Protein Surface  Ribbon
Inhibitor TZY
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 36 kinases in KIF 1ZZLA_TZY (MAPK14, PDB code: 1ZZL, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
AGC        PRKG2        203 
CAMK       BRSK1         50 
CAMK       BRSK2         19 
CMGC       CDK2           4 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
TK         FGFR2        481 
TK         FYN          271 
AGC        GRK6         186 
TK         HCK          241 
CMGC       MAPK10        64 
CMGC       MAPK14        24 
CMGC       MAPK9         26 
CAMK       MARK1         60 
CAMK       MARK2         53 
CAMK       MARK4         59 
Other      NEK1           4 
CMGC       NLK          126 
CAMK       NUAK1         55 
AGC        PDPK1         82 
CAMK       PHKG1         20 
Other      PLK1          53 
Other      PLK3          62 
CAMK       PRKD1        583 
CAMK       PRKD2        551 
CAMK       PRKD3        576 
AGC        PRKG1        375 
AGC        RPS6KA1       62 
AGC        RPS6KA2       59 
AGC        RPS6KA3       68 
AGC        RPS6KA6       73 
CAMK       STK17A        61 
CAMK       TSSK1B        12 


----L-EIIATLGVGGFGRV---ELVKVK-------NENV---AFAMKCIRKKHIVDTK--QQ-EHVY------SEKRILEEL--CSPFIVKLYRTFKD------NKYVYMLLEACLGGELWSILR--DRG-----------------SFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYL----KLVDFGFAKK------IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPPFSGV---DQMMTYNLILKGIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
-----YRLEKTLGKGQTGLV---KLGVHC-------ITGQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--EHPHVLKLHDVYEN------KKYLYLVLEHVSGGELFDYLV--KKG-----------------RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLV---KLGVHC-------VTCQ---KVAIKIVNREKLSESV--LM-KVER-------EIAILKLI--EHPHVLKLHDVYEN------KKYLYLVLEHVSGGELFDYLV--KKG-----------------RLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNI----RIADFGMASL------QVGDSLLET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----FQKVEKIGEGTYGVV---YKARNK-------LTGE---VVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
----W-DLVQTLGEGAYGEV---QLAVNR-------VTEE---AVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--NHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE--PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL----KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEV---KLAFER-------KTCK---KVAIKIISKRKFAIGS--AR-EADPALN-VETEIEILKKL--NHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV--GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
-----YDTGEELGSGQFAVV---KKCREK-------STGL---QYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--QHPNVITLHEVYEN------KTDVILILELVAGGELFDFLA--EKE-----------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-----YDIGEELGSGQFAIV---KKCREK-------STGL---EYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--LHHNVITLHDVYEN------RTDVVLILELVSGGELFDFLA--QKE-----------------SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANITAVSYDFDEEFFSQTS-----------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI-----------
-----YEMGEELGSGQFAIV---RKCRQK-------GTGK---EYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--RHPNIITLHDIFEN------KTDVVLILELVSGGELFDFLA--EKE-----------------SLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
-----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAV---TVAVKMLK-DDAT-EKDLSD-LV-S-------EMEMMKMIG-KHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLR---ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM----KIADFGLARDI--N--N--IDYYKKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LQLIKRLGNGQFGEV---WMGTWN--------GNT---KVAIKTLK-PGTM-SP--ES-FL-E-------EAQIMKKL--KHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLK---DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC----KIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-------------
----F-RQYRVLGKGGFGEV---CACQVR-------ATGK---MYACKKLEKKRIKKRK--GE-AMAL------NEKQILEKV--NSRFVVSLAYAYET------KDALCLVLTLMNGGDLKFHIYHMGQA-----------------GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI----RISDLGLAVH------VPEGQTIKG---RVGTVGYMAPEVVK------NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
-----LKLEKKLGAGQFGEV---WMATYN--------KHT---KVAVKTMK-PGSM-SV--EA-FL-A-------EANVMKTL--QHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLK---SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC----KIADFGLARVI-----E--DNEYTAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-----YQNLSPVGSGAYGSV---CAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AK-RTYR-------ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL----KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
-----YQQLKPIGSGAQGIV---CAAFDT-------VLGI---NVAVKKLSRPFQNQTH--AK-RAYR-------ELVLLKCV--NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART------ACTNFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
-----YRLQKTIGKGNFAKV---KLARHV-------LTGR---EVAVKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--NHPNIVKLFEVIET------EKTLYLVMEYASGGEVFDYLV--AHG-----------------RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNI----KIADFGFSNE------FTVGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKLLVLNPIKRGS-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------LTGK---EVAVKIIDKTQLNSSS--LQ-KLFR-------EVRIMKVL--NHPNIVKLFEVIET------EKTLYLVMEYASGGEVFDYLV--AHG-----------------RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNI----KIADFGFSNE------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLRTIGKGNFAKV---KLARHI-------LTGR---EVAIKIIDKTQLNPSS--LQ-KLFR-------EVRIMKGL--NHPNIVKLFEVIET------EKTLYLVMEYASAGEVFDYLV--SHG-----------------RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANI----KIADFGFSNE------FTLGSKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GSLPFDGH---NLKELRERVLRGKYRVPFYMS---------------------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
----Y-VRLQKIGEGSFGKA---ILVKST-------EDGR---QYVIKEINISRMSSKE--RE-ESRR-------EVAVLANM--KHPNIVQYRESFEE------NGSLYIVMDYCEGGDLFKRINAQKGV-----------------LFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTV----QLGDFGIARVL-----NSTVELART---CIGTPYYLSPEICE------NKPYNNKSDIWALGCVLYELCT-LKHAFEAG---SMKNLVLKIISGSFPPVSLHYS--------------------------------------YDLRSLVSQLFKRNPRDRPS-----VNSILEKGF-I----------
--IEP---DRPIGYGAFGVV---WSVTDP-------RDGK---RVALKKMPNVFQNLVS--CK-RVFR-------ELKMLCFF--KHDNVLSALDILQPPH-IDYFEEIYVVTELMQS-DLHKIIV--SPQ-----------------PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVL----KICDFGLARVE----ELDESRHMTQ---EVVTQYYRAPEILM-----GSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL-----------
-----YELQETLGKGTYGKV---KRATER-------FSGR---VVAIKSIRKDKIKDEQ--DM-VHIR------REIEIMSSL--NHPHIISIYEVFEN------KDKIVIIMEYASKGELYDYIS--ERR-----------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI----KIADFGLSNL------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP----------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
----F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--DHPFFVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR--KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI----QITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIHK-------PTSQ---EYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SGHPNIIQLKDTYET------NTFFFLVFDLMKRGELFDYLT--EKV-----------------TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNI----KLTDFGFSCQ------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
---YV--RGRFLGKGGFAKC---FEISDA-------DTKE---VFAGKIVPKSLLLKPH--QR-EKMS------MEISIHRSL--AHQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK--RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEV----KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS------KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
---YL--KGRLLGKGGFARC---YEATDT-------ETGS---AYAVKVIPQSRVAKPH--QR-EKIL------NEIELHRDL--QHRHIVRFSHHFED------ADNIYIFLELCSRKSLAHIWK--ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMEL----KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL------RQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
---PD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKIIDKLRFPTKQ--ES-QLRN-------EVAILQNL--HHPGVVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKG-----------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVV---YGGKHR-------KTGR---DVAVKVIDKLRFPTKQ--ES-QLRN-------EVAILQSL--RHPGIVNLECMFET------PEKVFVVMEKLHGDMLEMILS-SEKG-----------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKVIDKMRFPTKQ--ES-QLRN-------EVAILQNL--HHPGIVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKS-----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP-QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
----F-NIIDTLGVGGFGRV---ELVQLKS------EESK---TFAMKILKKRHIVDTR--QQ-EHIR------SEKQIMQGA--HSDFIVRLYRTFKD------SKYLYMLMEACLGGELWTILR--DRG-----------------SFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYA----KLVDFGFAKK------IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPPFSGP---DPMKTYNIILRGIDMIEFPKKIA-------------------------------------KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF-----------
-----FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKATLKVRD--RV-RTKM-------ERDILADV--NHPFVVKLHYAFQT------EGKLYLILDFLRGGDLFTRLS--KEV-----------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEA-----IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKATLKVRD--RV-RSKM-------ERDILAEV--NHPFIVKLHYAFQT------EGKLYLILDFLRGGDLFTRLS--KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI----KITDFGLSKEA-----IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS---------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FELLKVLGQGSFGKV---FLVKKI-------SGSDARQLYAMKVLKKATLKVRD--RV-RTKM-------ERDILVEV--NHPFIVKLHYAFQT------EGKLYLILDFLRGGDLFTRLS--KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKES-----IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS---------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKASLKVRD--RV-RTKM-------ERDILVEV--NHPFIVKLHYAFQT------EGKLYLILDFLRGGDVFTRLS--KEV-----------------LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI----KLTDFGLSKES-----VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS---------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
--LCP---GRELGRGKFAVV---RKCIKK-------DSGK---EFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QDNPWVINLHEVYET------ASEMILVLEYAAGGEIFDQCVADREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLG-DIKIVDFGLSRI------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISPFLGN---DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL-----------
YLLGI-----NLGEGSYAKV---KSAYSE-------RLKF---NVAIKIIDRKKAPADF--LE-KFLP------REIEILAML--NHCSIIKTYEIFET-----SHGKVYIVMELAVQGDLLELIK--TRG-----------------ALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNI----KLSDFSFSKRCLR-DDSGRMALSKT---FCGSPAYAAPEVLQ-----GIPYQPKVYDIWSLGVILYIMVC-GSMPYDDS---NIKKMLRIQKEHRVNFPRSKHLT-------------------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM-----------