Protein Surface  Ribbon
Inhibitor BI4
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 82 kinases in KIF 3OTUA_BI4 (PDPK1, PDB code: 3OTU, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
AGC        PRKG2        203 
AGC        AKT3         148 
Other      AURKC         43 
CAMK       CAMK2A        13 
CAMK       CAMK2D        14 
CMGC       CDC2           4 
CMGC       CDK15        103 
CMGC       CDK2           4 
CMGC       CDK3           4 
CMGC       CDK4           6 
CMGC       CDK7       2.7.11.23 
CMGC       CDKL2          4 
CMGC       CDKL5         13 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
CMGC       CSNK2A1       39 
CMGC       CSNK2A2       40 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
CMGC       DYRK1A       150 
CMGC       DYRK1B       111 
TK         EGFR         712 
Other      GAK           40 
AGC        GRK1         190 
AGC        GRK4         187 
AGC        GRK7         191 
CMGC       GSK3A        119 
CMGC       GSK3B         56 
CMGC       HIPK1        190 
CMGC       HIPK2        199 
CMGC       HIPK3        197 
CMGC       HIPK4         -1 
CMGC       ICK            4 
TK         JAK2         849 
TK         JAK3         822 
STE        MAP3K2       356 
STE        MAP3K3       362 
CMGC       MAPK14        24 
CMGC       MAPK15        13 
CAMK       MAPKAPK2      64 
CAMK       MARK2         53 
CAMK       MELK          11 
CAMK       NUAK1         55 
CAMK       NUAK2         97 
STE        PAK3         268 
CMGC       PCTK1        165 
AGC        PDPK1         82 
CMGC       PFTK1        117 
CAMK       PHKG1         20 
CAMK       PIM1          38 
CAMK       PIM2         132 
CAMK       PIM3          40 
AGC        PKN2         657 
Other      PLK4          12 
CAMK       PRKAA2        16 
AGC        PRKACA        44 
AGC        PRKACB        44 
AGC        PRKCB        342 
AGC        PRKCD        349 
AGC        PRKCH        355 
AGC        PRKCI        245 
AGC        PRKCQ        380 
AGC        PRKCZ        252 
CAMK       PRKD2        551 
AGC        PRKG1        375 
CMGC       PRPF4B       687 
AGC        RPS6KA1       62 
AGC        RPS6KA2       59 
AGC        RPS6KA3       68 
AGC        RPS6KA6       73 
AGC        RPS6KB1       91 
STE        SLK           34 
CAMK       STK11         49 
CAMK       STK17A        61 
STE        STK24         24 
CAMK       STK33        116 
Other      TLK1         477 
Other      TLK2         440 
STE        YSK4        1162 


---L-EIIATLGVGGFGRV---ELVKV---K----N-ENV---AFAMKCIRKKHIVD---TK--QQ-EHVY------SEKRILEEL-C------SPF-----IVKLYRTFK--D--------NKYVY--MLLEA-CLGG--ELWSILR----DRG--SF---DEPTSKFCVACVTEAFDYLHR--L--GIIYRDLKPENLILD--AEGYL---------KLVDFGFAKK---------------IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPP---------------FS-GV---------DQMMTYNLILKGIEKMDFPRKIT-------------------------------------------------------------------------RRPEDLIRRLCRQNPTERLGNL-KNGIN-DIKKHRWL--------------
--FD--YLKLLGKGTFGKV---ILVRE---K----A-SGK---YYAMKILKKEVIIA---KD--EV-AHTL------TESRVLKNT-R------HPF-----LTSLKYSFQ--T--------KDRLC--FVMEY-VNGG--ELFFHLS----RER--VF---SEDRTRFYGAEIVSALDYLHS--G--KIVYRDLKLENLMLD--KDGHI---------KITDFGLCKEG--------------ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ---------DHEKLFELILMEDIKFPRTLS---------------------------------------------------------------------------SDAKSLLSGLLIKDPNKRLGGG-PDDAK-EIMRHSFF--------------
----FEIGRPLGKGKFGNV---YLARL---K----E-SHF---IVALKVLFKSQIEK---EG--LE-HQLR------REIEIQAHL-Q------HPN-----ILRLYNYFH--D--------ARRVY--LILEY-APRG--ELYKELQ----KSE--KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--FRGEV---------KIADFGWSV----------------HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA---------SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV--------------
----YQLFEELGKGAFSVV---RRCVK---V----L-AGQ---EYAAKIINTKKLSA---RD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGHHY--LIFDL-VTGG--ELFEDIV----ARE--YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLLLA--SKLKGA------AVKLADFGLAIEV--------------EGEQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDLWACGVILYILLV-GYPP---------------FW-DE---------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPSKRIT------AA-EALKHPWI--------------
----YQLFEELGKGAFSVV---RRCMK---I----P-TGQ---EYAAKIINTKKLSA---RD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGFHY--LVFDL-VTGG--ELFEDIV----ARE--YY---SEADASHCIQQILESVNHCHL--N--GIVHRDLKPENLLLA--SKSKGA------AVKLADFGLAIEV--------------QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPP---------------FW-DE---------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT------AS-EALKHPWI--------------
----YTKIEKIGEGTYGVV---YKGRH---K----T-TGQ---VVAMKKIRLESEEE---GV--PS-TAIR-------EISLLKEL-R------HPN-----IVSLQDVLM--Q--------DSRLY--LIFEF-LSM---DLKKYLDS-IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--R--RVLHRDLKPQNLLID--DKGTI---------KLADFGLARAF--------------GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
--YL--NLEKLGEGSYATV---YKGIS---R----I-NGQ---LVALKVISMNAEEG---VP---F-TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T--------KETLT--FVFEY-MHT---DLAQYMS---QHPG--GL---HPHNVRLFMFQLLRGLAYIHH--Q--HVLHRDLKPQNLLIS--HLGEL---------KLADFGLARAK--------------SIPSQTYSS---EVVTLWYRPPDALL-----GATEYSSELDIWGAGCIFIEMFQ-GQPL---------------FP-GV-----SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS------AQ-EALVHDYF--------------
----FQKVEKIGEGTYGVV---YKARN---K----L-TGE---VVALKKIRLDTETE---GV--PS-TAIR-------EISLLKEL-N------HPN-----IVKLLDVIH--T--------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT--GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLLIN--TEGAI---------KLADFGLARAF--------------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
----FQKVEKIGEGTYGVV---YKAKN---R----E-TGQ---LVALKKIRLDLEME---GV--PS-TAIR-------EISLLKEL-K------HPN-----IVRLLDVVH--N--------ERKLY--LVFEF-LSQ---DLKKYMDS--TPGS--EL---PLHLIKSYLFQLLQGVSFCHS--H--RVIHRDLKPQNLLIN--ELGAI---------KLADFGLARAF--------------GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RKAL---------------FP-GD------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT------AK-TALAHPYF--------------
---Y-EPVAEIGVGAYGTV---YKARD---P----H-SGH---FVALKSVRVPNGGGGGGGL--PI-STVR-------EVALLRRL-EA---FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEH-VDQ---DLRTYLDK--APPP--GL---PAETIKDLMRQFLRGLDFLHA--N--CIVHRDLKPENILVT--SGGTV---------KLADFGLARI---------------YSYQMALTP---VVVTLWYRAPEVLL------QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
----YEKLDFLGEGQFATV---YKARD---K----N-TNQ---IVAIKKIKLGHRSE---AK--DG-INRTA----LREIKLLQEL-S------HPN-----IIGLLDAFG--H--------KSNIS--LVFDF-MET---DLEVIIK---DNSL--VL---TPSHIKAYMLMTLQGLEYLHQ--H--WILHRDLKPNNLLLD--ENGVL---------KLADFGLAKSF--------------GSPNRAYTH---QVVTRWYRAPELLF-----GARMYGVGVDMWAVGCILAELLL-RVPF---------------LP-GD------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------AT-QALKMKYF--------------
----YENLGLVGEGSYGMV---MKCRN---K----D-TGR---IVAIKKFLESDDDK---MV--KK-IAMR-------EIKLLKQL-R------HEN-----LVNLLEVCK--K--------KKRWY--LVFEF-VDHT--ILDDLEL----FPN--GL---DYQVVQKYLFQIINGIGFCHS--H--NIIHRDIKPENILVS--QSGVV---------KLCDFGFARTL--------------AAPGEVYTD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GEPL---------------FP-GD------SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF------CA-ELLHHDFF--------------
----FEILGVVGEGAYGVV---LKCRH---K----E-THE---IVAIKKFKDSEENE---EV--KE-TTLR-------ELKMLRTL-K------QEN-----IVELKEAFR--R--------RGKLY--LVFEY-VEK---NMLELLE---EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--N--DIVHRDIKPENLLIS--HNDVL---------KLCDFGFARNL-------------SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQPL---------------FP-GE------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL------TE-QCLNHPTF--------------
---W-DLVQTLGEGAYGEV---QLAVN---R----V-TEE---AVAVKIVDMKRAVD---CP--EN-I-KK-------EICINKML-N------HEN-----VVKFYGHRR--E--------GNIQY--LFLEY-CSGG--ELFDRIE----PDI--GM---PEPDAQRFFHQLMAGVVYLHG--I--GITHRDIKPENLLLD--ERDNL---------KISDFGLATVFR------------YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP--------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEV---KLAFE---R----K-TCK---KVAIKIISKRKFAI---GS--AR-EADPALN-VETEIEILKKL-N------HPC-----IIKIKNFF---D--------AEDYY--IVLEL-MEGG--ELFDKVV----GNK--RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--SQEEDC------LIKITDFGHSKI---------------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT------TE-EALRHPWL--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-NNE---KVVVKILKPVKKKK---IK--R-------------EIKILENLRG------GPN-----IITLADIVK--DP------VSRTPA--LVFEH-VNNT--DFKQLY-------Q--TL---TDYDIRFYMYEILKALDYCHS--M--GIMHRDVKPHNVMID-HEHRKL---------RLIDWGLAEF---------------YHPGQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-NNE---RVVVKILKPVKKKK---IK--R-------------EVKILENLRG------GTN-----IIKLIDTVK--DP------VSKTPA--LVFEY-INNT--DFKQLY-------Q--IL---TDFDIRFYMYELLKALDYCHS--K--GIMHRDVKPHNVMID-HQQKKL---------RLIDWGLAEF---------------YHPAQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ------DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT------AK-EAMEHPYF--------------
----YDTGEELGSGQFAVV---KKCRE---K----S-TGL---QYAAKFIKKRRTKS---SR--RG-VSREDI---EREVSILKEI-Q------HPN-----VITLHEVYE--N--------KTDVI--LILEL-VAGG--ELFDFLA----EKE--SL---TEEEATEFLKQILNGVYYLHS--L--QIAHFDLKPENIMLL--DRNVPKP-----RIKIIDFGLAHK---------------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP---------------FL-GD---------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT------IQ-DSLQHPWI--------------
----YDIGEELGSGQFAIV---KKCRE---K----S-TGL---EYAAKFIKKRQSRA---SR--RG-VSREEI---EREVSILRQV-L------HHN-----VITLHDVYE--N--------RTDVV--LILEL-VSGG--ELFDFLA----QKE--SL---SEEEATSFIKQILDGVNYLHT--K--KIAHFDLKPENIMLL--DKNIPIP-----HIKLIDFGLAHE---------------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP---------------FL-GD---------TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT------IQ-EALRHPWI--------------
----YEMGEELGSGQFAIV---RKCRQ---K----G-TGK---EYAAKFIKKRRLSS---SR--RG-VSREEI---EREVNILREI-R------HPN-----IITLHDIFE--N--------KTDVV--LILEL-VSGG--ELFDFLA----EKE--SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--DKNVPNP-----RIKLIDFGIAHK---------------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP---------------FL-GE---------TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT------IA-QSLEHSWI--------------
----YEIDSLIGKGSFGQV---VKAYD---R----V-EQE---WVAIKIIKNKKAFL---NQ--AQ-I----------EVRLLELMNK------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEM-LSY---NLYDLLR-----NT--NFRGVSLNLTRKFAQQMCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI---------KIVDFGSSCQ-----------------LGQRIYQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GEPL---------------FS-GA------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ------PY-YALQHSFF--------------
----YEIDSLIGKGSFGQV---VKAYD---H----Q-TQE---LVAIKIIKNKKAFL---NQ--AQ-I----------ELRLLELMNQ------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEL-LSY---NLYDLLR-----NT--HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI---------KIVDFGSSCQ-----------------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GEPL---------------FS-GS------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS------PL-GALQHGFF--------------
---F-KKIKVLGSGAFGTV---YKGLW---IPEGEK-VKI---PVAIKELR-EATS----PKANKE-IL-D-------EAYVMASV-D------NPH-----VCRLLGICL-----------TSTVQ--LITQL-MPFG--CLLDYVR-----EHKDNI---GSQYLLNWCVQIAKGMNYLED--R--RLVHRDLAARNVLVK--TPQHV---------KITDFGLAKLL-------G------A--EEKEYHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI------PASEISSILEKGERLPQPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF------------
--LR--VRRVLAEGGFAFV---YEAQD---V----G-SGR---EYALKRLLSNEEEK---NR--AI---IQ-------EVCFMKKLSG------HPN-----IVQFCSAAS--IGKEESDTGQAEFL--LLTEL-CKG---QLVEFLKK-MESRG--PL---SCDTVLKIFYQTCRAVQHMHR--QKPPIIHRDLKVENLLLS--NQGTI---------KLCDFGSATTISHYPDY--SWSAQRRALVEEEIT---RNTTPMYRTPEIIDL---YSNFPIGEKQDIWALGCILYLLCF-RQHP---------------FE-DG---------AKLRIVNGKYS-IPPHDTQY----------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS------IA-EVVHQ---L-------------
FLDF----RVLGKGGFGEV---SACQM---K----A-TGK---LYACKKLNKKRLKK---RK--GY-QGAM------VEKKILMKV-H------SRF-----IVSLAYAFE--T--------KADLC--LVMTI-MNGG--DIRYHIYNVNEENP--GF---PEPRALFYTAQIICGLEHLHQ--R--RIVYRDLKPENVLLD--NDGNV---------RISDLGLAVEL--------------LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGP---------------FR-AR-----GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEV---CACQV---R----A-TGK---MYACKKLQKKRIKK---RK--GE-AMAL------NEKRILEKV-Q------SRF-----VVSLAYAYE--T--------KDALC--LVLTI-MNGG--DLKFHIYN--LGNP--GF---DEQRAVFYAAELCCGLEDLQR--E--RIVYRDLKPENILLD--DRGHI---------RISDLGLATE---------------IPEGQRVRG---RVGTVGYMAPEVVN------NEKYTFSPDWWGLGCLIYEMIQ-GHSP---------------FK-KY------KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-------------
---F-TEFRVLGKGGFGEV---CAVQV---K----N-TGK---MYACKKLDKKRLKK---KG--GE-KMAL------LEKEILEKV-S------SPF-----IVSLAYAFE--S--------KTHLC--LVMSL-MNGG--DLKFHIYN--VGTR--GL---DMSRVIFYSAQIACGMLHLHE--L--GIVYRDMKPENVLLD--DLGNC---------RLSDLGLAVE---------------MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTP---------------FK-DY-----KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG------SR-E-------KSDDPR--------
----YTDIKVIGNGSFGVV---YQARL---A----E-TRE---LVAIKKVLQDKRFK---NR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDELYLNLVLEY-VPETVYRVARHFT---KAKL--TI---PILYVKVYMYQLFRSLAYIHS--Q--GVCHRDIKPQNLLVD-PDTAVL---------KLCDFGSAKQ---------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVV---YQAKL---C----D-SGE---LVAIKKVLQDKRFK---NR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--F--GICHRDIKPQNLLLD-PDTAVL---------KLCDFGSAKQ---------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
----YEVLEFLGRGTFGQV---AKCWK---R----S-TKE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILSRL-S------SENADEYNFVRSYECFQ--H--------KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKYIRPILQQVATALMKLKS--L--GLIHADLKPENIMLV--DPVRQPY-----RVKVIDFGSAS----------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL---------------YP-GA------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT------PL-KTLNHQFV--------------
----YEVLEFLGRGTFGQV---VKCWK---R----G-TNE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILARL-STE-SADDYN-----FVRAYECFQ--H--------KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKYIRPVLQQVATALMKLKS--L--GLIHADLKPENIMLV--DPSRQPY-----RVKVIDFGSAS----------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL---------------YP-GA------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQV---VKCWK---R----G-TNE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILARL-S------TENADEYNFVRAYECFQ--H--------RNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKVIRPILQQVATALKKLKS--L--GLIHADLKPENIMLV--DPVRQPY-----RVKVIDFGSAS----------------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL---------------YP-GA------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT------PA-ETLNHPFV--------------
----YDIIEVLGKGTFGEV---AKGWR---R----S-TGE---MVAIKILKNDAYRN---RI--IK-N----------ELKLLHCM-RGL-DPEEAH-----VIRFLEFFH--D--------ALKFY--LVFEL-LEQ---NLFEFQK-----EN--NFAPLPARHIRTVTLQVLTALARLKE--L--AIIHADLKPENIMLV--DQTRCPF-----RVKVIDFGSASIF--------------SEVRYVKEP---YIQSRFYRAPEILL------GLPFCEKVDVWSLGCVMAELHL-GWPL---------------YP-GN------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS------PS-AALRHPFV--------------
----YTTIRQLGDGTYGSV---LLGRS---I----E-SGE---LIAIKKMKRKFYSW---EE--C--MNLR-------EVKSLKKL-N------HAN-----VVKLKEVIR--E--------NDHLY--FIFEY-MKE---NLYQLIK---ERNK--LF---PESAIRNIMYQILQGLAFIHK--H--GFFHRDLKPENLLCM--GPELV---------KIADFGLARE---------------IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LRPL---------------FP-GA------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT------AS-QALRYPYF--------------
----LKFLQQLGKGNFGSV---EMCRY---DPLQDN-TGE---VVAVKKLQ-HSTE-----EHLRD-FE-R-------EIEILKSL-Q------HDN-----IVKYKGVCYSAG--------RRNLK--LIMEY-LPYG--SLRDYLQ-----KHKERI---DHIKLLQYTSQICKGMEYLGT--K--RYIHRDLATRNILVE--NENRV---------KIGDFGLTKVL------PQ------D--KEYYKVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM------IVFHLIELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV------------
---L-KYISQLGKGNFGSV---ELCRY---DPLGDN-TGA---LVAVKQLQ-HSGP----DQ-QRD-FQ-R-------EIQILKAL-H------SDF-----IVKYRGVSYGPG--------RQSLR--LVMEY-LPSG--CLRDFLQ-----RHRARL---DASRLLLYSSQICKGMEYLGS--R--RCVHRDLAARNILVE--SEAHV---------KIADFGLAKLL------PL------D--KDYYVVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P----ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
----WRLGKLLGQGAFGRV---YLCYD---V----D-TGR---ELAVKQVQFDPDSP---ET--SK-EVNAL----ECEIQLLKNL-L------HER-----IVQYYGCLR--DP------QEKTLS--IFMEY-MPGG--SIKDQLK----AYG--AL---TENVTRKYTRQILEGVHYLHS--N--MIVHRDIKGANILRD--STGNV---------KLGDFGASKRLQ-----------TICLSGTGMKS---VTGTPYWMSPEVIS------GEGYGRKADIWSVACTVVEMLT-EKPP---------------WA-EF---------EAMAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS------AD-ELLRHMF-V-------------
---W-RRGKLLGQGAFGRV---YLCYD---V----D-TGR---ELASKQVQFDPDSP---ET--SK-EVSAL----ECEIQLLKNL-Q------HER-----IVQYYGCLR--DR------AEKTLT--IFMEY-MPGG--SVKDQLK----AYG--AL---TESVTRKYTRQILEGMSYLHS--N--MIVHRDIKGANILRD--SAGNV---------KLGDFGASKRLQ-----------TICMSGTGMRS---VTGTPYWMSPEVIS------GEGYGRKADVWSLGCTVVEMLT-EKPP---------------WA-EY---------EAMAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS------AE-ELLTHHF-A-------------
----YQNLSPVGSGAYGSV---CAAFD---T----K-TGL---RVAVKKLSRPFQSI---IH--AK-RTYR-------ELRLLKHM-K------HEN-----VIGLLDVFT--PARS--LEEFNDVY--LVTHL-MGA---DLNNIVK-----CQ--KL---TDDHVQFLIYQILRGLKYIHS--A--DIIHRDLKPSNLAVN--EDCEL---------KILDFGLAR-----------------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
--YL--LRRQLGQGAYGIV---WKAVD---R----R-TGE---VVAIKKIFDAFRDK---TD--AQ-RTFR-------EITLLQEFGD------HPN-----IISLLDVIR--AE------NDRDIY--LVFEF-MDT---DLNAVIR----KGG--LL---QDVHVRSIFYQLLRATRFLHS--G--HVVHRDQKPSNVLLD--ANCTV---------KLCDFGLARSLGD---------LPEGPEDQAVTE---YVATRWYRAPEVLL-----SSHRYTLGVDMWSLGCILGEMLR-GRPL---------------FP-GT------STLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRP----------------------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDKRLS------AT-QALQHPYV--------------
-KVT---SQVLGLGINGKV---LQIFN---K----R-TQE---KFALKMLQDCPKAR-------------R-------EVELHWRASQ------CPH-----IVRIVDVYE--NLY----AGRKCLL--IVMEC-LDGG--ELFSRIQD--RGDQ--AF---TEREASEIMKSIGEAIQYLHS--I--NIAHRDVKPENLLYT--SKRPNA------ILKLTDFGFAKE---------------TTSHNSLTT---PCYTPYYVAPEVLG------PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FY-SN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT------IT-EFMNHPWI--------------
----YRLLKTIGKGNFAKV---KLARH---I----L-TGK---EVAVKIIDKTQLNS---SS--LQ-KLFR-------EVRIMKVL-N------HPN-----IVKLFEVIE--T--------EKTLY--LVMEY-ASGG--EVFDYLV----AHG--RM---KEKEARAKFRQIVSAVQYCHQ--K--FIVHRDLKAENLLLD--ADMNI---------KIADFGFSNE---------------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLP---------------FD-GQ---------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT------LE-QIMKDRWM--------------
----YELHETIGTGGFAKV---KLACH---I----L-TGE---MVAIKIMDKNTLGS---DL--PR-IKT--------EIEALKNL-R------HQH-----ICQLYHVLE--T--------ANKIF--MVLEY-CPGG--ELFDYII----SQD--RL---SEEETRVVFRQIVSAVAYVHS--Q--GYAHRDLKPENLLFD--EYHKL---------KLIDFGLCAKP-------------KGNKDYHLQT---CCGSLAYAAPELIQ-----GKSYLGSEADVWSMGILLYVLMC-GFLP---------------FD-DD---------NVMALYKKIMRGKYDVPKWLS---------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS------MK-NLLNHPWI--------------
----YELQETLGKGTYGKV---KRATE---R----F-SGR---VVAIKSIRKDKIKD---EQ--DM-VHIR------REIEIMSSL-N------HPH-----IISIYEVFE--N--------KDKIV--IIMEY-ASKG--ELYDYIS----ERR--RL---SERETRHFFRQIVSAVHYCHK--N--GVVHRDLKLENILLD--DNCNI---------KIADFGLSNL---------------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMP---------------FD-GF---------DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKV---KKARE---S----S-GR----LVAIKSIRKDKIKD---EQ--DL-MHIR------REIEIMSSL-N------HPH-----IIAIHEVFE--N--------SSKIV--IVMEY-ASRG--DLYDYIS----ERQ--QL---SEREARHFFRQIVSAVHYCHQ--N--RVVHRDLKLENILLD--ANGNI---------KIADFGLSNL---------------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMP---------------FD-GH---------DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT------LE-DVASHWW-V-------------
----YTRFEKIGQGASGTV---YTALD---I----A-TGQ---EVAIKQMNLQQQPK---KE--LI-I--N-------EILVMREN-K------NPN-----IVNYLDSYL--V--------GDELW--VVMEY-LAGG--SLTDVVT-----ET--CM---DEGQIAAVCRECLQALDFLHS--N--QVIHRDIKSDNILLG--MDGSV---------KLTDFGFCAQI--------------TPEQSKRST---MVGTPYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMVE-GEPP---------------YL-NE------NPLRALYLIATNGTPELQNPERLS---------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS------AK-ELLQHPFL--------------
---Y-IKLDKLGEGTYATV---YKGKS---K----L-TDN---LVALKEIRLEHEEG---AP--C--TAIR-------EVSLLKDL-K------HAN-----IVTLHDIIH--T--------EKSLT--LVFEY-LDK---DLKQYLD---DCGN--II---NMHNVKLFLFQLLRGLAYCHR--Q--KVLHRDLKPQNLLIN--ERGEL---------KLADFGLARAK--------------SIPTKTYSN---EVVTLWYRPPDILL-----GSTDYSTQIDMWGVGCIFYEMAT-GRPL---------------FP-GS------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS------AE-DAMKHPFF--------------
---F-KFGKILGEGSFSTV---VLARE---L----A-TSR---EYAIKILEKRHIIK---EN--KVPYVTR-------ERDVMSRL-D------HPF-----FVKLYFTFQ--D--------DEKLY--FGLSY-AKNG--ELLKYIR----KIG--SF---DETCTRFYTAEIVSALEYLHG--K--GIIHRDLKPENILLN--EDMHI---------QITDFGTAKVLS------------PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG---------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
----YEKLEKLGEGSYATV---YKGKS---K----V-NGK---LVALKVIRLQEEEG---TP--F--TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T--------KETLT--LVFEY-VHT---DLCQYMD---KHPG--GL---HPDNVKLFLFQLLRGLSYIHQ--R--YILHRDLKPQNLLIS--DTGEL---------KLADFGLARAK--------------SVPSHTYSN---EVVTLWYRPPDVLL-----GSTEYSTCLDMWGVGCIFVEMIQ-GVAA---------------FP-GM-----KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS------AQ-AALSHEYF--------------
----YEPKEILGRGVSSVV---RRCIH---K----P-TSQ---EYAVKVIDVTGGGS---FS--PE-EVRELREATLKEVDILRKVSG------HPN-----IIQLKDTYE--T--------NTFFF--LVFDL-MKRG--ELFDYLT----EKV--TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--DNMNI---------KLTDFGFSCQ---------------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPP---------------FW-HR---------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT------AE-EALAHPFF--------------
----YQVGPLLGSGGFGSV---YSGIR---V----S-DNL---PVAIKHVEKDRISD---WG--EL-PNGTRV---PMEVVLLKKV-S------SGFS---GVIRLLDWFE--R--------PDSFV--LILER-PEPV-QDLFDFIT----ERG--AL---QEELARSFFWQVLEAVRHCHN--C--GVLHRDIKDENILID-LNRGEL---------KLIDFGSGA----------------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FE-HD---------------EEIIRGQVFFRQRVS---------------------------------------------------------------------------SECQHLIRWCLALRPSDRPT------FE-EIQNHPWM--------------
----YRLGPLLGKGGFGTV---FAGHR---L----T-DRL---QVAIKVIPRNRVLG---WS--PL-SDSVTC---PLEVALLWKV-GAG--GGHPG-----VIRLLDWFE--T--------QEGFM--LVLERPLPAQ--DLFDYIT----EKG--PL---GEGPSRCFFGQVVAAIQHCHS--R--GVVHRDIKDENILID-LRRGCA---------KLIDFGSGA----------------LLHDEPYTD---FDGTRVYSPPEWIS-----RHQYHALPATVWSLGILLYDMVC-GDIP---------------FE-RD---------------QEILEAELHFPAHVS---------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS------LE-EILLDPWM--------------
----YQVGAVLGSGGFGTV---YAGSR---I----A-DGL---PVAVKHVVKERVTE---WG--SL-GGATV----PLEVVLLRKV-GAA--GGARG-----VIRLLDWFE--R--------PDGFL--LVLER-PEPA-QDLFDFIT----ERG--AL---DEPLARRFFAQVLAAVRHCHS--C--GVVHRDIKDENLLVD-LRSGEL---------KLIDFGSGA----------------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIP---------------FE-QD---------------EEILRGRLLFRRRVS---------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS------LD-QIAAHPWM--------------
--FR--CCAVLGRGHFGKV---LLAEY---K----N-TNE---MFAIKALKKGDIVA---RD--EV-DSLM------CEKRIFETV-NS---VRHPF-----LVNLFACFQ--T--------KEHVC--FVMEY-AAGG--DLMMHIH-----TD--VF---SEPRAVFYAACVVLGLQYLHE--H--KIVYRDLKLDNLLLD--TEGFV---------KIADFGLCKEG--------------MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESP---------------FP-GD---------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF--------------
---F-KVGNLLGKGSFAGV---YRAES---I----H-TGL---EVAIKMIDKKAMYK---AG--MV-QRVQ------NEVKIHCQL-K------HPS-----ILELYNYFE--D--------SNYVY--LVLEM-CHNG--EMNRYLK---NRVK--PF---SENEARHFMHQIITGMLYLHS--H--GILHRDLTLSNLLLT--RNMNI---------KIADFGLATQL--------------KMPHEKHYT---LCGTPNYISPEIAT------RSAHGLESDVWSLGCMFYTLLI-GRPP---------------FD-TD---------TVKNTLNKVVLADYEMPSFLS---------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS------LS-SVLDHPFM--------------
----YVLGDTLGVGTFGKV---KIGEH---Q----L-TGH---KVAVKILNRQKIRS---LD--VV-GKIK------REIQNLKLF-R------HPH-----IIKLYQVIS--T--------PTDFF--MVMEY-VSGG--ELFDYIC----KHG--RV---EEMEARRLFQQILSAVDYCHR--H--MVVHRDLKPENVLLD--AHMNA---------KIADFGLSNM---------------MSDGEFLRT---SCGSPNYAAPEVIS-----GRLYAGPEVDIWSCGVILYALLC-GTLP---------------FD-DE---------HVPTLFKKIRGGVFYIPEYLN---------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT------IK-DIREHEWF--------------
---F-ERIKTLGTGSFGRV---MLVKH---K----E-TGN---HYAMKILDKQKVVK---LK--QI-EHTL------NEKRILQAV-N------FPF-----LVKLEFSFK--D--------NSNLY--MVMEY-VPGG--EMFSHLR----RIG--RF---SEPHARFYAAQIVLTFEYLHS--L--DLIYRDLKPENLLID--QQGYI---------QVTDFGFAK-----------------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPP---------------FF-AD---------QPIQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVN-DIKNHKWF--------------
---F-ERKKTLGTGSFGRV---MLVKH---K----A-TEQ---YYAMKILDKQKVVK---LK--QI-EHTL------NEKRILQAV-N------FPF-----LVRLEYAFK--D--------NSNLY--MVMEY-VPGG--EMFSHLR----RIG--RF---SEPHARFYAAQIVLTFEYLHS--L--DLIYRDLKPENLLID--HQGYI---------QVTDFGFAK-----------------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPP---------------FF-AD---------QPIQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVS-DIKTHKWF--------------
---F-NFLMVLGKGSFGKV---MLSER---K----G-TDE---LYAVKILKKDVVIQ---DD--DV-ECTM------VEKRVLALPGK------PPF-----LTQLHSCFQ--T--------MDRLY--FVMEY-VNGG--DLMYHIQ----QVG--RF---KEPHAVFYAAEIAIGLFFLQS--K--GIIYRDLKLDNVMLD--SEGHI---------KIADFGMCKEN--------------IWDGVTTKT---FCGTPDYIAPEIIA------YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FE-GE---------DEDELFQSIMEHNVAYPKSMS---------------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKV---LLGEL---K----G-RGE---YFAIKALKKDVVLI---DD--DV-ECTM------VEKRVLTLAAE------NPF-----LTHLICTFQ--T--------KDHLF--FVMEF-LNGG--DLMYHIQ----DKG--RF---ELYRATFYAAEIMCGLQFLHS--K--GIIYRDLKLDNVLLD--RDGHI---------KIADFGMCKEN--------------IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD---------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
----FEFIRVLGKGSFGKV---MLARV---K----E-TGD---LYAVKVLKKDVILQ---DD--DV-ECTM------TEKRILSLARN------HPF-----LTQLFCCFQ--T--------PDRLF--FVMEF-VNGG--DLMFHIQ----KSR--RF---DEARARFYAAEIISALMFLHD--K--GIIYRDLKLDNVLLD--HEGHC---------KLADFGMCKEG--------------ICNGVTTAT---FCGTPDYIAPEILQ------EMLYGPAVDWWAMGVLLYEMLC-GHAP---------------FE-AE---------NEDDLFEAILNDEVVYPTWLH---------------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
---F-DLLRVIGRGSYAKV---LLVRL---K----K-TDR---IYAMKVVKKELVND---DE--DI-DWVQ------TEKHVFEQASN------HPF-----LVGLHSCFQ--T--------ESRLF--FVIEY-VNGG--DLMFHMQ----RQR--KL---PEEHARFYSAEISLALNYLHE--R--GIIYRDLKLDNVLLD--SEGHI---------KLTDYGMCKEG--------------LRPGDTTST---FCGTPNYIAPEILR------GEDYGFSVDWWALGVLMFEMMA-GRSP---------------FD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS---------------------------------------------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFA-DIQGHPF-F-------------
--FI--LHKMLGKGSFGKV---FLAEF---K----K-TNQ---FFAIKALKKDVVLM---DD--DV-ECTM------VEKRVLSLAWE------HPF-----LTHMFCTFQ--T--------KENLF--FVMEY-LNGG--DLMYHIQ----SCH--KF---DLSRATFYAAEIILGLQFLHS--K--GIVYRDLKLDNILLD--KDGHI---------KIADFGMCKEN--------------MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ---------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
---F-DLIRVIGRGSYAKV---LLVRL---K----K-NDQ---IYAMKVVKKELVHD---DE--DI-DWVQ------TEKHVFEQASS------NPF-----LVGLHSCFQ--T--------TSRLF--LVIEY-VNGG--DLMFHMQ----RQR--KL---PEEHARFYAAEICIALNFLHE--R--GIIYRDLKLDNVLLD--ADGHI---------KLTDYGMCKEG--------------LGPGDTTST---FCGTPNYIAPEILR------GEEYGFSVDWWALGVLMFEMMA-GRSP---------------FD-IITD--NPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF-----
--PD----EVLGSGQFGVV---YGGKH---R----K-TGR---DVAVKVIDKLRFPT---KQ--ES-QLRN-------EVAILQSL-R------HPG-----IVNLECMFE--T--------PEKVF--VVMEK-LHGD--MLEMILS---SEKG--RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP------QVKLCDFGFARI---------------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFP---------------FN-ED-----------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
---F-NIIDTLGVGGFGRV---ELVQL---KS---E-ESK---TFAMKILKKRHIVD---TR--QQ-EHIR------SEKQIMQGA-H------SDF-----IVRLYRTFK--D--------SKYLY--MLMEA-CLGG--ELWTILR----DRG--SF---EDSTTRFYTACVVEAFAYLHS--K--GIIYRDLKPENLILD--HRGYA---------KLVDFGFAKK---------------IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPP---------------FS-GP---------DPMKTYNIILRGIDMIEFPKKIA-------------------------------------------------------------------------KNAANLIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF--------------
YNVY----GYTGQGVFSNV---VRARD---N----ARANQ---EVAVKIIRNNELMQ---KT--G----LK-------ELEFLKKL-NDADPDDKFH-----CLRLFRHFY--H--------KQHLC--LVFEP-LSM---NLREVLKK-YGKDV--GL---HIKAVRSYSQQLFLALKLLKR--C--NILHADIKPDNILVN--ESKTI--------LKLCDFGSAS----------------HVADNDITP---YLVSRFYRAPEIII------GKSYDYGIDMWSVGCTLYELYT-GKIL---------------FP-GK------TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS------IN-QALQHAFI--------------
----FELLKVLGQGSFGKVFLVRKVTR---P----D-SGH---LYAMKVLKKATLKV---RD--RV-RTKM-------ERDILADV-N------HPF-----VVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALGLDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KLTDFGLSKEA--------------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQ-GK---------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAE-EIKRHV--FY------------
----FELLKVLGQGSYGKV---FLVRK---V----K-GSDAGQLYAMKVLKKATLKV---RD--RV-RSKM-------ERDILAEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KITDFGLSKEA--------------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLP---------------FQ-GK---------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG-IDGVE-EIKRHPFF--------------
----FELLKVLGQGSFGKV---FLVKK---I----S-GSDARQLYAMKVLKKATLKV---RD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KLTDFGLSKES--------------IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLP---------------FQ-GK---------DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG-PDGVE-EIKRHSFF--------------
----FELLKVLGQGSFGKV---FLVRK---K----T-GPDAGQLYAMKVLKKASLKV---RD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DVFTRLS----KEV--LF---TEEDVKFYLAELALALDHLHQ--L--GIVYRDLKPENILLD--EIGHI---------KLTDFGLSKES--------------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLP---------------FQ-GK---------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS---EGVE-EIKRHLFF--------------
----FELLRVLGKGGYGKV---FQVRKVTGA----N-TGK---IFAMKVLKKAMIVR---NA--KD-TAHTK-----AERNILEEV-K------HPF-----IVDLIYAFQ--T--------GGKLY--LILEY-LSGG--ELFMQLE----REG--IF---MEDTACFYLAEISMALGHLHQ--K--GIIYRDLKPENIMLN--HQGHV---------KLTDFGLCKES--------------IHDGTVTHT---FCGTIEYMAPEILM------RSGHNRAVDWWSLGALMYDMLT-GAPP---------------FT-GE---------NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF--------------
----WEIIGELGDGAFGKV---YKAQN---K----E-TSV---LAAAKVIDTKSEEE---LE--DY-M--V-------EIDILASC-D------HPN-----IVKLLDAFY--Y--------ENNLW--ILIEF-CAGG--AVDAVML---ELER--PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--LDGDI---------KLADFGVSAKN--------------TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPP---------------HH-EL------NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT------TS-QLLQHPFV--------------
-YLM---GDLLGEGSYGKV---KEVLD---S----E-TLC---RRAVKILKKKKLRR---IP--NG-EANVK-----KEIQLLRRL-R------HKN-----VIQLVDVLY--NE------EKQKMY--MVMEY-CVCGMQEMLDSVP-----EK--RF---PVCQAHGYFCQLIDGLEYLHS--Q--GIVHKDIKPGNLLLT--TGGTL---------KISDLGVAEALH------------PFAADDTCRT---SQGSPAFQPPEIAN----GLDTFSGFKVDIWSAGVTLYNITT-GLYP---------------FE-GD---------NIYKLFENIGKGSYAIPGDCG---------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS------IR-QIRQHSWF--------------
-LCP---GRELGRGKFAVV---RKCIK---K----D-SGK---EFAAKFMRKRRKGQ---DC--RM-EIIH-------EIAVLELAQD------NPW-----VINLHEVYE--T--------ASEMI--LVLEY-AAGG--EIFDQCVA--DREE--AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNILLT--SESPLG------DIKIVDFGLSRI---------------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISP---------------FL-GN---------DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
----FTKLEKIGKGSFGEV---FKGID---N----R-TQK---VVAIKIIDLEEAED---EI--ED-IQ-Q-------EITVLSQC-D------SPY-----VTKYYGSYL--K--------DTKLW--IIMEY-LGGG--SALDLLE-----PG--PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVLLS--EHGEV---------KLADFGVAGQL--------------TDTQIKRNT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GEPP---------------HS-EL------HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT------AK-ELLKHKFI--------------
----YTFGRILGKGSFGIV---IEATD---K----E-TET---KWAIKKVNKEKAGS---SA--VK-LLER-------EVNILKSV-K------HEH-----IIHLEQVFE--T--------PKKMY--LVMEL-CEDG--ELKEILD----RKG--HF---SENETRWIIQSLASAIAYLHN--N--DIVHRDLKLENIMVK--SSLIDDNNEINLNIKVTDFGLAVKK-------------QSRSEAMLQA---TCGTPIYMAPEVIS------AHDYSQQCDIWSIGVVMYMLLR-GEPP---------------FL-AS---------SEEKLFELIRKGELHFENAVWNSIS-----------------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
--YL--LLHLLGRGGFSEV---YKAFD---L----Y-EQR---YAAVKIHQLNKSWR---DE--KK-ENYHKH--ACREYRIHKEL-D------HPR-----IVKLYDYFS--L-------DTDTFC--TVLEY-CEGN--DLDFYLK----QHK--LM---SEKEARSIVMQIVNALRYLNE--IKPPIIHYDLKPGNILLV--DGTACG------EIKITDFGLSKIMDDD--------SYGVDGMDLTSQ---GAGTYWYLPPECFVV--GKEPPKISNKVDVWSVGVIFFQCLY-GRKP---------------FG-HN-------QSQQDILQENTILKATEVQFPVKPVVS-----------------------------------------------------------------------SEAKAFIRRCLAYRKEDRFD------VH-QLANDPYL--------------
--YL--LLHLLGRGGFSEV---YKAFD---L----T-EQR---YVAVKIHQLNKNWR---DE--KK-ENYHKH--ACREYRIHKEL-D------HPR-----IVKLYDYFS--L-------DTDSFC--TVLEY-CEGN--DLDFYLK----QHK--LM---SEKEARSIIMQIVNALKYLNE--IKPPIIHYDLKPGNILLV--NGTACG------EIKITDFGLSKIMDDD-------SYNSVDGMELTSQ---GAGTYWYLPPECFVV--GKEPPKISNKVDVWSVGVIFYQCLY-GRKP---------------FG-HN-------QSQQDILQENTILKATEVQFPPKPVVT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID------VQ-QLACDPYL--------------
----WTKGEILGKGAYGTV---YCGLT---S----Q-GQ----LIAVKQVALDTSNK---LA--AE-KEYRKL---QEEVDLLKAL-K------HVN-----IVAYLGTCL--Q--------ENTVS--IFMEF-VPGG--SISSIIN----RFG--PL---PEMVFCKYTKQILQGVAYLHE--N--CVVHRDIKGNNVMLM--PTGII---------KLIDFGCARRLAWA--------GLNGTHSDMLKS---MHGTPYWMAPEVIN------ESGYGRKSDIWSIGCTVFEMAT-GKPP---------------LA-SM--------DRMAAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS------AL-QLLKHSFL--------------