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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK PTK2B 203
TK ABL1 261
Other AURKA 133
TK EGFR 712
Other EIF2AK2 267
TK EPHA2 613
TK EPHA3 621
TK ERBB3 709
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK LCK 245
Other NEK2 8
TK PTK2 422
TK SRC 270
TK ZAP70 338
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-KD-CT-LDNKEKFM-SEAVIMKNL-DHPHIVKLIGIIE------------------------------EEPTWIIMELYPYGELGHYLE-----RN---------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVASPECVKLGDFGLSRYI--E--DEDY-YKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGK-QPFFWLENKDVIGVLEKGDRLPKPDLCP---PVLYTLMTRCWDYDPSDRPRFTELVCS--L---
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTR-----------------------------EPPFYIITEFMTYGNLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTY-TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQVYELLEKDYRMERPEGCP---EKVYELMRACWQWNPSDRPSFAEIHQA--F---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVYLILEYAPLGTVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN---TYQETYKRISRVEFTFPDFVT-EGARDLISRLLKHNPSQRPMLREVLEHPWI---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL------------------------------TSTVQLITQLMPFGCLLDYVR-----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS-KPYDGIPASEISSILEKGERLPQPPICT---IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYNN-EKAER--------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLVDTKQVKIGDFGLVTS---LKNDGKR-TR---SKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK--KEKTLLQKLLSKKPEDRPNTSEILR----TLT
---V-TRQKVIGAGEFGEVYKGMLKT---SSGKKEVPVAIKTLK-AG-YT-EKQRVDFL-GEAGIMGQF-SHHNIIRLEGVISK-----------------------------YKPMMIITEYMENGALDKFLR-----EK---------------DGEFSVLQLVGMLRGIAAGMKYLANM-----NYVHRDLAARNILVNSNLVCKVSDFGLSRVL-ED--DPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGE-RPYWELSNHEVMKAINDGFRLPTPMDCP---SAIYQLMMQCWQQERARRPKFADIVSIL-----
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-VG-YT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVTK-----------------------------SKPVMIVTEYMENGSLDSFLR-----KH---------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILINSNLVCKVSDFGLSRVL-ED--DPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGE-RPYWEMSNQDVIKAVDEGYRLPPPMDCP---AALYQLMLDCWQKDRNNRPKFEQIVSIL-----
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-DK-SG-RQSFQAVT-DHMLAIGSL-DHAHIVRLLGLCP------------------------------GSSLQLVTQYLPLGSLLDHVR-----QH---------------RGALGPQLLLNWGVQIAKGMYYLEEH-----GMVHRNLAARNVLLKSPSQVQVADFGVADLL-PP--DDKQ-LLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGA-EPYAGLRLAEVPDLLEKGERLAQPQICT---IDVYMVMVKCWMIDENIRPTFKELANE--F---
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACTQ-----------------------------DGPLYVIVEYASKGNLREYLR-----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVTENNVMKIADFGLARDI-NN--IDYY-KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG-SPYPGIPVEELFKLLKEGHRMDKPANCT---NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM-SV--EAFL-AEANVMKTL-QHDKLVKLHAVVT------------------------------KEPIYIITEFMAKGSLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSASLVCKIADFGLARVI--E--DNEY-TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR-IPYPGMSNPEVIRALERGYRMPRPENCP---EELYNIMMRCWKNRPEERPTFEYIQSV--L---
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVSQ-----------------------------GQPTLVIMELMTRGDLKSYLR-----SLRPEM------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE-QPYQGLSNEQVLRFVMEGGLLDKPDNCP---DMLFELMRMCWQYNPKMRPSFLEIISS--I---
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVSK-----------------------------GQPTLVVMELMAHGDLKSYLR-----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNEQVLKFVMDGGYLDQPDNCP---ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT------------------------------QEPIYIITEYMENGSLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR-IPYPGMTNPEVIQNLERGYRMVRPDNCP---EELYQLMRLCWKERPEDRPTFDYLRSV--L---
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYGS-MTEAE--KQMLVSEVNLLREL-KHPNIVRYYDRIIDR---------------------------TNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL--NHDTSFA-KT---FVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCA-LM-PPFTAF---SQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL-I--
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT------------------------------ENPVWIIMELCTLGELRSFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--E--DSTY-YKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGV-KPFQGVKNNDVIGRIENGERLPMPPNCP---PTLYSLMTKCWAYDPSRRPRFTELKAQL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS------------------------------EEPIYIVTEYMSKGSLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR-VPYPGMVNREVLDQVERGYRMPCPPECP---ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ------------------------------AEALMLVMEMAGGGPLHKFLV-----GK---------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKMKGPEVMAFIEQGKRMECPPECP---PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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