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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
AGC AKT1 150
AGC AKT3 148
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK1G 23
CAMK CAMK2A 13
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CAMK CASK 12
CMGC CDC2 4
CMGC CDC2L5 705
AGC CDC42BPA 77
AGC CDC42BPB 76
AGC CDC42BPG 71
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC DMPK 81
Other EIF2AK2 267
Other EIF2AK4 590
TK EPHA8 635
TK FRK 234
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CAMK HUNK 61
CMGC ICK 4
Other IKBKE 9
TKL IRAK4 186
TK JAK1 875
CAMK KIAA0999 66
TKL LIMK1 339
TKL LIMK2 331
TK LYN 247
CMGC MAK 4
STE MAP2K5 166
STE MAP3K1 1242
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
STE MAP3K5 677
STE MAP3K6 645
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK14 24
CMGC MAPK6 20
CAMK MAPKAPK2 64
CAMK MAPKAPK5 22
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
AGC MAST1 374
CAMK MGC42105 74
CAMK MKNK2 84
Other NEK1 4
Other NEK2 8
Other NEK4 6
Other NEK5 4
Other NEK8 4
Other NEK9 52
CMGC NLK 126
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK4 321
STE PAK6 407
CAMK PASK 999
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
AGC PDPK1 82
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKACA 44
AGC PRKACB 44
AGC PRKACG 44
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCI 245
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
AGC ROCK1 76
AGC ROCK2 92
AGC RPS6KA1 62
AGC RPS6KA3 68
AGC RPS6KA4 33
AGC RPS6KA5 49
AGC RPS6KA6 73
AGC RPS6KB1 91
AGC RPS6KB2 67
Other SBK1 53
AGC SGK1 98
Other SGK110 98
AGC SGK2 35
AGC SGK3 162
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
TK SRC 270
STE STK10 36
CAMK STK11 49
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
AGC STK32A 23
AGC STK32B 23
AGC STK32C 93
CAMK STK33 116
Other STK35 202
Other STK36 4
AGC STK38 89
AGC STK38L 90
Other TBK1 9
Other TLK2 440
CAMK TSSK1B 12
CAMK TSSK2 12
Other ULK3 14
STE YSK4 1162
--------------------------------FELLKVLGQGSYGKV---FLVRK---V-----KGSDAGQLYAM-KVLKKAT-LK-V---RD--R-V-RSKM-------------------------ERDI-L-AEV--N----HPF--IVKLH-YAFQ-T-------------------------------------EGK--LY--LILDF-LRGG--DLF-TRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALALDHLHS-L-----GIIYRDLKPENIL--LD---EEGHI---------KITDFGLSKEA-----------------------------------IDHDK-RA--------------YS---FCGTIEYMAPEV----VN------------------RRG--HTQSADWWSFGVLMFEMLT-GS-LP--------------FQ-GK---------------DR-KETMA--LILKAKLGMPQFLS------------------------------------------GEAQS-LLRALFKRNPCN--RLGAG--IDGVE-EIKRHPFF-------------------------------------------------------
-------------------------------F-EYLKLLGKGTFGKV---ILVKE---K-----ATGR---YYAM-KILKKEV-IV-A---KD--E-V-AHTL------------------------TENRV-L-QNS--R----HPF--LTALK-YSFQ-T-------------------------------------HDR--LC--FVMEY-ANGG--ELF-FHLS-----------------------RER-----------------VF--SEDRARFYGAEIVSALDYLHSEK-----NVVYRDLKLENLM--LD---KDGHI---------KITDFGLCKEG-----------------------------------IKDGA-TM--------------KT---FCGTPEYLAPEV----LE------------------DND--YGRAVDWWGLGVVMYEMMC-GR-LP--------------FY-NQ---------------DH-EKLFE--LILMEEIRFPRTLG------------------------------------------PEAKS-LLSGLLKKDPKQ--RLGGG--SEDAK-EIMQHRFF-------------------------------------------------------
------------------------------FD--YLKLLGKGTFGKV---ILVRE---K-----ASGK---YYAM-KILKKEV-II-A---KD--E-V-AHTL------------------------TESRV-L-KNT--R----HPF--LTSLK-YSFQ-T-------------------------------------KDR--LC--FVMEY-VNGG--ELF-FHLS-----------------------RER-----------------VF--SEDRTRFYGAEIVSALDYLHS-G-----KIVYRDLKLENLM--LD---KDGHI---------KITDFGLCKEG-----------------------------------ITDAA-TM--------------KT---FCGTPEYLAPEV----LE------------------DND--YGRAVDWWGLGVVMYEMMC-GR-LP--------------FY-NQ---------------DH-EKLFE--LILMEDIKFPRTLS------------------------------------------SDAKS-LLSGLLIKDPNK--RLGGG--PDDAK-EIMRHSFF-------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-----QSKF---ILAL-KVLFKAQLEK-A---GV--E-H-QLRR-------------------------EVEI-Q-SHL--R----HPN--ILRLY-GYFH-D-------------------------------------ATR--VY--LILEY-APLG--TVY-RELQ-----------------------KLS-----------------KF--DEQRTATYITELANALSYCHS-K-----RVIHRDIKPENLL--LG---SAGEL---------KIADFGWSV-------------------------------------HAPSS-RR--------------TT---LCGTLDYLPPEM----IE------------------GRM--HDEKVDLWSLGVLCYEFLV-GK-PP--------------FE-AN---------------TY-QETYK--RISRVEFTFPDFVT------------------------------------------EGARD-LISRLLKHNPSQ--RPM-------LR-EVLEHPWI-------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNV---YLARE---K-----KSHF---IVAL-KVLFKSQ-IE-K---EG--V-E-HQLR------------------------REIEI-Q-AHL--H----HPN--ILRLY-NYFY-D-------------------------------------RRR--IY--LILEY-APRG--ELY-KELQ-----------------------KSC-----------------TF--DEQRTATIMEELADALMYCHG-K-----KVIHRDIKPENLL--LG---LKGEL---------KIADFGWSV-------------------------------------HAPSL-RR--------------KT---MCGTLDYLPPEM----IE------------------GRM--HNEKVDLWCIGVLCYELLV-GN-PP--------------FE-SA---------------SH-NETYR--RIVKVDLKFPASVP------------------------------------------MGAQD-LISKLLRHNPSE--RLP-------LA-QVSAHPWV-------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNV---YLARL---K-----ESHF---IVAL-KVLFKSQ-IE-K---EG--L-E-HQLR------------------------REIEI-Q-AHL--Q----HPN--ILRLY-NYFH-D-------------------------------------ARR--VY--LILEY-APRG--ELY-KELQ-----------------------KSE-----------------KL--DEQRTATIIEELADALTYCHD-K-----KVIHRDIKPENLL--LG---FRGEV---------KIADFGWSV-------------------------------------HTPSL-RR--------------KT---MCGTLDYLPPEM----IE------------------GRT--YDEKVDLWCIGVLCYELLV-GY-PP--------------FE-SA---------------SH-SETYR--RILKVDVRFPLSMP------------------------------------------LGARD-LISRLLRYQPLE--RLP-------LA-QILKHPWV-------------------------------------------------------
-------------------------------L-RLVRKLGSGQFGEV---WMGYY---K------NNM---KVAI-KTLK-EG-TM-----SP--E-A-FL-G-------------------------EANV-M-KAL--Q----HER--LVRLY-AVVT---------------------------------------KEP--IY--IVTEY-MARG--CLL-DFLK------------------------TD--------------EGSRL--SLPRLIDMSAQIAEGMAYIER-M-----NSIHRDLRAANIL--VS---EALCC---------KIADFGLARII--------------------------------------DS-EY--------------TAQEGAKFPIKWTAPEA----IH------------------FGV--FTIKADVWSFGVLLMEVVTYGR-VP--------------YP-GM------------SNPEV-IRNLE--RGYRMPRPDTCP--------------------------------------------PELYRGVIAECWRSRPEE--RPT-------FE-FLQSV--L-------------------------------------------------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-----ITGQ---KVAI-KIVNREK-LS-E---SV--L-M-KVER-------------------------EIAI-L-KLI--E----HPH--VLKLH-DVYE-N-------------------------------------KKY--LY--LVLEH-VSGG--ELF-DYLV-----------------------KKG-----------------RL--TPKEARKFFRQIVSALDFCHS-Y-----SICHRDLKPENLL--LD---EKNNI---------RIADFGMASL------------------------------------QVGDS-LL--------------ET---SCGSPHYACPEV----IK-----------------GEKY--DGRRADMWSCGVILFALLV-GA-LP--------------FD-DD---------------NL-RQLLE--KVKRGVFHMPHFIP------------------------------------------PDCQS-LLRGMIEVEPEK--RLS-------LE-QIQKHPW-Y------------------------------------------------------
--------------------------------YRLEKTLGKGQTGLV---KLGVH---C-----VTCQ---KVAI-KIVNREK-LS-E---SV--L-M-KVER-------------------------EIAI-L-KLI--E----HPH--VLKLH-DVYE-N-------------------------------------KKY--LY--LVLEH-VSGG--ELF-DYLV-----------------------KKG-----------------RL--TPKEARKFFRQIISALDFCHS-H-----SICHRDLKPENLL--LD---EKNNI---------RIADFGMASL------------------------------------QVGDS-LL--------------ET---SCGSPHYACPEV----IR-----------------GEKY--DGRKADVWSCGVILFALLV-GA-LP--------------FD-DD---------------NL-RQLLE--KVKRGVFHMPHFIP------------------------------------------PDCQS-LLRGMIEVDAAR--RLT-------LE-HIQKHIW-Y------------------------------------------------------
------------------------------FI--FMEVLGSGAFSEV---FLVKQ---R-----LTGK---LFAL-KCIKKSP-AF-R---DS--S-L-E--N-------------------------EIAV-L-KKI--K----HEN--IVTLE-DIYE-S-------------------------------------TTH--YY--LVMQL-VSGG--ELF-DRIL-----------------------ERG-----------------VY--TEKDASLVIQQVLSAVKYLHE-N-----GIVHRDLKPENLL--YLTPEENSKI---------MITDFGLSK-------------------------------------MEQNG-IM--------------ST---ACGTPGYVAPEV----LA------------------QKP--YSKAVDCWSIGVITYILLC-GY-PP--------------FY-EE---------------TE-SKLFE--KIKEGYYEFESPFW-D-D-IS-----------------------------------ESAKD-FICHLLEKDPNE--RYT-------CE-KALSHPWI-------------------------------------------------------
--------------------------------YQLFEELGKGAFSVV---RRCVK---V-----LAGQ---EYAA-KIINTKK-LS-A---RD--H-Q-KLER-------------------------EARI-C-RLL--K----HPN--IVRLH-DSIS-E-------------------------------------EGH--HY--LIFDL-VTGG--ELF-EDIV-----------------------ARE-----------------YY--SEADASHCIQQILEAVLHCHQ-M-----GVVHRDLKPENLL--LA---SKLKGA------AVKLADFGLAIEV-----------------------------------EGEQQ-AW--------------FG---FAGTPGYLSPEV----LR------------------KDP--YGKPVDLWACGVILYILLV-GY-PP--------------FW-DE---------------DQ-HRLYQ--QIKAGAYDFPSPEW-D-T-VT-----------------------------------PEAKD-LINKMLTINPSK--RIT-------AA-EALKHPWI-------------------------------------------------------
--------------------------------YQLYEDIGKGAFSVV---RRCVK---L-----CTGH---EYAA-KIINTKK-LS-A---RD--H-Q-KLER-------------------------EARI-C-RLL--K----HSN--IVRLH-DSIS-E-------------------------------------EGF--HY--LVFDL-VTGG--ELF-EDIV-----------------------ARE-----------------YY--SEADASHCIQQILEAVLHCHQ-M-----GVVHRDLKPENLL--LA---SKCKGA------AVKLADFGLAIEV-----------------------------------QGDQQ-AW--------------FG---FAGTPGYLSPEV----LR------------------KEA--YGKPVDIWACGVILYILLV-GY-PP--------------FW-DE---------------DQ-HKLYQ--QIKAGAYDFPSPEW-D-T-VT-----------------------------------PEAKN-LINQMLTINPAK--RIT-------AH-EALKHPWV-------------------------------------------------------
--------------------------------YQLFEELGKGAFSVV---RRCMK---I-----PTGQ---EYAA-KIINTKK-LS-A---RD--H-Q-KLER-------------------------EARI-C-RLL--K----HPN--IVRLH-DSIS-E-------------------------------------EGF--HY--LVFDL-VTGG--ELF-EDIV-----------------------ARE-----------------YY--SEADASHCIQQILESVNHCHL-N-----GIVHRDLKPENLL--LA---SKSKGA------AVKLADFGLAIEV-----------------------------------QGDQQ-AW--------------FG---FAGTPGYLSPEV----LR------------------KDP--YGKPVDMWACGVILYILLV-GY-PP--------------FW-DE---------------DQ-HRLYQ--QIKAGAYDFPSPEW-D-T-VT-----------------------------------PEAKD-LINKMLTINPAK--RIT-------AS-EALKHPWI-------------------------------------------------------
--------------------------------YQLFEELGKGAFSVV---RRCVK---K-----TSTQ---EYAA-KIINTKK-LS-A---RD--H-Q-KLER-------------------------EARI-C-RLL--K----HPN--IVRLH-DSIS-E-------------------------------------EGF--HY--LVFDL-VTGG--ELF-EDIV-----------------------ARE-----------------YY--SEADASHCIHQILESVNHIHQ-H-----DIVHRDLKPENLL--LA---SKCKGA------AVKLADFGLAIEV-----------------------------------QGEQQ-AW--------------FG---FAGTPGYLSPEV----LR------------------KDP--YGKPVDIWACGVILYILLV-GY-PP--------------FW-DE---------------DQ-HKLYQ--QIKAGAYDFPSPEW-D-T-VT-----------------------------------PEAKN-LINQMLTINPAK--RIT-------AD-QALKHPWV-------------------------------------------------------
--------------------------------YKLQSEIGKGAYGVV---RLAYN---E-----SEDR---HYAM-KVLSKKK-LL-K---QY--G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAI-L-KKL--D----HVN--VVKLI-EVLD-DP-----------------------------------AEDN--LY--LVFDL-LRKG--PVM-EVPC------------------------DK-----------------PF--SEEQARLYLRDVILGLEYLHC-Q-----KIVHRDIKPSNLL--LG---DDGHV---------KIADFGVSNQF-----------------------------------EGNDA-QL--------------SS---TAGTPAFMAPEA----ISD---------------SGQSF--SGKALDVWATGVTLYCFVY-GK-CP--------------FI-DD---------------FI-LALHR--KIKNEPVVFPEEPE-I-S--------------------------------------EELKD-LILKMLDKNPET--RIG-------VP-DIKLHPWV-------------------------------------------------------
--------------------------------YTLKDEIGKGSYGVV---KLAYN---E-----NDNT---YYAM-KVLSKKK-LI-R---QA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAI-L-KKL--D----HPN--VVKLV-EVLD-DP-----------------------------------NEDH--LY--MVFEL-VNQG--PVM-EVPT------------------------LK-----------------PL--SEDQARFYFQDLIKGIEYLHY-Q-----KIIHRDIKPSNLL--VG---EDGHI---------KIADFGVSNEF-----------------------------------KGSDA-LL--------------SN---TVGTPAFMAPES----LS-----------------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CP--------------FM-DE---------------RI-MCLHS--KIKSQALEFPDQPD-I-A--------------------------------------EDLKD-LITRMLDKNPES--RIV-------VP-EIKLHPWV-------------------------------------------------------
--------------------------------YELCEVIGKGPFSVV---RRCIN---R-----ETGQ---QFAV-KIVDVAK-FT-S---SP--G-L-STEDL----------------------KREASI-C-HML--K----HPH--IVELL-ETYS-S-------------------------------------DGM--LY--MVFEF-MDGA--DLCFEIVKR--------------------ADAGF-----------------VY--SEAVASHYMRQILEALRYCHD-N-----NIIHRDVKPHCVL--LA---SKENSA------PVKLGGFGVAIQL-----------------------------------GESGL-VA--------------GG---RVGTPHFMAPEV----VK------------------REP--YGKPVDVWGCGVILFILLS-GC-LP--------------FY-GT----------------K-ERLFE--GIIKGKYKMNPRQW-S-H-IS-----------------------------------ESAKD-LVRRMLMLDPAE--RIT-------VY-EALNHPWL-------------------------------------------------------
--------------------------------YTKIEKIGEGTYGVV---YKGRH---K-----TTGQ---VVAM-KKIRLES-EE-E---GV--P-S-TAIR-------------------------EISL-L-KEL--R----HPN--IVSLQ-DVLM-Q-------------------------------------DSR--LY--LIFEF-LSM---DLK-KYLDS--------------------IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHS-R-----RVLHRDLKPQNLL--ID---DKGTI---------KLADFGLARAF-----------------------------------GIPIR-VY--------------TH---EVVTLWYRSPEV----LL-----------------GSAR--YSTPVDIWSIGTIFAELAT-KK-PL--------------FH-GD------------SEIDQ-LFRIF--RALGTPNNEVWPEV-E-S-LQDYKNTFPKWKP-------------GSLASHVKNLDENGLD-LLSKMLIYDPAK--RIS-------GK-MALNHPYF-------------------------------------------------------
-------------------------------F-DIIGIIGEGTYGQV---YKARD---K-----DTGE---MVAL-KKVRLDN-EK-E---GF--P-I-TAIR-------------------------EIKI-L-RQL--T----HQS--IINMK-EIVT-DKEDAL---------------------------DFKKDKGA--FY--LVFEY-MDH---DLM-GLLE----------------------SGLV-----------------HF--NENHIKSFMRQLMEGLDYCHK-K-----NFLHRDIKCSNIL--LN---NRGQI---------KLADFGLARLY----------------------------------SSEESR-PY--------------TN---KVITLWYRPPEL----LL-----------------GEER--YTPAIDVWSCGCILGELFT-KK-PI--------------FQ-AN------------QELAQ-LELIS--RICGSPCPAVWPDV-I-K-LPYFNTMKPKKQY------------RRKLREEFVFIPAAALD-LFDYMLALDPSK--RCT-------AE-QALQCEF-L------------------------------------------------------
--------------------------------FEILKVIGRGAFGEV---AVVKL---K-----NADK---VFAM-KILNKWE-ML-K---RA--E-T-ACFR------------------------EERDV-L-VNG--D----NKW--ITTLH-YAFQ-D-------------------------------------DNN--LY--LVMDY-YVGG--DLL-TLLS----------------------KFED-----------------RL--PEDMARFYLAEMVIAIDSVHQ-L-----HYVHRDIKPDNIL--MD---MNGHI---------RLADFGSCLKL----------------------------------MEDGTV-QS--------------SV---AVGTPDYISPEI----LQAM-------------EDGKGR--YGPECDWWSLGVCMYEMLY-GE-TP--------------FY-AE------------SLV----ETYG--KIMNHKERFQFPAQVT-D-VS-----------------------------------ENAKD-LIRRLICSREHR---LGQ----NGIE-DFKKHPFF-------------------------------------------------------
--------------------------------FEIIKVIGRGAFGEV---AVVKM---K-----NTER---IYAM-KILNKWE-ML-K---RA--E-T-ACFR------------------------EERDV-L-VNG--D----CQW--ITALH-YAFQ-D-------------------------------------ENH--LY--LVMDY-YVGG--DLL-TLLS----------------------KFED-----------------KL--PEDMARFYIGEMVLAIDSIHQ-L-----HYVHRDIKPDNVL--LD---VNGHI---------RLADFGSCLKM-----------------------------------NDDGTVQS--------------SV---AVGTPDYISPEI----LQAM-------------EDGMGK--YGPECDWWSLGVCMYEMLY-GE-TP--------------FY-AE---------------SL-VETYG--KIMNHEERFQFPSHVT-D-VS-----------------------------------EEAKD-LIQRLICSRE-R--RLGQ----NGIE-DFKKHAF-F------------------------------------------------------
--------------------------------FEILKVIGRGAFGEV---TVVRQ---R-----DTGQ---IFAM-KMLHKWE-ML-K---RA--E-T-ACFR------------------------EERDV-L-VKG--D----SRW--VTTLH-YAFQ-D-------------------------------------EEY--LY--LVMDY-YAGG--DLL-TLLS----------------------RFED-----------------RL--PPELAQFYLAEMVLAIHSLHQ-L-----GYVHRDVKPDNVL--LD---VNGHI---------RLADFGSCLRL-----------------------------------NTNGMVDS--------------SV---AVGTPDYISPEI----LQAM-------------EEGKGH--YGPQCDWWSLGVCAYELLF-GE-TP--------------FY-AE------------SLVET-YGKIM-----NHEDHLQFPPD-VPD-VP-----------------------------------ASAQD-LIRQLLCRQEERLGRGG-------LD-DFRNHPFF-------------------------------------------------------
------------------------------YL--NLEKLGEGSYATV---YKGIS---R-----INGQ---LVAL-KVISMNA-EE-G---VP----F-TAIR-------------------------EASL-L-KGL--K----HAN--IVLLH-DIIH-T-------------------------------------KET--LT--FVFEY-MHT---DLA-QYMS----------------------QHPG-----------------GL--HPHNVRLFMFQLLRGLAYIHH-Q-----HVLHRDLKPQNLL--IS---HLGEL---------KLADFGLARAK-----------------------------------SIPSQ-TY--------------SS---EVVTLWYRPPDA----LL-----------------GATE--YSSELDIWGAGCIFIEMFQ-GQ-PL--------------FP-GV-----------SNILEQ-LEKIW--EVLGVPTEDTWPGV-S-K-LPNYNPEWFPLPTP----------RSLHVVWNRLGRVPEAED-LASQMLKGFPRD--RVS-------AQ-EALVHDYF-------------------------------------------------------
--------------------------------FQKVEKIGEGTYGVV---YKARN---K-----LTGE---VVAL-KKIRLDT-ET-E---GV--P-S-TAIR-------------------------EISL-L-KEL--N----HPN--IVKLL-DVIH-T-------------------------------------ENK--LY--LVFEF-LHQ---DLK-KFMDA---------------------SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHS-H-----RVLHRDLKPQNLL--IN---TEGAI---------KLADFGLARAF-----------------------------------GVPVR-TY--------------TH---EVVTLWYRAPEI----LL-----------------GCKY--YSTAVDIWSLGCIFAEMVT-RR-AL--------------FP-GD------------SEIDQ-LFRIF--RTLGTPDEVVWPGV-T-S-MPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-------AK-AALAHPFF-------------------------------------------------------
--------------------------------FQKVEKIGEGTYGVV---YKAKN---R-----ETGQ---LVAL-KKIRLDL-EM-E---GV--P-S-TAIR-------------------------EISL-L-KEL--K----HPN--IVRLL-DVVH-N-------------------------------------ERK--LY--LVFEF-LSQ---DLK-KYMDS---------------------TPGS-----------------EL--PLHLIKSYLFQLLQGVSFCHS-H-----RVIHRDLKPQNLL--IN---ELGAI---------KLADFGLARAF-----------------------------------GVPLR-TY--------------TH---EVVTLWYRAPEI----LL-----------------GSKF--YTTAVDIWSIGCIFAEMVT-RK-AL--------------FP-GD------------SEIDQ-LFRIF--RMLGTPSEDTWPGV-T-Q-LPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQ--RIT-------AK-TALAHPYF-------------------------------------------------------
-------------------------------Y-EPVAEIGVGAYGTV---YKARD---P-----HSGH---FVAL-KSVRVPN-GG-GGGGGL--P-I-STVR-------------------------EVAL-L-RRL--EA-FEHPN--VVRLM-DVCA-TSR--------------------------------TDREIK--VT--LVFEH-VDQ---DLR-TYLDK---------------------APPP-----------------GL--PAETIKDLMRQFLRGLDFLHA-N-----CIVHRDLKPENIL--VT---SGGTV---------KLADFGLARI------------------------------------YSYQM-AL--------------TP---VVVTLWYRAPEV----LL------------------QST--YATPVDMWSVGCIFAEMFR-RK-PL--------------FC-GN------------SEADQ-LGKIF--DLIGLPPEDDWPRD-V-S-LPRGAFPPRGPR---------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RIS-------AF-RALQHSYL-------------------------------------------------------
--------------------------------YEKLEKIGEGTYGTV---FKAKN---R-----ETHE---IVAL-KRVRLDD-DD-E---GV--P-S-SALR-------------------------EICL-L-KEL--K----HKN--IVRLH-DVLH-S-------------------------------------DKK--LT--LVFEF-CDQ---DLK-KYFD----------------------SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHS-R-----NVLHRDLKPQNLL--IN---RNGEL---------KLADFGLARAF-----------------------------------GIPVR-CY--------------SA---EVVTLWYRPPDV----LF-----------------GAKL--YSTSIDMWSAGCIFAELANAGR-PL--------------FP-GN------------DVDDQ-LKRIF--RLLGTPTEEQWPSM-T-K-LPDYKPYPMYPAT-------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQ--RIS-------AE-EALQHPYF-------------------------------------------------------
--------------------------------YECVAEIGEGAYGKV---FKARD---L-----KNGG--RFVAL-KRVRVQT-GE-E---GM--P-L-STIR-------------------------EVAV-L-RHL--ET-FEHPN--VVRLF-DVCT-VSR--------------------------------TDRETK--LT--LVFEH-VDQ---DLT-TYLDK---------------------VPEP-----------------GV--PTETIKDMMFQLLRGLDFLHS-H-----RVVHRDLKPQNIL--VT---SSGQI---------KLADFGLARI------------------------------------YSFQM-AL--------------TS---VVVTLWYRAPEV----LL------------------QSS--YATPVDLWSVGCIFAEMFR-RK-PL--------------FR-GS------------SDVDQ-LGKIL--DVIGLPGEEDWPRD-V-A-LPRQAFHSKSAQ---------------PIEKFVTDIDELGKD-LLLKCLTFNPAK--RIS-------AY-SALSHPYF-------------------------------------------------------
--------------------------------YEKLAKIGQGTFGEV---FKARH---R-----KTGQ---KVAL-KKVLMEN-EK-E---GF--P-I-TALR-------------------------EIKI-L-QLL--K----HEN--VVNLI-EICR-TKASP-----------------------------YNRCKGS--IY--LVFDF-CEH---DLA-GLLS----------------------NVLV-----------------KF--TLSEIKRVMQMLLNGLYYIHR-N-----KILHRDMKAANVL--IT---RDGVL---------KLADFGLARAFSL-------------------------------AKNSQPN-RY--------------TN---RVVTLWYRPPEL----LL-----------------GERD--YGPPIDLWGAGCIMAEMWT-RS-PI--------------MQ-GN------------TEQHQ-LALIS--QLCGSITPEVWPNV-D-N-YELYEKLELVKGQK----------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQ--RID-------SD-DALNHDFF-------------------------------------------------------
--------------------------------YEKIGKIGEGSYGVV---FKCRN---R-----DTGQ---IVAI-KKFLESE-DD-P---VI--K-K-IALR-------------------------EIRM-L-KQL--K----HPN--LVNLL-EVFR-R-------------------------------------KRR--LH--LVFEY-CDHT--VLH-ELDR-----------------------YQR-----------------GV--PEHLVKSITWQTLQAVNFCHK-H-----NCIHRDVKPENIL--IT---KHSVI---------KLCDFGFARLL-----------------------------------AGPSD-YY--------------TD---YVATRWYRSPEL----LV-----------------GDTQ--YGPPVDVWAIGCVFAELLS-GV-PL--------------WP-GK------------SDVDQ-LYLIR--KTLGDLIPRHQQVF-S-T-NQYFSGVKIPDPED-----------MEPLELKFPNISYPALG-LLKGCLHMDPTQ--RLT-------CE-QLLHHPYF-------------------------------------------------------
--------------------------------YENLGLVGEGSYGMV---MKCRN---K-----DTGR---IVAI-KKFLESD-DD-K---MV--K-K-IAMR-------------------------EIKL-L-KQL--R----HEN--LVNLL-EVCK-K-------------------------------------KKR--WY--LVFEF-VDHT--ILD-DLEL-----------------------FPN-----------------GL--DYQVVQKYLFQIINGIGFCHS-H-----NIIHRDIKPENIL--VS---QSGVV---------KLCDFGFARTL-----------------------------------AAPGE-VY--------------TD---YVATRWYRAPEL----LV-----------------GDVK--YGKAVDVWAIGCLVTEMFM-GE-PL--------------FP-GD------------SDIDQ-LYHIM--MCLGNLIPRHQELF-N-K-NPVFAGVRLPEIKE-----------REPLERRYPKLSEVVID-LAKKCLHIDPDK--RPF-------CA-ELLHHDFF-------------------------------------------------------
--------------------------------YETLGKVGEGSYGTV---MKCKH---K-----NTGQ---IVAI-KIFYERP-EQ-S---VN--K---IAMR-------------------------EIKF-L-KQF--H----HEN--LVNLI-EVFR-Q-------------------------------------KKK--IH--LVFEF-IDHT--VLD-ELQH-----------------------YCH-----------------GL--ESKRLRKYLFQILRAIDYLHS-N-----NIIHRDIKPENIL--VS---QSGIT---------KLCDFGFARTL-----------------------------------AAPGD-IY--------------TD---YVATRWYRAPEL----VL-----------------KDTS--YGKPVDIWALGCMIIEMAT-GN-PY--------------LP-SS------------SDLDL-LHKIV--LKVGN-LSPHLQNI-F-S-KSPIFAGVVLPQVQ----------HPKNARKKYPKLNGLLAD-IVHACLQIDPAD--RIS-------SS-DLLHHEYF-------------------------------------------------------
--------------------------------FEILGVVGEGAYGVV---LKCRH---K-----ETHE---IVAI-KKFKDSE-EN-E---EV--K-E-TTLR-------------------------ELKM-L-RTL--K----QEN--IVELK-EAFR-R-------------------------------------RGK--LY--LVFEY-VEK---NML-ELLE----------------------EMPN-----------------GV--PPEKVKSYIYQLIKAIHWCHK-N-----DIVHRDIKPENLL--IS---HNDVL---------KLCDFGFARNL----------------------------------SEGNNA-NY--------------TE---YVATRWYRSPEL----LL------------------GAP--YGKSVDMWSVGCILGELSD-GQ-PL--------------FP-GE------------SEIDQ-LFTIQ--KVLGPLPSEQMKLF-Y-S-NPRFHGLRFPAVNH----------PQSLERRYLGILNSVLLD-LMKNLLKLDPAD--RYL-------TE-QCLNHPTF-------------------------------------------------------
-------------------------------W-DLVQTLGEGAYGEV---QLAVN---R-----VTEE---AVAV-KIVDMKR-AV-D---CP--E-N-I-KK-------------------------EICI-N-KML--N----HEN--VVKFY-GHRR-E-------------------------------------GNI--QY--LFLEY-CSGG--ELF-DRIE-----------------------PDI-----------------GM--PEPDAQRFFHQLMAGVVYLHG-I-----GITHRDIKPENLL--LD---ERDNL---------KISDFGLATVFR---------------------------------YNNRER-LL--------------NK---MCGTLPYVAPEL----LK-----------------RREF--HAEPVDVWSCGIVLTAMLA-GE-LP--------------WD-QP--------------SDS-CQEYS--DWKEKKTYLNPWKK-I----D-----------------------------------SAPLA-LLHKILVENPSA--RIT-------IP-DIKKDRW-Y------------------------------------------------------
------------------------------YI--MSKTLGSGACGEV---KLAFE---R-----KTCK---KVAI-KIISKRK-FA-I---GS--A-R-EADPALN-------------------VETEIEI-L-KKL--N----HPC--IIKIK-NFF--D-------------------------------------AED--YY--IVLEL-MEGG--ELF-DKVV-----------------------GNK-----------------RL--KEATCKLYFYQMLLAVQYLHE-N-----GIIHRDLKPENVL--LS---SQEEDC------LIKITDFGHSKI------------------------------------LGETS-LM--------------RT---LCGTPTYLAPEV----LVS---------------VGTAG--YNRAVDCWSLGVILFICLS-GY-PP--------------FS-EH--------------RTQ-VSLKD--QITSGKYNFIPEVW-A-E-VS-----------------------------------EKALD-LVKKLLVVDPKA--RFT-------TE-EALRHPWL-------------------------------------------------------
-------------------------------W-EMRERLGTGGFGNV---CLYQH---R-----ELDL---KIAI-KSCRLEL-ST-K---NR--E-R--WCH-------------------------EIQI-M-KKL--N----HAN--VVKAC-DVPE-ELN--------------------------------ILIHDV--PL--LAMEY-CSGG--DLR-KLLNK--------------------PENCC-----------------GL--KESQILSLLSDIGSGIRYLHE-N-----KIIHRDLKPENIV--LQ---DVGGKI------IHKIIDLGYAKD------------------------------------VDQGS-LC--------------TS---FVGTLQYLAPEL----FE------------------NKP--YTATVDYWSFGTMVFECIA-GY-RP--------------FL-HHLQPFT-WHEKIKKKDPK-CIFAC--EEMSGEVRFSSHLP-Q-P-NSLCS-----------------------------LVVEPMEN-WLQLMLNWDPQQ--RG-------------------GPVDLTLKQ----------------------------------------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-----TNNE---KVVV-KILKPVK-KK-K---IK--R--------------------------------EIKI-L-ENL-RG----GPN--IITLA-DIVK-DP-----------------------------------VSRT--PA--LVFEH-VNNT--DFK-QLY--------------------------Q-----------------TL--TDYDIRFYMYEILKALDYCHS-M-----GIMHRDVKPHNVM--ID--HEHRKL---------RLIDWGLAEF------------------------------------YHPGQ-EY--------------NV---RVASRYFKGPEL----LV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RK-EP--------------FFHGH------------DNYDQ-LVRIA--KVLGTEDLYDYIDK-Y-N-IELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALD-FLDKLLRYDHQS--RLT-------AR-EAMEHPYF-------------------------------------------------------
--------------------------------YQLVRKLGRGKYSEV---FEAIN---I-----TNNE---RVVV-KILKPVK-KK-K---IK--R--------------------------------EVKI-L-ENL-RG----GTN--IIKLI-DTVK-DP-----------------------------------VSKT--PA--LVFEY-INNT--DFK-QLY--------------------------Q-----------------IL--TDFDIRFYMYELLKALDYCHS-K-----GIMHRDVKPHNVM--ID--HQQKKL---------RLIDWGLAEF------------------------------------YHPAQ-EY--------------NV---RVASRYFKGPEL----LV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RR-EP--------------FFHGQ------------DNYDQ-LVRIA--KVLGTEELYGYLKK-Y-H-IDLDPHFNDILGQHSRK-----RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQ--RLT-------AK-EAMEHPYF-------------------------------------------------------
--------------------------------YDTGEELGSGQFAVV---KKCRE---K-----STGL---QYAA-KFIKKRR-TK-S---SR--R-G-VSREDI---------------------EREVSI-L-KEI--Q----HPN--VITLH-EVYE-N-------------------------------------KTD--VI--LILEL-VAGG--ELF-DFLA-----------------------EKE-----------------SL--TEEEATEFLKQILNGVYYLHS-L-----QIAHFDLKPENIM--LL---DRNVPKP-----RIKIIDFGLAHK------------------------------------IDFGN-EF--------------KN---IFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SP--------------FL-GD---------------TK-QETLA--NVSAVNYEFEDEYF-S-N-TS-----------------------------------ALAKD-FIRRLLVKDPKK--RMT-------IQ-DSLQHPWI-------------------------------------------------------
--------------------------------YDIGEELGSGQFAIV---KKCRE---K-----STGL---EYAA-KFIKKRQ-SR-A---SR--R-G-VSREEI---------------------EREVSI-L-RQV--L----HHN--VITLH-DVYE-N-------------------------------------RTD--VV--LILEL-VSGG--ELF-DFLA-----------------------QKE-----------------SL--SEEEATSFIKQILDGVNYLHT-K-----KIAHFDLKPENIM--LL---DKNIPIP-----HIKLIDFGLAHE------------------------------------IEDGV-EF--------------KN---IFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SP--------------FL-GD---------------TK-QETLA--NITAVSYDFDEEFF-S-Q-TS-----------------------------------ELAKD-FIRKLLVKETRK--RLT-------IQ-EALRHPWI-------------------------------------------------------
--------------------------------YEMGEELGSGQFAIV---RKCRQ---K-----GTGK---EYAA-KFIKKRR-LS-S---SR--R-G-VSREEI---------------------EREVNI-L-REI--R----HPN--IITLH-DIFE-N-------------------------------------KTD--VV--LILEL-VSGG--ELF-DFLA-----------------------EKE-----------------SL--TEDEATQFLKQILDGVHYLHS-K-----RIAHFDLKPENIM--LL---DKNVPNP-----RIKLIDFGIAHK------------------------------------IEAGN-EF--------------KN---IFGTPEFVAPEI----VN------------------YEP--LGLEADMWSIGVITYILLS-GA-SP--------------FL-GE---------------TK-QETLT--NISAVNYDFDEEYF-S-N-TS-----------------------------------ELAKD-FIRRLLVKDPKR--RMT-------IA-QSLEHSWI-------------------------------------------------------
--------------------------------FEILKVIGRGAFSEV---AVVKM---K-----QTGQ---VYAM-KIMNKWD-ML-K---RG--E-V-SCFR------------------------EERDV-L-VNG--D----RRW--ITQLH-FAFQ-D-------------------------------------ENY--LY--LVMEY-YVGG--DLL-TLLS----------------------KFGE-----------------RI--PAEMARFYLAEIVMAIDSVHR-L-----GYVHRDIKPDNIL--LD---RCGHI---------RLADFGSCLKL----------------------------------RADGTV-RS--------------LV---AVGTPDYLSPEI----LQAVG-----------GGPGTGS--YGPECDWWALGVFAYEMFY-GQ-TP--------------FY-AD------------STAET-YGKIV--HYKE---HLSLPLV-D-EGVP-----------------------------------EEARD-FIQRLLCPP-ET--RLGR----GGAG-DFRTHPFF-------------------------------------------------------
-------------------------------F-KEIELIGSGGFGQV---FKAKH---R-----IDGK---TYVI-KRVKYNN-EK-A---ER-----------------------------------EVKA-L-AKL--D----HVN--IVHYN-GCWD-GFDYDPETSDDSLES--------SDYDPENSKNSSRSKTKC--LF--IQMEF-CDKG--TLE-QWIEK---------------------RRGE-----------------KL--DKVLALELFEQITKGVDYIHS-K-----KLIHRDLKPSNIF--LV---DTKQV---------KIGDFGLVTS------------------------------------LKNDG-KR--------------TR---SKGTLRYMSPEQ----IS------------------SQD--YGKEVDLYALGLILAELLH-VCDTA--------------FE-T--------------------SKFF--TDLRDGIISDIFDK-------------------------------------------KEKT-LLQKLLSKKPED--RPN-------TS-EILR----TLT----------------------------------------------------
EDENSKSQNQDEDCNEKNGCHESEPSVTTEAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------HY--LY--IQMEY-CEKS--TLR-DTID-----------------------QGL-----------------YR--DTVRLWRLFREILDGLAYIHE-K-----GMIHRDLKPVNIF--LD---SDDHV---------KIGDFGLATDHLAFSADSKQ-----------------DDQTGDLIKSDPSG-HL--------------TG---MVGTALYVSPEV---QGS-----------------TKSA--YNQKVDLFSLGIIFFEMSY-HP-MV--------------TA-SE---------------RI-FVLNQ--LRDPTSPKFPEDFD-D-G-EH-----------------------------------AKQKS-VISWLLNHDPAK--RPT-------AT-ELLKSEL-L------------------------------------------------------
--------------------------------IHIEKIIGSGDSGEV---CYGRL---R--VPGQRDV---PVAI-KALK-AG-YT-----ERQRR-D-FL-S-------------------------EASI-M-GQF--D----HPN--IIRLE-GVVT-R-------------------------------------GRL--AM--IVTEY-MENG--SLD-TFLR------------------------TH---------------DGQF--TIMQLVGMLRGVGAGMRYLSD-L-----GYVHRDLAARNVL--VD---SNLVC---------KVSDFGLSRVL-------------E---------------------D--DP-DA-------------AYTTTGGKIPIRWTAPEA----IA------------------FRT--FSSASDVWSFGVVMWEVLAYGE-RP--------------YW-NM------------TNRDV-ISSVE--EGYRLPAPMGCP--------------------------------------------HALHQ-LMLDCWHKDRAQ--RPR-------FS-QIVSVL---------------------------------------------------------
--------------------------------IQLLKRLGSGQFGEV---WEGLW---N------NTT---PVAV-KTLK-PG-SM-----DP--N-D-FL-R-------------------------EAQI-M-KNL--R----HPK--LIQLY-AVCT-L-------------------------------------EDP--IY--IITEL-MRHG--SLQ-EYLQ------------------------ND--------------TGSKI--HLTQQVDMAAQVASGMAYLES-R-----NYIHRDLAARNVL--VG---EHNIY---------KVADFGLARVFK-----------VD---------------------N--ED-IY--------------ESRHEIKLPVKWTAPEA----IR------------------SNK--FSIKSDVWSFGILLYEIITYGK-MP--------------YS-GM------------TGAQV-IQMLA--QNYRLPQPSNCP--------------------------------------------QQFYN-IMLECWNAEPKE--RPT-------FE-TLRWK--L-------------------------------------------------------
--------------------------------LQLIKRLGNGQFGEV---WMGTW---N------GNT---KVAI-KTLK-PG-TM-----SP--E-S-FL-E-------------------------EAQI-M-KKL--K----HDK--LVQLY-AVVS---------------------------------------EEP--IY--IVTEY-MNKG--SLL-DFLK------------------------DG--------------EGRAL--KLPNLVDMAAQVAAGMAYIER-M-----NYIHRDLRSANIL--VG---NGLIC---------KIADFGLARLI-----------------------------------E--DN-EY--------------TARQGAKFPIKWTAPEA----AL------------------YGR--FTIKSDVWSFGILLTELVTKGR-VP--------------YP-GM------------NNREV-LEQVE--RGYRMPCPQDCP--------------------------------------------ISLHE-LMIHCWKKDPEE--RPT-------FE-YLQSFL---------------------------------------------------------
----------------------------FLDF----RVLGKGGFGEV---SACQM---K-----ATGK---LYAC-KKLNKKR-LK-K---RK--G-Y-QGAM------------------------VEKKI-L-MKV--H----SRF--IVSLA-YAFE-T-------------------------------------KAD--LC--LVMTI-MNGG--DIR-YHIYNV-------------------NEENP-----------------GF--PEPRALFYTAQIICGLEHLHQ-R-----RIVYRDLKPENVL--LD---NDGNV---------RISDLGLAVEL-----------------------------------LDGQS-KT--------------KG---YAGTPGFMAPEL----LQ------------------GEE--YDFSVDYFALGVTLYEMIA-AR-GP--------------FR-AR-----------GEKVEN-KELKH--RIISEPVKYPDKFS------------------------------------------QASKD-FCEALLEKDPEK--RLG-------FR-D-------ETCDKLRAHPLF-------------------------------------------
------------------------------FR--HYRVLGKGGFGEV---CACQV---R-----ATGK---MYAC-KKLQKKR-IK-K---RK--G-E-AMAL------------------------NEKRI-L-EKV--Q----SRF--VVSLA-YAYE-T-------------------------------------KDA--LC--LVLTI-MNGG--DLK-FHIYN---------------------LGNP-----------------GF--DEQRAVFYAAELCCGLEDLQR-E-----RIVYRDLKPENIL--LD---DRGHI---------RISDLGLATE------------------------------------IPEGQ-RV--------------RG---RVGTVGYMAPEV----VN------------------NEK--YTFSPDWWGLGCLIYEMIQ-GH-SP--------------FK-KY------------KEKVK-WEEVD--QRIKNDTEEYSE-----K-FS-----------------------------------EDAKS-ICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F------------------------------------------------------
-------------------------------F-RQYRVLGKGGFGEV---CACQV---R-----ATGK---MYAC-KRLEKKR-IK-K---RK--G-E-SMAL------------------------NEKQI-L-EKV--N----SQF--VVNLA-YAYE-T-------------------------------------KDA--LC--LVLTI-MNGG--DLK-FHIYN---------------------MGNP-----------------GF--EEERALFYAAEILCGLEDLHR-E-----NTVYRDLKPENIL--LD---DYGHI---------RISDLGLAVK------------------------------------IPEGD-LI--------------RG---RVGTVGYMAPEV----LN------------------NQR--YGLSPDYWGLGCLIYEMIE-GQ-SP--------------FR-GR---------------KE-KVKRE--EVDRRVLETEEVYS-H-K-FS-----------------------------------EEAKS-ICKMLLTKDAKQ--RLGCQ--EEGAA-EVKRHPFF-------------------------------------------------------
-------------------------------F-RQYRVLGKGGFGEV---CACQV---R-----ATGK---MYAC-KKLEKKR-IK-K---RK--G-E-AMAL------------------------NEKQI-L-EKV--N----SRF--VVSLA-YAYE-T-------------------------------------KDA--LC--LVLTL-MNGG--DLK-FHIYH---------------------MGQA-----------------GF--PEARAVFYAAEICCGLEDLHR-E-----RIVYRDLKPENIL--LD---DHGHI---------RISDLGLAVH------------------------------------VPEGQ-TI--------------KG---RVGTVGYMAPEV----VK------------------NER--YTFSPDWWALGCLLYEMIA-GQ-SP--------------FQ-QR------------KKKIK-REEVE--RLVK-EVPEEYSER-----FS-----------------------------------PQARS-LCSQLLCKDPAE--RLGCR--GGSAR-EVKEHPLF-------------------------------------------------------
-------------------------------F-TEFRVLGKGGFGEV---CAVQV---K-----NTGK---MYAC-KKLDKKR-LK-K---KG--G-E-KMAL------------------------LEKEI-L-EKV--S----SPF--IVSLA-YAFE-S-------------------------------------KTH--LC--LVMSL-MNGG--DLK-FHIYN---------------------VGTR-----------------GL--DMSRVIFYSAQIACGMLHLHE-L-----GIVYRDMKPENVL--LD---DLGNC---------RLSDLGLAVE------------------------------------MKGGK-PI--------------TQ---RAGTNGYMAPEI----LM-----------------EKVS--YSYPVDWFAMGCSIYEMVA-GR-TP--------------FK-DY-----------KEKVSK-EDLKQ--RTLQDEVKFQHDNF------T-----------------------------------EEAKD-ICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR-------------------------------------------------
--------------------------------YTDIKVIGNGSFGVV---YQARL---A-----ETRE---LVAI-KKVLQDK-RF-K---NR-----------------------------------ELQI-M-RKL--D----HCN--IVRLR-YFFY-SSG---------------------------------EKKDE--LYLNLVLEY-VPETVYRVA-RHFT----------------------KAKL-----------------TI--PILYVKVYMYQLFRSLAYIHS-Q-----GVCHRDIKPQNLL--VD--PDTAVL---------KLCDFGSAKQ------------------------------------LVRGE-PN--------------VS---YICSRYYRAPEL----IF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PI--------------FP-GD------------SGVDQ-LVEII--KVLGTPTREQIREM-N-P-NYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSS--RLS-------PL-EACAHSFF-------------------------------------------------------
--------------------------------YTDTKVIGNGSFGVV---YQAKL---C-----DSGE---LVAI-KKVLQDK-RF-K---NR-----------------------------------ELQI-M-RKL--D----HCN--IVRLR-YFFY-SSG---------------------------------EKKDE--VYLNLVLDY-VPETVYRVA----RHY-------------------SRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHS-F-----GICHRDIKPQNLL--LD--PDTAVL---------KLCDFGSAKQ------------------------------------LVRGE-PN--------------VS---YICSRYYRAPEL----IF-----------------GATD--YTSSIDVWSAGCVLAELLL-GQ-PI--------------FP-GD------------SGVDQ-LVEII--KVLGTPTREQIREM-N-P-NYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTA--RLT-------PL-EACAHSFF-------------------------------------------------------
--------------------------------LKLEKKLGAGQFGEV---WMATY---N------KHT---KVAV-KTMK-PG-SM-----SV--E-A-FL-A-------------------------EANV-M-KTL--Q----HDK--LVKLH-AVVT---------------------------------------KEP--IY--IITEF-MAKG--SLL-DFLK------------------------SD--------------EGSKQ--PLPKLIDFSAQIAEGMAFIEQ-R-----NYIHRDLRAANIL--VS---ASLVC---------KIADFGLARVI-----------------------------------E--DN-EY--------------TAREGAKFPIKWTAPEA----IN------------------FGS--FTIKSDVWSFGILLMEIVTYGR-IP--------------YP-GM------------SNPEV-IRALE--RGYRMPRPENCP--------------------------------------------EELYN-IMMRCWKNRPEE--RPT-------FE-YIQSV--L-------------------------------------------------------
-----------------------------IGS----RKLGEGSFAKV---REGLH---V-----LTGE---KVAI-KVIDKKR-AK-K---DT--Y-V-TKNLR-----------------------REGQI-Q-QMI--R----HPN--ITQLL-DILE-T-------------------------------------ENS--YY--LVMEL-CPGG--NLM-HKIY-----------------------EKK-----------------RL--EESEARRYIRQLISAVEHLHR-A-----GVVHRDLKIENLL--LD---EDNNI---------KLIDFGLSNCAG---------------------------------ILGYSD-PF--------------ST---QCGSPAYAAPEL----LA------------------RKK--YGPKIDVWSIGVNMYAMLT-GT-LP--------------FT-VE-------------PFSL-RALYQ--KMVD-KEMNPLPTQ-----LS-----------------------------------TGAIS-FLRSLLEPDPVK--RPN-------IQ-QALANRWL-------------------------------------------------------
--------------------------------YTTIRQLGDGTYGSV---LLGRS---I-----ESGE---LIAI-KKMKRKF-YS-W---EE--C---MNLR-------------------------EVKS-L-KKL--N----HAN--VVKLK-EVIR-E-------------------------------------NDH--LY--FIFEY-MKE---NLY-QLIK----------------------ERNK-----------------LF--PESAIRNIMYQILQGLAFIHK-H-----GFFHRDLKPENLL--CM---GPELV---------KIADFGLARE------------------------------------IRSKP-PY--------------TD---YVSTRWYRAPEV----LL-----------------RSTN--YSSPIDVWAVGCIMAEVYT-LR-PL--------------FP-GA------------SEIDT-IFKIC--QVLGTPKKTDWPEG-Y-Q-LSSAMNFRWPQCV------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKK--RPT-------AS-QALRYPYF-------------------------------------------------------
-------------------------------W-HTDDLLGQGATASV---YKARN---K-----KSGE---LVAV-KVFNTTS-YL-R---PR--E-V--QVR-------------------------EFEV-L-RKL--N----HQN--IVKLF-AVEE-TG-----------------------------------GSRQ--KV--LVMEY-CSSG--SLL-SVLES--------------------PENAF-----------------GL--PEDEFLVVLRCVVAGMNHLRE-N-----GIVHRDIKPGNIMRLVG---EEGQSI-------YKLTDFGAARE------------------------------------LDDDE-KF--------------VS---VYGTEEYLHPDM----YERAV----------LRKPQQKA--FGVTVDLWSIGVTLYHAAT-GS-LP--------------FI-PF-----------GGPRRN-KEIMY--RITTEKPAGAIA-------------------------------------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
-----------------------------VGG----NKMGEGGFGVV---YKGYV---N-----NTT-----VAV-KKLAAMV-DI-T---TE--ELK-QQFD------------------------QEIKV-M-AKC--Q----HEN--LVELL-GFSS-D-------------------------------------GDD--LC--LVYVY-MPNG--SLL-DRLSC--------------------LDGTP-----------------PL--SWHMRCKIAQGAANGINFLHE-N-----HHIHRDIKSANIL--LD---EAFTA---------KISDFGLARASE---------------------------------KFAQTV-MT--------------SR---IVGTTAYMAPEA----LR-------------------GE--ITPKSDIYSFGVVLLEIIT-GL-PA--------------VD-EH------------REPQL-LLDIK--EEIEDEEKTIEDYI-D-K-KMNDAD---------------------------STSVEAMYS-VASQCLHEKKNK--RPD-------IK-KVQQ----LLQ----------------------------------------------------
-------------------------------L-KRIRDLGEGHFGKV---ELCRY---DP-EGDNTGE---QVAV-KSLK-PE-SG-----GNHIA-D-LK-K-------------------------EIEI-L-RNL--Y----HEN--IVKYK-GICTED--------------------------------------GGNGIK--LIMEF-LPSG--SLK-EYLP------------------------KN---------------KNKI--NLKQQLKYAVQICKGMDYLGS-R-----QYVHRDLAARNVL--VE---SEHQV---------KIGDFGLTKAI------------ET---------------------D--KE-YY--------------TVKDDRDSPVFWYAPEC----LM------------------QSK--FYIASDVWSFGVTLHELLTYCD-SDSSPMALFLKMIGPTHG-QM------------TVTRL-VNTLK--EGKRLPCPPNCP--------------------------------------------DEVYQ-LMRKCWEFQPSN--RTS-------FQ-NLIE---GF------------------------------------------------------
--------------------------------YEIDRTIGKGNFAVV---KRATH---L-----VTKA---KVAI-KIIDKTQ-LD-E---EN--L-K-KIFR-------------------------EVQI-M-KML--C----HPH--IIRLY-QVME-T-------------------------------------ERM--IY--LVTEY-ASGG--EIF-DHLV-----------------------AHG-----------------RM--AEKEARRKFKQIVTAVYFCHC-R-----NIVHRDLKAENLL--LD---ANLNI---------KIADFGFSNL------------------------------------FTPGQ-LL--------------KT---WCGSPPYAAPEL----FE-----------------GKEY--DGPKVDIWSLGVVLYVLVC-GA-LP--------------FD-GS---------------TL-QNLRA--RVLSGKFRIPFFMS------------------------------------------TECEH-LIRHMLVLDPNK--RLS-------ME-QICKHKWM-------------------------------------------------------
------------------------------LI--HGEVLGKGCFGQA---IKVTH---R-----ETGE---VMVM-KELI--R-FD-----EETQR-T-FL-K-------------------------EVKV-M-RCL--E----HPN--VLKFI-GVLY-K-------------------------------------DKR--LN--FITEY-IKGG--TLR-GIIK------------------------SM---------------DSQY--PWSQRVSFAKDIASGMAYLHS-M-----NIIHRDLNSHNCL--VR---ENKNV---------VVADFGLARLM-------------V---------------------D--EK-TQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM----IN------------------GRS--YDEKVDVFSFGIVLCEIIGRVN-AD--------------PD-YL-P----------RTMDF-GLNVR--GFLDRYCPPNCP--------------------------------------------PSFFP-ITVRCCDLDPEK--RPS-------FV-KLEH---WL------------------------------------------------------
------------------------------LI--HGEVLGKGFFGQA---IKVTH---K------ATG---KVMVMKEL--IR-CD-----EETQK-T-FL-T-------------------------EVKV-M-RSL--D----HPN--VLKFI-GVLY-K-------------------------------------DKK--LN--LLTEY-IEGG--TLK-DFLR------------------------SM----------------DPF--PWQQKVRFAKGIASGMAYLHS-M-----CIIHRDLNSHNCL--IK---LDKTV---------VVADFGLSRLIVEERKRAPMEKATT----------------------------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM----LN------------------GKS--YDETVDIFSFGIVLCEIIGQVY-AD--------------PD-CL-P----------RTLDF-GLNVK--LFWEKFVPTDCP--------------------------------------------PAFFP-LAAICCRLEPES--RPA-------FS-KLED---SF------------------------------------------------------
--------------------------------IKLVKRLGAGQFGEV---WMGYY---N------NST---KVAV-KTLK-PG-TM-----SV--Q-A-FL-E-------------------------EANL-M-KTL--Q----HDK--LVRLY-AVVT-R-------------------------------------EEP--IY--IITEY-MAKG--SLL-DFLK------------------------SD--------------EGGKV--LLPKLIDFSAQIAEGMAYIER-K-----NYIHRDLRAANVL--VS---ESLMC---------KIADFGLARVI-----------------------------------E--DN-EY--------------TAREGAKFPIKWTAPEA----IN------------------FGC--FTIKSDVWSFGILLYEIVTYGK-IP--------------YP-GR------------TNADV-MTALS--QGYRMPRVENCP--------------------------------------------DELYD-IMKMCWKEKAEE--RPT-------FD-YLQSV--L-------------------------------------------------------
--------------------------------YTTMRQLGDGTYGSV---LMGKS---N-----ESGE---LVAI-KRMKRKF-YS-W---DE--C-M--NLR-------------------------EVKS-L-KKL--N----HAN--VIKLK-EVIR-E-------------------------------------NDH--LY--FIFEY-MKE---NLY-QLMK----------------------DRNK-----------------LF--PESVIRNIMYQILQGLAFIHK-H-----GFFHRDMKPENLL--CM---GPELV---------KIADFGLARE------------------------------------LRSQP-PY--------------TD---YVSTRWYRAPEV----LL-----------------RSSV--YSSPIDVWAVGSIMAELYM-LR-PL--------------FP-GT------------SEVDE-IFKIC--QVLGTPKKSDWPEG-Y-Q-LASSMNFRFPQCV------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKK--RPT-------AS-QALKHPYF-------------------------------------------------------
-----------------------------IRY---RDTLGHGNGGTV---YKAYH---V-----PSGK---ILAV-KVILLDI-TL-E---LQ--K-Q-I-MS-------------------------ELEI-L-YKC--D----SSY--IIGFY-GAFF-V-------------------------------------ENR--IS--ICTEF-MDGG--SLD----------------------------VYR-----------------KM--PEHVLGRIAVAVVKGLTYLWS-L-----KILHRDVKPSNML--VN---TRGQV---------KLCDFGVST-------------------------------------QLVNS-IA--------------KT---YVGTNAYMAPER----IS------------------GEQ--YGIHSDVWSLGISFMELAL-GR-FP--------------YP-QI------------QKNQG-SLMPL--QLLQCIVDEDSPVL-P-V-GEF---------------------------------SEPFVH-FITQCMRKQPKE--RPA-------PE-ELMGHPFI-------------------------------------------------------
------------------------------WL--KGQQIGLGAFSSC---YQAQD---V-----GTGT---LMAV-KQVTYVR-NT-S---SE--Q-E-EVVEAL---------------------REEIRM-M-SHL--N----HPN--IIRML-GATC-E-------------------------------------KSN--YN--LFIEW-MAGG--SVA-HLLS-----------------------KYG-----------------AF--KESVVINYTEQLLRGLSYLHE-N-----QIIHRDVKGANLL--ID---STGQR--------LRIADFGAAARLAS-------------------------------KGTGAGE-FQ--------------GQ---LLGTIAFMAPEV----LR------------------GQQ--YGRSCDVWSVGCAIIEMAC-AK-PP--------------WN-AE------------KHSNH-LALIF--KIASATTAPSIPSH-L-S--------------------------------------PGLRD-VALRCLELQPQD--RPP-------SR-ELLKHPVF-------------------------------------------------------
-----------------------------ERV-----VLGKGTYGIV---YAGRD---L-----SNQV---RIAI-KEIPERD-SR-Y---SQ--P-L-H--E-------------------------EIAL-H-KYL--K----HRN--IVQYL-GSVS-E-------------------------------------NGY--IK--IFMEQ-VPGG--SLS-ALLR----------------------SKWG-----------------PM--KEPTIKFYTKQILEGLKYLHE-N-----QIVHRDIKGDNVL--VN--TYSGVV---------KISDFGTSKRL-----------------------------------AGVNP-CT--------------ET---FTGTLQYMAPEI----ID----------------QGPRG--YGAPADIWSLGCTIIEMAT-SK-PP--------------FH-EL--------------GEP-QAAMF--KVGMFKIHPEIPEA-L-S--------------------------------------AEARA-FILSCFEPDPHK--RAT-------TA-ELLREGF-L------------------------------------------------------
--------------------------------WRLGKLLGQGAFGRV---YLCYD---V-----DTGR---ELAV-KQVQFDP-DS-P---ET--S-K-EVNAL----------------------ECEIQL-L-KNL--L----HER--IVQYY-GCLR-DP-----------------------------------QEKT--LS--IFMEY-MPGG--SIK-DQLK-----------------------AYG-----------------AL--TENVTRKYTRQILEGVHYLHS-N-----MIVHRDIKGANIL--RD---STGNV---------KLGDFGASKRLQ--------------------------------TICLSGT-GM--------------KS---VTGTPYWMSPEV----IS------------------GEG--YGRKADIWSVACTVVEMLT-EK-PP--------------WA-EF---------------EA-MAAIF--KIATQPTNPKLPPH-V-S--------------------------------------DYTRD-FLKRIFV-EAKL--RPS-------AD-ELLRHMF-V------------------------------------------------------
-------------------------------W-RRGKLLGQGAFGRV---YLCYD---V-----DTGR---ELAS-KQVQFDP-DS-P---ET--S-K-EVSAL----------------------ECEIQL-L-KNL--Q----HER--IVQYY-GCLR-DR-----------------------------------AEKT--LT--IFMEY-MPGG--SVK-DQLK-----------------------AYG-----------------AL--TESVTRKYTRQILEGMSYLHS-N-----MIVHRDIKGANIL--RD---SAGNV---------KLGDFGASKRLQ--------------------------------TICMSGT-GM--------------RS---VTGTPYWMSPEV----IS------------------GEG--YGRKADVWSLGCTVVEMLT-EK-PP--------------WA-EY---------------EA-MAAIF--KIATQPTNPQLPSH-I-S--------------------------------------EHGRD-FLRRIFV-EARQ--RPS-------AE-ELLTHHF-A------------------------------------------------------
-------------------------------W-QRGNKIGEGQYGKV---YTCIS---V-----DTGE---LMAM-KEIRFQP-ND-H---KT--I-K-ETAD-------------------------ELKI-F-EGI--K----HPN--LVRYF-GVEL-H-------------------------------------REE--MY--IFMEY-CDEG--TLE-EVS-------------------------RL-----------------GL--QEHVIRLYSKQITIAINVLHE-H-----GIVHRDIKGANIF--LT---SSGLI---------KLGDFGCSVKLKN-------------------------------NAQTMPG-EV--------------NS---TLGTAAYMAPEV----ITR---------------AKGEG--HGRAADIWSLGCVVIEMVT-GK-RP--------------WH-EY-------------EHNF-QIMYK--VGMGHKPPIPERLS------------------------------------------PEGKD-FLSHCLESDPKM--RWT-------AS-QLLDHSFV-------------------------------------------------------
-----------------------------DRV-----VLGKGTYGIV---YAGRD---L-----SNQV---RIAI-KEIPERD-SR-Y---SQ--P-L-H--E-------------------------EIAL-H-KHL--K----HKN--IVQYL-GSFS-E-------------------------------------NGF--IK--IFMEQ-VPGG--SLS-ALLR----------------------SKWG-----------------PLKDNEQTIGFYTKQILEGLKYLHD-N-----QIVHRDIKGDNVL--IN--TYSGVL---------KISDFGTSKRL-----------------------------------AGINP-CT--------------ET---FTGTLQYMAPEI----ID----------------KGPRG--YGKAADIWSLGCTIIEMAT-GK-PP--------------FY-EL--------------GEP-QAAMF--KVGMFKVHPEIPES-M-S--------------------------------------AEAKA-FILKCFEPDPDK--RAC-------AN-DLLVDEF-L------------------------------------------------------
-----------------------------ERL-----VLGKGTYGVV---YAGRD---R-----HTRV---RIAI-KEIPERD-SR-F---SQ--P-L-H--E-------------------------EIAL-H-RRL--R----HKN--IVRYL-GSAS-Q-------------------------------------GGY--LK--IFMEE-VPGG--SLS-SLLR----------------------SVWG-----------------PLKDNESTISFYTRQILQGLGYLHD-N-----HIVHRDIKGDNVL--IN--TFSGLL---------KISDFGTSKRL-----------------------------------AGITP-CT--------------ET---FTGTLQYMAPEI----ID----------------QGPRG--YGKAADIWSLGCTVIEMAT-GR-PP--------------FH-EL--------------GSP-QAAMF--QVGMYKVHPPMPSS-L-S--------------------------------------AEAQA-FLLRTFEPDPRL--RAS-------AQ-TLLGDPFL-------------------------------------------------------
--------------------------------YTNLSYIGEGAYGMV---CSAYD---N-----VNKV---RVAI-KKISPFE-HQ-T---YC--Q-R-T-LR-------------------------EIKI-L-LRF--R----HEN--IIGIN-DIIR-APT--------------------------------IEQMKD--VY--IVQDL-MET---DLY-KLLK------------------------TQ-----------------HL--SNDHICYFLYQILRGLKYIHS-A-----NVLHRDLKPSNLL--LN---TTCDL---------KICDFGLARVAD--------------------------------PDHDHTG-FL--------------TE---YVATRWYRAPEI----ML-----------------NSKG--YTKSIDIWSVGCILAEMLS-NR-PI--------------FP-GK------------HYLDQ-LNHIL--GILGSPSQEDLNCI-I-N-LKARNYLLSLPHKN-----------KVPWNRLFPNADSKALD-LLDKMLTFNPHK--RIE-------VE-QALAHPYL-------------------------------------------------------
--------------------------------YQNLKPIGSGAQGIV---CAAYD---A-----VLDR---NVAI-KKLSRPF-QN-Q---TH--A-K-RAYR-------------------------ELVL-M-KCV--N----HKN--IISLL-NVFT-PQKT-------------------------------LEEFQD--VY--LVMEL-MDA---NLC-QVIQ-------------------------M-----------------EL--DHERMSYLLYQMLCGIKHLHS-A-----GIIHRDLKPSNIV--VK---SDCTL---------KILDFGLART------------------------------------AGTSF-MM--------------TP---YVVTRYYRAPEV----IL------------------GMG--YKENVDIWSVGCIMGEMVR-HK-IL--------------FP-GR------------DYIDQ-WNKVI--EQLGTPCPEFMKKL-Q-P-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RIS-------VD-DALQHPYI-------------------------------------------------------
--------------------------------YRDLQPVGSGAYGAV---CSAVD---G-----RTGA---KVAI-KKLYRPF-QS-E---LF--A-K-RAYR-------------------------ELRL-L-KHM--R----HEN--VIGLL-DVFT-PDET-------------------------------LDDFTD--FY--LVMPF-MGT---DLG-KLMK------------------------HE-----------------KL--GEDRIQFLVYQMLKGLRYIHA-A-----GIIHRDLKPGNLA--VN---EDCEL---------KILDFGLAR--------------------------------------QADS-EM--------------TG---YVVTRWYRAPEV----IL-----------------NWMR--YTQTVDIWSVGCIMAEMIT-GK-TL--------------FK-GS------------DHLDQ-LKEIM--KVTGTPPAEFVQRL-Q-S-DEAKNYMKGLPELE-----------KKDFASILTNASPLAVN-LLEKMLVLDAEQ--RVT-------AG-EALAHPYF-------------------------------------------------------
----------------------------YVSP----THVGSGAYGSV---CSAID---K-----RSGE---KVAI-KKLSRPF-QS-E---IF--A-K-RAYR-------------------------ELLL-L-KHM--Q----HEN--VIGLL-DVFT-PASS-------------------------------LRNFYD--FY--LVMPF-MQT---DLQ-KIM-------------------------GM-----------------EF--SEEKIQYLVYQMLKGLKYIHS-A-----GVVHRDLKPGNLA--VN---EDCEL---------KILDFGLAR--------------------------------------HADA-EM--------------TG---YVVTRWYRAPEV----IL-----------------SWMH--YNQTVDIWSVGCIMAEMLT-GK-TL--------------FK-GK------------DYLDQ-LTQIL--KVTGVPGTEFVQKL-N-D-KAAKSYIQSLPQTP-----------RKDFTQLFPRASPQAAD-LLEKMLELDVDK--RLT-------AA-QALTHPFF-------------------------------------------------------
--------------------------------YQNLSPVGSGAYGSV---CAAFD---T-----KTGL---RVAV-KKLSRPF-QS-I---IH--A-K-RTYR-------------------------ELRL-L-KHM--K----HEN--VIGLL-DVFT-PARS-------------------------------LEEFND--VY--LVTHL-MGA---DLN-NIVK------------------------CQ-----------------KL--TDDHVQFLIYQILRGLKYIHS-A-----DIIHRDLKPSNLA--VN---EDCEL---------KILDFGLAR--------------------------------------HTDD-EM--------------TG---YVATRWYRAPEI----ML-----------------NWMH--YNQTVDIWSVGCIMAELLT-GR-TL--------------FP-GT------------DHIDQ-LKLIL--RLVGTPGAELLKKI-S-S-ESARNYIQSLTQMP-----------KMNFANVFIGANPLAVD-LLEKMLVLDSDK--RIT-------AA-QALAHAYF-------------------------------------------------------
------------------------------YM--DLKPLGCGGNGLV---FSAVD---N-----DCDK---RVAI-KKIVLTD-PQ-S---VK--H----ALR-------------------------EIKI-I-RRL--D----HDN--IVKVF-EILG-PSGSQLTD-----------------------DVGSLTELNS--VY--IVQEY-MET---DLA-NVLE------------------------QG-----------------PL--LEEHARLFMYQLLRGLKYIHS-A-----NVLHRDLKPANLF--IN--TEDLVL---------KIGDFGLARIMD--------------------------------PHYSHKG-HL--------------SE---GLVTKWYRSPRL----LL-----------------SPNN--YTKAIDMWAAGCIFAEMLT-GK-TL--------------FA-GA------------HELEQ-MQLIL--ESIPVVHEEDRQEL-L-S-VIPVYIRNDMTEP------------HKPLTQLLPGISREALD-FLEQILTFSPMD--RLT-------AE-EALSHPYM-------------------------------------------------------
-----------------------------KVT---SQVLGLGINGKV---LQIFN---K-----RTQE---KFAL-KMLQDCP-KA-R--------------R-------------------------EVEL-H-WRA-SQ----CPH--IVRIV-DVYE-NLY---------------------------------AGRKC--LL--IVMEC-LDGG--ELF-SRIQD---------------------RGDQ-----------------AF--TEREASEIMKSIGEAIQYLHS-I-----NIAHRDVKPENLL--YT---SKRPNA------ILKLTDFGFAKE------------------------------------TTSHN-SL--------------TT---PCYTPYYVAPEV----LG------------------PEK--YDKSCDMWSLGVIMYILLC-GY-PP--------------FY-SN-----------HGLAIS-PGMKT--RIRMGQYEFPNPEW-S-E-VS-----------------------------------EEVKM-LIRNLLKTEPTQ--RMT-------IT-EFMNHPWI-------------------------------------------------------
-----------------------------INW---TQKLGAGISGPV---RVCVK---K-----STQE---RFAL-KILLDRP-KA-R--------------N-------------------------EVRL-H-MMC-AT----HPN--IVQII-EVFA-NSVQFP---------------------------HESSPRAR--LL--IVMEM-MEGG--ELF-HRIS-----------------------QHR-----------------HF--TEKQASQVTKQIALALRHCHL-L-----NIAHRDLKPENLL--FK---DNS-LDA-----PVKLCDFGFAK--------------------------------------IDQG-DL--------------MT---PQFTPYYVAPQV----LEAQRRHQKEKSGIIPTSPTPYT--YNKSCDLWSLGVIIYVMLC-GY-PP--------------FY-SKH----------HSRTIP-KDMRR--KIMTGSFEFPEEEW-S-Q-IS-----------------------------------EMAKD-VVRKLLKVKPEE--RLT-------IE-GVLDHPWL-------------------------------------------------------
--------------------------------YRLQKTIGKGNFAKV---KLARH---V-----LTGR---EVAV-KIIDKTQ-LN-P---TS--L-Q-KLFR-------------------------EVRI-M-KIL--N----HPN--IVKLF-EVIE-T-------------------------------------EKT--LY--LVMEY-ASGG--EVF-DYLV-----------------------AHG-----------------RM--KEKEARAKFRQIVSAVQYCHQ-K-----YIVHRDLKAENLL--LD---GDMNI---------KIADFGFSNE------------------------------------FTVGN-KL--------------DT---FCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GS-LP--------------FD-GQ---------------NL-KELRE--RVLRGKYRIPFYMS------------------------------------------TDCEN-LLKKLLVLNPIK--RGS-------LE-QIMKDRWM-------------------------------------------------------
--------------------------------YRLLKTIGKGNFAKV---KLARH---I-----LTGK---EVAV-KIIDKTQ-LN-S---SS--L-Q-KLFR-------------------------EVRI-M-KVL--N----HPN--IVKLF-EVIE-T-------------------------------------EKT--LY--LVMEY-ASGG--EVF-DYLV-----------------------AHG-----------------RM--KEKEARAKFRQIVSAVQYCHQ-K-----FIVHRDLKAENLL--LD---ADMNI---------KIADFGFSNE------------------------------------FTFGN-KL--------------DT---FCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GS-LP--------------FD-GQ---------------NL-KELRE--RVLRGKYRIPFYMS------------------------------------------TDCEN-LLKKFLILNPSK--RGT-------LE-QIMKDRWM-------------------------------------------------------
--------------------------------YRLLKTIGKGNFAKV---KLARH---I-----LTGR---EVAI-KIIDKTQ-LN-P---TS--L-Q-KLFR-------------------------EVRI-M-KIL--N----HPN--IVKLF-EVIE-T-------------------------------------EKT--LY--LIMEY-ASGG--EVF-DYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QV--SFDLLSLMFTFIVSAVQYCHQ-K-----RIVHRDLKAENLL--LD---ADMNI---------KIADFGFSNE------------------------------------FTVGG-KL--------------DT---FCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GS-LP--------------FD-GQ---------------NL-KELRE--RVLRGKYRIPFYMS------------------------------------------TDCEN-LLKRFLVLNPIK--RGT-------LE-QIMKDRWI-------------------------------------------------------
--------------------------------YRLLRTIGKGNFAKV---KLARH---I-----LTGR---EVAI-KIIDKTQ-LN-P---SS--L-Q-KLFR-------------------------EVRI-M-KGL--N----HPN--IVKLF-EVIE-T-------------------------------------EKT--LY--LVMEY-ASAG--EVF-DYLV-----------------------SHG-----------------RM--KEKEARAKFRQIVSAVHYCHQ-K-----NIVHRDLKAENLL--LD---AEANI---------KIADFGFSNE------------------------------------FTLGS-KL--------------DT---FCGSPPYAAPEL----FQ-----------------GKKY--DGPEVDIWSLGVILYTLVS-GS-LP--------------FD-GH---------------NL-KELRE--RVLRGKYRVPFYMS------------------------------------------TDCES-ILRRFLVLNPAK--RCT-------LE-QIMKDKWI-------------------------------------------------------
------------------------------FD--TIKLISNGAYGAV---YLVRH---R-----DTRQ---RFAM-KKINKQN-LILR---NQ--I-Q-QAFV-------------------------ERDI-L-TFA--E----NPF--VVGMF-CSFE-T-------------------------------------RRH--LC--MVMEY-VEGG--DCA-TLLK-----------------------NIG-----------------AL--PVEMARMYFAETVLALEYLHN-Y-----GIVHRDLKPDNLL--IT---SMGHI---------KLTDFGLSKMGLMSLTTN--------------------LYEGHIEKDAREF-LD--------------KQ---VCGTPEYIAPEV----IL------------------RQG--YGKPVDWWAMGIILYEFLV-GC-VP--------------FF-GD---------------TP-EELFG--QVISDDILWPEGDE---A-LP-----------------------------------TEAQL-LISSLLQTNPLV--RLGA----GGAF-EVKQHSFF-------------------------------------------------------
--------------------------------YRIRGEIGSGNFSQV---KLGIH---S-----LTKE---KVAI-KILDKTK-LD-Q---KT--Q-R-LLSR-------------------------EISS-M-EKL--H----HPN--IIRLY-EVVE-T-------------------------------------LSK--LH--LVMEY-AGGG--ELF-GKIS-----------------------TEG-----------------KL--SEPESKLIFSQIVSAVKHMHE-N-----QIIHRDLKAENVF--YT---SNTCV---------KVGDFGFSTV------------------------------------SKKGE-ML--------------NT---FCGSPPYAAPEL----FR-----------------DEHY--IGIYVDIWALGVLLYFMVT-GT-MP--------------FR-AE---------------TV-AKLKK--SILEGTYSVPPHV-------S-----------------------------------EPCHR-LIRGVLQQIPTE--RYG-------ID-CIMNDEWM-------------------------------------------------------
----------------------------QLQE----DVLGEGAHARV---QTCIN---L-----ITSQ---EYAV-KIIEKQP-GH-I---RS--R----VFR-------------------------EVEM-L-YQC-QG----HRN--VLELI-EFFE-E-------------------------------------EDR--FY--LVFEK-MRGG--SIL-SHIH-----------------------KRR-----------------HF--NELEASVVVQDVASALDFLHN-K-----GIAHRDLKPENIL--CE---HPNQVS------PVKICDFDLGSGIKLN----------------------------GDCSPISTP-EL--------------LT---PCGSAEYMAPEV----VEAF-------------SEEASI--YDKRCDLWSLGVILYILLS-GY-PP--------------FV-GRCGSDCGWDRGEACPACQ-NMLFE--SIQEGKYEFPDKDW-A-H-IS-----------------------------------CAAKD-LISKLLVRDAKQ--RLS-------AA-QVLQHPWV-------------------------------------------------------
-------------------------------Y-VRLQKIGEGSFGKA---ILVKS---T-----EDGR---QYVI-KEINISR-MS-S---KE--R-E-ESRR-------------------------EVAV-L-ANM--K----HPN--IVQYR-ESFE-E-------------------------------------NGS--LY--IVMDY-CEGG--DLF-KRINA---------------------QKGV-----------------LF--QEDQILDWFVQICLALKHVHD-R-----KILHRDIKSQNIF--LT---KDGTV---------QLGDFGIARVL-----------------------------------NSTVE-LA--------------RT---CIGTPYYLSPEI----CE------------------NKP--YNNKSDIWALGCVLYELCT-LK-HA--------------FE-AG---------------SM-KNLVL--KIISGSFPPVSLHY-S----------------------------------------YDLRS-LVSQLFKRNPRD--RPS-------VN-SILEKGF-I------------------------------------------------------
--------------------------------YEVLYTIGTGSYGRC---QKIRR---K-----SDGK---ILVW-KELDYGS-MT-E---AE--K-Q-MLVS-------------------------EVNL-L-REL--K----HPN--IVRYY-DRII-DR-----------------------------------TNTT--LY--IVMEY-CEGG--DLA-SVITKG-------------------TKERQ-----------------YL--DEEFVLRVMTQLTLALKECHR-RSDGGHTVLHRDLKPANVF--LD---GKQNV---------KLGDFGLARIL-----------------------------------NHDTS-FA--------------KT---FVGTPYYMSPEQ----MN------------------RMS--YNEKSDIWSLGCLLYELCA-LM-PP--------------FT-AF---------------SQ-KELAG--KIREGKFRRIPYRY------S-----------------------------------DELNE-IITRMLNLKDYH--RPS-------VE-EILENPL-I------------------------------------------------------
-------------------------------Y-CYLRVVGKGSYGEV---TLVKH---R-----RDGK---QYVI-KKLNLRN-AS-S---RE--R-R-AAEQ-------------------------EAQL-L-SQL--K----HPN--IVTYK-ESWE-G------------------------------------GDGL--LY--IVMGF-CEGG--DLY-RKLKE---------------------QKGQ-----------------LL--PENQVVEWFVQIAMALQYLHE-K-----HILHRDLKTQNVF--LT---RTNII---------KVGDLGIARVL-----------------------------------ENHCD-MA--------------ST---LIGTPYYMSPEL----FS------------------NKP--YNYKSDVWALGCCVYEMAT-LK-HA--------------FN-AK---------------DM-NSLVY--RIIEGKLPPMPRDY------S-----------------------------------PELAE-LIRTMLSKRPEE--RPS-------VR-SILRQPYI-------------------------------------------------------
--------------------------------YDVIKAIGQGAFGKA---YLAKG---K-----SDSK---HCVI-KEINFEK-MP-I---QE--K-E-ASKK-------------------------EVIL-L-EKM--K----HPN--IVAFF-NSFQ-E-------------------------------------NGR--LF--IVMEY-CDGG--DLM-KRINR---------------------QRGV-----------------LF--SEDQILGWFVQISLGLKHIHD-R-----KILHRDIKAQNIF--LS---KNGMV--------AKLGDFGIARVL-----------------------------------NNSME-LA--------------RT---CIGTPYYLSPEI----CQ------------------NKP--YNNKTDIWSLGCVLYELCT-LK-HP--------------FE-GN---------------NL-QQLVL--KICQAHFAPISPGF------S-----------------------------------RELHS-LISQLFQVSPRD--RPS-------IN-SILKRPFL-------------------------------------------------------
--------------------------------YERIRVVGRGAFGIV---HLCLR---K-----ADQK---LVII-KQIPVEQ-MT-K---EE--R-Q-AAQN-------------------------ECQV-L-KLL--N----HPN--VIEYY-ENFL-E-------------------------------------DKA--LM--IAMEY-APGG--TLA-EFIQK---------------------RCNS-----------------LL--EEETILHFFVQILLALHHVHT-H-----LILHRDLKTQNIL--LD--KHRMVV---------KIGDFGISKI------------------------------------LSSKS-KA--------------YT---VVGTPCYISPEL----CE------------------GKP--YNQKSDIWALGCVLYELAS-LK-RA--------------FE-AA---------------NL-PALVL--KIMSGTFAPISDRY------S-----------------------------------PELRQ-LVLSLLSLEPAQ--RPP-------LS-HIMAQP--LC-----------------------------------------------------
-----------------------------YIP---IRVLGRGAFGEA---TLYRR---T-----EDDS---LVVW-KEVDLTR-LS-E---KE--R-R-DALN-------------------------EIVI-L-ALL--Q----HDN--IIAYY-NHFM-D-------------------------------------NTT--LL--IELEY-CNGG--NLY-DKILR---------------------QKDK-----------------LF--EEEMVVWYLFQIVSAVSCIHK-A-----GILHRDIKTLNIF--LT---KANLI---------KLGDYGLAKKL-----------------------------------NSEYS-MA--------------ET---LVGTPYYMSPEL----CQ------------------GVK--YNFKSDIWAVGCVIFELLT-LK-RT--------------FD-AT---------------NP-LNLCV--KIVQGIRAMEVDSS---Q-YS-----------------------------------LELIQ-MVHSCLDQDPEQ--RPT-------AD-ELLDRPL-L------------------------------------------------------
-----------------------------IEP---DRPIGYGAFGVV---WSVTD---P-----RDGK---RVAL-KKMPNVF-QN-L---VS--C-K-RVFR-------------------------ELKM-L-CFF--K----HDN--VLSAL-DILQ-PPH--------------------------------IDYFEE--IY--VVTEL-MQS---DLH-KIIV-----------------------SPQ-----------------PL--SSDHVKVFLYQILRGLKYLHS-A-----GILHRDIKPGNLL--VN---SNCVL---------KICDFGLARVE----------------------------------ELDESR-HM--------------TQ---EVVTQYYRAPEI----LM-----------------GSRH--YSNAIDIWSVGCIFAELLG-RR-IL--------------FQ-AQ------------SPIQQ-LDLIT--DLLGTPSLEAMRTA-C-E-GAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSK--RIS-------AK-DALAHPYL-------------------------------------------------------
------------------------------IV--LKWELGEGAFGKV---FLAEC---HNLLPEQDKM---LVAV-KALK-EA-SE-----SA-RQ-D-FQ-R-------------------------EAEL-L-TML--Q----HQH--IVRFF-GVCT-E-------------------------------------GRP--LL--MVFEY-MRHG--DLN-RFLR------------------------SHGPDAKL-LAGGEDVAPGPL--GLGQLLAVASQVAAGMVYLAG-L-----HFVHRDLATRNCL--VG---QGLVV---------KIGDFGMSRDI-------------Y---------------------S--TD-YY--------------RVGGRTMLPIRWMPPES----IL------------------YRK--FTTESDVWSFGVVLWEIFTYGK-QP--------------WY-QL------------SNTEA-IDCIT--QGRELERPRACP--------------------------------------------PEVYA-IMRGCWQREPQQ--RHS-------IK-DVHARL---------------------------------------------------------
-------------------------------I-VLKRELGEGAFGKV---FLAEC---YNLCPEQDKI---LVAV-KTLK-DA-SD-----NA-RK-D-FH-R-------------------------EAEL-L-TNL--Q----HEH--IVKFY-GVCV-E-------------------------------------GDP--LI--MVFEY-MKHG--DLN-KFLR------------------------AHGPDAV---LMAEGNPPTEL--TQSQMLHIAQQIAAGMVYLAS-Q-----HFVHRDLATRNCL--VG---ENLLV---------KIGDFGMSRDV-------------Y---------------------S--TD-YY--------------RVGGHTMLPIRWMPPES----IM------------------YRK--FTTESDVWSLGVVLWEIFTYGK-QP--------------WY-QL------------SNNEV-IECIT--QGRVLQRPRTCP--------------------------------------------QEVYE-LMLGCWQREPHM--RKN-------IK-GIHTL--L-------------------------------------------------------
-------------------------------I-VLKRELGEGAFGKV---FLAEC---YNLSPTKDKM---LVAV-KALK-DP-TL-----AA-RK-D-FQ-R-------------------------EAEL-L-TNL--Q----HEH--IVKFY-GVCG-D-------------------------------------GDP--LI--MVFEY-MKHG--DLN-KFLR------------------------AHGPDAMILVDGQPRQAKGEL--GLSQMLHIASQIASGMVYLAS-Q-----HFVHRDLATRNCL--VG---ANLLV---------KIGDFGMSRDV-------------Y---------------------S--TD-YYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES----IM------------------YRK--FTTESDVWSFGVILWEIFTYGK-QP--------------WF-QL------------SNTEV-IECIT--QGRVLERPRVCP--------------------------------------------KEVYD-VMLGCWQREPQQ--RLN-------IK-EIYKIL---------------------------------------------------------
--------------------------------YELQETLGKGTYGKV---KRATE---R-----FSGR---VVAI-KSIRKDK-IK-D---EQ--D-M-VHIR------------------------REIEI-M-SSL--N----HPH--IISIY-EVFE-N-------------------------------------KDK--IV--IIMEY-ASKG--ELY-DYIS-----------------------ERR-----------------RL--SERETRHFFRQIVSAVHYCHK-N-----GVVHRDLKLENIL--LD---DNCNI---------KIADFGLSNL------------------------------------YQKDK-FL--------------QT---FCGSPLYASPEI----VN-----------------GRPY--RGPEVDSWALGVLLYTLVY-GT-MP--------------FD-GF---------------DH-KNLIR--QISSGEYREPTQP-------------------------------------------SDARG-LIRWMLMVNPDR--RAT-------IE-DIANHWW-V------------------------------------------------------
--------------------------------YEFLETLGKGTYGKV---KKARE---S-----SGR----LVAI-KSIRKDK-IK-D---EQ--D-L-MHIR------------------------REIEI-M-SSL--N----HPH--IIAIH-EVFE-N-------------------------------------SSK--IV--IVMEY-ASRG--DLY-DYIS-----------------------ERQ-----------------QL--SEREARHFFRQIVSAVHYCHQ-N-----RVVHRDLKLENIL--LD---ANGNI---------KIADFGLSNL------------------------------------YHQGK-FL--------------QT---FCGSPLYASPEI----VN-----------------GKPY--TGPEVDSWSLGVLLYILVH-GT-MP--------------FD-GH---------------DH-KILVK--QISNGAYREPPK--------P-----------------------------------SDACG-LIRWLLMVNPTR--RAT-------LE-DVASHWW-V------------------------------------------------------
--------------------------------YTRFEKIGQGASGTV---YTAMD---V-----ATGQ---EVAI-KQMNLQQ-QP-K---KE--L-I-I--N-------------------------EILV-M-REN--K----NPN--IVNYL-DSYL-V-------------------------------------GDE--LW--VVMEY-LAGG--SLT-DVVT------------------------ET-----------------CM--DEGQIAAVCRECLQALEFLHS-N-----QVIHRDIKSDNIL--LG---MDGSV---------KLTDFGFCAQI-----------------------------------TPEQS-KR--------------ST---MVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMIE-GE-PP--------------YL-NE------------NPLRA-LYLIA--TNGTPELQNPEKLS------------------------------------------AIFRD-FLNRCLEMDVEK--RGS-------AK-ELLQHQFL-------------------------------------------------------
--------------------------------YTRYEKIGQGASGTV---FTATD---V-----ALGQ---EVAI-KQINLQK-QP-K---KE--L-I-I--N-------------------------EILV-M-KEL--K----NPN--IVNFL-DSYL-V-------------------------------------GDE--LF--VVMEY-LAGG--SLT-DVVT------------------------ET-----------------CM--DEAQIAAVCRECLQALEFLHA-N-----QVIHRDIKSDNVL--LG---MEGSV---------KLTDFGFCAQI-----------------------------------TPEQS-KR--------------ST---MVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMVE-GE-PP--------------YL-NE------------NPLRA-LYLIA--TNGTPELQNPEKLS------------------------------------------PIFRD-FLNRCLEMDVEK--RGS-------AK-ELLQHPFL-------------------------------------------------------
--------------------------------YTRFEKIGQGASGTV---YTALD---I-----ATGQ---EVAI-KQMNLQQ-QP-K---KE--L-I-I--N-------------------------EILV-M-REN--K----NPN--IVNYL-DSYL-V-------------------------------------GDE--LW--VVMEY-LAGG--SLT-DVVT------------------------ET-----------------CM--DEGQIAAVCRECLQALDFLHS-N-----QVIHRDIKSDNIL--LG---MDGSV---------KLTDFGFCAQI-----------------------------------TPEQS-KR--------------ST---MVGTPYWMAPEV----VT------------------RKA--YGPKVDIWSLGIMAIEMVE-GE-PP--------------YL-NE------------NPLRA-LYLIA--TNGTPELQNPERLS------------------------------------------AVFRD-FLNRCLEMDVDR--RGS-------AK-ELLQHPFL-------------------------------------------------------
----------------------------DNFI-----KIGEGSTGIV---CIATV---R-----SSGK---LVAV-KKMDLRK-QQ-R---RE--L----LFN-------------------------EVVI-M-RDY--Q----HEN--VVEMY-NSYL-V-------------------------------------GDE--LW--VVMEF-LEGG--ALT-DIVT------------------------HT-----------------RM--NEEQIAAVCLAVLQALSVLHA-Q-----GVIHRDIKSDSIL--LT---HDGRV---------KLSDFGFCAQV-----------------------------------SKEVP-RR--------------KS---LVGTPYWMAPEL----IS------------------RLP--YGPEVDIWSLGIMVIEMVD-GE-PP--------------YF-NE------------PPLKA-MKMIR--DNLPPRLKNLHKVS------------------------------------------PSLKG-FLDRLLVRDPAQ--RAT-------AA-ELLKHPFL-------------------------------------------------------
----------------------------DSYV-----KIGEGSTGIV---CLARE---K-----HSGR---QVAV-KMMDLRK-QQ-R---RE--L----LFN-------------------------EVVI-M-RDY--Q----HFN--VVEMY-KSYL-V-------------------------------------GEE--LW--VLMEF-LQGG--ALT-DIVS------------------------QV-----------------RL--NEEQIATVCEAVLQALAYLHA-Q-----GVIHRDIKSDSIL--LT---LDGRV---------KLSDFGFCAQI-----------------------------------SKDVP-KR--------------KS---LVGTPYWMAPEV----IS------------------RSL--YATEVDIWSLGIMVIEMVD-GE-PP--------------YF-SD------------SPVQA-MKRLR--DSPPPKLKNSHKVS------------------------------------------PVLRD-FLERMLVRDPQE--RAT-------AQ-ELLDHPFL-------------------------------------------------------
--------------------------------YSTMSPLGSGAFGFV---WTAVD---K-----EKNK---EVVV-KFIKKEK-VL-E---DC--W-I-EDPKLGK-------------------VTLEIAI-L-SRV--E----HAN--IIKVL-DIFE-N-------------------------------------QGF--FQ--LVMEK-HGSG-LDLF-AFID-----------------------RHP-----------------RL--DEPLASYIFRQLVSAVGYLRL-K-----DIIHRDIKDENIV--IA---EDFTI---------KLIDFGSAAY------------------------------------LERGK-LF--------------YT---FCGTIEYCAPEV----LM-----------------GNPY--RGPELEMWSLGVTLYTLVF-EE-NP--------------FC-EL------------------EETVE--AAIHPPYLVS----------------------------------------------KELMS-LVSGLLQPVPER--RTT-------LE-KLVTDPWV-------------------------------------------------------
-------------------------------Y-IKLDKLGEGTYATV---YKGKS---K-----LTDN---LVAL-KEIRLEH-EE-G---AP--C---TAIR-------------------------EVSL-L-KDL--K----HAN--IVTLH-DIIH-T-------------------------------------EKS--LT--LVFEY-LDK---DLK-QYLD----------------------DCGN-----------------II--NMHNVKLFLFQLLRGLAYCHR-Q-----KVLHRDLKPQNLL--IN---ERGEL---------KLADFGLARAK-----------------------------------SIPTK-TY--------------SN---EVVTLWYRPPDI----LL-----------------GSTD--YSTQIDMWGVGCIFYEMAT-GR-PL--------------FP-GS------------TVEEQ-LHFIF--RILGTPTEETWPGI-L-S-NEEFKTYNYPKYR------------AEALLSHAPRLDSDGAD-LLTKLLQFEGRN--RIS-------AE-DAMKHPFF-------------------------------------------------------
-------------------------------Y-IKLEKLGEGTYATV---YKGRS---K-----LTEN---LVAL-KEIRLEH-EE-G---AP--C---TAIR-------------------------EVSL-L-KDL--K----HAN--IVTLH-DIVH-T-------------------------------------DKS--LT--LVFEY-LDK---DLK-QYMD----------------------DCGN-----------------IM--SMHNVKLFLYQILRGLAYCHR-R-----KVLHRDLKPQNLL--IN---EKGEL---------KLADFGLARAK-----------------------------------SVPTK-TY--------------SN---EVVTLWYRPPDV----LL-----------------GSSE--YSTQIDMWGVGCIFFEMAS-GR-PL--------------FP-GS------------TVEDE-LHLIF--RLLGTPSQETWPGI-S-S-NEEFKNYNFPKYK------------PQPLINHAPRLDSEGIE-LITKFLQYESKK--RVS-------AE-EAMKHVYF-------------------------------------------------------
--------------------------------YVKLDKLGEGTYATV---FKGRS---K-----LTEN---LVAL-KEIRLEH-EE-G---AP--C---TAIR-------------------------EVSL-L-KNL--K----HAN--IVTLH-DLIH-T-------------------------------------DRS--LT--LVFEY-LDS---DLK-QYLD-----------------------HCG-----------------NL-MSMHNVKIFMFQLLRGLAYCHH-R-----KILHRDLKPQNLL--IN---ERGEL---------KLADFGLARAK-----------------------------------SVPTK-TY--------------SN---EVVTLWYRPPDV----LL-----------------GSTE--YSTPIDMWGVGCIHYEMAT-GR-PL--------------FP-GS------------TVKEE-LHLIF--RLLGTPTEETWPGV-T-A-FSEFRTYSFPCYL------------PQPLINHAPRLDTDGIH-LLSSLLLYESKS--RMS-------AE-AALSHSYF-------------------------------------------------------
-------------------------------F-KFGKILGEGSFSTV---VLARE---L-----ATSR---EYAI-KILEKRH-II-K---EN--K-VPYVTR-------------------------ERDV-M-SRL--D----HPF--FVKLY-FTFQ-D-------------------------------------DEK--LY--FGLSY-AKNG--ELL-KYIR-----------------------KIG-----------------SF--DETCTRFYTAEIVSALEYLHG-K-----GIIHRDLKPENIL--LN---EDMHI---------QITDFGTAKVLS---------------------------------PESKQA-RA--------------NS---FVGTAQYVSPEL----LT------------------EKS--ACKSSDLWALGCIIYQLVA-GL-PP--------------FR-AG---------------NE-YLIFQ--KIIKLEYDFPEKFF------------------------------------------PKARD-LVEKLLVLDATK--RLG-------CE-EM------EGYGPLKAHPF--------------------------------------------
--------------------------------YEKLEKLGEGSYATV---YKGKS---K-----VNGK---LVAL-KVIRLQE-EE-G---TP--F---TAIR-------------------------EASL-L-KGL--K----HAN--IVLLH-DIIH-T-------------------------------------KET--LT--LVFEY-VHT---DLC-QYMD----------------------KHPG-----------------GL--HPDNVKLFLFQLLRGLSYIHQ-R-----YILHRDLKPQNLL--IS---DTGEL---------KLADFGLARAK-----------------------------------SVPSH-TY--------------SN---EVVTLWYRPPDV----LL-----------------GSTE--YSTCLDMWGVGCIFVEMIQ-GV-AA--------------FP-GM-----------KDIQDQ-LERIF--LVLGTPNEDTWPGV-H-S-LPHFKPERFTLYSS----------KNLRQAWNKLSYVNHAED-LASKLLQCSPKN--RLS-------AQ-AALSHEYF-------------------------------------------------------
--------------------------------YEPKEILGRGVSSVV---RRCIH---K-----PTSQ---EYAV-KVIDVTG-GG-S---FS--P-E-EVRELRE------------------ATLKEVDI-L-RKV-SG----HPN--IIQLK-DTYE-T-------------------------------------NTF--FF--LVFDL-MKRG--ELF-DYLT-----------------------EKV-----------------TL--SEKETRKIMRALLEVICTLHK-L-----NIVHRDLKPENIL--LD---DNMNI---------KLTDFGFSCQ------------------------------------LEPGE-RL--------------RE---VCGTPSYLAPEI----IECS------------MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PP--------------FW-HR---------------KQ-MLMLR--MIMSGNYQFGSPEW-D-D-YS-----------------------------------DTVKD-LVSRFLVVQPQN--RYT-------AE-EALAHPFF-------------------------------------------------------
-----------------------------YDP---KDVIGRGVSSVV---RRCVH---R-----ATGH---EFAV-KIMEVTA-ER-L---SP--E-Q-LEEVREA-------------------TRRETHI-L-RQV-AG----HPH--IITLI-DSYE-S-------------------------------------SSF--MF--LVFDL-MRKG--ELF-DYLT-----------------------EKV-----------------AL--SEKETRSIMRSLLEAVSFLHA-N-----NIVHRDLKPENIL--LD---DNMQI---------RLSDFGFSCH------------------------------------LEPGE-KL--------------RE---LCGTPGYLAPEI----LKCS------------MDETHPG--YGKEVDLWACGVILFTLLA-GS-PP--------------FW-HR---------------RQ-ILMLR--MIMEGQYQFSSPEW-D-D-RS-----------------------------------STVKD-LISRLLQVDPEA--RLT-------AE-QALQHPFF-------------------------------------------------------
--------------------------------YQVGPLLGSGGFGSV---YSGIR---V-----SDNL---PVAI-KHVEKDR-IS-D---WG--E-L-PNGTRV---------------------PMEVVL-L-KKV--S----SGFSGVIRLL-DWFE-R-------------------------------------PDS--FV--LILER-PEPV-QDLF-DFIT-----------------------ERG-----------------AL--QEELARSFFWQVLEAVRHCHN-C-----GVLHRDIKDENIL--ID--LNRGEL---------KLIDFGSGA-------------------------------------LLKDT-VY--------------TD---FDGTRVYSPPEW----IR-----------------YHRY--HGRSAAVWSLGILLYDMVC-GD-IP--------------FE-HD----------------------E--EIIRGQVFFRQRVS------------------------------------------SECQH-LIRWCLALRPSD--RPT-------FE-EIQNHPWM-------------------------------------------------------
--------------------------------YRLGPLLGKGGFGTV---FAGHR---L-----TDRL---QVAI-KVIPRNR-VL-G---WS--P-L-SDSVTC---------------------PLEVAL-L-WKV--GAGGGHPG--VIRLL-DWFE-T-------------------------------------QEG--FM--LVLERPLPAQ--DLF-DYIT-----------------------EKG-----------------PL--GEGPSRCFFGQVVAAIQHCHS-R-----GVVHRDIKDENIL--ID--LRRGCA---------KLIDFGSGA-------------------------------------LLHDE-PY--------------TD---FDGTRVYSPPEW----IS-----------------RHQY--HALPATVWSLGILLYDMVC-GD-IP--------------FE-RD----------------------Q--EILEAELHFPAHVS------------------------------------------PDCCA-LIRRCLAPKPSS--RPS-------LE-EILLDPWM-------------------------------------------------------
--------------------------------YQVGAVLGSGGFGTV---YAGSR---I-----ADGL---PVAV-KHVVKER-VT-E---WG--S-L-GGATV----------------------PLEVVL-L-RKV--GAAGGARG--VIRLL-DWFE-R-------------------------------------PDG--FL--LVLER-PEPA-QDLF-DFIT-----------------------ERG-----------------AL--DEPLARRFFAQVLAAVRHCHS-C-----GVVHRDIKDENLL--VD--LRSGEL---------KLIDFGSGA-------------------------------------LLKDT-VY--------------TD---FDGTRVYSPPEW----IR-----------------YHRY--HGRSATVWSLGVLLYDMVC-GD-IP--------------FE-QD----------------------E--EILRGRLLFRRRVS------------------------------------------PECQQ-LIRWCLSLRPSE--RPS-------LD-QIAAHPWM-------------------------------------------------------
-------------------------------F-KFLAVLGRGHFGKV---LLSEF---R-----PSGE---LFAI-KALKKGD-IV-A---RD--E-V-ESLM------------------------CEKRI-L-AAV--TS-AGHPF--LVNLF-GCFQ-T-------------------------------------PEH--VC--FVMEY-SAGG--DLM-LHIH------------------------SD-----------------VF--SEPRAIFYSACVVLGLQFLHE-H-----KIVYRDLKLDNLL--LD---TEGYV---------KIADFGLCKEG-----------------------------------MGYGD-RT--------------ST---FCGTPEFLAPEV----LT------------------DTS--YTRAVDWWGLGVLLYEMLV-GE-SP--------------FP-GD---------------DE-EEVFD--SIVNDEVRYPRFLS------------------------------------------AEAIG-IMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF-------------------------------------------------------
------------------------------FR--CCAVLGRGHFGKV---LLAEY---K-----NTNE---MFAI-KALKKGD-IV-A---RD--E-V-DSLM------------------------CEKRI-F-ETV--NS-VRHPF--LVNLF-ACFQ-T-------------------------------------KEH--VC--FVMEY-AAGG--DLM-MHIH------------------------TD-----------------VF--SEPRAVFYAACVVLGLQYLHE-H-----KIVYRDLKLDNLL--LD---TEGFV---------KIADFGLCKEG-----------------------------------MGYGD-RT--------------ST---FCGTPEFLAPEV----LT------------------ETS--YTRAVDWWGLGVLIYEMLV-GE-SP--------------FP-GD---------------DE-EEVFD--SIVNDEVRYPRFLS------------------------------------------TEAIS-IMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF-------------------------------------------------------
------------------------------YV--RGRFLGKGGFAKC---FEISD---A-----DTKE---VFAG-KIVPKSL-LL-K---PH--Q-R-EKMS------------------------MEISI-H-RSL--A----HQH--VVGFH-GFFE-D-------------------------------------NDF--VF--VVLEL-CRRR--SLL-ELHK-----------------------RRK-----------------AL--TEPEARYYLRQIVLGCQYLHR-N-----RVIHRDLKLGNLF--LN---EDLEV---------KIGDFGLATKV-----------------------------------EYDGE-RK--------------KT---LCGTPNYIAPEV----LS------------------KKG--HSFEVDVWSIGCIMYTLLV-GK-PP--------------FE-TS---------------CL-KETYL--RIKKNEYSIPKHIN------------------------------------------PVAAS-LIQKMLQTDPTA--RPT-------IN-ELLNDEFF-------------------------------------------------------
-------------------------------Y-CRGKVLGKGGFAKC---YEMTD---L-----TNNK---VYAA-KIIPHSR-VA-K---PH--Q-R-EKID------------------------KEIEL-H-RIL--H----HKH--VVQFY-HYFE-D-------------------------------------KEN--IY--ILLEY-CSRR--SMA-HILK-----------------------ARK-----------------VL--TEPEVRYYLRQIVSGLKYLHE-Q-----EILHRDLKLGNFF--IN---EAMEL---------KVGDFGLAARL-----------------------------------EPLEH-RR--------------RT---ICGTPNYLSPEV----LN------------------KQG--HGCESDIWALGCVMYTMLL-GR-PP--------------FE-TT---------------NL-KETYR--CIREARYTMPSSLL------------------------------------------APAKH-LIASMLSKNPED--RPS-------LD-DIIRHDFF-------------------------------------------------------
------------------------------YL--KGRLLGKGGFARC---YEATD---T-----ETGS---AYAV-KVIPQSR-VA-K---PH--Q-R-EKIL------------------------NEIEL-H-RDL--Q----HRH--IVRFS-HHFE-D-------------------------------------ADN--IY--IFLEL-CSRK--SLA-HIWK-----------------------ARH-----------------TL--LEPEVRYYLRQILSGLKYLHQ-R-----GILHRDLKLGNFF--IT---ENMEL---------KVGDFGLAARL-----------------------------------EPPEQ-RK--------------KT---ICGTPNYVAPEV----LL------------------RQG--HGPEADVWSLGCVMYTLLC-GS-PP--------------FE-TA---------------DL-KETYR--CIKQVHYTLPASLS------------------------------------------LPARQ-LLAAILRASPRD--RPS-------ID-QILRHDFF-------------------------------------------------------
-------------------------------F-ERIKTLGTGSFGRV---MLVKH---K-----ETGN---HYAM-KILDKQK-VV-K---LK--Q-I-EHTL------------------------NEKRI-L-QAV--N----FPF--LVKLE-FSFK-D-------------------------------------NSN--LY--MVMEY-VPGG--EMF-SHLR-----------------------RIG-----------------RF--SEPHARFYAAQIVLTFEYLHS-L-----DLIYRDLKPENLL--ID---QQGYI---------QVTDFGFAK--------------------------------------RVKG-RT--------------WT---LCGTPEYLAPEI----IL------------------SKG--YNKAVDWWALGVLIYEMAA-GY-PP--------------FF-AD---------------QP-IQIYE--KIVSGKVRFPSHFS------------------------------------------SDLKD-LLRNLLQVDLTK--RFGNL--KNGVN-DIKNHKWF-------------------------------------------------------
-------------------------------F-ERKKTLGTGSFGRV---MLVKH---K-----ATEQ---YYAM-KILDKQK-VV-K---LK--Q-I-EHTL------------------------NEKRI-L-QAV--N----FPF--LVRLE-YAFK-D-------------------------------------NSN--LY--MVMEY-VPGG--EMF-SHLR-----------------------RIG-----------------RF--SEPHARFYAAQIVLTFEYLHS-L-----DLIYRDLKPENLL--ID---HQGYI---------QVTDFGFAK--------------------------------------RVKG-RT--------------WT---LCGTPEYLAPEI----IL------------------SKG--YNKAVDWWALGVLIYEMAA-GY-PP--------------FF-AD---------------QP-IQIYE--KIVSGKVRFPSHFS------------------------------------------SDLKD-LLRNLLQVDLTK--RFGNL--KNGVS-DIKTHKWF-------------------------------------------------------
--------------------------------FERLRTLGMGSFGRV---MLVRH---Q-----ETGG---HYAM-KILNKQK-VV-K---MK--Q-V-EHIL------------------------NEKRI-L-QAI--D----FPF--LVKLQ-FSFK-D-------------------------------------NSY--LY--LVMEY-VPGG--EMF-SRLQ-----------------------RVG-----------------RF--SEPHACFYAAQVVLAVQYLHS-L-----DLIHRDLKPENLL--ID---QQGYL---------QVTDFGFAK--------------------------------------RVKG-RT--------------WT---LCGTPEYLAPEI----IL------------------SKG--YNKAVDWWALGVLIYEMAV-GF-PP--------------FY-AD---------------QP-IQIYE--KIVSGRVRFPSKLS------------------------------------------SDLKH-LLRSLLQVDLTK--RFGNL--RNGVG-DIKNHKWF-------------------------------------------------------
-------------------------------F-NFLMVLGKGSFGKV---MLADR---K-----GTEE---LYAI-KILKKDV-VI-Q---DD--D-V-ECTM------------------------VEKRV-L-ALL-DK----PPF--LTQLH-SCFQ-T-------------------------------------VDR--LY--FVMEY-VNGG--DLM-YHIQ-----------------------QVG-----------------KF--KEPQAVFYAAEISIGLFFLHK-R-----GIIYRDLKLDNVM--LD---SEGHI---------KIADFGMCKEH-----------------------------------MMDGV-TT--------------RT---FCGTPDYIAPEI----IA------------------YQP--YGKSVDWWAYGVLLYEMLA-GQ-PP--------------FD-GE---------------DE-DELFQ--SIMEHNVSYPKSLS------------------------------------------KEAVS-VCKGLMTKHPAK--RLG-------C----------GPEGERDVREHAFF-----------------------------------------
-------------------------------F-NFLMVLGKGSFGKV---MLSER---K-----GTDE---LYAV-KILKKDV-VI-Q---DD--D-V-ECTM------------------------VEKRV-L-ALP-GK----PPF--LTQLH-SCFQ-T-------------------------------------MDR--LY--FVMEY-VNGG--DLM-YHIQ-----------------------QVG-----------------RF--KEPHAVFYAAEIAIGLFFLQS-K-----GIIYRDLKLDNVM--LD---SEGHI---------KIADFGMCKEN-----------------------------------IWDGV-TT--------------KT---FCGTPDYIAPEI----IA------------------YQP--YGKSVDWWAFGVLLYEMLA-GQ-AP--------------FE-GE---------------DE-DELFQ--SIMEHNVAYPKSMS------------------------------------------KEAVA-ICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF-----------------------------------------
------------------------------FI--FHKVLGKGSFGKV---LLGEL---K-----GRGE---YFAI-KALKKDV-VL-I---DD--D-V-ECTM------------------------VEKRV-L-TLA-AE----NPF--LTHLI-CTFQ-T-------------------------------------KDH--LF--FVMEF-LNGG--DLM-YHIQ-----------------------DKG-----------------RF--ELYRATFYAAEIMCGLQFLHS-K-----GIIYRDLKLDNVL--LD---RDGHI---------KIADFGMCKEN-----------------------------------IFGES-RA--------------ST---FCGTPDYIAPEI----LQ------------------GLK--YTFSVDWWSFGVLLYEMLI-GQ-SP--------------FH-GD---------------DE-DELFE--SIRVDTPHYPRWIT------------------------------------------KESKD-ILEKLFEREPTK--RLG------VTG-NIKIHPFF-------------------------------------------------------
-------------------------------F-NFIKVLGKGSFGKV---MLAEL---K-----GKDE---VYAV-KVLKKDV-IL-Q---DD--D-V-DCTM------------------------TEKRI-L-ALA-RK----HPY--LTQLY-CCFQ-T-------------------------------------KDR--LF--FVMEY-VNGG--DLM-FQIQ-----------------------RSR-----------------KF--DEPRSRFYAAEVTSALMFLHQ-H-----GVIYRDLKLDNIL--LD---AEGHC---------KLADFGMCKEG-----------------------------------ILNGV-TT--------------TT---FCGTPDYIAPEI----LQ------------------ELE--YGPSVDWWALGVLMYEMMA-GQ-PP--------------FE-AD---------------NE-DDLFE--SILHDDVLYPVWLS------------------------------------------KEAVS-ILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF-----------------------------------------------------
--------------------------------FEFIRVLGKGSFGKV---MLARV---K-----ETGD---LYAV-KVLKKDV-IL-Q---DD--D-V-ECTM------------------------TEKRI-L-SLA-RN----HPF--LTQLF-CCFQ-T-------------------------------------PDR--LF--FVMEF-VNGG--DLM-FHIQ-----------------------KSR-----------------RF--DEARARFYAAEIISALMFLHD-K-----GIIYRDLKLDNVL--LD---HEGHC---------KLADFGMCKEG-----------------------------------ICNGV-TT--------------AT---FCGTPDYIAPEI----LQ------------------EML--YGPAVDWWAMGVLLYEMLC-GH-AP--------------FE-AE---------------NE-DDLFE--AILNDEVVYPTWLH------------------------------------------EDATG-ILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F------------------------------------------------------
-------------------------------F-DLLRVIGRGSYAKV---LLVRL---K-----KTDR---IYAM-KVVKKEL-VN-D---DE--D-I-DWVQ------------------------TEKHV-F-EQA-SN----HPF--LVGLH-SCFQ-T-------------------------------------ESR--LF--FVIEY-VNGG--DLM-FHMQ-----------------------RQR-----------------KL--PEEHARFYSAEISLALNYLHE-R-----GIIYRDLKLDNVL--LD---SEGHI---------KLTDYGMCKEG-----------------------------------LRPGD-TT--------------ST---FCGTPNYIAPEI----LR------------------GED--YGFSVDWWALGVLMFEMMA-GR-SP--------------FD-IVGSS------DNPDQNTE-DYLFQ--VILEKQIRIPRSLS------------------------------------------VKAAS-VLKSFLNKDPKE--RLGCHP-QTGFA-DIQGHPF-F------------------------------------------------------
------------------------------FI--LHKMLGKGSFGKV---FLAEF---K-----KTNQ---FFAI-KALKKDV-VL-M---DD--D-V-ECTM------------------------VEKRV-L-SLA-WE----HPF--LTHMF-CTFQ-T-------------------------------------KEN--LF--FVMEY-LNGG--DLM-YHIQ-----------------------SCH-----------------KF--DLSRATFYAAEIILGLQFLHS-K-----GIVYRDLKLDNIL--LD---KDGHI---------KIADFGMCKEN-----------------------------------MLGDA-KT--------------NT---FCGTPDYIAPEI----LL------------------GQK--YNHSVDWWSFGVLLYEMLI-GQ-SP--------------FH-GQ---------------DE-EELFH--SIRMDNPFYPRWLE------------------------------------------KEAKD-LLVKLFVREPEK--RLG-------VRGDIRQHPLF-------------------------------------------------------
-------------------------------F-DLIRVIGRGSYAKV---LLVRL---K-----KNDQ---IYAM-KVVKKEL-VH-D---DE--D-I-DWVQ------------------------TEKHV-F-EQA-SS----NPF--LVGLH-SCFQ-T-------------------------------------TSR--LF--LVIEY-VNGG--DLM-FHMQ-----------------------RQR-----------------KL--PEEHARFYAAEICIALNFLHE-R-----GIIYRDLKLDNVL--LD---ADGHI---------KLTDYGMCKEG-----------------------------------LGPGD-TT--------------ST---FCGTPNYIAPEI----LR------------------GEE--YGFSVDWWALGVLMFEMMA-GR-SP--------------FD-IITD--------NPDMNTE-DYLFQ--VILEKPIRIPRFLS------------------------------------------VKASH-VLKGFLNKDPKE--RLGCRP-QTGF----------SDIKSHAFF----------------------------------------------
------------------------------PD----EVLGSGQFGIV---YGGKH---R-----KTGR---DVAI-KIIDKLR-FP-T---KQ--E-S-QLRN-------------------------EVAI-L-QNL--H----HPG--VVNLE-CMFE-T-------------------------------------PER--VF--VVMEK-LHGD--MLE-MILS----------------------SEKG-----------------RL--PEHITKFLITQILVALRHLHF-K-----NIVHCDLKPENVL--LA---SADPFP------QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEV----LR------------------NKG--YNRSLDMWSVGVIIYVSLS-GT-FP--------------FN-ED------------------EDIHD--QIQNAAFMYPPNPW-K-E-IS-----------------------------------HEAID-LINNLLQVKMRK--RYS-------VD-KTLSHPWL-------------------------------------------------------
------------------------------PD----EVLGSGQFGVV---YGGKH---R-----KTGR---DVAV-KVIDKLR-FP-T---KQ--E-S-QLRN-------------------------EVAI-L-QSL--R----HPG--IVNLE-CMFE-T-------------------------------------PEK--VF--VVMEK-LHGD--MLE-MILS----------------------SEKG-----------------RL--PERLTKFLITQILVALRHLHF-K-----NIVHCDLKPENVL--LA---SADPFP------QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEV----LL------------------NQG--YNRSLDMWSVGVIMYVSLS-GT-FP--------------FN-ED------------------EDIND--QIQNAAFMYPASPW-S-H-IS-----------------------------------AGAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL-------------------------------------------------------
-----------------------------FAD----EVLGSGQFGIV---YGGKH---R-----KTGR---DVAI-KVIDKMR-FP-T---KQ--E-S-QLRN-------------------------EVAI-L-QNL--H----HPG--IVNLE-CMFE-T-------------------------------------PER--VF--VVMEK-LHGD--MLE-MILS----------------------SEKS-----------------RL--PERITKFMVTQILVALRNLHF-K-----NIVHCDLKPENVL--LA---SAEPFP------QVKLCDFGFARI------------------------------------IGEKS-FR--------------RS---VVGTPAYLAPEV----LR------------------SKG--YNRSLDMWSVGVIIYVSLS-GT-FP--------------FN-ED------------------EDIND--QIQNAAFMYPPNPW-R-E-IS-----------------------------------GEAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL-------------------------------------------------------
-------------------------------F-NIIDTLGVGGFGRV---ELVQL---KS----EESK---TFAM-KILKKRH-IV-D---TR--Q-Q-EHIR------------------------SEKQI-M-QGA--H----SDF--IVRLY-RTFK-D-------------------------------------SKY--LY--MLMEA-CLGG--ELW-TILR-----------------------DRG-----------------SF--EDSTTRFYTACVVEAFAYLHS-K-----GIIYRDLKPENLI--LD---HRGYA---------KLVDFGFAKK------------------------------------IGFGK-KT--------------WT---FCGTPEYVAPEI----IL------------------NKG--HDISADYWSLGILMYELLT-GS-PP--------------FS-GP---------------DP-MKTYN--IILRGIDMIEFPKK-I-A--------------------------------------KNAAN-LIKKLCRDNPSE--RLGNL--KNGVK-DIQKHKWF-------------------------------------------------------
-------------------------------L-EIIATLGVGGFGRV---ELVKV---K-----NENV---AFAM-KCIRKKH-IV-D---TK--Q-Q-EHVY------------------------SEKRI-L-EEL--C----SPF--IVKLY-RTFK-D-------------------------------------NKY--VY--MLLEA-CLGG--ELW-SILR-----------------------DRG-----------------SF--DEPTSKFCVACVTEAFDYLHR-L-----GIIYRDLKPENLI--LD---AEGYL---------KLVDFGFAKK------------------------------------IGSGQ-KT--------------WT---FCGTPEYVAPEV----IL------------------NKG--HDFSVDFWSLGILVYELLT-GN-PP--------------FS-GV---------------DQ-MMTYN--LILKGIEKMDFPRK-I-T--------------------------------------RRPED-LIRRLCRQNPTE--RLGNL--KNGIN-DIKKHRWL-------------------------------------------------------
------------------------------FD--TLATVGTGTFGRV---HLVKE---K-----TAKH---FFAL-KVMSIPD-VI-R---LK--Q-E-QHVH------------------------NEKSV-L-KEV--S----HPF--LIRLF-WTWH-D-------------------------------------ERF--LY--MLMEY-VPGG--ELF-SYLR-----------------------NRG-----------------RF--SSTTGLFYSAEIICAIEYLHS-K-----EIVYRDLKPENIL--LD---RDGHI---------KLTDFGFAKK--------------------------------------LVD-RT--------------WT---LCGTPEYLAPEV----IQ------------------SKG--HGRAVDWWALGILIFEMLS-GF-PP--------------FF-DD---------------NP-FGIYQ--KILAGKIDFPRHLD------------------------------------------FHVKD-LIKKLLVVDRTR--RLGNM--KNGAN-DVKHHRWF-------------------------------------------------------
--------------------------------YEVVKVIGRGAFGEV---QLVRH---K-----STRK---VYAM-KLLSKFE-MI-K---RS--D-S-AFFW------------------------EERDI-M-AFA--N----SPW--VVQLF-YAFQ-D-------------------------------------DRY--LY--MVMEY-MPGG--DLV-NLMS------------------------NY-----------------DV--PEKWARFYTAEVVLALDAIHS-M-----GFIHRDVKPDNML--LD---KSGHL---------KLADFGTCMKM----------------------------------NKEGMV-RC--------------DT---AVGTPDYISPEV----LKS--------------QGGDGY--YGRECDWWSVGVFLYEMLV-GD-TP--------------FY-AD---------------SL-VGTYS--KIMNHKNSLTFPDD-N-D-IS-----------------------------------KEAKN-LICAFLTDREVRLGRNG-------VE-EIKRHLFF-------------------------------------------------------
--------------------------------YDVVKVIGRGAFGEV---QLVRH---K-----ASQK---VYAM-KLLSKFE-MI-K---RS--D-S-AFFW------------------------EERDI-M-AFA--N----SPW--VVQLF-YAFQ-D-------------------------------------DRY--LY--MVMEY-MPGG--DLV-NLMS------------------------NY-----------------DV--PEKWAKFYTAEVVLALDAIHS-M-----GLIHRDVKPDNML--LD---KHGHL---------KLADFGTCMKM----------------------------------DETGMV-HC--------------DT---AVGTPDYISPEV----LKS--------------QGGDGF--YGRECDWWSVGVFLYEMLV-GD-TP--------------FY-AD---------------SL-VGTYS--KIMDHKNSLCFPED-A-E-IS-----------------------------------KHAKN-LICAFLTDREVRLGRNG-------VE-EIRQHPFF-------------------------------------------------------
--------------------------------FELLKVLGQGSFGKVFLVRKVTR---P-----DSGH---LYAM-KVLKKAT-LK-V---RD--R-V-RTKM-------------------------ERDI-L-ADV--N----HPF--VVKLH-YAFQ-T-------------------------------------EGK--LY--LILDF-LRGG--DLF-TRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALGLDHLHS-L-----GIIYRDLKPENIL--LD---EEGHI---------KLTDFGLSKEA-----------------------------------IDHEK-KA--------------YS---FCGTVEYMAPEV----VN------------------RQG--HSHSADWWSYGVLMFEMLT-GS-LP--------------FQ-GK---------------DR-KETMT--LILKAKLGMPQFLS------------------------------------------TEAQS-LLRALFKRNPAN--RLGSG--PDGAE-EIKRHV--FY-----------------------------------------------------
--------------------------------FELLKVLGQGSFGKV---FLVKK---I-----SGSDARQLYAM-KVLKKAT-LK-V---RD--R-V-RTKM-------------------------ERDI-L-VEV--N----HPF--IVKLH-YAFQ-T-------------------------------------EGK--LY--LILDF-LRGG--DLF-TRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALALDHLHS-L-----GIIYRDLKPENIL--LD---EEGHI---------KLTDFGLSKES-----------------------------------IDHEK-KA--------------YS---FCGTVEYMAPEV----VN------------------RRG--HTQSADWWSFGVLMFEMLT-GT-LP--------------FQ-GK---------------DR-KETMT--MILKAKLGMPQFLS------------------------------------------PEAQS-LLRMLFKRNPAN--RLGAG--PDGVE-EIKRHSFF-------------------------------------------------------
-----------------------------REP-----ALGQGSFSVC---RRCRQ---R-----QSGQ---EFAV-KILSRRL-EA-N---TQ--R--------------------------------EVAA-L-RLC-QS----HPN--VVNLH-EVHH-D-------------------------------------QLH--TY--LVLEL-LRGG--ELL-EHIR-----------------------KKR-----------------HF--SESEASQILRSLVSAVSFMHEEA-----GVVHRDLKPENIL--YA---DDT-PGA-----PVKIIDFGFARLR----------------------------------PQSPGV-PM--------------QT---PCFTLQYAAPEL----LA------------------QQG--YDESCDLWSLGVILYMMLS-GQ-VP--------------FQ-GASG--------QGGQSQA-AEIMC--KIREGRFSLDGEAW-Q-G-VS-----------------------------------EEAKE-LVRGLLTVDPAK--RLK-------LE-GLRGSSW-L------------------------------------------------------
--------------------------------FELLKVLGTGAYGKV---FLVRKISGH-----DTGK---LYAM-KVLKKAT-IV-Q---KA--K-T-TEHTR-----------------------TERQV-L-EHI-RQ----SPF--LVTLH-YAFQ-T-------------------------------------ETK--LH--LILDY-INGG--ELF-THLS-----------------------QRE-----------------RF--TEHEVQIYVGEIVLALEHLHK-L-----GIIYRDIKLENIL--LD---SNGHV---------VLTDFGLSKEF----------------------------------VADETE-RA--------------YS---FCGTIEYMAPDI----VR----------------GGDSG--HDKAVDWWSLGVLMYELLT-GA-SP--------------FT-VD-----------GEKNSQ-AEISR--RILKSEPPYPQEMS------------------------------------------ALAKD-LIQRLLMKDPKK--RLGCG--PRDAD-EIKEHLFF-------------------------------------------------------
--------------------------------FELLKVLGQGSFGKV---FLVRK---K-----TGPDAGQLYAM-KVLKKAS-LK-V---RD--R-V-RTKM-------------------------ERDI-L-VEV--N----HPF--IVKLH-YAFQ-T-------------------------------------EGK--LY--LILDF-LRGG--DVF-TRLS-----------------------KEV-----------------LF--TEEDVKFYLAELALALDHLHQ-L-----GIVYRDLKPENIL--LD---EIGHI---------KLTDFGLSKES-----------------------------------VDQEK-KA--------------YS---FCGTVEYMAPEV----VN------------------RRG--HSQSADWWSYGVLMFEMLT-GT-LP--------------FQ-GK---------------DR-NETMN--MILKAKLGMPQFLS------------------------------------------AEAQS-LLRMLFKRNPAN--RLGS----EGVE-EIKRHLFF-------------------------------------------------------
--------------------------------FELLRVLGKGGYGKV---FQVRKVTGA-----NTGK---IFAM-KVLKKAM-IV-R---NA--K-D-TAHTK-----------------------AERNI-L-EEV--K----HPF--IVDLI-YAFQ-T-------------------------------------GGK--LY--LILEY-LSGG--ELF-MQLE-----------------------REG-----------------IF--MEDTACFYLAEISMALGHLHQ-K-----GIIYRDLKPENIM--LN---HQGHV---------KLTDFGLCKES-----------------------------------IHDGT-VT--------------HT---FCGTIEYMAPEI----LM------------------RSG--HNRAVDWWSLGALMYDMLT-GA-PP--------------FT-GE---------------NR-KKTID--KILKCKLNLPPYLT------------------------------------------QEARD-LLKKLLKRNAAS--RLGAG--PGDAG-EVQAHPFF-------------------------------------------------------
--------------------------------FELLRVLGKGGYGKV---FQVRK---V-----QGTNLGKIYAM-KVLRKAK-IV-R---NA--K-D-TAHTR-----------------------AERNI-L-ESV--K----HPF--IVELA-YAFQ-T-------------------------------------GGK--LY--LILEC-LSGG--ELF-THLE-----------------------REG-----------------IF--LEDTACFYLAEITLALGHLHS-Q-----GIIYRDLKPENIM--LS---SQGHI---------KLTDFGLCKES-----------------------------------IHEGA-VT--------------HT---FCGTIEYMAPEI----LV------------------RSG--HNRAVDWWSLGALMYDMLT-GS-PP--------------FT-AE---------------NR-KKTMD--KIIRGKLALPPYLT------------------------------------------PDARD-LVKKFLKRNPSQ--RIGGG--PGDAA-DVQRHPFF-------------------------------------------------------
--------------------------------YELVRELGKGTYGKV---DLVVY---K-----GTGT---KMAL-KFVNKSK-TK-L---KN--F-----LR-------------------------EVSI-T-NSL-SS----SPF--IIKVF-DVVF-E------------------------------------TEDC--YV--FAQEY-APAG--DLF-DIIP-----------------------PQV-----------------GL--PEDTVKRCVQQLGLALDFMHG-R-----QLVHRDIKPENVL--LFD-RECRRV---------KLADFGMTR--------------------------------------RVGC-RV--------------KR---VSGTIPYTAPEV----CQAG-------------RADGLA--VDTGVDVWAFGVLIFCVLT-GN-FP--------------WE-AA------------SGADAFFEEFV--RWQRGRLPGLPSQW-R-R-FT-----------------------------------EPALR-MFQRLLALEPER--RGP-------AK-EVF-----RFLKH--------------------------------------------------
--------------------------------FHFLKVIGKGSFGKV---LLARH---K-----AEEV---FYAV-KVLQKKA-IL-K---KK--E-E-KHIM------------------------SERNV-LLKNV--K----HPF--LVGLH-FSFQ-T-------------------------------------ADK--LY--FVLDY-INGG--ELF-YHLQ-----------------------RER-----------------CF--LEPRARFYAAEIASALGYLHS-L-----NIVYRDLKPENIL--LD---SQGHI---------VLTDFGLCKEN-----------------------------------IEHNS-TT--------------ST---FCGTPEYLAPEV----LH------------------KQP--YDRTVDWWCLGAVLYEMLY-GL-PP--------------FY-SR---------------NT-AEMYD--NILNKPLQLKPNIT------------------------------------------NSARH-LLEGLLQKDRTK--RLGAK---DDFM-EIKSHV--FF-----------------------------------------------------
--------------------------------YHLIRKLGSGSYGRV---LLAQP---H-----QGGP---AVAL-KLLRRDL-VL-R---ST--F-----LR-------------------------EFCV-G-RCV-SA----HPG--LLQTLAGPLQ-T-------------------------------------PRY--FA--FAQEY-APCG--DLS-GMLQ------------------------ER-----------------GL--PELLVKRVVAQLAGALDFLHS-R-----GLVHADVKPDNVL--VF----DPVCS------RVALGDLGLTR--------------------------------------PEGS-PT--------------PA---PPVPLPTAPPEL----CLLL-------------PPDTLP--LRPAVDSWGLGVLLFCAAT-AC-FP--------------WD-VAL---------APN--PE-FEAFAGWVTTKPQPPQPPPPW-D-Q-FA-----------------------------------PPALA-LLQGLLDLDPET--RS-------------------PPLAVLDF-----------------------------------------------
-------------------------------F-DFLKVIGKGNYGKV---LLAKR---K-----SDGA---FYAV-KVLQKKS-IL-K---KK--E-Q-SHIM------------------------AERSVLL-KNV--R----HPF--LVGLR-YSFQ-T-------------------------------------PEK--LY--FVLDY-VNGG--ELF-FHLQ-----------------------RER-----------------RF--LEPRARFYAAEVASAIGYLHS-L-----NIIYRDLKPENIL--LD---CQGHV---------VLTDFGLCKEG-----------------------------------VEPED-TT--------------ST---FCGTPEYLAPEV----LR------------------KEP--YDRAVDWWCLGAVLYEMLH-GL-PP--------------FY-SQ---------------DV-SQMYE--NILHQPLQIPGGRT------------------------------------------VAACD-LLQSLLHKDQRQ--RLGSK---ADFL-EIKNHVFF-------------------------------------------------------
-------------------------------F-DFLKVIGKGSFGKV---LLAKR---K-----LDGK---FYAV-KVLQKKI-VL-N---RK--E-Q-KHIM------------------------AERNV-LLKNV--K----HPF--LVGLH-YSFQ-T-------------------------------------TEK--LY--FVLDF-VNGG--ELF-FHLQ-----------------------RER-----------------SF--PEHRARFYAAEIASALGYLHS-I-----KIVYRDLKPENIL--LD---SVGHV---------VLTDFGLCKEG-----------------------------------IAISD-TT--------------TT---FCGTPEYLAPEV----IR------------------KQP--YDNTVDWWCLGAVLYEMLY-GL-PP--------------FY-CR---------------DV-AEMYD--NILHKPLSLRPGVS------------------------------------------LTAWS-ILEELLEKDRQN--RLGAK---EDFL-EIQNHPFF-------------------------------------------------------
--------------------------------YDIERTLGKGNFAVV---KLARH---R-----VTKT---QVAI-KIIDKTR-LD-S---SN--L-E-KIYR-------------------------EVQL-M-KLL--N----HPH--IIKLY-QVME-T-------------------------------------KDM--LY--IVTEF-AKNG--EMF-DYLT-----------------------SNG-----------------HL--SENEARKKFWQILSAVEYCHD-H-----HIVHRDLKTENLL--LD---GNMDI---------KLADFGFGNF------------------------------------YKSGE-PL--------------ST---WCGSPPYAAPEV----FE-----------------GKEY--EGPQLDIWSLGVVLYVLVC-GS-LP--------------FD-GP---------------NL-PTLRQ--RVLEGRFRIPFFMS------------------------------------------QDCES-LIRRMLVVDPAR--RIT-------IA-QIRQHRWM-------------------------------------------------------
--------------------------------YDIEGTLGKGNFAVV---KLGRH---R-----ITKT---EVAI-KIIDKSQ-LD-A---VN--L-E-KIYR-------------------------EVQI-M-KML--D----HPH--IIKLY-QVME-T-------------------------------------KSM--LY--LVTEY-AKNG--EIF-DYLA-----------------------NHG-----------------RL--NESEARRKFWQILSAVDYCHG-R-----KIVHRDLKAENLL--LD---NNMNI---------KIADFGFGNF------------------------------------FKSGE-LL--------------AT---WCGSPPYAAPEV----FE-----------------GQQY--EGPQLDIWSMGVVLYVLVC-GA-LP--------------FD-GP---------------TL-PILRQ--RVLEGRFRIPYFMS------------------------------------------EDCEH-LIRRMLVLDPSK--RLT-------IA-QIKEHKWM-------------------------------------------------------
--------------------------------WEIIGELGDGAFGKV---YKAQN---K-----ETSV---LAAA-KVIDTKS-EE-E---LE--D-Y-M--V-------------------------EIDI-L-ASC--D----HPN--IVKLL-DAFY-Y-------------------------------------ENN--LW--ILIEF-CAGG--AVD-AVML----------------------ELER-----------------PL--TESQIQVVCKQTLDALNYLHD-N-----KIIHRDLKAGNIL--FT---LDGDI---------KLADFGVSAKN-----------------------------------TRTIQ-RR--------------DS---FIGTPYWMAPEV----VMCE-------------TSKDRP--YDYKADVWSLGITLIEMAE-IE-PP--------------HH-EL------------NPMRV-LLKIA--KSEPPTLAQPSRWS------------------------------------------SNFKD-FLKKCLEKNVDA--RWT-------TS-QLLQHPFV-------------------------------------------------------
--------------------------------YDLDKTLGRGHFAVV---KLARH---V-----FTGE---KVAV-KVIDKTK-LD-T---LA--T-G-HLFQ-------------------------EVRC-M-KLV--Q----HPN--IVRLY-EVID-T-------------------------------------QTK--LY--LILEL-GDGG--DMF-DYIM----------------------KHEE-----------------GL--NEDLAKKYFAQIVHAISYCHK-L-----HVVHRDLKPENVV--FF--EKQGLV---------KLTDFGFSNK------------------------------------FQPGK-KL--------------TT---SCGSLAYSAPEI----LL-----------------GDEY--DAPAVDIWSLGVILFMLVC-GQ-PP--------------FQ-EA---------------ND-SETLT--MIMDCKYTVPSHVS------------------------------------------KECKD-LITRMLQRDPKR--RAS-------LE-EIENHPWL-------------------------------------------------------
-------------------------------L-RLEVKLGQGCFGEV---WMGTW---N------GTT---RVAI-KTLK-PG-TM-----SP--E-A-FL-Q-------------------------EAQV-M-KKL--R----HEK--LVQLY-AVVS---------------------------------------EEP--IY--IVTEY-MSKG--SLL-DFLK------------------------GE--------------TGKYL--RLPQLVDMAAQIASGMAYVER-M-----NYVHRDLRAANIL--VG---ENLVC---------KVADFGLARLI-----------------------------------E--DN-EY--------------TARQGAKFPIKWTAPEA----AL------------------YGR--FTIKSDVWSFGILLTELTTKGR-VP--------------YP-GM------------VNREV-LDQVE--RGYRMPCPPECP--------------------------------------------ESLHD-LMCQCWRKEPEE--RPT-------FE-YLQAF--L-------------------------------------------------------
--------------------------------WEIVGELGDGAFGKV---YKAKN---K-----ETGA---LAAA-KVIETKS-EE-E---LE--D-Y-I--V-------------------------EIEI-L-ATC--D----HPY--IVKLL-GAYY-H-------------------------------------DGK--LW--IMIEF-CPGG--AVD-AIML----------------------ELDR-----------------GL--TEPQIQVVCRQMLEALNFLHS-K-----RIIHRDLKAGNVL--MT---LEGDI---------RLADFGVSAKN-----------------------------------LKTLQ-KR--------------DS---FIGTPYWMAPEV----VMCE-------------TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PP--------------HH-EL------------NPMRV-LLKIA--KSDPPTLLTPSKWS------------------------------------------VEFRD-FLKIALDKNPET--RPS-------AA-QLLEHPFV-------------------------------------------------------
-----------------------------YLM---GDLLGEGSYGKV---KEVLD---S-----ETLC---RRAV-KILKKKK-LR-R---IP--N-G-EANVK-----------------------KEIQL-L-RRL--R----HKN--VIQLV-DVLY-NE-----------------------------------EKQK--MY--MVMEY-CVCGMQEML-DSVP------------------------EK-----------------RF--PVCQAHGYFCQLIDGLEYLHS-Q-----GIVHKDIKPGNLL--LT---TGGTL---------KISDLGVAEALH---------------------------------PFAADD-TC--------------RT---SQGSPAFQPPEI----AN----------------GLDTF--SGFKVDIWSAGVTLYNITT-GL-YP--------------FE-GD---------------NI-YKLFE--NIGKGSYAIPGDCG------------------------------------------PPLSD-LLKGMLEYEPAK--RFS-------IR-QIRQHSWF-------------------------------------------------------
-----------------------------LCP---GRELGRGKFAVV---RKCIK---K-----DSGK---EFAA-KFMRKRR-KG-Q---DC--R-M-EIIH-------------------------EIAV-L-ELA-QD----NPW--VINLH-EVYE-T-------------------------------------ASE--MI--LVLEY-AAGG--EIF-DQCVA---------------------DREE-----------------AF--KEKDVQRLMRQILEGVHFLHT-R-----DVVHLDLKPQNIL--LT---SESPLG------DIKIVDFGLSRI------------------------------------LKNSE-EL--------------RE---IMGTPEYVAPEI----LS------------------YDP--ISMATDMWSIGVLTYVMLT-GI-SP--------------FL-GN---------------DK-QETFL--NISQMNLSYSEEEF-D-V-LS-----------------------------------ESAVD-FIRTLLVKKPED--RAT-------AE-ECLKHPWL-------------------------------------------------------
-----------------------------ILT---SKELGRGKFAVV---RQCIS---K-----STGQ---EYAA-KFLKKRR-RG-Q---DC--R-A-EILH-------------------------EIAV-L-ELA-KS----CPR--VINLH-EVYE-N-------------------------------------TSE--II--LILEY-AAGG--EIF-SLCLP---------------------ELAE-----------------MV--SENDVIRLIKQILEGVYYLHQ-N-----NIVHLDLKPQNIL--LS---SIYPLG------DIKIVDFGMSRK------------------------------------IGHAC-EL--------------RE---IMGTPEYLAPEI----LN------------------YDP--ITTATDMWNIGIIAYMLLT-HT-SP--------------FV-GE---------------DN-QETYL--NISQVNVDYSEETF-S-S-VS-----------------------------------QLATD-FIQSLLVKNPEK--RPT-------AE-ICLSHSWL-------------------------------------------------------
--------------------------------FTKLEKIGKGSFGEV---FKGID---N-----RTQK---VVAI-KIIDLEE-AE-D---EI--E-D-IQ-Q-------------------------EITV-L-SQC--D----SPY--VTKYY-GSYL-K-------------------------------------DTK--LW--IIMEY-LGGG--SAL-DLLE------------------------PG-----------------PL--DETQIATILREILKGLDYLHS-E-----KKIHRDIKAANVL--LS---EHGEV---------KLADFGVAGQL-----------------------------------TDTQI-KR--------------NT---FVGTPFWMAPEV----IK------------------QSA--YDSKADIWSLGITAIELAR-GE-PP--------------HS-EL------------HPMKV-LFLIP--KNNPPTLEGNYS--------------------------------------------KPLKE-FVEACLNKEPSF--RPT-------AK-ELLKHKFI-------------------------------------------------------
-------------------------------F-TKLDRIGKGSFGEV---YKGID---N-----HTKE---VVAI-KIIDLEE-AE-D---EI--E-D-IQ-Q-------------------------EITV-L-SQC--D----SPY--ITRYF-GSYL-K-------------------------------------STK--LW--IIMEY-LGGG--SAL-DLLK------------------------PG-----------------PL--EETYIATILREILKGLDYLHS-E-----RKIHRDIKAANVL--LS---EQGDV---------KLADFGVAGQL-----------------------------------TDTQI-KR--------------NT---FVGTPFWMAPEV----IK------------------QSA--YDFKADIWSLGITAIELAK-GE-PP--------------NS-DL------------HPMRV-LFLIP--KNSPPTLEGQHS--------------------------------------------KPFKE-FVEACLNKDPRF--RPT-------AK-ELLKHKFI-------------------------------------------------------
--------------------------------FEILRAIGKGSFGKV---CIVQK---N-----DTKK---MYAM-KYMNKQK-CV-E---RN--E-V-RNVF------------------------KELQI-M-QGL--E----HPF--LVNLW-YSFQ-D-------------------------------------EED--MF--MVVDL-LLGG--DLR-YHLQ-----------------------QNV-----------------HF--KEETVKLFICELVMALDYLQN-Q-----RIIHRDMKPDNIL--LD---EHGHV---------HITDFNIAAM------------------------------------LPRET-QI--------------TT---MAGTKPYMAPEMF--SSR-----------------KGAG--YSFAVDWWSLGVTAYELLR-GR-RP--------------YH-IR------------SSTSS-KEIVH--TFETTVVTYPSAWS------------------------------------------QEMVS-LLKKLLEPNPDQ--RFS------QLS-DVQNFPY-M------------------------------------------------------
--------------------------------FQILRAIGKGSFGKV---CIVQK---R-----DTKK---MYAM-KYMNKQK-CI-E---RD--E-V-RNVF------------------------RELQI-M-QGL--E----HPF--LVNLW-YSFQ-D-------------------------------------EED--MF--MVVDL-LLGG--DLR-YHLQ-----------------------QNV-----------------HF--TEGTVKLYICELALALEYLQR-Y-----HIIHRDIKPDNIL--LD---EHGHV---------HITDFNIATV------------------------------------VKGAE-RA--------------SS---MAGTKPYMAPEV----FQVY-------------MDRGPG--YSYPVDWWSLGITAYELLR-GW-RP--------------YE-IH------------SVTPI-DEILN--MFKVERVHYSSTWC------------------------------------------KGMVA-LLRKLLTKDPES--RVS------SLH-DIQS----VPYL---------------------------------------------------
--------------------------------FQILRAIGKGSFGKV---CIVQK---R-----DTEK---MYAM-KYMNKQQ-CI-E---RD--E-V-RNVF------------------------RELEI-L-QEI--E----HVF--LVNLW-YSFQ-D-------------------------------------EED--MF--MVVDL-LLGG--DLR-YHLQ-----------------------QNV-----------------QF--SEDTVRLYICEMALALDYLRG-Q-----HIIHRDVKPDNIL--LD---ERGHA---------HLTDFNIATI------------------------------------IKDGE-RA--------------TA---LAGTKPYMAPEIFHSFVN-----------------GGTG--YSFEVDWWSVGVMAYELLR-GW-RP--------------YD-IH------------SSNAV-ESLVQ--LFSTVSVQYVPTWS------------------------------------------KEMVA-LLRKLLTVNPEH--RLS-------SL-Q-------DVQAAPA------------------------------------------------
--------------------------------YTFGRILGKGSFGIV---IEATD---K-----ETET---KWAI-KKVNKEK-AG-S---SA--V-K-LLER-------------------------EVNI-L-KSV--K----HEH--IIHLE-QVFE-T-------------------------------------PKK--MY--LVMEL-CEDG--ELK-EILD-----------------------RKG-----------------HF--SENETRWIIQSLASAIAYLHN-N-----DIVHRDLKLENIM--VK---SSLIDDNNEINLNIKVTDFGLAVKK----------------------------------QSRSEA-ML--------------QA---TCGTPIYMAPEV----IS------------------AHD--YSQQCDIWSIGVVMYMLLR-GE-PP--------------FL-AS---------------SE-EKLFE--LIRKGELHFENAVW-N-S-IS-----------------------------------DCAKS-VLKQLMKVDPAH--RIT-------AK-ELLDNQWL-------------------------------------------------------
--------------------------------YSLLAEIGRGSYGVV---YEAVA---G-----RSGA---RVAV-KKIRCDA-PE-N---VE--L----ALA-------------------------EFWA-L-TSLKRR----HQN--VVQFE-ECVL-QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY--LW--FVMEF-CEGG--DLN-QYVL------------------------SR-----------------RP--DPATNKSFMLQLTSAIAFLHK-N-----HIVHRDLKPDNIL--IT---ERSGTP------ILKVADFGLSKVCAGLAPRGK------------------EGNQDNKNVNVNKY-WL--------------SS---ACGSDFYMAPEV----WE-------------------GH--YTAKADIFALGIIIWAMIE-RI-TF--------------ID-SE------------TKKEL-LGTYI--KQGTEIVPVGEALL-E-N-PKMELHIPQ---------------------KRRTSMSEGIKQ-LLKDMLAANPQD--RPD-------AF-EL------ETRM---------------------------------------------------
--------------------------------YHVLEMIGEGSFGRV---YKGRR---K-----YSAQ---VVAL-KFIPKLG-RS-E---KE--L-R-NLQR-------------------------EIEI-M-RGL--R----HPN--IVHML-DSFE-T-------------------------------------DKE--VV--VVTDY-AEG---ELF-QILE-----------------------DDG-----------------KL--PEDQVQAIAAQLVSALYYLHS-H-----RILHRDMKPQNIL--LA---KGGGI---------KLCDFGFARAM-----------------------------------STNTM-VL--------------TS---IKGTPLYMSPEL----VE------------------ERP--YDHTADLWSVGCILYELAV-GT-PP--------------FY-AT---------------SI-FQLVS--LILKDPVRWPSTIS------------------------------------------PCFKN-FLQGLLTKDPRQ--RLS-------WP-DLLYHPFI-------------------------------------------------------
-------------------------------F-ESLKVIGRGAFGEV---RLVQK---K-----DTGH---VYAM-KILRKAD-ML-E---KE--Q-V-GHIR------------------------AERDI-L-VEA--D----SLW--VVKMF-YSFQ-D-------------------------------------KLN--LY--LIMEF-LPGG--DMM-TLLM-----------------------KKD-----------------TL--TEEETQFYIAETVLAIDSIHQ-L-----GFIHRDIKPDNLL--LD---SKGHV---------KLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQ-LA--------------FS---TVGTPDYIAPEV----FM------------------QTG--YNKLCDWWSLGVIMYEMLI-GY-PP--------------FC-SE---------------TP-QETYK--KVMNWKETLTFPPE-V-P-IS-----------------------------------EKAKD-LILRFCCEW--------------------------EHRIGAPGVEEIKSNSFF-------------------------------------
-------------------------------F-ESLKVIGRGAFGEV---RLVQK---K-----DTGH---IYAM-KILRKSD-ML-E---KE--Q-V-AHIR------------------------AERDI-L-VEA--D----GAW--VVKMF-YSFQ-D-------------------------------------KRN--LY--LIMEF-LPGG--DMM-TLLM-----------------------KKD-----------------TL--TEEETQFYISETVLAIDAIHQ-L-----GFIHRDIKPDNLL--LD---AKGHV---------KLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQ-LA--------------YS---TVGTPDYIAPEV----FM------------------QTG--YNKLCDWWSLGVIMYEMLI-GY-PP--------------FC-SE---------------TP-QETYR--KVMNWKETLVFPPE-V-P-IS-----------------------------------EKAKD-LILRFCI-DSEN--RIGN----SGVE-EIKGHPFF-------------------------------------------------------
-----------------------------WLL---SDILGQGATANV---FRGRH---K-----KTGD---LFAI-KVFNNIS-FL-R---PV--D-V-Q-MR-------------------------EFEV-L-KKL--N----HKN--IVKLF-AIEE-ET-----------------------------------TTRH--KV--LIMEF-CPCG--SLY-TVLEE--------------------PSNAY-----------------GL--PESEFLIVLRDVVGGMNHLRE-N-----GIVHRDIKPGNIMRVIG---EDGQSV-------YKLTDFGAARE------------------------------------LEDDE-QF--------------VS---LYGTEEYLHPDM----YERAV----------LRKDHQKK--YGATVDLWSIGVTFYHAAT-GS-LP--------------FR-PF-----------EGPRRN-KEVMY--KIITGKPSGAISGV-Q-K-AENGPIDWSGDM--------------PVSCSLSRGLQV----------------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY-
------------------------------YL--LLHLLGRGGFSEV---YKAFD---L-----TEQR---YVAV-KIHQLNK-NW-R---DE--K-K-ENYHKH--------------------ACREYRI-H-KEL--D----HPR--IVKLY-DYFS-L------------------------------------DTDS--FC--TVLEY-CEGN--DLD-FYLK-----------------------QHK-----------------LM--SEKEARSIIMQIVNALKYLNE-IK---PPIIHYDLKPGNIL--LV---NGTACG------EIKITDFGLSKIMDDD----------------------------SYNSVDGME-LT--------------SQ---GAGTYWYLPPEC----FVV--------------GKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KP--------------FG-HN-------------QSQQ-DILQE--NTILKATEVQFPPK-P-V-VT-----------------------------------PEAKA-FIRRCLAYRKED--RID-------VQ-QLACDPYL-------------------------------------------------------
---------------------------YLLGI-----NLGEGSYAKV---KSAYS---E-----RLKF---NVAI-KIIDRKK-AP-A---DF--L-E-KFLP------------------------REIEI-L-AML--N----HCS--IIKTY-EIFE-T------------------------------------SHGK--VY--IVMEL-AVQG--DLL-ELIK-----------------------TRG-----------------AL--HEDEARKKFHQLSLAIKYCHD-L-----DVVHRDLKCDNLL--LD---KDFNI---------KLSDFSFSKRCLR-------------------------------DDSGRMA-LS--------------KT---FCGSPAYAAPEV----LQ-----------------GIPY--QPKVYDIWSLGVILYIMVC-GS-MP--------------YD-DS---------------NI-KKMLR--IQKEHRVNFPRSKH-L-T--------------------------------------GECKD-LIYHMLQPDVNR--RLH-------ID-EILSHCWM-------------------------------------------------------
---------------------------YIVGI-----NLGKGSYAKV---KSAYS---E-----RLKF---NVAV-KIIDRKK-TP-T---DF--V-E-RF-LP-----------------------REMDI-L-ATV--N----HGS--IIKTY-EIFE-T------------------------------------SDGR--IY--IIMEL-GVQG--DLL-EFIK-----------------------CQG-----------------AL--HEDVARKMFRQLSSAVKYCHD-L-----DIVHRDLKCENLL--LD---KDFNI---------KLSDFGFSKRCLR-------------------------------DSNGRII-LS--------------KT---FCGSAAYAAPEV----LQ-----------------SIPY--QPKVYDIWSLGVILYIMVC-GS-MP--------------YD-DS---------------DI-RKMLR--IQKEHRVDFPRSKN-L-T--------------------------------------CECKD-LIYRMLQPDVSQ--RLH-------ID-EILSHSWL-------------------------------------------------------
------------------------------FI--LTERLGSGTYATV---YKAYA---KK----DTRE---VVAI-KCVAKKS-LN-K---AS--V-E-NLLT-------------------------EIEI-L-KGI--R----HPH--IVQLK-DFQW-D-------------------------------------SDN--IY--LIMEF-CAGG--DLS-RFIH-----------------------TRR-----------------IL--PEKVARVFMQQLASALQFLHE-R-----NISHLDLKPQNIL--LSS-LEKPHL---------KLADFGFAQH------------------------------------MSPWD-EK--------------HV---LRGSPLYMAPEM----VC------------------QRQ--YDARVDLWSMGVILYEALF-GQ-PP--------------FA-SR------------SFSEL-EEKIR--SNRVIELPLRPLLS------------------------------------------RDCRD-LLQRLLERDPSR--RIS-------FQ-DFFAHPWV-------------------------------------------------------
--------------------------------WTKGEILGKGAYGTV---YCGLT---S-----QGQ----LIAV-KQVALDT-SN-K---LA--A-E-KEYRKL---------------------QEEVDL-L-KAL--K----HVN--IVAYL-GTCL-Q-------------------------------------ENT--VS--IFMEF-VPGG--SIS-SIIN-----------------------RFG-----------------PL--PEMVFCKYTKQILQGVAYLHE-N-----CVVHRDIKGNNVM--LM---PTGII---------KLIDFGCARRLAWA-----------------------------GLNGTHSD-ML--------------KS---MHGTPYWMAPEV----IN------------------ESG--YGRKSDIWSIGCTVFEMAT-GK-PP--------------LA-SM--------------DRM-AAMFY--IGAHRGLMPPLPDH-F-S--------------------------------------ENAAD-FVRMCLTRDQHE--RPS-------AL-QLLKHSFL-------------------------------------------------------
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