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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK RET 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TKL ANKK1 25
Other AURKA 133
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
CAMK DCLK3 356
TK DDR1 572
TK DDR2 563
Other DSTYK 651
TK EGFR 712
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FYN 271
TK HCK 241
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TKL LRRK2 1886
TK LTK 510
STE MAP2K1 68
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K7 36
TKL MAP3K9 144
CAMK MARK1 60
TK MATK 235
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
STE PAK2 249
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PKN1 615
AGC PKN2 657
Other PLK2 82
AGC PRKCQ 380
TK PTK2 422
TK PTK6 191
TKL RIPK4 22
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
STE STK25 20
Other STK36 4
TK SYK 371
TK TEC 370
TKL TESK1 57
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
TKL ZAK 16
TK ZAP70 338
----L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAVKML---K-E--N-AS-PSE---LR-D-LL-S-EFNVLKQV--N---HPHVIKLYGACS--Q-------DGP------LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAE--M-----K---LVHRDLAARNILVAE--------GR-KM--------KISDFGLSRDV---Y--E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI----PPERLFNLL----KT----GHR---MERPDNCS--------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL----------------------------------------------------------
-----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAVKTL---K-E--D-TM-EV-----E-E-FL-K-EAAVMKEI--K---HPNLVQLLGVCT--R-------EPP------FYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEK--K-----N---FIHRDLAARNCLVGE--------NH-LV--------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI----DLSQVYELL----EK----DYR---MERPEGCP--------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------------------------------------------------------
-----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAVKTL---K-E--D-TM-EV-----E-E-FL-K-EAAVMKEI--K---HPNLVQLLGVCT--L-------EPP------FYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NR-EEVTAVVLLYMATQISSAMEYLEK--K-----N---FIHRDLAARNCLVGE--------NH-VV--------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI----DLSQVYDLL----EK----GYR---MEQPEGCP--------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F--------------------------------------------------------
----I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAVKTL---P-E--V-CS-EQD---EL-D-FL-M-EALIISKF--N---HQNIVRCIGVSL--Q-------SLP------RFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEE--N-----H---FIHRDIAARNCLLTCP-----GPGR-VA--------KIGDFGMARDI---Y--R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK----SNQEVLEFV----TS----GGR---MDPPKNCP--------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I--------------------------------------------------------
--WRL------VASGGFSQV---FQARHR----------------RWRT---EYAIKCAPCLP-P--D-AA-SSD---VN-Y-LI-E-EAAKMKKI--K---FQHIVSIYGVCK-----------QP------LGIVMEFMANGSLEKVLS----TH-----------------------------------------------------------------------------------------------------SLCWKLRFRIIHETSLAMNFLHS--I-----KP-PLLHLDLKPGNILLDS--------NM-HV--------KISDFGLSKWME-QS--T--RMQY--------------IERSALRGMLSYIPPEMFL-----ESNKAPGPKYDVYSFAIVIWELLT-QK-KP---------------YSGF----NMMMIIIRV----AA----GMRPSLQPVSDQWPSEA-----------------------------------------QQMVD-LMKRCWDQDPKKRPC-----FL-DIT----IET------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLAREK----------------QSKF---ILALKVL---FKA--QLEKAGV-----E-H-QLRR-EVEIQSHL--R---HPNILRLYGYFH--D-------ATR------VYLILEYAPLGTVYRELQ---KLS-----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHS--K-----R---VIHRDIKPENLLLGS--------AG-EL--------KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM--HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN-------TYQETY----KR----ISR---VEFTFPDFVT------------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI--------------------------------------------------------
----V-ALGKTLGEGEFGAV---MEGQLN--------------QDDSIL---KVAVKTM---K-I-AI-CT-RSE---LE-D-FL-S-EAVCMKEF--D---HPNVMRLIGVCF--Q-------GSERESFPAPVVILPFMKHGDLHSFLL----YSRL---------------------------------------------------------------------------------------------GDQP-VYLPTQMLVKFMADIASGMEYLST--K-----R---FIHRDLAARNCMLNE--------NM-SV--------CVADFGLSKKI---Y--N--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV--YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV----ENSEIYDYL----RQ----GNR---LKQPADCL--------------------------------------------DGLYA-LMSRCWELNPQDRPS-----FT-ELREDL----------------------------------------------------------
----L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAIKTL---K-E--G-TM-SP-----E-A-FL-G-EANVMKAL--Q---HERLVRLYAVVT----------KEP------IYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EG-SRLSLPRLIDMSAQIAEGMAYIER--M-----N---SIHRDLRAANILVSE--------AL-CC--------KIADFGLARII---------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV--FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM----SNPEVIRNL----ER----GYR---MPRPDTCP--------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------------------------------------------------------
-----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAVKMI---K-E--G-SM-SE-----D-E-FF-Q-EAQTMMKL--S---HPKLVKFYGVCS--K-------EYP------IYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------G-KGLEPSQLLEMCYDVCEGMAFLES--H-----Q---FIHRDLAARNCLVDR--------DL-CV--------KVSDFGMTRYV------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK--YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY----DNSQVVLKV----SQ----GHR---LYRPHLAS--------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I--------------------------------------------------------
-----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAIKMI---K-E--G-SM-SE-----D-E-FI-E-EAKVMMNL--S---HEKLVQLYGVCT--K-------QRP------IFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------R-HRFQTQQLLEMCKDVCEAMEYLES--K-----Q---FLHRDLAARNCLVND--------QG-VV--------KVSDFGLSRYV------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK--FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF----TNSETAEHI----AQ----GLR---LYRPHLAS--------------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I--------------------------------------------------------
-----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAVKML---K-S--T-AH-ADE---KE-A-LM-S-ELKIMSHLG-Q---HENIVNLLGACT--H-------GGP------VLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLAS--K-----N---CIHRDVAARNVLLTN--------GH-VA--------KIGDFGLARDI---M--N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV--YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L--VNSKFYKLV----KD----GYQ---MAQPAFAP--------------------------------------------KNIYS-IMQACWALEPTHRPT-----FQ-QICSFL----------------------------------------------------------
-----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAVKCI---K-N--D-AT-AQ-------A-FL-A-EASVMTQL--R---HSNLVQLLGVIV-EE-------KGG------LYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GR-SVLGGDCLLKFSLDVCEAMEYLEG--N-----N---FVHRDLAARNVLVSE--------DN-VA--------KVSDFGLTKEA------------S--------------STQDTGKLPVKWTAPEALR-----EKK--FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI----PLKDVVPRV----EK----GYK---MDAPDGCP--------------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL----------------------------------------------------------
-----YETGRVIGDGNFAVV---KECRHR----------------ETRQ---AYAMKII---DKS--R-LKGKE-----D-M-V-DS-EILIIQSL--S---HPNIVKLHEVYE--T-------DME------IYLILEYVQGGDLFDAII---ESV-----------------------------------------------------------------------------------------------------KFPEPDAALMIMDLCKALVHMHD--K-----S---IVHRDLKPENLLVQR--------NE-DKST----TLKLADFGLAK---------HVVRPI--------------FT---VCGTPTYVAPEILS-----EKG--YGLEVDMWAAGVILYILLC-GF-PP---------------FRSP-----ERDQDELF----NI----IQL---GHFEFLPPYW-DNIS-------------------------------------DAAKD-LVSRLLVVDPKKRYT-----AH-QVLQHPWI--------------------------------------------------------
-----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKIL---R-P--D-AT-KNA---RN-D-FL-K-EVKIMSRL--K---DPNIIRLLGVCV--Q-------DDP------LCMITDYMENGDLNQFLS----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLAT--L-----N---FVHRDLATRNCLVGE--------NF-TI--------KIADFGMSRNL---Y--A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL----TDEQVIENAGEFFRD----QGRQVYLSRPPACP--------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FS-QLHRFL----------------------------------------------------------
-----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAVKML---R-A--D-AN-KNA---RN-D-FL-K-EIKIMSRL--K---DPNIIHLLAVCI--T-------DDP------LCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSS--L-----N---FVHRDLATRNCLVGK--------NY-TI--------KIADFGMSRNL---Y--S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK--FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL----SDEQVIENT----GEFFRDQGRQTYLPQPAICP--------------------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQ-EIHL---LL-------------------------------------------------------
----K--LGQELGRGQYGVV---YLCDNW----------------GGHF---PCALKSV---VPP--D-EKHWN-----D----LAL-EFHYMRSL-PK---HERLVDLHGSVI--DYNYGGGSSIA------VLLIMERLHR-DLYTGLK-----A-----------------------------------------------------------------------------------------------------GLTLETRLQIALDVVEGIRFLHS--Q-----G---LVHRDIKLKNVLLDK--------QN-RA--------KITDLGFCK---------PEAMMS--------------GS---IVGTPIHMAPELFT------GK--YDNSVDVYAFGILFWYICS-GS-VK---------------LPEAF--ERCASKDHLW----NN----VRR---GARPERLPVF----D-------------------------------------EECWQ-LMEACWDGDPLKRP-----------------LLGIVQPML-----------------------------------------------
----F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAIKEL---R-E--A-TS-PKA---NK-E-IL-D-EAYVMASV--D---NPHVCRLLGICL----------TST------VQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLED--R-----R---LVHRDLAARNVLVKT--------PQ-HV--------KITDFGLAKLL---G--A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI----PASEISSIL----EK----GER---LPQPPICT--------------------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF------------------------------------------------------
----L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAIKVL---R-E--N-TS-PKA---NK-E-IL-D-EAYVMAGV--G---SPYVSRLLGICL----------TST------VQLVTQLMPYGCLLDHVR----EN--------------------------------------------------------------------------------------------------R-GRLGSQDLLNWCMQIAKGMSYLED--V-----R---LVHRDLAARNVLVKS--------PN-HV--------KITDFGLARLL---D--I--DETE--------------YHADGGKVPIKWMALESIL-----RRR--FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI----PAREIPDLL----EK----GER---LPQPPICT--------------------------------------------IDVYM-IMVKCWMIDSECRPR-----FR-ELVSE--F--------------------------------------------------------
----L-RKLKVLGSGVFGTV---HKGVWIP------------EGESIKI---PVCIKVI---E-D--K-SG-RQS---FQ-A-VT-D-HMLAIGSL--D---HAHIVRLLGLCP----------GSS------LQLVTQYLPLGSLLDHVR----QH--------------------------------------------------------------------------------------------------R-GALGPQLLLNWGVQIAKGMYYLEE--H-----G---MVHRNLAARNVLLKS--------PS-QV--------QVADFGVADLL---P--P--DDKQ--------------LLYSEAKTPIKWMALESIH-----FGK--YTHQSDVWSYGVTVWELMTFGA-EP---------------YAGL----RLAEVPDLL----EK----GER---LAQPQICT--------------------------------------------IDVYM-VMVKCWMIDENIRPT-----FK-ELANE--F--------------------------------------------------------
----L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAIKIL---N-E--T-TG-PKA---NV-E-FM-D-EALIMASM--D---HPHLVRLLGVCL----------SPT------IQLVTQLMPHGCLLEYVH----EH--------------------------------------------------------------------------------------------------K-DNIGSQLLLNWCVQIAKGMMYLEE--R-----R---LVHRDLAARNVLVKS--------PN-HV--------KITDFGLARLL---E--G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK--FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI----PTREIPDLL----EK----GER---LPQPPICT--------------------------------------------IDVYM-VMVKCWMIDADSRPK-----FK-ELAAE--F--------------------------------------------------------
---VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAVKTC---K-E--D-LP-QEL---KI-K-FL-Q-EAKILKQY--D---HPNIVKLIGVCT--Q-------RQP------VYIIMELVSGGDFLTFLR----RK--------------------------------------------------------------------------------------------------K-DELKLKQLVKFSLDAAAGMLYLES--K-----N---CIHRDLAARNCLVGE--------NN-VL--------KISDFGMSRQE------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR--YSSESDVWSFGILLWETFSLGV-CP---------------YPGM----TNQQAREQV----ER----GYR---MSAPQHCP--------------------------------------------EDISK-IMMKCWDYKPENRPK-----FS-ELQKEL----------------------------------------------------------
----L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAVKSC---R-E--T-LP-PDL---KA-K-FL-Q-EARILKQY--S---HPNIVRLIGVCT--Q-------KQP------IYIVMELVQGGDFLTFLR----TE--------------------------------------------------------------------------------------------------G-ARLRVKTLLQMVGDAAAGMEYLES--K-----C---CIHRDLAARNCLVTE--------KN-VL--------KISDFGMSREE---A--D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR--YSSESDVWSFGILLWETFSLGA-SP---------------YPNL----SNQQTREFV----EK----GGR---LPCPELCP--------------------------------------------DAVFR-LMEQCWAYEPGQRPS-----FS-TIYQEL----------------------------------------------------------
----L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAVKML---K-S--D-AT-EKD---LS-D-LI-S-EMEMMKMIG-K---HKNIINLLGACT--Q-------DGP------LYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLAS--K-----K---CIHRDLAARNVLVTE--------DN-VM--------KIADFGLARDI---H--H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV----PVEELFKLL----KE----GHR---MDKPSNCT--------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAVKML---K-D--D-AT-EKD---LS-D-LV-S-EMEMMKMIG-K---HKNIINLLGACT--Q-------DGP------LYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLAS--Q-----K---CIHRDLAARNVLVTE--------NN-VM--------KIADFGLARDI---N--N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI----PVEELFKLL----KE----GHR---MDKPANCT--------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAVKML---K-D--D-AT-DKD---LS-D-LV-S-EMEMMKMIG-K---HKNIINLLGACT--Q-------GGP------LYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLAS--Q-----K---CIHRDLAARNVLVTE--------DN-VM--------KIADFGLARDV---H--N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI----PVEELFKLL----KE----GHR---MDKPANCT--------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL----------------------------------------------------------
----L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAVKML---K-D--N-AS-DKD---LA-D-LV-S-EMEVMKLIG-R---HKNIINLLGVCT--Q-------EGP------LYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLES--R-----K---CIHRDLAARNVLVTE--------DN-VM--------KIADFGLARGV---H--H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI----PVEELFSLL----RE----GHR---MDRPPHCP--------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL----------------------------------------------------------
-----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAVKTL---K-P--G-TM-SP-----K-A-FL-E-EAQVMKLL--R---HDKLVQLYAVVS----------EEP------IYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EG-QDLRLPQLVDMAAQVAEGMAYMER--M-----N---YIHRDLRAANILVGE--------RL-AC--------KIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR--FTIKSDVWSFGILLTELITKGR-IP---------------YPGM----NKREVLEQV----EQ----GYH---MPCPPGCP--------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL----------------------------------------------------------
-----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAIKTL---K-P--G-TM-SP-----E-S-FL-E-EAQIMKKL--K---HDKLVQLYAVVS----------EEP------IYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EG-RALKLPNLVDMAAQVAAGMAYIER--M-----N---YIHRDLRSANILVGN--------GL-IC--------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR--FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM----NNREVLEQV----ER----GYR---MPCPQDCP--------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL----------------------------------------------------------
-----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAVKTM---K-P--G-SM-SV-----E-A-FL-A-EANVMKTL--Q---HDKLVKLHAVVT----------KEP------IYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQ--R-----N---YIHRDLRAANILVSA--------SL-VC--------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS--FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM----SNPEVIRAL----ER----GYR---MPRPENCP--------------------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L--------------------------------------------------------
--VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAVKKL---AAM--V-DITTE-----ELK-QQFDQEIKVMAKC--Q---HENLVELLGFSS--D-------GDD------LCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHE--N-----H---HIHRDIKSANILLDE--------AF-TA--------KISDFGLARASE----KFAQTVMT--------------SR---IVGTTAYMAPEALR------GE--ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH----REPQLLLDI----KE----EIE---DEEKTIEDYI-DKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ-----------------------------------------------------
-----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAIKTI---R-E--G-AM-SE-----E-D-FI-E-EAEVMMKL--S---HPKLVQLYGVCL--E-------QAP------ICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEE--A-----C---VIHRDLAARNCLVGE--------NQ-VI--------KVSDFGMTRFV------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR--YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR----SNSEVVEDI----ST----GFR---LYKPRLAS--------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL----------------------------------------------------------
-----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAVKKL---Q-H--S-TE--EH---LR-D-FE-R-EIEILKSL--Q---HDNIVKYKGVCYSAG-------RRN------LKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGT--K-----R---YIHRDLATRNILVEN--------EN-RV--------KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM----IVFHLIELL----KN----NGR---LPRPDGCP--------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------------------------------------------------------
----L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAVKQL---Q-H--S-GP-DQ----QR-D-FQ-R-EIQILKAL--H---SDFIVKYRGVSYGPG-------RQS------LRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGS--R-----R---CVHRDLAARNILVES--------EA-HV--------KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI--FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P--ALCRLLELL----EE----GQR---LPAPPACP--------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------------------------------------------------------
-----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAVKML---K-P--S-AH-LTE---RE-A-LM-S-ELKVLSYLG-N---HMNIVNLLGACT--I-------GGP------TLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LALDLEDLLSFSYQVAKGMAFLAS--K-----N---CIHRDLAARNILLTH--------GR-IT--------KICDFGLARDI---K--N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV--YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P--VDSKFYKMI----KE----GFR---MLSPEHAP--------------------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I--------------------------------------------------------
-----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAVKSL---K-Q--G-SM-SP-----D-A-FL-A-EANLMKQL--Q---HQRLVRLYAVVT----------QEP------IYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEE--R-----N---YIHRDLRAANILVSD--------TL-SC--------KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM----TNPEVIQNL----ER----GYR---MVRPDNCP--------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------------------------------------------------------
--EFL------LGDGSFGSV---YRAAYE----------------GEE-----VAVKIF---NKH--T-SLRLL-----R-Q------ELVVLCHL--H---HPSLISLLAAGI--R-------P--------RMLVMELASKGSLDRLLQ--QDKA-----------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHS--A-----M---IIYRDLKPHNVLLFT--------LY--PNAA--IIAKIADYGIAQ--------YCCRMGI--------------KT---SEGTPGFRAPEVAR----GNVI--YNQQADVYSFGLLLYDILTTGG-RI---------------VEGLK-FPNEFDELEIQ----GK----LPD---PVKEYGCAPW------------------------------------------PMVEK-LIKQCLKENPQERPT-----SA-QVF-----DIL-----------------------------------------------------
----V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAIKTL---P-E--L-CS-PQD---EL-D-FL-M-EALIISKF--R---HQNIVRCVGLSL--R-------ATP------RLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEE--N-----H---FIHRDIAARNCLLSCA-----GPSR-VA--------KIGDFGMARDI---Y--R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI--FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR----TNQEVLDFV----VG----GGR---MDPPRGCP--------------------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL----------------------------------------------------------
-----FEKISELGAGNGGVV---FKVSHK----------------PSGL----VMARKL---IHL--E-IKPAI-----R-N-QIIR-ELQVLHEC--N---SPYIVGFYGAFY--S-------DGE------ISICMEHMDGGSLDQVLK---KAG-----------------------------------------------------------------------------------------------------RIPEQILGKVSIAVIKGLTYLRE-KH-----K---IMHRDVKPSNILVNS--------RG-EI--------KLCDFGVSG--------QLIDSMA--------------NS---FVGTRSYMSPERLQ-----GTH--YSVQSDIWSMGLSLVEMAV-GR-YP---------------IPPP----DAKELELMF----GC----QVE---GDAAETPPRP-RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-----LK-QLMVHAFI--------------------------------------------------------
-----LRLEEVIGIGGFGKV---YRGSWR------------------GE---LVAVKAA---R-Q--D-PD-EDISVTAE-S-VR-Q-EARLFAML--A---HPNIIALKAVCL--E-------EPN------LCLVMEYAAGGPLSRALA----GR-----------------------------------------------------------------------------------------------------RVPPHVLVNWAVQIARGMHYLHC--E-----ALVPVIHRDLKSNNILLLQPIESDDMEHK-TL--------KITDFGLAREW-----------HK--------------TTQMSAAGTYAWMAPEVIK-----AST--FSKGSDVWSFGVLLWELLT-GE-VP---------------YRGI----DCLAVAYGV---AVN----KLT---LPIPSTCP--------------------------------------------EPFAQ-LMADCWAQDPHRRPD-----FA-SILQQL----------------------------------------------------------
LDLQW------VGSGAQGAV---FLGRFH------------------GE---EVAVKKV---R-D--L-KE-T---------------DIKHLRKL--K---HPNIITFKGVCT--Q-------APC------YCILMEFCAQGQLYEVLR----AG----------------------------------------------------------------------------------------------------RPVTPSLLVDWSMGIAGGMNYLHL--H-----K---IIHRDLKSPNMLITY--------DD-VV--------KISDFGTSKEL----------SDK--------------STKMSFAGTVAWMAPEVIR-----NEP--VSEKVDIWSFGVVLWELLT-GE-IP---------------YKDV----DSSAIIWGV---GSN----SLH---LPVPSSCP--------------------------------------------DGFKI-LLRQCWNSKPRNRPS-----FR-QILLH--L--------------------------------------------------------
-ISEL----QWLGSGAQGAV---FLGKFR------------------AE---EVAIKKV---R-E--Q-NE-TD---------------IKHLRKL--K---HPNIIAFKGVCT--Q-------APC------YCIIMEYCAHGQLYEVLR----AG----------------------------------------------------------------------------------------------------RKITPRLLVDWSTGIASGMNYLHL--H-----K---IIHRDLKSPNVLVTH--------TD-AV--------KISDFGTSKEL----------SDK--------------STKMSFAGTVAWMAPEVIR-----NEP--VSEKVDIWSFGVVLWELLT-GE-IP---------------YKDV----DSSAIIWGV---GSN----SLH---LPVPSTCP--------------------------------------------DGFKI-LMKQTWQSKPRNRPS-----FR-QTLMH--L--------------------------------------------------------
-----IEVEEVVGRGAFGVV---CKAKWR------------------AK---DVAIKQI---E-------S-ESE---RK-A-FI-V-ELRQLSRV--N---HPNIVKLYGACL-----------NP------VCLVMEYAEGGSLYNVLH----GA-------------------------------------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS--M-----QPKALIHRDLKPPNLLLVA--------GGTVL--------KICDFGTACDI------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN--YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG--PAFRIMWAV----HN----GTR---PPLIKNLP--------------------------------------------KPIES-LMTRCWSKDPSQRPS-----ME-EIVKI--M--------------------------------------------------------
----L-TLEEIIGIGGFGKV---YRAFWI----------------GDE-----VAVKAA---RHDP-D-EDISQ-----T-I-ENVRQEAKLFAML--K---HPNIIALRGVCL--K-------EPN------LCLVMEFARGGPLNRVLS----GK-----------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHD--EA--IVP---IIHRDLKSSNILILQ--------KV-ENGDLSNKILKITDFGLAR--------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----ASM--FSKGSDVWSYGVLLWELLT-GE-VP---------------FRGI-------DGLAVA----YG----VAM---NKLALPIPST-CP---------------------------------------EPFAK-LMEDCWNPDPHSRPS-----FT-NILDQ---LT------------------------------------------------------
-----YRLQKTIGKGNFAKV---KLARHV----------------LTGR---EVAVKII---DKT--Q-LNPTS-----L-Q-KLFR-EVRIMKIL--N---HPNIVKLFEVIE--T-------EKT------LYLVMEYASGGEVFDYLV---AHG-----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQ--K-----Y---IVHRDLKAENLLLDG--------DM-NI--------KIADFGFSNE-------FTVGNKL--------------DT---FCGSPPYAAPELFQ----GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ-------NLKELR----ER----VLR---GKYRIPFYMS------------------------------------------TDCEN-LLKKLLVLNPIKRGS-----LE-QIMKDRWM--------------------------------------------------------
-----LTLGAQIGEGEFGAV---LQGEYL------------------GQ---KVAVKNI---K-C--D-VT-AQ-------A-FL-D-ETAVMTKM--Q---HENLVRLLGVIL----------HQG------LYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------------------------------------GR-ALVNTAQLLQFSLHVAEGMEYLES--K-----K---LVHRDLAARNILVSE--------DL-VA--------KVSDFGLAKAE------------R--------------KGLDSSRLPVKWTAPEALK-----HGK--FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM----SLKEVSEAV----EK----GYR---MEPPEGCP--------------------------------------------GPVHV-LMSSCWEAEPARRPP-----FR-KLAEKL----------------------------------------------------------
----L-ILGKILGEGEFGSV---MEGNLK-------------QEDGTSL---KVAVKTM---KLD--N-SS-QRE---IE-E-FL-S-EAACMKDF--S---HPNVIRLLGVCI--E-------MSSQG-IPKPMVILPFMKYGDLHTYLL----YSRL---------------------------------------------------------------------------------------------ETGP-KHIPLQTLLKFMVDIALGMEYLSN--R-----N---FLHRDLAARNCMLRD--------DM-TV--------CVADFGLSKKI---Y--S--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV--YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV----QNHEMYDYL----LH----GHR---LKQPEDCL--------------------------------------------DELYE-IMYSCWRTDPLDRPT-----FS-VLRLQ--L--------------------------------------------------------
-----VHFNEVIGRGHFGCV---YHGTLL-------------DNDGKKI---HCAVKSL---N-R--I-TD-IGE---VS-Q-FL-T-EGIIMKDF--S---HPNVLSLLGICL-RS-------EGS------PLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLAS--K-----K---FVHRDLAARNCMLDE--------KF-TV--------KVADFGLARDM---Y--D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK--FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV----NTFDITVYL----LQ----GRR---LLQPEYCP--------------------------------------------DPLYE-VMLKCWHPKAEMRPS-----FS-ELVSR--I--------------------------------------------------------
--THS---DRVIGKGHFGVV---YHGEYI-------------DQAQNRI---QCAIKSL---S-R--I-TE-MQQ---VE-A-FL-R-EGLLMRGL--N---HPNVLALIGIML-PP-------EGL------PHVLLPYMCHGDLLQFIR----SP--------------------------------------------------------------------------------------------------Q-RNPTVKDLISFGLQVARSMEYLAE--Q-----K---FVHRDLAARNCMLDE--------SF-TV--------KVADFGLARDI---L--D--REYYS------------VQQHRHARLPVKWMALESLQ-----TYR--FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI----DPFDLTHFL----AQ----GRR---LPQPEYCP--------------------------------------------DSLYQ-VMQQCWEADPAVRPT-----FR-VLV----GEV------------------------------------------------------
---IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAVKAL---K-E--A-SE-SA----RQ-D-FQ-R-EAELLTML--Q---HQHIVRFFGVCT--E-------GRP------LLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAP-GPLGLGQLLAVASQVAAGMVYLAG--L-----H---FVHRDLATRNCLVGQ--------GL-VV--------KIGDFGMSRDI---Y--S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL----SNTEAIDCI----TQ----GRE---LERPRACP--------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL----------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAVKTL---K-D--A-SD-NA----RK-D-FH-R-EAELLTNL--Q---HEHIVKFYGVCV--E-------GDP------LIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLAS--Q-----H---FVHRDLATRNCLVGE--------NL-LV--------KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL----SNNEVIECI----TQ----GRV---LQRPRTCP--------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L--------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAVKAL---K-D--P-TL-AA----RK-D-FQ-R-EAELLTNL--Q---HEHIVKFYGVCG--D-------GDP------LIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLAS--Q-----H---FVHRDLATRNCLVGA--------NL-LV--------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL----SNTEVIECI----TQ----GRV---LERPRVCP--------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL----------------------------------------------------------
-----YTRYEKIGQGASGTV---FTATDV----------------ALGQ---EVAIKQI---NLQ--K-QPKKE-----L-I-I--N-EILVMKEL--K---NPNIVNFLDSYL--V-------GDE------LFVVMEYLAGGSLTDVVT----ET-----------------------------------------------------------------------------------------------------CMDEAQIAAVCRECLQALEFLHA--N-----Q---VIHRDIKSDNVLLGM--------EG-SV--------KLTDFGFCAQI------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE----NPLRALYLI----AT----NGT---PELQNPEKLS------------------------------------------PIFRD-FLNRCLEMDVEKRGS-----AK-ELLQHPFL--------------------------------------------------------
----L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAVKML---K-P--T-AR-SSE---KQ-A-LM-S-ELKIMTHLG-P---HLNIVNLLGACT--K-------SGP------IYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGLTLLDLLSFTYQVARGMEFLAS--K-----N---CVHRDLAARNVLLAQ--------GK-IV--------KICDFGLARDI---M--H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL--YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M--VDSTFYNKI----KS----GYR---MAKPDHAT--------------------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV-------------------------------------------------------
----L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAVKML---K-S--T-AR-SSE---KQ-A-LM-S-ELKIMSHLG-P---HLNVVNLLGACT--K-------GGP------IYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVLSYMDLVGFSYQVANGMEFLAS--K-----N---CVHRDLAARNVLICE--------GK-LV--------KICDFGLARDI---M--R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL--YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P--MNEQFYNAI----KR----GYR---MAQPAHAS--------------------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL-------------------------------------------------------
----F-KFGKILGEGSFSTV---VLAREL----------------ATSR---EYAIKIL---EKR--H-IIKEN-----K-VPYVTR-ERDVMSRL--D---HPFFVKLYFTFQ--D-------DEK------LYFGLSYAKNGELLKYIR---KIG-----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHG--K-----G---IIHRDLKPENILLNE--------DM-HI--------QITDFGTAKVLS----PESKQARA--------------NS---FVGTAQYVSPELLT-----EKS--ACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG-------NEYLIF----QK----IIK---LEYDFPEKFF------------------------------------------PKARD-LVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF---------------------------------------------
----F-KFLAVLGRGHFGKV---LLSEFR----------------PSGE---LFAIKAL---KKG--D-IVARD-----E-V-ESLMCEKRILAAV--TSAGHPFLVNLFGCFQ--T-------PEH------VCFVMEYSAGGDLMLHIH----SD-----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHE--H-----K---IVYRDLKLDNLLLDT--------EG-YV--------KIADFGLCKEG------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----DTS--YTRAVDWWGLGVLLYEMLV-GE-SP---------------FPGD-------DEEEVF----DS----IVN---DEVRYPRFLS------------------------------------------AEAIG-IMRRLLRRNPERRLGSSERDAE-DVKKQPFF--------------------------------------------------------
---FR--CCAVLGRGHFGKV---LLAEYK----------------NTNE---MFAIKAL---KKG--D-IVARD-----E-V-DSLMCEKRIFETV--NSVRHPFLVNLFACFQ--T-------KEH------VCFVMEYAAGGDLMMHIH----TD-----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHE--H-----K---IVYRDLKLDNLLLDT--------EG-FV--------KIADFGLCKEG------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----ETS--YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD-------DEEEVF----DS----IVN---DEVRYPRFLS------------------------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF--------------------------------------------------------
----Y-CRGKVLGKGGFAKC---YEMTDL----------------TNNK---VYAAKII---PHS--R-VAKPH-----Q-R-EKIDKEIELHRIL--H---HKHVVQFYHYFE--D-------KEN------IYILLEYCSRRSMAHILK---ARK-----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHE--Q-----E---ILHRDLKLGNFFINE--------AM-EL--------KVGDFGLAARL------EPLEHRR--------------RT---ICGTPNYLSPEVLN-----KQG--HGCESDIWALGCVMYTMLL-GR-PP---------------FETT-------NLKETY----RC----IRE---ARYTMPSSLL------------------------------------------APAKH-LIASMLSKNPEDRPS-----LD-DIIRHDFF--------------------------------------------------------
---FI--LHKMLGKGSFGKV---FLAEFK----------------KTNQ---FFAIKAL---KKD--V-VLMDD-----D-V-ECTMVEKRVLSLA-WE---HPFLTHMFCTFQ--T-------KEN------LFFVMEYLNGGDLMYHIQ---SCH-----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHS--K-----G---IVYRDLKLDNILLDK--------DG-HI--------KIADFGMCKEN------MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQK--YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ-------DEEELF----HS----IRM---DNPFYPRWLE------------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------------------------------------------------------
-----IELGRCIGEGQFGDV---HQGIYM-------------SPENPAL---AVAIKTC---K-N--C-TS-DSV---RE-K-FL-Q-EALTMRQF--D---HPHIVKLIGVIT----------ENP------VWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLES--K-----R---FVHRDIAARNVLVSS--------ND-CV--------KLGDFGLSRYM------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR--FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV----KNNDVIGRI----EN----GER---LPMPPNCP--------------------------------------------PTLYS-LMTKCWAYDPSRRPR-----FT-ELKAQL----------------------------------------------------------
----F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAIKVI---S-R--D-NL-LH----QQ-M-LQ-S-EIQAMKKL--R---HKHILALYAVVS--V-------GDP------VYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DE-KVLPVSELLDIAWQVAEGMCYLES--Q-----N---YIHRDLAARNILVGE--------NT-LC--------KVGDFGLARLI---------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH--YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM----SNHEAFLRV----DA----GYR---MPCPLECP--------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL----------------------------------------------------------
-FTGW----EKVGSGGFGQV---YKVRHV----------------HWKT---WLAIKCS---PSL--H-VDDRE-----R-M-ELLE-EAKKMEMA--K---FRYILPVYGIC-----------REP------VGLVMEYMETGSLEKLLA----SE-----------------------------------------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHC--MA---PP---LLHLDLKPANILLDA--------HY-HV--------KISDFGLAKCNG---LSHSHDLSM--------------DG---LFGTIAYLPPERIR---EKSRL--FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE---KNILHIMVKV----VK----GHR---PELPPVCRAR-PRAC-------------------------------------SHLIR-LMQRCWQGDPRVRPT-----FQ---------GNGLN---------------------------------------------------
-----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAMKVL---KKA--T-LKVRD-----R-V-RTKM-ERDILADV--N---HPFVVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHS--L-----G---IIYRDLKPENILLDE--------EG-HI--------KLTDFGLSKEA------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RQG--HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK-------DRKETM----TL----ILK---AKLGMPQFLS------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAE-EIKRHV--FY------------------------------------------------------
-----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAMKVL---KKA--T-LKVRD-----R-V-RSKM-ERDILAEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS--L-----G---IIYRDLKPENILLDE--------EG-HI--------KITDFGLSKEA------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----RRG--HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK-------DRKETM----AL----ILK---AKLGMPQFLS------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVE-EIKRHPFF--------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAMKVL---KKA--T-LKVRD-----R-V-RTKM-ERDILVEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS--L-----G---IIYRDLKPENILLDE--------EG-HI--------KLTDFGLSKES------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RRG--HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK-------DRKETM----TM----ILK---AKLGMPQFLS------------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVE-EIKRHSFF--------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVRKK----------------TGPDAGQLYAMKVL---KKA--S-LKVRD-----R-V-RTKM-ERDILVEV--N---HPFIVKLHYAFQ--T-------EGK------LYLILDFLRGGDVFTRLS---KEV-----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQ--L-----G---IVYRDLKPENILLDE--------IG-HI--------KLTDFGLSKES------VDQEKKA--------------YS---FCGTVEYMAPEVVN-----RRG--HSQSADWWSYGVLMFEMLT-GT-LP---------------FQGK-------DRNETM----NM----ILK---AKLGMPQFLS------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVE-EIKRHLFF--------------------------------------------------------
-----WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAAKVI---DTK--S-EEELE-----D-Y-M--V-EIDILASC--D---HPNIVKLLDAFY--Y-------ENN------LWILIEFCAGGAVDAVML--ELER-----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD--N-----K---IIHRDLKAGNILFTL--------DG-DI--------KLADFGVSAKN------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP--YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL----NPMRVLLKI----AK----SEP---PTLAQPSRWS------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TS-QLLQHPFV--------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAIKTL---K-P--G-TM-SP-----E-A-FL-Q-EAQVMKKL--R---HEKLVQLYAVVS----------EEP------IYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVER--M-----N---YVHRDLRAANILVGE--------NL-VC--------KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM----VNREVLDQV----ER----GYR---MPCPPECP--------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L--------------------------------------------------------
---FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAIKVI---K-S--A-NM-K-----LT-D-LA-K-EIQTLKGL--R---HERLIRLHAVCS--G-------GEP------VYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------------------------------------EG-RALRLPPLLGFACQVAEGMSYLEE--Q-----R---VVHRDLAARNVLVDD--------GL-AC--------KVADFGLARLL------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV--FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM----TNHETLQQI----MR----GYR---LPRPAACP--------------------------------------------AEVYV-LMLECWRSSPEERPS-----FA-TLREKL----------------------------------------------------------
-----FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAIKII---DLE--E-AEDEI-----E-D-IQ-Q-EITVLSQC--D---SPYVTKYYGSYL--K-------DTK------LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHS--E-----K---KIHRDIKAANVLLSE--------HG-EV--------KLADFGVAGQL------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL----HPMKVLFLI----PK----NNP---PTLEGNYS--------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI--------------------------------------------------------
----F-TKLDRIGKGSFGEV---YKGIDN----------------HTKE---VVAIKII---DLE--E-AEDEI-----E-D-IQ-Q-EITVLSQC--D---SPYITRYFGSYL--K-------STK------LWIIMEYLGGGSALDLLK----PG-----------------------------------------------------------------------------------------------------PLEETYIATILREILKGLDYLHS--E-----R---KIHRDIKAANVLLSE--------QG-DV--------KLADFGVAGQL------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA--YDFKADIWSLGITAIELAK-GE-PP---------------NSDL----HPMRVLFLI----PK----NSP---PTLEGQHS--------------------------------------------KPFKE-FVEACLNKDPRFRPT-----AK-ELLKHKFI--------------------------------------------------------
-----YHVLEMIGEGSFGRV---YKGRRK----------------YSAQ---VVALKFI---PKL--G-RSEKE-----L-R-NLQR-EIEIMRGL--R---HPNIVHMLDSFE--T-------DKE------VVVVTDYAEG-ELFQILE---DDG-----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHS--H-----R---ILHRDMKPQNILLAK--------GG-GI--------KLCDFGFARAM------STNTMVL--------------TS---IKGTPLYMSPELVE-----ERP--YDHTADLWSVGCILYELAV-GT-PP---------------FYAT-------SIFQLV----SL----ILK---DPVRWPSTIS------------------------------------------PCFKN-FLQGLLTKDPRQRLS-----WP-DLLYHPFI--------------------------------------------------------
--TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAVKIL---K-N--E-AN-DPA--LKD-E-LL-A-EANVMQQL--D---NPYIVRMIGICE----------AES------WMLVMEMAELGPLNKYLQ----QN----------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE--S-----N---FVHRDLAARNVLLVT--------QH-YA--------KISDFGLSKAL---R--A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK--FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM----KGSEVTAML----EK----GER---MGCPAGCP--------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL------------------------------------------------------
-----LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAIKAI---R-E--G-AM-CE-----E-D-FI-E-EAKVMMKL--T---HPKLVQLYGVCT--Q-------QKP------IYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------------------------------------Q-GHFSRDVLLSMCQDVCEGMEYLER--N-----S---FIHRDLAARNCLVSE--------AG-VV--------KVSDFGMARYV------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR--FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY----TNYEVVTMV----TR----GHR---LYQPKLAS--------------------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I--------------------------------------------------------
----F-HCAEKIGAGFFSEV---YKVRHR----------------QSGQ---VMVLKMN---KLP--S-NRGNT-----------LR-EVQLMNRL--R---HPNILRFMGVCV--H-------QGQ------LHALTEYMNGGTLEQLLS---SPE-----------------------------------------------------------------------------------------------------PLSWPVRLHLALDIARGLRYLHS--K-----G---VFHRDLTSKNCLVRR--------ED-RGF-----TAVVGDFGLAEKIPV--YREGARKEP--------------LA---VVGSPYWMAPEVLR-----GEL--YDEKADVFAFGIVLCELIA-R--VP-----------------------------------------------------------------------------------------------------------------------------------------ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL
----L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAVKCL---K-PDVL-SQ-PEA---MD-D-FI-R-EVNAMHSL--D---HRNLIRLYGVVL----------TPP------MKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLES--K-----R---FIHRDLAARNLLLAT--------RD-LV--------KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT--FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL----NGSQILHKI---DKE----GER---LPRPEDCP--------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L--------------------------------------------------------
-----IEFHEIIGSGSFGKV---YKGRCR------------------NK---IVAIKRY---R-ANTY-CS-KSD---VD-M-FC-R-EVSILCQL--N---HPCVIQFVGACL-ND-------PSQ------FAIVTQYISGGSLFSLLH----EQ--------------------------------------------------------------------------------------------------K-RILDLQSKLIIAVDVAKGMEYLHNLTQ-----P---IIHRDLNSHNILLYE--------DG-HA--------VVADFGESRFL---Q--S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCT-RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL----KPAAAAADM---AYH----HIR---PPIGYSIP--------------------------------------------KPISS-LLIRGWNACPEGRPE-----FS-EVVMKL----------------------------------------------------------
----L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAIKAI---N-E--G-SM-SE-----E-D-FI-E-EAKVMMKL--S---HSKLVQLYGVCI--Q-------RKP------LYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------K-GKLRKEMLLSVCQDICEGMEYLER--N-----G---YIHRDLAARNCLVSS--------TC-IV--------KISDFGMTRYV------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK--YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK----SNLQVVEAI----SE----GFR---LYRPHLAP--------------------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV-------------------------------------------------------
----L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAVKAL---K-A--D-CG-PQH---RS-G-WK-Q-EIDILRTL--Y---HEHIIKYKGCCEDQG-------EKS------LQLVMEYVPLGSLRDYLP----RH-----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHA--Q-----H---YIHRDLAARNVLLDN--------DR-LV--------KIGDFGLAKAV--PE--G--HEYY--------------RVREDGDSPVFWYAPECLK-----EYK--FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM----TVLRLTELL----ER----GER---LPRPDKCP--------------------------------------------CEVYH-LMKNCWETEASFRPT-----FE-NLIP---IL-------------------------------------------------------
----F-TLGRMLGKGEFGSV---REAQLK-------------QEDGSFV---KVAVKML---K-A-DI-IA-SSD---IE-E-FL-R-EAACMKEF--D---HPHVAKLVGVSL--R-------SRAKGRLPIPMVILPFMKHGDLHAFLL----ASRI---------------------------------------------------------------------------------------------GENP-FNLPLQTLIRFMVDIACGMEYLSS--R-----N---FIHRDLAARNCMLAE--------DM-TV--------CVADFGLSRKI---Y--S--GDYY--------------RQGCASKLPVKWLALESLA-----DNL--YTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI----ENAEIYNYL----IG----GNR---LKQPPECM--------------------------------------------EDVYD-LMYQCWSADPKQRPS-----FT-CLRME--L--------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAIKTL---K-P--G-TM-MP-----E-A-FL-Q-EAQIMKKL--R---HDKLVPLYAVVS----------EEP------IYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DG-KYLKLPQLVDMAAQIADGMAYIER--M-----N---YIHRDLRAANILVGE--------NL-VC--------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM----VNREVLEQV----ER----GYR---MPCPQGCP--------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL----------------------------------------------------------
----L-QFFENCGGGSFGSV---YRAKWI----------------SQDK---EVAVKKL--------------------L-K-IE-K-EAEILSVL--S---HRNIIQFYGVIL--E-------PPN------YGIVTEYASLGSLYDYIN----SN-------------------------------------------------------------------------------------------------RS-EEMDMDHIMTWATDVAKGMHYLHM--EAPV--K---VIHRDLKSRNVVIAA--------DG-VL--------KICDFGASRFH-----------NH--------------TTHMSLVGTFPWMAPEVIQ-----SLP--VSETCDTYSYGVVLWEMLTR-E-VP---------------FKGL----EGLQVAWLV---VEK----NER---LTIPSSCP--------------------------------------------RSFAE-LLHQCWEADAKKRPS-----FK-QIISIL----------------------------------------------------------
-LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAIKVL---K-Q--G-TE-KAD---TE-E-MM-R-EAQIMHQL--D---NPYIVRLIGVCQ----------AEA------LMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------R-EEIPVSNVAELLHQVSMGMKYLEE--K-----N---FVHRDLAARNVLLVN--------RH-YA--------KISDFGLSKAL--GA--D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK--FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM----KGPEVMAFI----EQ----GKR---MECPPECP--------------------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M--------------------------------------------------------
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