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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK PTK2B 203
TK ABL1 261
TKL BRAF 456
TK FLT1 827
TK FLT4 845
TK KDR 834
TK LCK 245
TK TEK 824
TK TIE1 839
V-VLNRILGEGFFGEVYEGVYT--NHKGEKINVAVKTCKK-DCTLDNKEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEPTWIIMELYPYGELGHYLERN------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKASVTRLPIKWMSPESINFRR---FTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVLEKGDR----LPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCS-L-
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
-LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMR----MRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
-LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKE-GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR---PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTR----MRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL-DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
-IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP---------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
-ITFEDLIGEGNFGQVIRAMIK---KDGLKMNAAIKMLKE-YASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP---------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----MEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
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