKYTRQILEGVHYLHS--N-----MIVHRDIKGANILRD----STGNV---------KLGDFGASKRLQ--------------------TICLSGTGM------------KS---VTGTPYWMSPEV----IS------------------GEGYGRKADIWSVACTVVEMLT-EK-PP---------------WA-EF------------EA-MAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS------AD-ELLRHMF-V-------------
-------------------------------W-RRGKLLGQGAFGRV---YLCYD---V-------D-TGR---ELAS-KQVQFDP-DSP---ET--S-K-EVSAL----ECEIQLLKNL--Q------HER-----IVQYYGCLR--DR---------------------------AEKTLT--IFMEY-MPGG--SVKDQLK---------AYG-------------------------AL---TESVTRKYTRQILEGMSYLHS--N-----MIVHRDIKGANILRD----SAGNV---------KLGDFGASKRLQ--------------------TICMSGTGM------------RS---VTGTPYWMSPEV----IS------------------GEGYGRKADVWSLGCTVVEMLT-EK-PP---------------WA-EY------------EA-MAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS------AE-ELLTHHF-A-------------
-------------------------------W-QRGNKIGEGQYGKV---YTCIS---V-------D-TGE---LMAM-KEIRFQP-NDH---KT--I-K-ETAD-------ELKIFEGI--K------HPN-----LVRYFGVEL--H-----------------------------REEMY--IFMEY-CDEG--TLEEVS-----------RL-------------------------GL---QEHVIRLYSKQITIAINVLHE--H-----GIVHRDIKGANIFLT----SSGLI---------KLGDFGCSVKLKN-------------------NAQTMPGEV------------NS---TLGTAAYMAPEV----ITR---------------AKGEGHGRAADIWSLGCVVIEMVT-GK-RP---------------WH-EY----------EHNF-QIMYKVGMGHKPPIPERLS---------------------------------------------------------------------------PEGKDFLSHCLESDPKMRWT------AS-QLLDHSFV--------------
-----------------------------DRV-----VLGKGTYGIV---YAGRD---L-------S-NQV---RIAI-KEIPERD-SRY---SQ--P-L-H--E-------EIALHKHL--K------HKN-----IVQYLGSFS--E-----------------------------NGFIK--IFMEQ-VPGG--SLSALLR--------SKWG-------------------------PLK-DNEQTIGFYTKQILEGLKYLHD--N-----QIVHRDIKGDNVLIN---TYSGVL---------KISDFGTSKRL-----------------------AGINPCT------------ET---FTGTLQYMAPEI----ID----------------KGPRGYGKAADIWSLGCTIIEMAT-GK-PP---------------FY-EL-----------GEP-QAAMFKVGMFKVHPEIPESMS-------------------------------------------------------------------------AEAKAFILKCFEPDPDKRAC------AN-DLLVDEF-L-------------
-----------------------------ERL-----VLGKGTYGVV---YAGRD---R-------H-TRV---RIAI-KEIPERD-SRF---SQ--P-L-H--E-------EIALHRRL--R------HKN-----IVRYLGSAS--Q-----------------------------GGYLK--IFMEE-VPGG--SLSSLLR--------SVWG-------------------------PLK-DNESTISFYTRQILQGLGYLHD--N-----HIVHRDIKGDNVLIN---TFSGLL---------KISDFGTSKRL-----------------------AGITPCT------------ET---FTGTLQYMAPEI----ID----------------QGPRGYGKAADIWSLGCTVIEMAT-GR-PP---------------FH-EL-----------GSP-QAAMFQVGMYKVHPPMPSSLS-------------------------------------------------------------------------AEAQAFLLRTFEPDPRLRAS------AQ-TLLGDPFL--------------
--------------------------------YTNLSYIGEGAYGMV---CSAYD---N-------V-NKV---RVAI-KKISPFE-HQT---YC--Q-R-T-LR-------EIKILLRF--R------HEN-----IIGINDIIR--APT------------------------IEQMKDVY--IVQDL-MET---DLYKLLK----------TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS--A-----NVLHRDLKPSNLLLN----TTCDL---------KICDFGLARVAD--------------------PDHDHTGFL------------TE---YVATRWYRAPEI----ML-----------------NSKGYTKSIDIWSVGCILAEMLS-NR-PI---------------FP-GK---------HYLDQ-LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE------VE-QALAHPYL--------------
--------------------------------YQNLKPIGSGAQGIV---CAAYD---A-------V-LDR---NVAI-KKLSRPF-QNQ---TH--A-K-RAYR-------ELVLMKCV--N------HKN-----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMEL-MDA---NLCQVIQ-----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART------------------------AGTSFMM------------TP---YVVTRYYRAPEV----IL------------------GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR---------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS------VD-DALQHPYI--------------
--------------------------------YRDLQPVGSGAYGAV---CSAVD---G-------R-TGA---KVAI-KKLYRPF-QSE---LF--A-K-RAYR-------ELRLLKHM--R------HEN-----VIGLLDVFT--PDET-----------------------LDDFTDFY--LVMPF-MGT---DLGKLMK----------HE-------------------------KL---GEDRIQFLVYQMLKGLRYIHA--A-----GIIHRDLKPGNLAVN----EDCEL---------KILDFGLAR--------------------------QADSEM------------TG---YVVTRWYRAPEV----IL-----------------NWMRYTQTVDIWSVGCIMAEMIT-GK-TL---------------FK-GS---------DHLDQ-LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------------------------------------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AG-EALAHPYF--------------
----------------------------YVSP----THVGSGAYGSV---CSAID---K-------R-SGE---KVAI-KKLSRPF-QSE---IF--A-K-RAYR-------ELLLLKHM--Q------HEN-----VIGLLDVFT--PASS-----------------------LRNFYDFY--LVMPF-MQT---DLQKIM-----------GM-------------------------EF---SEEKIQYLVYQMLKGLKYIHS--A-----GVVHRDLKPGNLAVN----EDCEL---------KILDFGLAR--------------------------HADAEM------------TG---YVVTRWYRAPEV----IL-----------------SWMHYNQTVDIWSVGCIMAEMLT-GK-TL---------------FK-GK---------DYLDQ-LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP-----------------------------------------------RKDFTQLFPRASPQAADLLEKMLELDVDKRLT------AA-QALTHPFF--------------
--------------------------------YQNLSPVGSGAYGSV---CAAFD---T-------K-TGL---RVAV-KKLSRPF-QSI---IH--A-K-RTYR-------ELRLLKHM--K------HEN-----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHL-MGA---DLNNIVK----------CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--A-----DIIHRDLKPSNLAVN----EDCEL---------KILDFGLAR--------------------------HTDDEM------------TG---YVATRWYRAPEI----ML-----------------NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT---------DHIDQ-LKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
------------------------------YL--LRRQLGQGAYGIV---WKAVD---R-------R-TGE---VVAI-KKIFDAF-RDK---TD--A-Q-RTFR-------EITLLQEF-GD------HPN-----IISLLDVIR--AE---------------------------NDRDIY--LVFEF-MDT---DLNAVIR---------KGG-------------------------LL---QDVHVRSIFYQLLRATRFLHS--G-----HVVHRDQKPSNVLLD----ANCTV---------KLCDFGLARSLGD------------------LPEGPEDQAV------------TE---YVATRWYRAPEV----LL-----------------SSHRYTLGVDMWSLGCILGEMLR-GR-PL---------------FP-GT---------STLHQ-LELILETIPPPSEEDLLALGSGCRASVLHQLGSRP----------------------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDKRLS------AT-QALQHPYV--------------
--------------------------------YTQLQYIGEGAYGMV---SSAYD---H-------V-RKT---RVAI-KKISPFE-HQT---YC--Q-R-T-LR-------EIQILLRF--R------HEN-----VIGIRDILR--AST------------------------LEAMRDVY--IVQDL-MET---DLYKLLK----------SQ-------------------------QL---SNDHICYFLYQILRGLKYIHS--A-----NVLHRDLKPSNLLIN----TTCDL---------KICDFGLARIAD--------------------PEHDHTGFL------------TE---YVATRWYRAPEI----ML-----------------NSKGYTKSIDIWSVGCILAEMLS-NR-PI---------------FP-GK---------HYLDQ-LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKT-----------------------------------------------KVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT------VE-EALAHPYL--------------
--------------------------------YEIIETIGNGAYGVV---SSARR---R-------L-TGQ---QVAI-KKIPNAF-DVV---TN--A-K-RTLR-------ELKILKHF--K------HDN-----IIAIKDILR--PTVP-----------------------YGEFKSVY--VVLDL-MES---DLHQIIH---------SSQ-------------------------PL---TLEHVRYFLYQLLRGLKYMHS--A-----QVIHRDLKPSNLLVN----ENCEL---------KIGDFGMARGLCT-------------------SPAEHQYFM------------TE---YVATRWYRAPEL----ML-----------------SLHEYTQAIDLWSVGCIFGEMLA-RR-QL---------------FP-GK---------NYVHQ-LQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ-----------------------------------------------PVPWETVYPGADRQALSLLGRMLRFEPSARIS------AA-AALRHPFL--------------
--------------------------------YQNLKPIGSGAQGIV---CAAYD---A-------I-LER---NVAI-KKLSRPF-QNQ---TH--A-K-RAYR-------ELVLMKCV--N------HKN-----IIGLLNVFT--PQKS-----------------------LEEFQDVY--IVMEL-MDA---NLCQVIQ-----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART------------------------AGTSFMM------------TP---YVVTRYYRAPEV----IL------------------GMGYKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR---------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VD-EALQHPYI--------------
--------------------------------YQQLKPIGSGAQGIV---CAAFD---T-------V-LGI---NVAV-KKLSRPF-QNQ---TH--A-K-RAYR-------ELVLLKCV--N------HKN-----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMEL-MDA---NLCQVIH-----------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----GIIHRDLKPSNIVVK----SDCTL---------KILDFGLART------------------------ACTNFMM------------TP---YVVTRYYRAPEV----IL------------------GMGYKENVDIWSVGCIMGELVK-GC-VI---------------FQ-GT---------DHIDQ-WNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS------VD-EALRHPYI--------------
-----------------------------KVT---SQVLGLGINGKV---LQIFN---K-------R-TQE---KFAL-KMLQDCP-KAR--------------R-------EVELHWRA-SQ------CPH-----IVRIVDVYE--NLY-------------------------AGRKCLL--IVMEC-LDGG--ELFSRIQD-------RGDQ-------------------------AF---TEREASEIMKSIGEAIQYLHS--I-----NIAHRDVKPENLLYT----SKRPNA------ILKLTDFGFAKE------------------------TTSHNSL------------TT---PCYTPYYVAPEV----LG------------------PEKYDKSCDMWSLGVIMYILLC-GY-PP---------------FY-SN--------HGLAIS-PGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT------IT-EFMNHPWI--------------
-----------------------------INW---TQKLGAGISGPV---RVCVK---K-------S-TQE---RFAL-KILLDRP-KAR--------------N-------EVRLHMMC-AT------HPN-----IVQIIEVFA--NSVQFP-------------------HESSPRARLL--IVMEM-MEGG--ELFHRIS---------QHR-------------------------HF---TEKQASQVTKQIALALRHCHL--L-----NIAHRDLKPENLLFK----DNS-LDA-----PVKLCDFGFAK--------------------------IDQGDL------------MT---PQFTPYYVAPQV----LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLC-GY-PP---------------FY-SKH-------HSRTIP-KDMRRKIMTGSFEFPEEEWSQIS-----------------------------------------------------------------------EMAKDVVRKLLKVKPEERLT------IE-GVLDHPWL--------------
--------------------------------YRLLKTIGKGNFAKV---KLARH---I-------L-TGK---EVAV-KIIDKTQ-LNS---SS--L-Q-KLFR-------EVRIMKVL--N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEY-ASGG--EVFDYLV---------AHG-------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----FIVHRDLKAENLLLD----ADMNI---------KIADFGFSNE------------------------FTFGNKL------------DT---FCGSPPYAAPEL----FQ-----------------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ------------NL-KELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT------LE-QIMKDRWM--------------
--------------------------------YRLLRTIGKGNFAKV---KLARH---I-------L-TGR---EVAI-KIIDKTQ-LNP---SS--L-Q-KLFR-------EVRIMKGL--N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEY-ASAG--EVFDYLV---------SHG-------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K-----NIVHRDLKAENLLLD----AEANI---------KIADFGFSNE------------------------FTLGSKL------------DT---FCGSPPYAAPEL----FQ-----------------GKKYDGPEVDIWSLGVILYTLVS-GS-LP---------------FD-GH------------NL-KELRERVLRGKYRVPFYMS---------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT------LE-QIMKDKWI--------------
--------------------------------LTLGAQIGEGEFGAV---LQGEY---L----------GQ---KVAV-KNIK-CD-VT----AQ----A-FL-D-------ETAVMTKM--Q------HEN-----LVRLLGVIL--------------------------------HQGLY--IVMEH-VSKG--NLVNFLR----------TR----------------------GRALV---NTAQLLQFSLHVAEGMEYLES--K-----KLVHRDLAARNILVS----EDLVA---------KVSDFGLAKAE-----------------------------R------------KGLDSSRLPVKWTAPEA----LK------------------HGKFTSKSDVWSFGVLLWEVFSYGR-AP---------------YP-KM---------SLKEV-SEAVEKGYRMEPPEGCP-----------------------------------------------------------------------------GPVHVLMSSCWEAEPARRPP------FR-KLAEKL----------------
--------------------------------YELHETIGTGGFAKV---KLACH---I-------L-TGE---MVAI-KIMDKNT-LGS---DL--P-R-IKT--------EIEALKNL--R------HQH-----ICQLYHVLE--T-----------------------------ANKIF--MVLEY-CPGG--ELFDYII---------SQD-------------------------RL---SEEETRVVFRQIVSAVAYVHS--Q-----GYAHRDLKPENLLFD----EYHKL---------KLIDFGLCAKP----------------------KGNKDYHL------------QT---CCGSLAYAAPEL----IQ-----------------GKSYLGSEADVWSMGILLYVLMC-GF-LP---------------FD-DD------------NV-MALYKKIMRGKYDVPKWLS---------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS------MK-NLLNHPWI--------------
--------------------------------YRIRGEIGSGNFSQV---KLGIH---S-------L-TKE---KVAI-KILDKTK-LDQ---KT--Q-R-LLSR-------EISSMEKL--H------HPN-----IIRLYEVVE--T-----------------------------LSKLH--LVMEY-AGGG--ELFGKIS---------TEG-------------------------KL---SEPESKLIFSQIVSAVKHMHE--N-----QIIHRDLKAENVFYT----SNTCV---------KVGDFGFSTV------------------------SKKGEML------------NT---FCGSPPYAAPEL----FR-----------------DEHYIGIYVDIWALGVLLYFMVT-GT-MP---------------FR-AE------------TV-AKLKKSILEGTYSVPPHV----S-----------------------------------------------------------------------EPCHRLIRGVLQQIPTERYG------ID-CIMNDEWM--------------
-------------------------------Y-VRLQKIGEGSFGKA---ILVKS---T-------E-DGR---QYVI-KEINISR-MSS---KE--R-E-ESRR-------EVAVLANM--K------HPN-----IVQYRESFE--E-----------------------------NGSLY--IVMDY-CEGG--DLFKRINA-------QKGV-------------------------LF---QEDQILDWFVQICLALKHVHD--R-----KILHRDIKSQNIFLT----KDGTV---------QLGDFGIARVL-----------------------NSTVELA------------RT---CIGTPYYLSPEI----CE------------------NKPYNNKSDIWALGCVLYELCT-LK-HA---------------FE-AG------------SM-KNLVLKIISGSFPPVSLHYS--------------------------------------------------------------------------YDLRSLVSQLFKRNPRDRPS------VN-SILEKGF-I-------------
--------------------------------YEVLYTIGTGSYGRC---QKIRR---K-------S-DGK---ILVW-KELDYGS-MTE---AE--K-Q-MLVS-------EVNLLREL--K------HPN-----IVRYYDRII--DR---------------------------TNTTLY--IVMEY-CEGG--DLASVITKG-----TKERQ-------------------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHTVLHRDLKPANVFLD----GKQNV---------KLGDFGLARIL-----------------------NHDTSFA------------KT---FVGTPYYMSPEQ----MN------------------RMSYNEKSDIWSLGCLLYELCA-LM-PP---------------FT-AF------------SQ-KELAGKIREGKFRRIPYRY---S-----------------------------------------------------------------------DELNEIITRMLNLKDYHRPS------VE-EILENPL-I-------------
-------------------------------Y-CYLRVVGKGSYGEV---TLVKH---R-------R-DGK---QYVI-KKLNLRN-ASS---RE--R-R-AAEQ-------EAQLLSQL--K------HPN-----IVTYKESWE--G----------------------------GDGLLY--IVMGF-CEGG--DLYRKLKE-------QKGQ-------------------------LL---PENQVVEWFVQIAMALQYLHE--K-----HILHRDLKTQNVFLT----RTNII---------KVGDLGIARVL-----------------------ENHCDMA------------ST---LIGTPYYMSPEL----FS------------------NKPYNYKSDVWALGCCVYEMAT-LK-HA---------------FN-AK------------DM-NSLVYRIIEGKLPPMPRDY---S-----------------------------------------------------------------------PELAELIRTMLSKRPEERPS------VR-SILRQPYI--------------
--------------------------------YDVIKAIGQGAFGKA---YLAKG---K-------S-DSK---HCVI-KEINFEK-MPI---QE--K-E-ASKK-------EVILLEKM--K------HPN-----IVAFFNSFQ--E-----------------------------NGRLF--IVMEY-CDGG--DLMKRINR-------QRGV-------------------------LF---SEDQILGWFVQISLGLKHIHD--R-----KILHRDIKAQNIFLS----KNGMV--------AKLGDFGIARVL-----------------------NNSMELA------------RT---CIGTPYYLSPEI----CQ------------------NKPYNNKTDIWSLGCVLYELCT-LK-HP---------------FE-GN------------NL-QQLVLKICQAHFAPISPGF---S-----------------------------------------------------------------------RELHSLISQLFQVSPRDRPS------IN-SILKRPFL--------------
--------------------------------YERIRVVGRGAFGIV---HLCLR---K-------A-DQK---LVII-KQIPVEQ-MTK---EE--R-Q-AAQN-------ECQVLKLL--N------HPN-----VIEYYENFL--E-----------------------------DKALM--IAMEY-APGG--TLAEFIQK-------RCNS-------------------------LL---EEETILHFFVQILLALHHVHT--H-----LILHRDLKTQNILLD---KHRMVV---------KIGDFGISKI------------------------LSSKSKA------------YT---VVGTPCYISPEL----CE------------------GKPYNQKSDIWALGCVLYELAS-LK-RA---------------FE-AA------------NL-PALVLKIMSGTFAPISDRY---S-----------------------------------------------------------------------PELRQLVLSLLSLEPAQRPP------LS-HIMAQP--LC------------
-----------------------------YIP---IRVLGRGAFGEA---TLYRR---T-------E-DDS---LVVW-KEVDLTR-LSE---KE--R-R-DALN-------EIVILALL--Q------HDN-----IIAYYNHFM--D-----------------------------NTTLL--IELEY-CNGG--NLYDKILR-------QKDK-------------------------LF---EEEMVVWYLFQIVSAVSCIHK--A-----GILHRDIKTLNIFLT----KANLI---------KLGDYGLAKKL-----------------------NSEYSMA------------ET---LVGTPYYMSPEL----CQ------------------GVKYNFKSDIWAVGCVIFELLT-LK-RT---------------FD-AT------------NP-LNLCVKIVQGIRAMEVDSS-QYS-----------------------------------------------------------------------LELIQMVHSCLDQDPEQRPT------AD-ELLDRPL-L-------------
--------------------------------YELQETLGKGTYGKV---KRATE---R-------F-SGR---VVAI-KSIRKDK-IKD---EQ--D-M-VHIR------REIEIMSSL--N------HPH-----IISIYEVFE--N-----------------------------KDKIV--IIMEY-ASKG--ELYDYIS---------ERR-------------------------RL---SERETRHFFRQIVSAVHYCHK--N-----GVVHRDLKLENILLD----DNCNI---------KIADFGLSNL------------------------YQKDKFL------------QT---FCGSPLYASPEI----VN-----------------GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FD-GF------------DH-KNLIRQISSGEYREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
--------------------------------YEFLETLGKGTYGKV---KKARE---S-------S-GR----LVAI-KSIRKDK-IKD---EQ--D-L-MHIR------REIEIMSSL--N------HPH-----IIAIHEVFE--N-----------------------------SSKIV--IVMEY-ASRG--DLYDYIS---------ERQ-------------------------QL---SEREARHFFRQIVSAVHYCHQ--N-----RVVHRDLKLENILLD----ANGNI---------KIADFGLSNL------------------------YHQGKFL------------QT---FCGSPLYASPEI----VN-----------------GKPYTGPEVDSWSLGVLLYILVH-GT-MP---------------FD-GH------------DH-KILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT------LE-DVASHWW-V-------------
--------------------------------YELQEVIGSGATAVV---QAAYC---A-------P-KKE---KVAI-KRINLEK-CQT---SM--D-E--LLK-------EIQAMSQC--H------HPN-----IVSYYTSFV--V-----------------------------KDELW--LVMKL-LSGG--SVLDIIKHIVA-KGEHKSG-------------------------VL---DESTIATILREVLEGLEYLHK--N-----GQIHRDVKAGNILLG----EDGSV---------QIADFGVSAFLAT------------------GGDITRNKVR------------KT---FVGTPCWMAPEV----ME-----------------QVRGYDFKADIWSFGITAIELAT-GA-AP---------------YH-KY---------PPMKV-LMLTLQNDPPSLETGVQDKE--MLK------------------------------------------------------------------KYGKSFRKMISLCLQKDPEKRPT------AA-ELLRHKFF--------------
--------------------------------YTRFEKIGQGASGTV---YTAMD---V-------A-TGQ---EVAI-KQMNLQQ-QPK---KE--L-I-I--N-------EILVMREN--K------NPN-----IVNYLDSYL--V-----------------------------GDELW--VVMEY-LAGG--SLTDVVT----------ET-------------------------CM---DEGQIAAVCRECLQALEFLHS--N-----QVIHRDIKSDNILLG----MDGSV---------KLTDFGFCAQI-----------------------TPEQSKR------------ST---MVGTPYWMAPEV----VT------------------RKAYGPKVDIWSLGIMAIEMIE-GE-PP---------------YL-NE---------NPLRA-LYLIATNGTPELQNPEKLS---------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS------AK-ELLQHQFL--------------
--------------------------------YTRYEKIGQGASGTV---FTATD---V-------A-LGQ---EVAI-KQINLQK-QPK---KE--L-I-I--N-------EILVMKEL--K------NPN-----IVNFLDSYL--V-----------------------------GDELF--VVMEY-LAGG--SLTDVVT----------ET-------------------------CM---DEAQIAAVCRECLQALEFLHA--N-----QVIHRDIKSDNVLLG----MEGSV---------KLTDFGFCAQI-----------------------TPEQSKR------------ST---MVGTPYWMAPEV----VT------------------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE---------NPLRA-LYLIATNGTPELQNPEKLS---------------------------------------------------------------------------PIFRDFLNRCLEMDVEKRGS------AK-ELLQHPFL--------------
--------------------------------YTRFEKIGQGASGTV---YTALD---I-------A-TGQ---EVAI-KQMNLQQ-QPK---KE--L-I-I--N-------EILVMREN--K------NPN-----IVNYLDSYL--V-----------------------------GDELW--VVMEY-LAGG--SLTDVVT----------ET-------------------------CM---DEGQIAAVCRECLQALDFLHS--N-----QVIHRDIKSDNILLG----MDGSV---------KLTDFGFCAQI-----------------------TPEQSKR------------ST---MVGTPYWMAPEV----VT------------------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE---------NPLRA-LYLIATNGTPELQNPERLS---------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS------AK-ELLQHPFL--------------
----------------------------DNFI-----KIGEGSTGIV---CIATV---R-------S-SGK---LVAV-KKMDLRK-QQR---RE--L----LFN-------EVVIMRDY--Q------HEN-----VVEMYNSYL--V-----------------------------GDELW--VVMEF-LEGG--ALTDIVT----------HT-------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q-----GVIHRDIKSDSILLT----HDGRV---------KLSDFGFCAQV-----------------------SKEVPRR------------KS---LVGTPYWMAPEL----IS------------------RLPYGPEVDIWSLGIMVIEMVD-GE-PP---------------YF-NE---------PPLKA-MKMIRDNLPPRLKNLHKVS---------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT------AA-ELLKHPFL--------------
----------------------------DSYV-----KIGEGSTGIV---CLARE---K-------H-SGR---QVAV-KMMDLRK-QQR---RE--L----LFN-------EVVIMRDY--Q------HFN-----VVEMYKSYL--V-----------------------------GEELW--VLMEF-LQGG--ALTDIVS----------QV-------------------------RL---NEEQIATVCEAVLQALAYLHA--Q-----GVIHRDIKSDSILLT----LDGRV---------KLSDFGFCAQI-----------------------SKDVPKR------------KS---LVGTPYWMAPEV----IS------------------RSLYATEVDIWSLGIMVIEMVD-GE-PP---------------YF-SD---------SPVQA-MKRLRDSPPPKLKNSHKVS---------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT------AQ-ELLDHPFL--------------
----------------------------ANFI-----KIGEGSTGIV---CIATE---K-------H-TGK---QVAV-KKMDLRK-QQR---RE--L----LFN-------EVVIMRDY--H------HDN-----VVDMYSSYL--V-----------------------------GDELW--VVMEF-LEGG--ALTDIVT----------HT-------------------------RM---NEEQIATVCLSVLRALSYLHN--Q-----GVIHRDIKSDSILLT----SDGRI---------KLSDFGFCAQV-----------------------SKEVPKR------------KS---LVGTPYWMAPEV----IS------------------RLPYGTEVDIWSLGIMVIEMID-GE-PP---------------YF-NE---------PPLQA-MRRIRDSLPPRVKDLHK----VS-----------------------------------------------------------------------SVLRGFLDLMLVREPSQRAT------AQ-ELLGHPFL--------------
-------------------------------Y-IKLDKLGEGTYATV---YKGKS---K-------L-TDN---LVAL-KEIRLEH-EEG---AP--C---TAIR-------EVSLLKDL--K------HAN-----IVTLHDIIH--T-----------------------------EKSLT--LVFEY-LDK---DLKQYLD--------DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--Q-----KVLHRDLKPQNLLIN----ERGEL---------KLADFGLARAK-----------------------SIPTKTY------------SN---EVVTLWYRPPDI----LL-----------------GSTDYSTQIDMWGVGCIFYEMAT-GR-PL---------------FP-GS---------TVEEQ-LHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS------AE-DAMKHPFF--------------
-------------------------------Y-IKLEKLGEGTYATV---YKGRS---K-------L-TEN---LVAL-KEIRLEH-EEG---AP--C---TAIR-------EVSLLKDL--K------HAN-----IVTLHDIVH--T-----------------------------DKSLT--LVFEY-LDK---DLKQYMD--------DCGN-------------------------IM---SMHNVKLFLYQILRGLAYCHR--R-----KVLHRDLKPQNLLIN----EKGEL---------KLADFGLARAK-----------------------SVPTKTY------------SN---EVVTLWYRPPDV----LL-----------------GSSEYSTQIDMWGVGCIFFEMAS-GR-PL---------------FP-GS---------TVEDE-LHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK------------------------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVS------AE-EAMKHVYF--------------
--------------------------------YVKLDKLGEGTYATV---FKGRS---K-------L-TEN---LVAL-KEIRLEH-EEG---AP--C---TAIR-------EVSLLKNL--K------HAN-----IVTLHDLIH--T-----------------------------DRSLT--LVFEY-LDS---DLKQYLD---------HCG-------------------------NL--MSMHNVKIFMFQLLRGLAYCHH--R-----KILHRDLKPQNLLIN----ERGEL---------KLADFGLARAK-----------------------SVPTKTY------------SN---EVVTLWYRPPDV----LL-----------------GSTEYSTPIDMWGVGCIHYEMAT-GR-PL---------------FP-GS---------TVKEE-LHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMS------AE-AALSHSYF--------------
-------------------------------F-KFGKILGEGSFSTV---VLARE---L-------A-TSR---EYAI-KILEKRH-IIK---EN--K-VPYVTR-------ERDVMSRL--D------HPF-----FVKLYFTFQ--D-----------------------------DEKLY--FGLSY-AKNG--ELLKYIR---------KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG--K-----GIIHRDLKPENILLN----EDMHI---------QITDFGTAKVLS---------------------PESKQARA------------NS---FVGTAQYVSPEL----LT------------------EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG------------NE-YLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
--------------------------------YEKLEKLGEGSYATV---YKGKS---K-------V-NGK---LVAL-KVIRLQE-EEG---TP--F---TAIR-------EASLLKGL--K------HAN-----IVLLHDIIH--T-----------------------------KETLT--LVFEY-VHT---DLCQYMD--------KHPG-------------------------GL---HPDNVKLFLFQLLRGLSYIHQ--R-----YILHRDLKPQNLLIS----DTGEL---------KLADFGLARAK-----------------------SVPSHTY------------SN---EVVTLWYRPPDV----LL-----------------GSTEYSTCLDMWGVGCIFVEMIQ-GV-AA---------------FP-GM--------KDIQDQ-LERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS------AQ-AALSHEYF--------------
--------------------------------YEPKEILGRGVSSVV---RRCIH---K-------P-TSQ---EYAV-KVIDVTG-GGS---FS--P-E-EVRELREATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T-----------------------------NTFFF--LVFDL-MKRG--ELFDYLT---------EKV-------------------------TL---SEKETRKIMRALLEVICTLHK--L-----NIVHRDLKPENILLD----DNMNI---------KLTDFGFSCQ------------------------LEPGERL------------RE---VCGTPSYLAPEI----IECS------------MNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PP---------------FW-HR------------KQ-MLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT------AE-EALAHPFF--------------
-----------------------------YDP---KDVIGRGVSSVV---RRCVH---R-------A-TGH---EFAV-KIMEVTA-ERL---SP--E-Q-LEEVREA-TRRETHILRQV-AG------HPH-----IITLIDSYE--S-----------------------------SSFMF--LVFDL-MRKG--ELFDYLT---------EKV-------------------------AL---SEKETRSIMRSLLEAVSFLHA--N-----NIVHRDLKPENILLD----DNMQI---------RLSDFGFSCH------------------------LEPGEKL------------RE---LCGTPGYLAPEI----LKCS------------MDETHPGYGKEVDLWACGVILFTLLA-GS-PP---------------FW-HR------------RQ-ILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT------AE-QALQHPFF--------------
--------------------------------YQVGPLLGSGGFGSV---YSGIR---V-------S-DNL---PVAI-KHVEKDR-ISD---WG--E-L-PNGTRV---PMEVVLLKKV--S------SGFS---GVIRLLDWFE--R-----------------------------PDSFV--LILER-PEPV-QDLFDFIT---------ERG-------------------------AL---QEELARSFFWQVLEAVRHCHN--C-----GVLHRDIKDENILID---LNRGEL---------KLIDFGSGA-------------------------LLKDTVY------------TD---FDGTRVYSPPEW----IR-----------------YHRYHGRSAAVWSLGILLYDMVC-GD-IP---------------FE-HD-------------------EEIIRGQVFFRQRVS---------------------------------------------------------------------------SECQHLIRWCLALRPSDRPT------FE-EIQNHPWM--------------
--------------------------------YRLGPLLGKGGFGTV---FAGHR---L-------T-DRL---QVAI-KVIPRNR-VLG---WS--P-L-SDSVTC---PLEVALLWKV--GAG--GGHPG-----VIRLLDWFE--T-----------------------------QEGFM--LVLERPLPAQ--DLFDYIT---------EKG-------------------------PL---GEGPSRCFFGQVVAAIQHCHS--R-----GVVHRDIKDENILID---LRRGCA---------KLIDFGSGA-------------------------LLHDEPY------------TD---FDGTRVYSPPEW----IS-----------------RHQYHALPATVWSLGILLYDMVC-GD-IP---------------FE-RD-------------------QEILEAELHFPAHVS---------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS------LE-EILLDPWM--------------
--------------------------------YQVGAVLGSGGFGTV---YAGSR---I-------A-DGL---PVAV-KHVVKER-VTE---WG--S-L-GGATV----PLEVVLLRKV--GAA--GGARG-----VIRLLDWFE--R-----------------------------PDGFL--LVLER-PEPA-QDLFDFIT---------ERG-------------------------AL---DEPLARRFFAQVLAAVRHCHS--C-----GVVHRDIKDENLLVD---LRSGEL---------KLIDFGSGA-------------------------LLKDTVY------------TD---FDGTRVYSPPEW----IR-----------------YHRYHGRSATVWSLGVLLYDMVC-GD-IP---------------FE-QD-------------------EEILRGRLLFRRRVS---------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS------LD-QIAAHPWM--------------
------------------------------FR--CCAVLGRGHFGKV---LLAEY---K-------N-TNE---MFAI-KALKKGD-IVA---RD--E-V-DSLM------CEKRIFETV--NS---VRHPF-----LVNLFACFQ--T-----------------------------KEHVC--FVMEY-AAGG--DLMMHIH----------TD-------------------------VF---SEPRAVFYAACVVLGLQYLHE--H-----KIVYRDLKLDNLLLD----TEGFV---------KIADFGLCKEG-----------------------MGYGDRT------------ST---FCGTPEFLAPEV----LT------------------ETSYTRAVDWWGLGVLIYEMLV-GE-SP---------------FP-GD------------DE-EEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF--------------
------------------------------YV--RGRFLGKGGFAKC---FEISD---A-------D-TKE---VFAG-KIVPKSL-LLK---PH--Q-R-EKMS------MEISIHRSL--A------HQH-----VVGFHGFFE--D-----------------------------NDFVF--VVLEL-CRRR--SLLELHK---------RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--N-----RVIHRDLKLGNLFLN----EDLEV---------KIGDFGLATKV-----------------------EYDGERK------------KT---LCGTPNYIAPEV----LS------------------KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS------------CL-KETYLRIKKNEYSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTARPT------IN-ELLNDEFF--------------
-------------------------------Y-CRGKVLGKGGFAKC---YEMTD---L-------T-NNK---VYAA-KIIPHSR-VAK---PH--Q-R-EKID------KEIELHRIL--H------HKH-----VVQFYHYFE--D-----------------------------KENIY--ILLEY-CSRR--SMAHILK---------ARK-------------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q-----EILHRDLKLGNFFIN----EAMEL---------KVGDFGLAARL-----------------------EPLEHRR------------RT---ICGTPNYLSPEV----LN------------------KQGHGCESDIWALGCVMYTMLL-GR-PP---------------FE-TT------------NL-KETYRCIREARYTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS------LD-DIIRHDFF--------------
------------------------------YL--KGRLLGKGGFARC---YEATD---T-------E-TGS---AYAV-KVIPQSR-VAK---PH--Q-R-EKIL------NEIELHRDL--Q------HRH-----IVRFSHHFE--D-----------------------------ADNIY--IFLEL-CSRK--SLAHIWK---------ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R-----GILHRDLKLGNFFIT----ENMEL---------KVGDFGLAARL-----------------------EPPEQRK------------KT---ICGTPNYVAPEV----LL------------------RQGHGPEADVWSLGCVMYTLLC-GS-PP---------------FE-TA------------DL-KETYRCIKQVHYTLPASLS---------------------------------------------------------------------------LPARQLLAAILRASPRDRPS------ID-QILRHDFF--------------
-------------------------------F-KVGNLLGKGSFAGV---YRAES---I-------H-TGL---EVAI-KMIDKKA-MYK---AG--M-V-QRVQ------NEVKIHCQL--K------HPS-----ILELYNYFE--D-----------------------------SNYVY--LVLEM-CHNG--EMNRYLK--------NRVK-------------------------PF---SENEARHFMHQIITGMLYLHS--H-----GILHRDLTLSNLLLT----RNMNI---------KIADFGLATQL-----------------------KMPHEKH------------YT---LCGTPNYISPEI----AT------------------RSAHGLESDVWSLGCMFYTLLI-GR-PP---------------FD-TD------------TV-KNTLNKVVLADYEMPSFLS---------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS------LS-SVLDHPFM--------------
-------------------------------Y-ILGDTLGVGTFGKV---KVGKH---E-------L-TGH---KVAV-KILNRQK-IRS---LD--V-V-GKIR------REIQNLKLF--R------HPH-----IIKLYQVIS--T-----------------------------PSDIF--MVMEY-VSGG--ELFDYIC---------KNG-------------------------RL---DEKESRRLFQQILSGVDYCHR--H-----MVVHRDLKPENVLLD----AHMNA---------KIADFGLSNM------------------------MSDGEFL------------RT---SCGSPNYAAPEV----IS-----------------GRLYAGPEVDIWSSGVILYALLC-GT-LP---------------FD-DD------------HV-PTLFKKICDGIFYTPQYLN---------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAT------IK-DIREHEWF--------------
--------------------------------YVLGDTLGVGTFGKV---KIGEH---Q-------L-TGH---KVAV-KILNRQK-IRS---LD--V-V-GKIK------REIQNLKLF--R------HPH-----IIKLYQVIS--T-----------------------------PTDFF--MVMEY-VSGG--ELFDYIC---------KHG-------------------------RV---EEMEARRLFQQILSAVDYCHR--H-----MVVHRDLKPENVLLD----AHMNA---------KIADFGLSNM------------------------MSDGEFL------------RT---SCGSPNYAAPEV----IS-----------------GRLYAGPEVDIWSCGVILYALLC-GT-LP---------------FD-DE------------HV-PTLFKKIRGGVFYIPEYLN---------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT------IK-DIREHEWF--------------
-------------------------------F-ERIKTLGTGSFGRV---MLVKH---K-------E-TGN---HYAM-KILDKQK-VVK---LK--Q-I-EHTL------NEKRILQAV--N------FPF-----LVKLEFSFK--D-----------------------------NSNLY--MVMEY-VPGG--EMFSHLR---------RIG-------------------------RF---SEPHARFYAAQIVLTFEYLHS--L-----DLIYRDLKPENLLID----QQGYI---------QVTDFGFAK--------------------------RVKGRT------------WT---LCGTPEYLAPEI----IL------------------SKGYNKAVDWWALGVLIYEMAA-GY-PP---------------FF-AD------------QP-IQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVN-DIKNHKWF--------------
-------------------------------F-ERKKTLGTGSFGRV---MLVKH---K-------A-TEQ---YYAM-KILDKQK-VVK---LK--Q-I-EHTL------NEKRILQAV--N------FPF-----LVRLEYAFK--D-----------------------------NSNLY--MVMEY-VPGG--EMFSHLR---------RIG-------------------------RF---SEPHARFYAAQIVLTFEYLHS--L-----DLIYRDLKPENLLID----HQGYI---------QVTDFGFAK--------------------------RVKGRT------------WT---LCGTPEYLAPEI----IL------------------SKGYNKAVDWWALGVLIYEMAA-GY-PP---------------FF-AD------------QP-IQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVS-DIKTHKWF--------------
--------------------------------FERLRTLGMGSFGRV---MLVRH---Q-------E-TGG---HYAM-KILNKQK-VVK---MK--Q-V-EHIL------NEKRILQAI--D------FPF-----LVKLQFSFK--D-----------------------------NSYLY--LVMEY-VPGG--EMFSRLQ---------RVG-------------------------RF---SEPHACFYAAQVVLAVQYLHS--L-----DLIHRDLKPENLLID----QQGYL---------QVTDFGFAK--------------------------RVKGRT------------WT---LCGTPEYLAPEI----IL------------------SKGYNKAVDWWALGVLIYEMAV-GF-PP---------------FY-AD------------QP-IQIYEKIVSGRVRFPSKLS---------------------------------------------------------------------------SDLKHLLRSLLQVDLTKRFGNL-RNGVG-DIKNHKWF--------------
-------------------------------F-NFLMVLGKGSFGKV---MLSER---K-------G-TDE---LYAV-KILKKDV-VIQ---DD--D-V-ECTM------VEKRVLALP-GK------PPF-----LTQLHSCFQ--T-----------------------------MDRLY--FVMEY-VNGG--DLMYHIQ---------QVG-------------------------RF---KEPHAVFYAAEIAIGLFFLQS--K-----GIIYRDLKLDNVMLD----SEGHI---------KIADFGMCKEN-----------------------IWDGVTT------------KT---FCGTPDYIAPEI----IA------------------YQPYGKSVDWWAFGVLLYEMLA-GQ-AP---------------FE-GE------------DE-DELFQSIMEHNVAYPKSMS---------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
------------------------------FI--FHKVLGKGSFGKV---LLGEL---K-------G-RGE---YFAI-KALKKDV-VLI---DD--D-V-ECTM------VEKRVLTLA-AE------NPF-----LTHLICTFQ--T-----------------------------KDHLF--FVMEF-LNGG--DLMYHIQ---------DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS--K-----GIIYRDLKLDNVLLD----RDGHI---------KIADFGMCKEN-----------------------IFGESRA------------ST---FCGTPDYIAPEI----LQ------------------GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD------------DE-DELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
--------------------------------FEFIRVLGKGSFGKV---MLARV---K-------E-TGD---LYAV-KVLKKDV-ILQ---DD--D-V-ECTM------TEKRILSLA-RN------HPF-----LTQLFCCFQ--T-----------------------------PDRLF--FVMEF-VNGG--DLMFHIQ---------KSR-------------------------RF---DEARARFYAAEIISALMFLHD--K-----GIIYRDLKLDNVLLD----HEGHC---------KLADFGMCKEG-----------------------ICNGVTT------------AT---FCGTPDYIAPEI----LQ------------------EMLYGPAVDWWAMGVLLYEMLC-GH-AP---------------FE-AE------------NE-DDLFEAILNDEVVYPTWLH---------------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
-------------------------------F-DLLRVIGRGSYAKV---LLVRL---K-------K-TDR---IYAM-KVVKKEL-VND---DE--D-I-DWVQ------TEKHVFEQA-SN------HPF-----LVGLHSCFQ--T-----------------------------ESRLF--FVIEY-VNGG--DLMFHMQ---------RQR-------------------------KL---PEEHARFYSAEISLALNYLHE--R-----GIIYRDLKLDNVLLD----SEGHI---------KLTDYGMCKEG-----------------------LRPGDTT------------ST---FCGTPNYIAPEI----LR------------------GEDYGFSVDWWALGVLMFEMMA-GR-SP---------------FD-IVGSS---DNPDQNTE-DYLFQVILEKQIRIPRSLS---------------------------------------------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFA-DIQGHPF-F-------------
------------------------------FI--LHKMLGKGSFGKV---FLAEF---K-------K-TNQ---FFAI-KALKKDV-VLM---DD--D-V-ECTM------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T-----------------------------KENLF--FVMEY-LNGG--DLMYHIQ---------SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS--K-----GIVYRDLKLDNILLD----KDGHI---------KIADFGMCKEN-----------------------MLGDAKT------------NT---FCGTPDYIAPEI----LL------------------GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ------------DE-EELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
-------------------------------F-DLIRVIGRGSYAKV---LLVRL---K-------K-NDQ---IYAM-KVVKKEL-VHD---DE--D-I-DWVQ------TEKHVFEQA-SS------NPF-----LVGLHSCFQ--T-----------------------------TSRLF--LVIEY-VNGG--DLMFHMQ---------RQR-------------------------KL---PEEHARFYAAEICIALNFLHE--R-----GIIYRDLKLDNVLLD----ADGHI---------KLTDYGMCKEG-----------------------LGPGDTT------------ST---FCGTPNYIAPEI----LR------------------GEEYGFSVDWWALGVLMFEMMA-GR-SP---------------FD-IITD-----NPDMNTE-DYLFQVILEKPIRIPRFLS---------------------------------------------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF-----
------------------------------PD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAI-KIIDKLR-FPT---KQ--E-S-QLRN-------EVAILQNL--H------HPG-----VVNLECMFE--T-----------------------------PERVF--VVMEK-LHGD--MLEMILS--------SEKG-------------------------RL---PEHITKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA----SADPFP------QVKLCDFGFARI------------------------IGEKSFR------------RS---VVGTPAYLAPEV----LR------------------NKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED---------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS------VD-KTLSHPWL--------------
------------------------------PD----EVLGSGQFGVV---YGGKH---R-------K-TGR---DVAV-KVIDKLR-FPT---KQ--E-S-QLRN-------EVAILQSL--R------HPG-----IVNLECMFE--T-----------------------------PEKVF--VVMEK-LHGD--MLEMILS--------SEKG-------------------------RL---PERLTKFLITQILVALRHLHF--K-----NIVHCDLKPENVLLA----SADPFP------QVKLCDFGFARI------------------------IGEKSFR------------RS---VVGTPAYLAPEV----LL------------------NQGYNRSLDMWSVGVIMYVSLS-GT-FP---------------FN-ED---------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
-----------------------------FAD----EVLGSGQFGIV---YGGKH---R-------K-TGR---DVAI-KVIDKMR-FPT---KQ--E-S-QLRN-------EVAILQNL--H------HPG-----IVNLECMFE--T-----------------------------PERVF--VVMEK-LHGD--MLEMILS--------SEKS-------------------------RL---PERITKFMVTQILVALRNLHF--K-----NIVHCDLKPENVLLA----SAEPFP------QVKLCDFGFARI------------------------IGEKSFR------------RS---VVGTPAYLAPEV----LR------------------SKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED---------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
-------------------------------F-NIIDTLGVGGFGRV---ELVQL---KS------E-ESK---TFAM-KILKKRH-IVD---TR--Q-Q-EHIR------SEKQIMQGA--H------SDF-----IVRLYRTFK--D-----------------------------SKYLY--MLMEA-CLGG--ELWTILR---------DRG-------------------------SF---EDSTTRFYTACVVEAFAYLHS--K-----GIIYRDLKPENLILD----HRGYA---------KLVDFGFAKK------------------------IGFGKKT------------WT---FCGTPEYVAPEI----IL------------------NKGHDISADYWSLGILMYELLT-GS-PP---------------FS-GP------------DP-MKTYNIILRGIDMIEFPKKIA-------------------------------------------------------------------------KNAANLIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF--------------
------------------------------FD--TLATVGTGTFGRV---HLVKE---K-------T-AKH---FFAL-KVMSIPD-VIR---LK--Q-E-QHVH------NEKSVLKEV--S------HPF-----LIRLFWTWH--D-----------------------------ERFLY--MLMEY-VPGG--ELFSYLR---------NRG-------------------------RF---SSTTGLFYSAEIICAIEYLHS--K-----EIVYRDLKPENILLD----RDGHI---------KLTDFGFAKK--------------------------LVDRT------------WT---LCGTPEYLAPEV----IQ------------------SKGHGRAVDWWALGILIFEMLS-GF-PP---------------FF-DD------------NP-FGIYQKILAGKIDFPRHLD---------------------------------------------------------------------------FHVKDLIKKLLVVDRTRRLGNM-KNGAN-DVKHHRWF--------------
----------------------------YNVY----GYTGQGVFSNV---VRARD---N-------ARANQ---EVAV-KIIRNNE-LMQ---KT--G-----LK-------ELEFLKKL--NDADPDDKFH-----CLRLFRHFY--H-----------------------------KQHLC--LVFEP-LSM---NLREVLKK------YGKDV-------------------------GL---HIKAVRSYSQQLFLALKLLKR--C-----NILHADIKPDNILVN----ESKTI--------LKLCDFGSAS-------------------------HVADNDI------------TP---YLVSRFYRAPEI----II------------------GKSYDYGIDMWSVGCTLYELYT-GK-IL---------------FP-GK---------TNNHM-LKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS------IN-QALQHAFI--------------
-------------------------------L-VLGKTLGEGEFGKV---VKATA---FH--LKGRA-GYT---TVAV-KMLK-EN-AS----PSELR-D-LL-S-------EFNVLKQV--N------HPH-----VIKLYGACS--Q-----------------------------DGPLL--LIVEY-AKYG--SLRGFLR----------ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M-----KLVHRDLAARNILVA----EGRKM---------KISDFGLSRDV-------------Y---------E--EDSY------------VKRSQGRIPVKWMAIES----LF------------------DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YP-GI---------PPERL-FNLLKTGHRMERPDNCS-----------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV------FA-DISKDL----------------
--------------------------------FELLKVLGQGSFGKVFLVRKVTR---P-------D-SGH---LYAM-KVLKKAT-LKV---RD--R-V-RTKM-------ERDILADV--N------HPF-----VVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS---------KEV-------------------------MF---TEEDVKFYLAELALGLDHLHS--L-----GIIYRDLKPENILLD----EEGHI---------KLTDFGLSKEA-----------------------IDHEKKA------------YS---FCGTVEYMAPEV----VN------------------RQGHSHSADWWSYGVLMFEMLT-GS-LP---------------FQ-GK------------DR-KETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAE-EIKRHV--FY------------
--------------------------------FELLKVLGQGSYGKV---FLVRK---V-------K-GSDAGQLYAM-KVLKKAT-LKV---RD--R-V-RSKM-------ERDILAEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS---------KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD----EEGHI---------KITDFGLSKEA-----------------------IDHDKRA------------YS---FCGTIEYMAPEV----VN------------------RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQ-GK------------DR-KETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG-IDGVE-EIKRHPFF--------------
--------------------------------FELLKVLGQGSFGKV---FLVKK---I-------S-GSDARQLYAM-KVLKKAT-LKV---RD--R-V-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DLFTRLS---------KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L-----GIIYRDLKPENILLD----EEGHI---------KLTDFGLSKES-----------------------IDHEKKA------------YS---FCGTVEYMAPEV----VN------------------RRGHTQSADWWSFGVLMFEMLT-GT-LP---------------FQ-GK------------DR-KETMTMILKAKLGMPQFLS---------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG-PDGVE-EIKRHSFF--------------
--------------------------------FELLKVLGQGSFGKV---FLVRK---K-------T-GPDAGQLYAM-KVLKKAS-LKV---RD--R-V-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDF-LRGG--DVFTRLS---------KEV-------------------------LF---TEEDVKFYLAELALALDHLHQ--L-----GIVYRDLKPENILLD----EIGHI---------KLTDFGLSKES-----------------------VDQEKKA------------YS---FCGTVEYMAPEV----VN------------------RRGHSQSADWWSYGVLMFEMLT-GT-LP---------------FQ-GK------------DR-NETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS---EGVE-EIKRHLFF--------------
--------------------------------FELLRVLGKGGYGKV---FQVRKVTGA-------N-TGK---IFAM-KVLKKAM-IVR---NA--K-D-TAHTK-----AERNILEEV--K------HPF-----IVDLIYAFQ--T-----------------------------GGKLY--LILEY-LSGG--ELFMQLE---------REG-------------------------IF---MEDTACFYLAEISMALGHLHQ--K-----GIIYRDLKPENIMLN----HQGHV---------KLTDFGLCKES-----------------------IHDGTVT------------HT---FCGTIEYMAPEI----LM------------------RSGHNRAVDWWSLGALMYDMLT-GA-PP---------------FT-GE------------NR-KKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF--------------
--------------------------------FELLRVLGKGGYGKV---FQVRK---V-------Q-GTNLGKIYAM-KVLRKAK-IVR---NA--K-D-TAHTR-----AERNILESV--K------HPF-----IVELAYAFQ--T-----------------------------GGKLY--LILEC-LSGG--ELFTHLE---------REG-------------------------IF---LEDTACFYLAEITLALGHLHS--Q-----GIIYRDLKPENIMLS----SQGHI---------KLTDFGLCKES-----------------------IHEGAVT------------HT---FCGTIEYMAPEI----LV------------------RSGHNRAVDWWSLGALMYDMLT-GS-PP---------------FT-AE------------NR-KKTMDKIIRGKLALPPYLT---------------------------------------------------------------------------PDARDLVKKFLKRNPSQRIGGG-PGDAA-DVQRHPFF--------------
--------------------------------YELVRELGKGTYGKV---DLVVY---K-------G-TGT---KMAL-KFVNKSK-TKL---KN--F-----LR-------EVSITNSL-SS------SPF-----IIKVFDVVF--E----------------------------TEDCYV--FAQEY-APAG--DLFDIIP---------PQV-------------------------GL---PEDTVKRCVQQLGLALDFMHG--R-----QLVHRDIKPENVLLFD--RECRRV---------KLADFGMTR--------------------------RVGCRV------------KR---VSGTIPYTAPEV----CQAG-------------RADGLAVDTGVDVWAFGVLIFCVLT-GN-FP---------------WE-AA---------SGADAFFEEFVRWQRGRLPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP------AK-EVF-----RFLKH---------
--------------------------------YDIERTLGKGNFAVV---KLARH---R-------V-TKT---QVAI-KIIDKTR-LDS---SN--L-E-KIYR-------EVQLMKLL--N------HPH-----IIKLYQVME--T-----------------------------KDMLY--IVTEF-AKNG--EMFDYLT---------SNG-------------------------HL---SENEARKKFWQILSAVEYCHD--H-----HIVHRDLKTENLLLD----GNMDI---------KLADFGFGNF------------------------YKSGEPL------------ST---WCGSPPYAAPEV----FE-----------------GKEYEGPQLDIWSLGVVLYVLVC-GS-LP---------------FD-GP------------NL-PTLRQRVLEGRFRIPFFMS---------------------------------------------------------------------------QDCESLIRRMLVVDPARRIT------IA-QIRQHRWM--------------
--------------------------------YDIEGTLGKGNFAVV---KLGRH---R-------I-TKT---EVAI-KIIDKSQ-LDA---VN--L-E-KIYR-------EVQIMKML--D------HPH-----IIKLYQVME--T-----------------------------KSMLY--LVTEY-AKNG--EIFDYLA---------NHG-------------------------RL---NESEARRKFWQILSAVDYCHG--R-----KIVHRDLKAENLLLD----NNMNI---------KIADFGFGNF------------------------FKSGELL------------AT---WCGSPPYAAPEV----FE-----------------GQQYEGPQLDIWSMGVVLYVLVC-GA-LP---------------FD-GP------------TL-PILRQRVLEGRFRIPYFMS---------------------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT------IA-QIKEHKWM--------------
--------------------------------WEIIGELGDGAFGKV---YKAQN---K-------E-TSV---LAAA-KVIDTKS-EEE---LE--D-Y-M--V-------EIDILASC--D------HPN-----IVKLLDAFY--Y-----------------------------ENNLW--ILIEF-CAGG--AVDAVML--------ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--N-----KIIHRDLKAGNILFT----LDGDI---------KLADFGVSAKN-----------------------TRTIQRR------------DS---FIGTPYWMAPEV----VMCE-------------TSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL---------NPMRV-LLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT------TS-QLLQHPFV--------------
--------------------------------YDLDKTLGRGHFAVV---KLARH---V-------F-TGE---KVAV-KVIDKTK-LDT---LA--T-G-HLFQ-------EVRCMKLV--Q------HPN-----IVRLYEVID--T-----------------------------QTKLY--LILEL-GDGG--DMFDYIM--------KHEE-------------------------GL---NEDLAKKYFAQIVHAISYCHK--L-----HVVHRDLKPENVVFF---EKQGLV---------KLTDFGFSNK------------------------FQPGKKL------------TT---SCGSLAYSAPEI----LL-----------------GDEYDAPAVDIWSLGVILFMLVC-GQ-PP---------------FQ-EA------------ND-SETLTMIMDCKYTVPSHVS---------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS------LE-EIENHPWL--------------
-----------------------------YLM---GDLLGEGSYGKV---KEVLD---S-------E-TLC---RRAV-KILKKKK-LRR---IP--N-G-EANVK-----KEIQLLRRL--R------HKN-----VIQLVDVLY--NE---------------------------EKQKMY--MVMEY-CVCGMQEMLDSVP----------EK-------------------------RF---PVCQAHGYFCQLIDGLEYLHS--Q-----GIVHKDIKPGNLLLT----TGGTL---------KISDLGVAEALH---------------------PFAADDTC------------RT---SQGSPAFQPPEI----AN----------------GLDTFSGFKVDIWSAGVTLYNITT-GL-YP---------------FE-GD------------NI-YKLFENIGKGSYAIPGDCG---------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS------IR-QIRQHSWF--------------
-----------------------------LCP---GRELGRGKFAVV---RKCIK---K-------D-SGK---EFAA-KFMRKRR-KGQ---DC--R-M-EIIH-------EIAVLELA-QD------NPW-----VINLHEVYE--T-----------------------------ASEMI--LVLEY-AAGG--EIFDQCVA-------DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT--R-----DVVHLDLKPQNILLT----SESPLG------DIKIVDFGLSRI------------------------LKNSEEL------------RE---IMGTPEYVAPEI----LS------------------YDPISMATDMWSIGVLTYVMLT-GI-SP---------------FL-GN------------DK-QETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
-----------------------------ILT---SKELGRGKFAVV---RQCIS---K-------S-TGQ---EYAA-KFLKKRR-RGQ---DC--R-A-EILH-------EIAVLELA-KS------CPR-----VINLHEVYE--N-----------------------------TSEII--LILEY-AAGG--EIFSLCLP-------ELAE-------------------------MV---SENDVIRLIKQILEGVYYLHQ--N-----NIVHLDLKPQNILLS----SIYPLG------DIKIVDFGMSRK------------------------IGHACEL------------RE---IMGTPEYLAPEI----LN------------------YDPITTATDMWNIGIIAYMLLT-HT-SP---------------FV-GE------------DN-QETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT------AE-ICLSHSWL--------------
--------------------------------FTKLEKIGKGSFGEV---FKGID---N-------R-TQK---VVAI-KIIDLEE-AED---EI--E-D-IQ-Q-------EITVLSQC--D------SPY-----VTKYYGSYL--K-----------------------------DTKLW--IIMEY-LGGG--SALDLLE----------PG-------------------------PL---DETQIATILREILKGLDYLHS--E-----KKIHRDIKAANVLLS----EHGEV---------KLADFGVAGQL-----------------------TDTQIKR------------NT---FVGTPFWMAPEV----IK------------------QSAYDSKADIWSLGITAIELAR-GE-PP---------------HS-EL---------HPMKV-LFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT------AK-ELLKHKFI--------------
--------------------------------FEILRAIGKGSFGKV---CIVQK---N-------D-TKK---MYAM-KYMNKQK-CVE---RN--E-V-RNVF------KELQIMQGL--E------HPF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDL-LLGG--DLRYHLQ---------QNV-------------------------HF---KEETVKLFICELVMALDYLQN--Q-----RIIHRDMKPDNILLD----EHGHV---------HITDFNIAAM------------------------LPRETQI------------TT---MAGTKPYMAPEMF--SSR-----------------KGAGYSFAVDWWSLGVTAYELLR-GR-RP---------------YH-IR---------SSTSS-KEIVHTFETTVVTYPSAWS---------------------------------------------------------------------------QEMVSLLKKLLEPNPDQRFS-----QLS-DVQNFPY-M-------------
--------------------------------FQILRAIGKGSFGKV---CIVQK---R-------D-TKK---MYAM-KYMNKQK-CIE---RD--E-V-RNVF------RELQIMQGL--E------HPF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDL-LLGG--DLRYHLQ---------QNV-------------------------HF---TEGTVKLYICELALALEYLQR--Y-----HIIHRDIKPDNILLD----EHGHV---------HITDFNIATV------------------------VKGAERA------------SS---MAGTKPYMAPEV----FQVY-------------MDRGPGYSYPVDWWSLGITAYELLR-GW-RP---------------YE-IH---------SVTPI-DEILNMFKVERVHYSSTWC---------------------------------------------------------------------------KGMVALLRKLLTKDPESRVS-----SLH-DIQS----VPYL----------
--------------------------------FQILRAIGKGSFGKV---CIVQK---R-------D-TEK---MYAM-KYMNKQQ-CIE---RD--E-V-RNVF------RELEILQEI--E------HVF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDL-LLGG--DLRYHLQ---------QNV-------------------------QF---SEDTVRLYICEMALALDYLRG--Q-----HIIHRDVKPDNILLD----ERGHA---------HLTDFNIATI------------------------IKDGERA------------TA---LAGTKPYMAPEIFHSFVN-----------------GGTGYSFEVDWWSVGVMAYELLR-GW-RP---------------YD-IH---------SSNAV-ESLVQLFSTVSVQYVPTWS---------------------------------------------------------------------------KEMVALLRKLLTVNPEHRLS------SL-Q-------DVQAAPA-------
--------------------------------YTFGRILGKGSFGIV---IEATD---K-------E-TET---KWAI-KKVNKEK-AGS---SA--V-K-LLER-------EVNILKSV--K------HEH-----IIHLEQVFE--T-----------------------------PKKMY--LVMEL-CEDG--ELKEILD---------RKG-------------------------HF---SENETRWIIQSLASAIAYLHN--N-----DIVHRDLKLENIMVK----SSLIDDNNEINLNIKVTDFGLAVKK----------------------QSRSEAML------------QA---TCGTPIYMAPEV----IS------------------AHDYSQQCDIWSIGVVMYMLLR-GE-PP---------------FL-AS------------SE-EKLFELIRKGELHFENAVWNSIS-----------------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
--------------------------------YHVLEMIGEGSFGRV---YKGRR---K-------Y-SAQ---VVAL-KFIPKLG-RSE---KE--L-R-NLQR-------EIEIMRGL--R------HPN-----IVHMLDSFE--T-----------------------------DKEVV--VVTDY-AEG---ELFQILE---------DDG-------------------------KL---PEDQVQAIAAQLVSALYYLHS--H-----RILHRDMKPQNILLA----KGGGI---------KLCDFGFARAM-----------------------STNTMVL------------TS---IKGTPLYMSPEL----VE------------------ERPYDHTADLWSVGCILYELAV-GT-PP---------------FY-AT------------SI-FQLVSLILKDPVRWPSTIS---------------------------------------------------------------------------PCFKNFLQGLLTKDPRQRLS------WP-DLLYHPFI--------------
--------------------------------YELQEVIGSGATAVV---QAALC---K-------P-RQE---RVAI-KRINLEK-CQT---SM--D-E--LLK-------EIQAMSQC--S------HPN-----VVTYYTSFV--V-----------------------------KDELW--LVMKL-LSGG--SMLDIIKYIVN-RGEHKNG-------------------------VL---EEAIIATILKEVLEGLDYLHR--N-----GQIHRDLKAGNILLG----EDGSV---------QIADFGVSAFLAT------------------GGDVTRNKVR------------KT---FVGTPCWMAPEV----ME-----------------QVRGYDFKADMWSFGITAIELAT-GA-AP---------------YH-KY---------PPMKV-LMLTLQNDPPTLETGVEDKE--MMK------------------------------------------------------------------KYGKSFRKLLSLCLQKDPSKRPT------AA-ELLKCKFF--------------
--------------------------------LTFMRELGSGLFGVV---RLGKW---R---------AQY---KVAI-KAIR-EG-AM----CE--E-D-FI-E-------EAKVMMKL--T------HPK-----LVQLYGVCT--Q-----------------------------QKPIY--IVTEF-MERG--CLLNFLR----------QR-----------------------QGHF---SRDVLLSMCQDVCEGMEYLER--N-----SFIHRDLAARNCLVS----EAGVV---------KVSDFGMARYV-----------------------L--DDQY------------TSSSGAKFPVKWCPPEV----FN------------------YSRFSSKSDVWSFGVLMWEVFTEGR-MP---------------FE-KY---------TNYEV-VTMVTRGHRLYQPKLAS-----------------------------------------------------------------------------NYVYEVMLRCWQEKPEGRPS------FE-DLLRT--I--------------
------------------------------YL--LLHLLGRGGFSEV---YKAFD---L-------Y-EQR---YAAV-KIHQLNK-SWR---DE--K-K-ENYHKH--ACREYRIHKEL--D------HPR-----IVKLYDYFS--L----------------------------DTDTFC--TVLEY-CEGN--DLDFYLK---------QHK-------------------------LM---SEKEARSIVMQIVNALRYLNE--IK---PPIIHYDLKPGNILLV----DGTACG------EIKITDFGLSKIMDDD-----------------SYGVDGMDLT------------SQ---GAGTYWYLPPEC----FVV--------------GKEPPKISNKVDVWSVGVIFFQCLY-GR-KP---------------FG-HN----------QSQQ-DILQENTILKATEVQFPVKPVVS-----------------------------------------------------------------------SEAKAFIRRCLAYRKEDRFD------VH-QLANDPYL--------------
------------------------------YL--LLHLLGRGGFSEV---YKAFD---L-------T-EQR---YVAV-KIHQLNK-NWR---DE--K-K-ENYHKH--ACREYRIHKEL--D------HPR-----IVKLYDYFS--L----------------------------DTDSFC--TVLEY-CEGN--DLDFYLK---------QHK-------------------------LM---SEKEARSIIMQIVNALKYLNE--IK---PPIIHYDLKPGNILLV----NGTACG------EIKITDFGLSKIMDDD----------------SYNSVDGMELT------------SQ---GAGTYWYLPPEC----FVV--------------GKEPPKISNKVDVWSVGVIFYQCLY-GR-KP---------------FG-HN----------QSQQ-DILQENTILKATEVQFPPKPVVT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID------VQ-QLACDPYL--------------
---------------------------YLLGI-----NLGEGSYAKV---KSAYS---E-------R-LKF---NVAI-KIIDRKK-APA---DF--L-E-KFLP------REIEILAML--N------HCS-----IIKTYEIFE--T----------------------------SHGKVY--IVMEL-AVQG--DLLELIK---------TRG-------------------------AL---HEDEARKKFHQLSLAIKYCHD--L-----DVVHRDLKCDNLLLD----KDFNI---------KLSDFSFSKRCLR-------------------DDSGRMALS------------KT---FCGSPAYAAPEV----LQ-----------------GIPYQPKVYDIWSLGVILYIMVC-GS-MP---------------YD-DS------------NI-KKMLRIQKEHRVNFPRSKHLT-------------------------------------------------------------------------GECKDLIYHMLQPDVNRRLH------ID-EILSHCWM--------------
---------------------------YIVGI-----NLGKGSYAKV---KSAYS---E-------R-LKF---NVAV-KIIDRKK-TPT---DF--V-E-RF-LP-----REMDILATV--N------HGS-----IIKTYEIFE--T----------------------------SDGRIY--IIMEL-GVQG--DLLEFIK---------CQG-------------------------AL---HEDVARKMFRQLSSAVKYCHD--L-----DIVHRDLKCENLLLD----KDFNI---------KLSDFGFSKRCLR-------------------DSNGRIILS------------KT---FCGSAAYAAPEV----LQ-----------------SIPYQPKVYDIWSLGVILYIMVC-GS-MP---------------YD-DS------------DI-RKMLRIQKEHRVDFPRSKNLT-------------------------------------------------------------------------CECKDLIYRMLQPDVSQRLH------ID-EILSHSWL--------------
--------------------------------YSILKQIGSGGSSKV---FQVLN---E-------K-KQ----IYAI-KYVNLEE-ADN---QT--L-D-SYRN-------EIAYLNKL-QQ-----HSDK-----IIRLYDYEI--T-----------------------------DQYIY--MVMEC-GNI---DLNSWLK---------KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--H-----GIVHSDLKPANFLIV-----DGML---------KLIDFGIANQMQ---------------------PDTTSVVK------------DS---QVGTVNYMPPEA----IKDMSSS-------RENGKSKSKISPKSDVWSLGCILYYMTY-GK-TP---------------FQ-QI-----------INQ-ISKLHAIIDPNHEIEFPDIPE-------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS------IP-ELLAHPYV--------------
-------------------------------L-AFIKEIGSGQFGVV---HLGEW---R---------SHI---QVAI-KAIN-EG-SM----SE--E-D-FI-E-------EAKVMMKL--S------HSK-----LVQLYGVCI--Q-----------------------------RKPLY--IVTEF-MENG--CLLNYLR----------EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER--N-----GYIHRDLAARNCLVS----STCIV---------KISDFGMTRYV-----------------------L--DDEY------------VSSFGAKFPIKWSPPEV----FL------------------FNKYSSKSDVWSFGVLMWEVFTEGK-MP---------------FE-NK---------SNLQV-VEAISEGFRLYRPHLAP-----------------------------------------------------------------------------MSIYEVMYSCWHEKPEGRPT------FA-ELLR---AV-------------
------------------------------FS--RKDLIGHGAFAVV---FKGRH---R-------E-KHD--LEVAV-KCINKKN-LAK---SQ--T---LLGK-------EIKILKEL--K------HEN-----IVALYDFQE--M-----------------------------ANSVY--LVMEY-CNGG--DLADYLH---------AMR-------------------------TL---SEDTIRLFLQQIAGAMRLLHS--K-----GIIHRDLKPQNILLS----NPAGRRANPNSIRVKIADFGFARY------------------------LQSNMMA------------AT---LCGSPMYMAPEV----IM------------------SQHYDGKADLWSIGTIVYQCLT-GK-AP---------------FQ-AS---------SPQDL-RLFYEKNKTLVPTIPRETS---------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD------FD-EFFHHPFL--------------
-------------------------------Y-SKRDLVGHGAFAVV---FRGRH---R-------Q-KTD--WEVAI-KSINKKN-LSK---SQ----I-LLGK-------EIKILKEL--Q------HEN-----IVALYDVQE--L-----------------------------PNSVF--LVMEY-CNGG--DLADYLQ---------AKG-------------------------TL---SEDTIRVFLHQIAAAMRILHS--K-----GIIHRDLKPQNILLS----YANRRKSSVSGIRIKIADFGFARY------------------------LHSNMMA------------AT---LCGSPMYMAPEV----IM------------------SQHYDAKADLWSIGTVIYQCLV-GK-PP---------------FQ-AN---------SPQDL-RMFYEKNRS--LMPSIPRETS-------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD------FE-AFFSHPFL--------------
------------------------------FI--LTERLGSGTYATV---YKAYA---KK------D-TRE---VVAI-KCVAKKS-LNK---AS--V-E-NLLT-------EIEILKGI--R------HPH-----IVQLKDFQW--D-----------------------------SDNIY--LIMEF-CAGG--DLSRFIH---------TRR-------------------------IL---PEKVARVFMQQLASALQFLHE--R-----NISHLDLKPQNILLSS--LEKPHL---------KLADFGFAQH------------------------MSPWDEK------------HV---LRGSPLYMAPEM----VC------------------QRQYDARVDLWSMGVILYEALF-GQ-PP---------------FA-SR---------SFSEL-EEKIRSNRVIELPLRPLLS---------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS------FQ-DFFAHPWV--------------
--------------------------------WTKGEILGKGAYGTV---YCGLT---S-------Q-GQ----LIAV-KQVALDT-SNK---LA--A-E-KEYRKL---QEEVDLLKAL--K------HVN-----IVAYLGTCL--Q-----------------------------ENTVS--IFMEF-VPGG--SISSIIN---------RFG-------------------------PL---PEMVFCKYTKQILQGVAYLHE--N-----CVVHRDIKGNNVMLM----PTGII---------KLIDFGCARRLAWA-----------------GLNGTHSDML------------KS---MHGTPYWMAPEV----IN------------------ESGYGRKSDIWSIGCTVFEMAT-GK-PP---------------LA-SM-----------DRM-AAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS------AL-QLLKHSFL--------------