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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
Other CHUK 15
CMGC CLK2 163
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
CAMK PRKD3 576
TK SRC 270
TK YES1 277
---FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN-----HPF-IVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEV---MF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KITDFGLSKEA----IDHDKRAYS---FCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK--------------DRKETMALILKAKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF---------
---YTKIEKIGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELR-----HPN-IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF---------
---FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELN-----HPN-IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---------
---FQKVEKIGEGTYGVVYKAKNRETGQ---LVALKKIRLDLEMEGVPSTAIREISLLKELK-----HPN-IVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS---EL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI-------------------KLADFGLARAF----GVPLRTYTH---EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGD-----------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF---------
---YEKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDDDDEGVPSSALREICLLKELK-----HKN-IVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF---------
---YEKLAKIGQGTFGEVFKARHRKTGQ---KVALKKVLMENEKEGFPITALREIKILQLLK-----HEN-VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSLAKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGN-----------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---------
--W-DLVQTLGEGAYGEVQLAVNRVTEE---AVAVKIVDMKRAVDCPENI-KKEICINKMLN-----HEN-VVKFYGHRRE--------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-------------------KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y--------
--W-EMRERLGTGGFGNVCLYQHRELDL---KIAIKSCRLELSTKNRER-WCHEIQIMKKLN-----HAN-VVKACDVPEELN---ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GL--KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI----------------IHKIIDLGYAKD-----VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ
---YEIVSTLGEGTFGRVVQCVDHRRGG--ARVALKIIKNVEKYKEAAR---LEINVLEKINEKDPDNKNLCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK----DNN---YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHHST---IVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTLFQTH-----------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF---------
---ITLERRLGTGCFGDVWLGTWN-GST---KVAVKTLK-PGTM-SPKAFL-EEAQVMKLLR-----HDK-LVQLYAVVS---------EEPIY--IVTEFMCHG--SLLDFLK-----NPEGQDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG-ERLAC-------------------KIADFGLARLI----K--DDEYNPCQGSKFPIKWTAPEAAL-FGRFTIKSDVWSFGILLTELITKGRIPYPGM-----------NKREVLEQVEQGYHMPCPPGCP-------------------------------------------ASLYEAMEQTWRLDPEERPT-----FEYLQSFL-----------
---LQLIKRLGNGQFGEVWMGTWN-GNT---KVAIKTLK-PGTM-SPESFL-EEAQIMKKLK-----HDK-LVQLYAVVS---------EEPIY--IVTEYMNKG--SLLDFLK-----DGEGRAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC-------------------KIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGM-----------NNREVLEQVERGYRMPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-----------
---YTDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDKRFKNR------ELQIMRKLD-----HCN-IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---------
---LKLVERLGAGQFGEVWMGYYN-GHT---KVAVKSLK-QGSM-SPDAFL-AEANLMKQLQ-----HQR-LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-----------TNPEVIQNLERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-----HKN-IISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M---EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI---------
LQG---LRPVGSGAYGSVCSAYDARLRQ---KVAVKKLSRPFQSLIHARRTYRELRLLKHLK-----HEN-VIGLLDVFTPATS--IEDFSEVY--LVTTLMGA---DLNNIVK-----CQ---AL--SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL-------------------RILDFGLAR-------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-------------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF---------
---YQNLSPVGSGAYGSVCAAFDTKTGL---RVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-----HEN-VIGLLDVFTPARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF---------
---YQNLKPIGSGAQGIVCAAYDAILER---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-----HKN-IIGLLNVFTPQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------M---EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI---------
---YQQLKPIGSGAQGIVCAAFDTVLGI---NVAVKKLSRPFQNQTHAKRAYRELVLLKCVN-----HKN-IISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIH------M---EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI---------
IEP---DRPIGYGAFGVVWSVTDPRDGK---RVALKKMPNVFQNLVSCKRVFRELKMLCFFK-----HDN-VLSALDILQPPH---IDYFEEIY--VVTELMQS---DLHKIIV----SPQ---PL--SSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVL-------------------KICDFGLARVE---ELDESRHMTQ---EVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQ-----------SPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL---------
FAD----EVLGSGQFGIVYGGKHRKTGR---DVAIKVIDKMRFPTKQESQLRNEVAILQNLH-----HPG-IVNLECMFET--------PERVF--VVMEKLHGD--MLEMILS---SEKS---RL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFP----------------QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED----------------EDINDQIQNAAFMYPPNPWREIS-------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL---------
--L-RLEVKLGQGCFGEVWMGTWN-GTT---RVAIKTLK-PGTM-SPEAFL-QEAQVMKKLR-----HEK-LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC-------------------KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-----------VNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---------
--L-RLEVKLGQGCFGEVWMGTWN-GTT---KVAIKTLK-PGTM-MPEAFL-QEAQIMKKLR-----HDK-LVPLYAVVS---------EEPIY--IVTEFMSKG--SLLDFLK-----EGDGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC-------------------KIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGM-----------VNREVLEQVERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL-----------
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