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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
Other CHUK 15
CMGC CLK2 163
CMGC CLK4 159
CMGC CSNK2A1 39
Other EIF2AK2 267
TK FGFR1 478
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
TK MET 1078
TK NTRK3 538
CAMK PIM1 38
CAMK PIM3 40
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
TK SRC 270
TK YES1 277
TK ZAP70 338
----FELLKVLGQGSYGKVFLVRKV-------K-GSDAGQLYAMKVLKKAT-LKV---RD--R-VRSKM----ERDILAEV--N-----HPF----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KITDFGLSKEA------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQ-GK--------------DRKETMALILKAKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCN--RLGAGIDGVE-EIKRHPFF--------------
----ITMKHKLGGGQYGEVYEGVWK-------K-YSL---TVAVKTLK-ED-TM----EV--E-EFL-K----EAAVMKEI--K-----HPN----LVQLLGVCT--R-----------------------------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV-------------------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI-----------DLSQVYELLEKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPS-----FA-EIHQA--F--------------
----FEIGRPLGKGKFGNVYLAREK-------Q-SKF---ILALKVLFKAQLEKA---GV--E-HQLRR----EVEIQSHL--R-----HPN----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL-------------------KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN--------------TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNVYLAREK-------K-SHF---IVALKVLFKSQ-IEK---EG--V-EHQLR---REIEIQAHL--H-----HPN----ILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL-------------------KIADFGWSV--------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA--------------SHNETYRRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLP-----LA-QVSAHPWV--------------
----YQLYEDIGKGAFSVVRRCVKL-------C-TGH---EYAAKIINTKK-LSA---RD--H-QKLER----EARICRLL--K-----HSN----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------YY--SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKCKGA----------------AVKLADFGLAIEV------QGDQQAW--------------FG---FAGTPGYLSPEVLR-----KEAYGKPVDIWACGVILYILLV-GY-PP---------------FW-DE--------------DQHKLYQQIKAGAYDFPSPEWDTVT-------------------------------------PEAKNLINQMLTINPAK--RIT-----AH-EALKHPWV--------------
----YTKIEKIGEGTYGVVYKGRHK-------T-TGQ---VVAMKKIRLES-EEE---GV--P-STAIR----EISLLKEL--R-----HPN----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GK-MALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-------L-TGE---VVALKKIRLDT-ETE---GV--P-STAIR----EISLLKEL--N-----HPN----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AK-AALAHPFF--------------
----FQKVEKIGEGTYGVVYKAKNR-------E-TGQ---LVALKKIRLDL-EME---GV--P-STAIR----EISLLKEL--K-----HPN----IVRLLDVVH--N-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-----------------EL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI-------------------KLADFGLARAF------GVPLRTY--------------TH---EVVTLWYRAPEILL----GSKFYTTAVDIWSIGCIFAEMVT-RK-AL---------------FP-GD-----------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AK-TALAHPYF--------------
---Y-EPVAEIGVGAYGTVYKARDP-------H-SGH---FVALKSVRVPN-GGGGGGGL--P-ISTVR----EVALLRRL--EA--FEHPN----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV-------------------KLADFGLARI-------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AF-RALQHSYL--------------
----YEKLEKIGEGTYGTVFKAKNR-------E-THE---IVALKRVRLDD-DDE---GV--P-SSALR----EICLLKEL--K-----HKN----IVRLHDVLH--S-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGR-PL---------------FP-GN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AE-EALQHPYF--------------
----YEKLAKIGQGTFGEVFKARHR-------K-TGQ---KVALKKVLMEN-EKE---GF--P-ITALR----EIKILQLL--K-----HEN----VVNLIEICR--TKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-----------------KF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWT-RS-PI---------------MQ-GN-----------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-----SD-DALNHDFF--------------
---W-DLVQTLGEGAYGEVQLAVNR-------V-TEE---AVAVKIVDMKR-AVD---CP--E-NI-KK----EICINKML--N-----HEN----VVKFYGHRR--E-----------------------------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-------------------KISDFGLATVFR----YNNRERLL--------------NK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSA--RIT-----IP-DIKKDRW-Y-------------
---W-EMRERLGTGGFGNVCLYQHR-------E-LDL---KIAIKSCRLEL-STK---NR--E-R-WCH----EIQIMKKL--N-----HAN----VVKACDVPE--ELN------------------------ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GL--KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI----------------IHKIIDLGYAKD-------VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKPYTATVDYWSFGTMVFECIA-GY-RP---------------FL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQ--RG-----------------GPVDLTLKQ-----
----YEIVSTLGEGTFGRVVQCVDH-------R-RGG--ARVALKIIKNVE-KYK---EA--A-R---L----EINVLEKI--NEKDPDNKN---LCVQMFDWFD--Y-----------------------------HGHMC--ISFELLGL---STFDFLK----DNN-----------------YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---------FDHEHH--------------ST---IVSTRHYRAPEVIL-----ELGWSQPCDVWSIGCIIFEYYV-GF-TL---------------FQ-TH-----------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLT-----LG-EALQHPFF--------------
----YEIVDTLGEGAFGKVVECIDH-------GMDGM---HVAVKIVKNVG-RYR---EA--A-RS-------EIQVLEHL--NS---TDPNSVFRCVQMLEWFD--H-----------------------------HGHVC--IVFELLGL---STYDFIK----ENS-----------------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV-KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQ-TH-----------DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LD-EALQHPFF--------------
----YQLVRKLGRGKYSEVFEAINI-------T-NNE---KVVVKILKPVK-KKK---IK--R----------EIKILENL-RG-----GPN----IITLADIVK--DP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL-------------------RLIDWGLAEF-------YHPGQEY--------------NV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AR-EAMEHPYF--------------
---F-KEIELIGSGGFGQVFKAKHR-------I-DGK---TYVIKRVKYNN-EKA---ER-------------EVKALAKL--D-----HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------------KL--DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQV-------------------KIGDFGLVTS-------LKNDGKR--------------TR---SKGTLRYMSPEQIS-----SQDYGKEVDLYALGLILAELLH-VCDTA---------------FE-T------------------SKFFTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN-----TS-EILR----TLT-----------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPN-RVT---KVAVKMLK-SD-AT----EKDLS-DLI-S----EMEMMKMIG-K-----HKN----IINLLGACT--Q-----------------------------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM-------------------KIADFGLARDI---H--H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YP-GV-----------PVEELFKLLKEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT-----FK-QLVEDL----------------
----ITLERRLGTGCFGDVWLGTWN---------GST---KVAVKTLK-PG-TM----SP--K-AFL-E----EAQVMKLL--R-----HDK----LVQLYAVVS--------------------------------EEPIY--IVTEFMCHG--SLLDFLK-----NP--------------EGQDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG-ERLAC-------------------KIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGRFTIKSDVWSFGILLTELITKGR-IP---------------YP-GM-----------NKREVLEQVEQGYHMPCPPGCP-------------------------------------------ASLYEAMEQTWRLDPEE--RPT-----FE-YLQSFL----------------
----LQLIKRLGNGQFGEVWMGTWN---------GNT---KVAIKTLK-PG-TM----SP--E-SFL-E----EAQIMKKL--K-----HDK----LVQLYAVVS--------------------------------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELVTKGR-VP---------------YP-GM-----------NNREVLEQVERGYRMPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEE--RPT-----FE-YLQSFL----------------
----YTDTKVIGNGSFGVVYQAKLC-------D-SGE---LVAIKKVLQDK-RFK---NR-------------ELQIMRKL--D-----HCN----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PL-EACAHSFF--------------
-VGG----NKMGEGGFGVVYKGYVN-------N-TT-----VAVKKLAAMV-DIT---TE--ELKQQFD---QEIKVMAKC--Q-----HEN----LVELLGFSS--D-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PL--SWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA-------------------KISDFGLARASE----KFAQTVMT--------------SR---IVGTTAYMAPEALR------GEITPKSDIYSFGVVLLEIIT-GL-PA---------------VD-EH-----------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNK--RPD-----IK-KVQQ----LLQ-----------
----LTFVQEIGSGQFGLVHLGYWL---------NKD---KVAIKTIR-EG-AM----SE--E-DFI-E----EAEVMMKL--S-----HPK----LVQLYGVCL--E-----------------------------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLF--AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI-------------------KVSDFGMTRFV------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YE-NR-----------SNSEVVEDISTGFRLYKPRLAS-------------------------------------------THVYQIMNHCWKERPED--RPA-----FS-RLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGE---VVAVKKLQ-HS-TE-----EHLR-DFE-R----EIEILKSL--Q-----HDN----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV-------------------KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELLKNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP---LGDN-TGA---LVAVKQLQ-HS-GP----DQ-QR-DFQ-R----EIQILKAL--H-----SDF----IVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV-------------------KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELLEEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYYN---------GHT---KVAVKSLK-QG-SM----SP--D-AFL-A----EANLMKQL--Q-----HQR----LVRLYAVVT--------------------------------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YP-GM-----------TNPEVIQNLERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FD-YLRSV--L--------------
----YQNLSPVGSGAYGSVCAAFDT-------K-TGL---RVAVKKLSRPF-QSI---IH--A-KRTYR----ELRLLKHM--K-----HEN----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR---------HTDDEM--------------TG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AA-QALAHAYF--------------
----YQNLKPIGSGAQGIVCAAYDA-------I-LER---NVAIKKLSRPF-QNQ---TH--A-KRAYR----ELVLMKCV--N-----HKN----IIGLLNVFT--PQKS-----------------------LEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-------AGTSFMM--------------TP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-----VD-EALQHPYI--------------
----YQQLKPIGSGAQGIVCAAFDT-------V-LGI---NVAVKKLSRPF-QNQ---TH--A-KRAYR----ELVLLKCV--N-----HKN----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIH------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-------ACTNFMM--------------TP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGELVK-GC-VI---------------FQ-GT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK--RIS-----VD-EALRHPYI--------------
----VHFNEVIGRGHFGCVYHGTLL----DNDG-KKI---HCAVKSLN-RI-TD----IGEVS-QFL-T----EGIIMKDF--S-----HPN----VLSLLGICL-RS-----------------------------EGSPL--VVLPYMKHG--DLRNFIR-----NE---------------THNP--TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTV-------------------KVADFGLARDM---Y--D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQKFTTKSDVWSFGVLLWELMTRGA-PP---------------YP-DV-----------NTFDITVYLLQGRRLLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEM--RPS-----FS-ELVSR--I--------------
---I-VLKRELGEGAFGKVFLAECYN--LSPTK-DKM---LVAVKALK-DP-TL----AA-RK-DFQ-R----EAELLTNL--Q-----HEH----IVKFYGVCG--D-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLV-------------------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WF-QL-----------SNTEVIECITQGRVLERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQ--RLN-----IK-EIYKIL----------------
----YQVGPLLGSGGFGSVYSGIRV-------S-DNL---PVAIKHVEKDR-ISD---WG--E-LPNGTRVPMEVVLLKKV--S-----SGFS--GVIRLLDWFE--R-----------------------------PDSFV--LILERPEPV-QDLFDFIT----ERG-----------------AL--QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL-------------------KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GD-IP---------------FE-HD--------------------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSD--RPT-----FE-EIQNHPWM--------------
----YQVGAVLGSGGFGTVYAGSRI-------A-DGL---PVAVKHVVKER-VTE---WG--S-LGGATV-PLEVVLLRKV--GAA-GGARG----VIRLLDWFE--R-----------------------------PDGFL--LVLERPEPA-QDLFDFIT----ERG-----------------AL--DEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL-------------------KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEWIR----YHRYHGRSATVWSLGVLLYDMVC-GD-IP---------------FE-QD--------------------EEILRGRLLFRRRVS-----------------------------------------PECQQLIRWCLSLRPSE--RPS-----LD-QIAAHPWM--------------
--YV--RGRFLGKGGFAKCFEISDA-------D-TKE---VFAGKIVPKSL-LLK---PH--Q-REKMS---MEISIHRSL--A-----HQH----VVGFHGFFE--D-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------AL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV-------------------KIGDFGLATKV------EYDGERK--------------KT---LCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS--------------CLKETYLRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT-----IN-ELLNDEFF--------------
---F-NFLMVLGKGSFGKVMLADRK-------G-TEE---LYAIKILKKDV-VIQ---DD--D-VECTM---VEKRVLALL-DK-----PPF----LTQLHSCFQ--T-----------------------------VDRLY--FVMEYVNGG--DLMYHIQ----QVG-----------------KF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI-------------------KIADFGMCKEH------MMDGVTT--------------RT---FCGTPDYIAPEIIA-----YQPYGKSVDWWAYGVLLYEMLA-GQ-PP---------------FD-GE--------------DEDELFQSIMEHNVSYPKSLS-----------------------------------------KEAVSVCKGLMTKHPAK--RLG-----C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGELK-------G-RGE---YFAIKALKKDV-VLI---DD--D-VECTM---VEKRVLTLA-AE-----NPF----LTHLICTFQ--T-----------------------------KDHLF--FVMEFLNGG--DLMYHIQ----DKG-----------------RF--ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI-------------------KIADFGMCKEN------IFGESRA--------------ST---FCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD--------------DEDELFESIRVDTPHYPRWIT-----------------------------------------KESKDILEKLFEREPTK--RLG----VTG-NIKIHPFF--------------
--FI--LHKMLGKGSFGKVFLAEFK-------K-TNQ---FFAIKALKKDV-VLM---DD--D-VECTM---VEKRVLSLA-WE-----HPF----LTHMFCTFQ--T-----------------------------KENLF--FVMEYLNGG--DLMYHIQ----SCH-----------------KF--DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI-------------------KIADFGMCKEN------MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ--------------DEEELFHSIRMDNPFYPRWLE-----------------------------------------KEAKDLLVKLFVREPEK--RLG-----VRGDIRQHPLF--------------
----YEVVKVIGRGAFGEVQLVRHK-------S-TRK---VYAMKLLSKFE-MIK---RS--D-SAFFW---EERDIMAFA--N-----SPW----VVQLFYAFQ--D-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV--PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLD-KSGHL-------------------KLADFGTCMKM-----NKEGMVRC--------------DT---AVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLV-GD-TP---------------FY-AD--------------SLVGTYSKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG-----VE-EIKRHLFF--------------
----YDVVKVIGRGAFGEVQLVRHK-------A-SQK---VYAMKLLSKFE-MIK---RS--D-SAFFW---EERDIMAFA--N-----SPW----VVQLFYAFQ--D-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV--PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL-------------------KLADFGTCMKM-----DETGMVHC--------------DT---AVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLV-GD-TP---------------FY-AD--------------SLVGTYSKIMDHKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNG-----VE-EIRQHPFF--------------
----WEIIGELGDGAFGKVYKAQNK-------E-TSV---LAAAKVIDTKS-EEE---LE--D-YM--V----EIDILASC--D-----HPN----IVKLLDAFY--Y-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PL--TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI-------------------KLADFGVSAKN------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL-----------NPMRVLLKIAKSEPPTLAQPSRWS-----------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TS-QLLQHPFV--------------
---L-RLEVKLGQGCFGEVWMGTWN---------GTT---RVAIKTLK-PG-TM----SP--E-AFL-Q----EAQVMKKL--R-----HEK----LVQLYAVVS--------------------------------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC-------------------KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YP-GM-----------VNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FE-YLQAF--L--------------
---L-RLEVKLGQGCFGEVWMGTWN---------GTT---KVAIKTLK-PG-TM----MP--E-AFL-Q----EAQIMKKL--R-----HDK----LVPLYAVVS--------------------------------EEPIY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YP-GM-----------VNREVLEQVERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR-----MRK-KQI---DVAIKVLK-QG-TE----KADTE-EMM-R----EAQIMHQL--D-----NPY----IVRLIGVCQ--------------------------------AEALM--LVMEMAGGG--PLHKFLV-----GK---------------REEI--PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYA-------------------KISDFGLSKAL--GA--D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRKFSSRSDVWSYGVTMWEALSYGQ-KP---------------YK-KM-----------KGPEVMAFIEQGKRMECPPECP-------------------------------------------PELYALMSDCWIYKWED--RPD-----FL-TVEQR--M--------------
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