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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
TK ABL1 261
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK1G 23
CAMK CAMK2A 13
CAMK CAMK2B 14
CAMK CAMK2D 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDK2 4
CMGC CDK4 6
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK DDR2 563
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
Other EIF2AK2 267
TK EPHB1 619
TK FER 563
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
TK HCK 241
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CAMK HUNK 61
CMGC ICK 4
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
STE MAP2K1 68
STE MAP2K3 64
STE MAP2K5 166
STE MAP2K6 53
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K7 36
TKL MAP3K9 144
CMGC MAPK10 64
CMGC MAPK9 26
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
AGC MAST1 374
TK MATK 235
TK MET 1078
CAMK MGC42105 74
TK MUSK 575
Other NEK2 8
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK3 268
CMGC PCTK1 165
CMGC PCTK3 172
AGC PDPK1 82
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
CMGC PRPF4B 687
AGC ROCK1 76
AGC ROCK2 92
AGC RPS6KA1 62
AGC RPS6KA3 68
AGC RPS6KA4 33
AGC RPS6KA5 49
AGC RPS6KA6 73
AGC RPS6KB1 91
Other SBK1 53
AGC SGK3 162
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
TK SRC 270
TK SRMS 230
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK25 20
CAMK STK33 116
Other STK35 202
Other TLK2 440
TK TNK2 150
Other TTK 525
Other ULK3 14
TK YES1 277
-----FELLKVLGQGSYGKV---FLVRK---V----------------K-G-SDAGQLYAMKVLKKA--TLK-V---RD-----R-V-RSKM-------------------------ERDIL-AEV--N------HPF-----IVKLHYAFQ--T-------------------------------------EGK------LYLILDFLRGG---DLFTRLS-----------------------KEV--------------------------MF---TEEDVKFYLAELALALDHLHS--L-----G---IIYRDLKPENILLD---E--------EG-HI-------------------KITDFGLSKEA--------------------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----------RRG--HTQSADWWSFGVLMFEMLT-GS--LP---------------FQ-GK--------------DR-KETM-AL----ILK---AKLGMPQFLS---------------------------------------------------------------------------GEAQS-LLRALFKRNPCN--RLGAGIDGVE-EIKRHPFF------------
-----ITMKHKLGGGQYGEV---YEGVW---K----------------K-Y-SL---TVAVKTLK-E--DTM-----EV-----E-E-FL-K-------------------------EAAVM-KEI--K------HPN-----LVQLLGVCT--R-------------------------------------EPP------FYIITEFMTYG---NLLDYLR------------------------EC----------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K-----N---FIHRDLAARNCLVG---E--------NH-LV-------------------KVADFGLSRLM--------------------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNK--FSIKSDVWAFGVLLWEIATYGM--SP---------------YP-GI-----------DLSQV-YELL-EK----DYR---MERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSD--RPS-----FA-EIHQA--F------------
-----FEIGRPLGKGKFGNV---YLARE---K----------------K-S-HF---IVALKVLFKS--QIE-K---EG-----V-E-HQLR------------------------REIEIQ-AHL--H------HPN-----ILRLYNYFY--D-------------------------------------RRR------IYLILEYAPRG---ELYKELQ-----------------------KSC--------------------------TF---DEQRTATIMEELADALMYCHG--K-----K---VIHRDIKPENLLLG---L--------KG-EL-------------------KIADFGWSV----------------------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRM--HNEKVDLWCIGVLCYELLV-GN--PP---------------FE-SA--------------SH-NETY-RR----IVK---VDLKFPASVP---------------------------------------------------------------------------MGAQD-LISKLLRHNPSE--RLP-----LA-QVSAHPWV------------
-----FEIGRPLGKGKFGNV---YLARL---K----------------E-S-HF---IVALKVLFKS--QIE-K---EG-----L-E-HQLR------------------------REIEIQ-AHL--Q------HPN-----ILRLYNYFH--D-------------------------------------ARR------VYLILEYAPRG---ELYKELQ-----------------------KSE--------------------------KL---DEQRTATIIEELADALTYCHD--K-----K---VIHRDIKPENLLLG---F--------RG-EV-------------------KIADFGWSV----------------------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRT--YDEKVDLWCIGVLCYELLV-GY--PP---------------FE-SA--------------SH-SETY-RR----ILK---VDVRFPLSMP---------------------------------------------------------------------------LGARD-LISRLLRYQPLE--RLP-----LA-QILKHPWV------------
----V-ALGKTLGEGEFGAV---MEGQL---N--------------QDD-S-IL---KVAVKTMK-I-AICT-----RSE---LE-D-FL-S-------------------------EAVCM-KEF--D------HPN-----VMRLIGVCF--Q-------------------------------------GSERESFPAPVVILPFMKHG---DLHSFLL------------------------YSRL------------------GDQP-VYL---PTQMLVKFMADIASGMEYLST--K-----R---FIHRDLAARNCMLN---E--------NM-SV-------------------CVADFGLSKKI----------Y---------N--GDYY--------------RQGRIAKMPVKWIAIESLA-----------DRV--YTSKSDVWSFGVTMWEIATRGQ--TP---------------YP-GV-----------ENSEI-YDYL-RQ----GNR---LKQPADCL-----------------------------------------------------------------------------DGLYA-LMSRCWELNPQD--RPS-----FT-ELREDL--------------
----L-RLVRKLGSGQFGEV---WMGYY---K------------------N-NM---KVAIKTLK-E--GTM-----SP-----E-A-FL-G-------------------------EANVM-KAL--Q------HER-----LVRLYAVVT----------------------------------------KEP------IYIVTEYMARG---CLLDFLK------------------------TD----------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M-----N---SIHRDLRAANILVS---E--------AL-CC-------------------KIADFGLARII-----------------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----------FGV--FTIKADVWSFGVLLMEVVTYGR--VP---------------YP-GM-----------SNPEV-IRNL-ER----GYR---MPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEE--RPT-----FE-FLQSV--L------------
-----YRLEKTLGKGQTGLV---KLGVH---C----------------I-T-GQ---KVAIKIVNRE--KLS-E---SV-----L-M-KVER-------------------------EIAIL-KLI--E------HPH-----VLKLHDVYE--N-------------------------------------KKY------LYLVLEHVSGG---ELFDYLV-----------------------KKG--------------------------RL---TPKEARKFFRQIVSALDFCHS--Y-----S---ICHRDLKPENLLLD---E--------KN-NI-------------------RIADFGMASL---------------------QVGDSLL--------------ET---SCGSPHYACPEVIK----------GEKY--DGRRADMWSCGVILFALLV-GA--LP---------------FD-DD--------------NL-RQLL-EK----VKR---GVFHMPHFIP---------------------------------------------------------------------------PDCQS-LLRGMIEVEPEK--RLS-----LE-QIQKHPW-Y-----------
-----YRLEKTLGKGQTGLV---KLGVH---C----------------V-T-CQ---KVAIKIVNRE--KLS-E---SV-----L-M-KVER-------------------------EIAIL-KLI--E------HPH-----VLKLHDVYE--N-------------------------------------KKY------LYLVLEHVSGG---ELFDYLV-----------------------KKG--------------------------RL---TPKEARKFFRQIISALDFCHS--H-----S---ICHRDLKPENLLLD---E--------KN-NI-------------------RIADFGMASL---------------------QVGDSLL--------------ET---SCGSPHYACPEVIR----------GEKY--DGRKADVWSCGVILFALLV-GA--LP---------------FD-DD--------------NL-RQLL-EK----VKR---GVFHMPHFIP---------------------------------------------------------------------------PDCQS-LLRGMIEVDAAR--RLT-----LE-HIQKHIW-Y-----------
---FI--FMEVLGSGAFSEV---FLVKQ---R----------------L-T-GK---LFALKCIKKS--PAF-R---DS-----S-L-E--N-------------------------EIAVL-KKI--K------HEN-----IVTLEDIYE--S-------------------------------------TTH------YYLVMQLVSGG---ELFDRIL-----------------------ERG--------------------------VY---TEKDASLVIQQVLSAVKYLHE--N-----G---IVHRDLKPENLLYLTPEE--------NS-KI-------------------MITDFGLSK----------------------MEQNGIM--------------ST---ACGTPGYVAPEVLA-----------QKP--YSKAVDCWSIGVITYILLC-GY--PP---------------FY-EE--------------TE-SKLF-EK----IKE---GYYEFESPFWDDIS-----------------------------------------------------------------------ESAKD-FICHLLEKDPNE--RYT-----CE-KALSHPWI------------
-----YQLFEELGKGAFSVV---RRCVK---V----------------L-A-GQ---EYAAKIINTK--KLS-A---RD-----H-Q-KLER-------------------------EARIC-RLL--K------HPN-----IVRLHDSIS--E-------------------------------------EGH------HYLIFDLVTGG---ELFEDIV-----------------------ARE--------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----G---VVHRDLKPENLLLA---S--------KL-KGA----------------AVKLADFGLAIEV--------------------EGEQQAW--------------FG---FAGTPGYLSPEVLR-----------KDP--YGKPVDLWACGVILYILLV-GY--PP---------------FW-DE--------------DQ-HRLY-QQ----IKA---GAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPSK--RIT-----AA-EALKHPWI------------
-----YQLYEDIGKGAFSVV---RRCVK---L----------------C-T-GH---EYAAKIINTK--KLS-A---RD-----H-Q-KLER-------------------------EARIC-RLL--K------HSN-----IVRLHDSIS--E-------------------------------------EGF------HYLVFDLVTGG---ELFEDIV-----------------------ARE--------------------------YY---SEADASHCIQQILEAVLHCHQ--M-----G---VVHRDLKPENLLLA---S--------KC-KGA----------------AVKLADFGLAIEV--------------------QGDQQAW--------------FG---FAGTPGYLSPEVLR-----------KEA--YGKPVDIWACGVILYILLV-GY--PP---------------FW-DE--------------DQ-HKLY-QQ----IKA---GAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKN-LINQMLTINPAK--RIT-----AH-EALKHPWV------------
-----YQLFEELGKGAFSVV---RRCMK---I----------------P-T-GQ---EYAAKIINTK--KLS-A---RD-----H-Q-KLER-------------------------EARIC-RLL--K------HPN-----IVRLHDSIS--E-------------------------------------EGF------HYLVFDLVTGG---ELFEDIV-----------------------ARE--------------------------YY---SEADASHCIQQILESVNHCHL--N-----G---IVHRDLKPENLLLA---S--------KS-KGA----------------AVKLADFGLAIEV--------------------QGDQQAW--------------FG---FAGTPGYLSPEVLR-----------KDP--YGKPVDMWACGVILYILLV-GY--PP---------------FW-DE--------------DQ-HRLY-QQ----IKA---GAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPAK--RIT-----AS-EALKHPWI------------
-----YKLQSEIGKGAYGVV---RLAYN---E----------------S-E-DR---HYAMKVLSKK--KLL-K---QY-----G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAIL-KKL--D------HVN-----VVKLIEVLD--DP-----------------------------------AEDN------LYLVFDLLRKG---PVMEVPC------------------------DK--------------------------PF---SEEQARLYLRDVILGLEYLHC--Q-----K---IVHRDIKPSNLLLG---D--------DG-HV-------------------KIADFGVSNQF--------------------EGNDAQL--------------SS---TAGTPAFMAPEAISD--------SGQSF--SGKALDVWATGVTLYCFVY-GK--CP---------------FI-DD--------------FI-LALH-RK----IKN---EPVVFPEEPEIS-------------------------------------------------------------------------EELKD-LILKMLDKNPET--RIG-----VP-DIKLHPWV------------
-----YTLKDEIGKGSYGVV---KLAYN---E----------------N-D-NT---YYAMKVLSKK--KLI-R---QA-----G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL-KKL--D------HPN-----VVKLVEVLD--DP-----------------------------------NEDH------LYMVFELVNQG---PVMEVPT------------------------LK--------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q-----K---IIHRDIKPSNLLVG---E--------DG-HI-------------------KIADFGVSNEF--------------------KGSDALL--------------SN---TVGTPAFMAPESLS----------ETRKIFSGKALDVWAMGVTLYCFVF-GQ--CP---------------FM-DE--------------RI-MCLH-SK----IKS---QALEFPDQPDIA-------------------------------------------------------------------------EDLKD-LITRMLDKNPES--RIV-----VP-EIKLHPWV------------
-----FQKVEKIGEGTYGVV---YKARN---K----------------L-T-GE---VVALKKIRLD--TET-E---GV-----P-S-TAIR-------------------------EISLL-KEL--N------HPN-----IVKLLDVIH--T-------------------------------------ENK------LYLVFEFLHQ----DLKKFMDA---------------------SALT--------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----R---VLHRDLKPQNLLIN---T--------EG-AI-------------------KLADFGLARAF--------------------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKY--YSTAVDIWSLGCIFAEMVT-RR--AL---------------FP-GD-----------SEIDQ-LFRI-FR----TLG---TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-----AK-AALAHPFF------------
----Y-EPVAEIGVGAYGTV---YKARD---P----------------H-S-GH---FVALKSVRVP--NGG-GGGGGL-----P-I-STVR-------------------------EVALL-RRL--EA---FEHPN-----VVRLMDVCA--TSR--------------------------------TDREIK------VTLVFEHVDQ----DLRTYLDK---------------------APPP--------------------------GL---PAETIKDLMRQFLRGLDFLHA--N-----C---IVHRDLKPENILVT---S--------GG-TV-------------------KLADFGLARI---------------------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QST--YATPVDMWSVGCIFAEMFR-RK--PL---------------FC-GN-----------SEADQ-LGKI-FD----LIG---LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RIS-----AF-RALQHSYL------------
-----YENLGLVGEGSYGMV---MKCRN---K----------------D-T-GR---IVAIKKFLES--DDD-K---MV-----K-K-IAMR-------------------------EIKLL-KQL--R------HEN-----LVNLLEVCK--K-------------------------------------KKR------WYLVFEFVDHT---ILDDLEL-----------------------FPN--------------------------GL---DYQVVQKYLFQIINGIGFCHS--H-----N---IIHRDIKPENILVS---Q--------SG-VV-------------------KLCDFGFARTL--------------------AAPGEVY--------------TD---YVATRWYRAPELLV----------GDVK--YGKAVDVWAIGCLVTEMFM-GE--PL---------------FP-GD-----------SDIDQ-LYHI-MM----CLG---NLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDK--RPF-----CA-ELLHHDFF------------
----W-DLVQTLGEGAYGEV---QLAVN---R----------------V-T-EE---AVAVKIVDMK--RAV-D---CP-----E-N-I-KK-------------------------EICIN-KML--N------HEN-----VVKFYGHRR--E-------------------------------------GNI------QYLFLEYCSGG---ELFDRIE-----------------------PDI--------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I-----G---ITHRDIKPENLLLD---E--------RD-NL-------------------KISDFGLATVFR------------------YNNRERLL--------------NK---MCGTLPYVAPELLK----------RREF--HAEPVDVWSCGIVLTAMLA-GE--LP---------------WD-QP-------------SDS-CQEY-SD----WKE---KKTYLNPWKKI--D-----------------------------------------------------------------------SAPLA-LLHKILVENPSA--RIT-----IP-DIKKDRW-Y-----------
---YI--MSKTLGSGACGEV---KLAFE---R----------------K-T-CK---KVAIKIISKR--KFA-I---GS-----A-R-EADPALN-------------------VETEIEIL-KKL--N------HPC-----IIKIKNFF---D-------------------------------------AED------YYIVLELMEGG---ELFDKVV-----------------------GNK--------------------------RL---KEATCKLYFYQMLLAVQYLHE--N-----G---IIHRDLKPENVLLS---S--------QE-EDC----------------LIKITDFGHSKI---------------------LGETSLM--------------RT---LCGTPTYLAPEVLVS--------VGTAG--YNRAVDCWSLGVILFICLS-GY--PP---------------FS-EH-------------RTQ-VSLK-DQ----ITS---GKYNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKA--RFT-----TE-EALRHPWL------------
----W-EMRERLGTGGFGNV---CLYQH---R----------------E-L-DL---KIAIKSCRLE--LST-K---NR-----E-R--WCH-------------------------EIQIM-KKL--N------HAN-----VVKACDVPE--ELN--------------------------------ILIHDV------PLLAMEYCSGG---DLRKLLNK--------------------PENCC--------------------------GL---KESQILSLLSDIGSGIRYLHE--N-----K---IIHRDLKPENIVLQ---D--------VG-GKI----------------IHKIIDLGYAKD---------------------VDQGSLC--------------TS---FVGTLQYLAPELFE-----------NKP--YTATVDYWSFGTMVFECIA-GY--RP---------------FL-HHLQPFTWHEKIKKKDPK-CIFA-CE----EMS---GEVRFSSHLPQPNSLCS-----------------------------------------------------------------LVVEPMEN-WLQLMLNWDPQQ--RG-----------------GPVDLTLKQ---
-----YEIVDTLGEGAFGKV---VECID---H----------------K-AGGR---HVAVKIVKNV--DRY-C---EA-----A-R-S----------------------------EIQVL-EHL--NT----TDPNST-FRCVQMLEWFE--H-------------------------------------HGH------ICIVFELLGL----STYDFIK-----------------------ENG--------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--N-----K---LTHTDLKPENILFV---Q--------SD-YTEAYNPKIKRDERTLINPDIKVVDFGSA-----------------------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GF--TV---------------FP-TH-----------DSKEH-LAMM-ER----ILG---PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY----------------------------------VSRRCKPLKEFMLSQDVEHERLFD-LIQKMLEYDPAK--RIT-----LR-EALKHPFF------------
-----YEIVSTLGEGTFGRV---VQCVD---H----------------R-R-GG--ARVALKIIKNV--EKY-K---EA-----A-R----L-------------------------EINVL-EKI--NEK-DPDNKN----LCVQMFDWFD--Y-------------------------------------HGH------MCISFELLGL----STFDFLK-----------------------DNN--------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--N-----K---LTHTDLKPENILFV---N--------SD-YELTYNLEKKRDERSVKSTAVRVVDFGSAT-----------------------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELG--WSQPCDVWSIGCIIFEYYV-GF--TL---------------FQ-TH-----------DNREH-LAMM-ER----ILG---PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAK--RLT-----LG-EALQHPFF------------
-----YEIVDTLGEGAFGKV---VECID---H----------------GMD-GM---HVAVKIVKNV--GRY-R---EA-----A-R-S----------------------------EIQVL-EHL--NS----TDPNSV-FRCVQMLEWFD--H-------------------------------------HGH------VCIVFELLGL----STYDFIK-----------------------ENS--------------------------FLP-FQIDHIRQMAYQICQSINFLHH--N-----K---LTHTDLKPENILFV---K--------SD-YVVKYNSKMKRDERTLKNTDIKVVDFGSA-----------------------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GF--TV---------------FQ-TH-----------DSKEH-LAMM-ER----ILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY----------------------------------VRRRCKPLKEFMLCHDEEHEKLFD-LVRRMLEYDPTQ--RIT-----LD-EALQHPFF------------
-----YQLVRKLGRGKYSEV---FEAIN---I----------------T-N-NE---KVVVKILKPV--KKK-K---IK-----R--------------------------------EIKIL-ENL-RG------GPN-----IITLADIVK--DP-----------------------------------VSRT------PALVFEHVNNT---DFKQLY--------------------------Q--------------------------TL---TDYDIRFYMYEILKALDYCHS--M-----G---IMHRDVKPHNVMID--HE--------HR-KL-------------------RLIDWGLAEF---------------------YHPGQEY--------------NV---RVASRYFKGPELLV----------DYQM--YDYSLDMWSLGCMLASMIF-RK--EP---------------FFHGH-----------DNYDQ-LVRI-AK----VLG---TEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQS--RLT-----AR-EAMEHPYF------------
-----YQLVRKLGRGKYSEV---FEAIN---I----------------T-N-NE---RVVVKILKPV--KKK-K---IK-----R--------------------------------EVKIL-ENL-RG------GTN-----IIKLIDTVK--DP-----------------------------------VSKT------PALVFEYINNT---DFKQLY--------------------------Q--------------------------IL---TDFDIRFYMYELLKALDYCHS--K-----G---IMHRDVKPHNVMID--HQ--------QK-KL-------------------RLIDWGLAEF---------------------YHPAQEY--------------NV---RVASRYFKGPELLV----------DYQM--YDYSLDMWSLGCMLASMIF-RR--EP---------------FFHGQ-----------DNYDQ-LVRI-AK----VLG---TEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQ--RLT-----AK-EAMEHPYF------------
-----YDTGEELGSGQFAVV---KKCRE---K----------------S-T-GL---QYAAKFIKKR--RTK-S---SR-----R-G-VSREDI---------------------EREVSIL-KEI--Q------HPN-----VITLHEVYE--N-------------------------------------KTD------VILILELVAGG---ELFDFLA-----------------------EKE--------------------------SL---TEEEATEFLKQILNGVYYLHS--L-----Q---IAHFDLKPENIMLL---D--------RN-VPKP---------------RIKIIDFGLAHK---------------------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GA--SP---------------FL-GD--------------TK-QETL-AN----VSA---VNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKD-FIRRLLVKDPKK--RMT-----IQ-DSLQHPWI------------
-----YDIGEELGSGQFAIV---KKCRE---K----------------S-T-GL---EYAAKFIKKR--QSR-A---SR-----R-G-VSREEI---------------------EREVSIL-RQV--L------HHN-----VITLHDVYE--N-------------------------------------RTD------VVLILELVSGG---ELFDFLA-----------------------QKE--------------------------SL---SEEEATSFIKQILDGVNYLHT--K-----K---IAHFDLKPENIMLL---D--------KN-IPIP---------------HIKLIDFGLAHE---------------------IEDGVEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GA--SP---------------FL-GD--------------TK-QETL-AN----ITA---VSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKD-FIRKLLVKETRK--RLT-----IQ-EALRHPWI------------
-----YEMGEELGSGQFAIV---RKCRQ---K----------------G-T-GK---EYAAKFIKKR--RLS-S---SR-----R-G-VSREEI---------------------EREVNIL-REI--R------HPN-----IITLHDIFE--N-------------------------------------KTD------VVLILELVSGG---ELFDFLA-----------------------EKE--------------------------SL---TEDEATQFLKQILDGVHYLHS--K-----R---IAHFDLKPENIMLL---D--------KN-VPNP---------------RIKLIDFGIAHK---------------------IEAGNEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GA--SP---------------FL-GE--------------TK-QETL-TN----ISA---VNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKR--RMT-----IA-QSLEHSWI------------
-----LTFKEKLGEGQFGEV---HLCEV---EGMEKFKDKDFALDVSAN-Q-PV---LVAVKMLR-A--DAN-----KNA---RN-D-FL-K-------------------------EIKIM-SRL--K------DPN-----IIHLLAVCI--T-------------------------------------DDP------LCMITEYMENG---DLNQFLS------------------------RHEPPN--------------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L-----N---FVHRDLATRNCLVG---K--------NY-TI-------------------KIADFGMSRNL----------Y---------S--GDYY--------------RIQGRAVLPIRWMSWESIL-----------LGK--FTTASDVWAFGVTLWETFTFCQE-QP---------------YS-QL-----------SDEQV-IENT-GEFFRDQGRQTYLPQPAICP-----------------------------------------------------------------------------DSVYK-LMLSCWRRDTKN--RPS-----FQ-EIHL---LL-----------
-----YEIDSLIGKGSFGQV---VKAYD---R----------------V-E-QE---WVAIKIIKNK--KAF-L---NQ-----A-Q-I----------------------------EVRLL-ELM-NK------HDTEMKYYIVHLKRHFM--F-------------------------------------RNH------LCLVFEMLSY----NLYDLLR------------------------NT--------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL-----S---IIHCDLKPENILLCN-PK--------RS-AI-------------------KIVDFGSSCQ-----------------------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GMP--YDLAIDMWSLGCILVEMHT-GE--PL---------------FS-GA-----------NEVDQ-MNKI-VE----VLG---IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKT--RIQ-----PY-YALQHSFF------------
-----YEIDSLIGKGSFGQV---VKAYD---H----------------Q-T-QE---LVAIKIIKNK--KAF-L---NQ-----A-Q-I----------------------------ELRLL-ELM-NQ------HDTEMKYYIVHLKRHFM--F-------------------------------------RNH------LCLVFELLSY----NLYDLLR------------------------NT--------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL-----S---IIHCDLKPENILLCN-PK--------RS-AI-------------------KIVDFGSSCQ-----------------------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GTP--YDLAIDMWSLGCILVEMHT-GE--PL---------------FS-GS-----------NEVDQ-MNRI-VE----VLG---IPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAA--RIS-----PL-GALQHGFF------------
-----YEVLKVIGKGSFGQV---VKAYD---H----------------K-V-HQ---HVALKMVRNE--KRF-H---RQ-----A-A-E----------------------------EIRIL-EHL--RKQDKDNTMN-----VIHMLENFT--F-------------------------------------RNH------ICMTFELLSM----NLYELIKK---------------------NKFQ--------------------------GF---SLPLVRKFAHSILQCLDALHK--N-----R---IIHCDLKPENILLK---Q--------QG-RSG-----------------IKVIDFGSSC-----------------------YEHQRV--------------YT---YIQSRFYRAPEVIL-----------GAR--YGMPIDMWSLGCILAELLT-GY--PL---------------LP-GE-----------DEGDQ-LACM-IE----LLG---MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAV--RMT-----PG-QALRHPWL------------
----F-KEIELIGSGGFGQV---FKAKH---R----------------I-D-GK---TYVIKRVKYN--NEK-A---ER--------------------------------------EVKAL-AKL--D------HVN-----IVHYNGCWD--GFDYDPETSDDSLES--------SDYDPENSKNSSRSKTKC------LFIQMEFCDKG---TLEQWIEK---------------------RRGE--------------------------KL---DKVLALELFEQITKGVDYIHS--K-----K---LIHRDLKPSNIFLV---D--------TK-QV-------------------KIGDFGLVTS---------------------LKNDGKR--------------TR---SKGTLRYMSPEQIS-----------SQD--YGKEVDLYALGLILAELLH-VC-DTA---------------FE-T-------------------SKF-FT----DLR---DGIISDIFDK----------------------------------------------------------------------------KEKT-LLQKLLSKKPED--RPN-----TS-EILR----TLT---------
----V-KIEEVIGAGEFGEV---YKGRL---K-------------LPGK-R-EI---YVAIKTLK-A--GYS-----EKQ---RR-D-FL-S-------------------------EASIM-GQF--D------HPN-----IIRLEGVVT--K-------------------------------------SRP------VMIITEFMENG---ALDSFLR------------------------QN-----------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M-----N---YVHRDLAARNILVN---S--------NL-VC-------------------KVSDFGLSRYLQ-------DDT---------S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----------YRK--FTSASDVWSYGIVMWEVMSFGE--RP---------------YW-DM-----------SNQDV-INAI-EQ----DYR---LPPPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNS--RPR-----FA-EIVNTL--------------
---VI--LGELLGKGNFGEV---YKGTL---K------------------D-KT---SVAVKTCK-E--DLP-----QEL---KI-K-FL-Q-------------------------EAKIL-KQY--D------HPN-----IVKLIGVCT--Q-------------------------------------RQP------VYIIMELVSGG---DFLTFLR------------------------RK-----------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K-----N---CIHRDLAARNCLVG---E--------NN-VL-------------------KISDFGMSRQE--------------------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----------YGR--YSSESDVWSFGILLWETFSLGV--CP---------------YP-GM-----------TNQQA-REQV-ER----GYR---MSAPQHCP-----------------------------------------------------------------------------EDISK-IMMKCWDYKPEN--RPK-----FS-ELQKEL--------------
----L-VLGKPLGEGCFGQV---VLAEA---IGL---------DKDKPN-R-VT---KVAVKMLK-S--DAT-----EKD---LS-D-LI-S-------------------------EMEMM-KMIG-K------HKN-----IINLLGACT--Q-------------------------------------DGP------LYVIVEYASKG---NLREYLQ------------------------ARRPPGLEY--------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K-----K---CIHRDLAARNVLVT---E--------DN-VM-------------------KIADFGLARDI----------H---------H--IDYY--------------KKTTNGRLPVKWMAPEALF-----------DRI--YTHQSDVWSFGVLLWEIFTLGG--SP---------------YP-GV-----------PVEEL-FKLL-KE----GHR---MDKPSNCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-----FK-QLVEDL--------------
-----LTLGKPLGEGCFGQV---VMAEA---VGI---------DKDKPK-E-AV---TVAVKMLK-D--DAT-----EKD---LS-D-LV-S-------------------------EMEMM-KMIG-K------HKN-----IINLLGACT--Q-------------------------------------DGP------LYVIVEYASKG---NLREYLR------------------------ARRPPGMEY--------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q-----K---CIHRDLAARNVLVT---E--------NN-VM-------------------KIADFGLARDI----------N---------N--IDYY--------------KKTTNGRLPVKWMAPEALF-----------DRV--YTHQSDVWSFGVLMWEIFTLGG--SP---------------YP-GI-----------PVEEL-FKLL-KE----GHR---MDKPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-----FK-QLVEDL--------------
-----LTLGKPLGEGCFGQV---VMAEA---IGI---------DKDRAA-K-PV---TVAVKMLK-D--DAT-----DKD---LS-D-LV-S-------------------------EMEMM-KMIG-K------HKN-----IINLLGACT--Q-------------------------------------GGP------LYVLVEYAAKG---NLREFLR------------------------ARRPPGLDY--------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q-----K---CIHRDLAARNVLVT---E--------DN-VM-------------------KIADFGLARDV----------H---------N--LDYY--------------KKTTNGRLPVKWMAPEALF-----------DRV--YTHQSDVWSFGVLLWEIFTLGG--SP---------------YP-GI-----------PVEEL-FKLL-KE----GHR---MDKPANCT-----------------------------------------------------------------------------HDLYM-IMRECWHAAPSQ--RPT-----FK-QLVEDL--------------
----L-VLGKPLGEGCFGQV---VRAEA---FGM---------DPARPD-Q-AS---TVAVKMLK-D--NAS-----DKD---LA-D-LV-S-------------------------EMEVM-KLIG-R------HKN-----IINLLGVCT--Q-------------------------------------EGP------LYVIVECAAKG---NLREFLR------------------------ARRPPGPDL--------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R-----K---CIHRDLAARNVLVT---E--------DN-VM-------------------KIADFGLARGV----------H---------H--IDYY--------------KKTSNGRLPVKWMAPEALF-----------DRV--YTHQSDVWSFGILLWEIFTLGG--SP---------------YP-GI-----------PVEEL-FSLL-RE----GHR---MDRPPHCP-----------------------------------------------------------------------------PELYG-LMRECWHAAPSQ--RPT-----FK-QLVEAL--------------
-----ITLERRLGTGCFGDV---WLGTW---N------------------G-ST---KVAVKTLK-P--GTM-----SP-----K-A-FL-E-------------------------EAQVM-KLL--R------HDK-----LVQLYAVVS----------------------------------------EEP------IYIVTEFMCHG---SLLDFLK------------------------NP----------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M-----N---YIHRDLRAANILVG---E--------RL-AC-------------------KIADFGLARLI--------------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----------FGR--FTIKSDVWSFGILLTELITKGR--IP---------------YP-GM-----------NKREV-LEQV-EQ----GYH---MPCPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEE--RPT-----FE-YLQSFL--------------
-----IQLLKRLGSGQFGEV---WEGLW---N------------------N-TT---PVAVKTLK-P--GSM-----DP-----N-D-FL-R-------------------------EAQIM-KNL--R------HPK-----LIQLYAVCT--L-------------------------------------EDP------IYIITELMRHG---SLQEYLQ------------------------ND----------------------TG-SKI---HLTQQVDMAAQVASGMAYLES--R-----N---YIHRDLAARNVLVG---E--------HN-IY-------------------KVADFGLARVFK--------VD---------N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----------SNK--FSIKSDVWSFGILLYEIITYGK--MP---------------YS-GM-----------TGAQV-IQML-AQ----NYR---LPQPSNCP-----------------------------------------------------------------------------QQFYN-IMLECWNAEPKE--RPT-----FE-TLRWK--L------------
-----LQLIKRLGNGQFGEV---WMGTW---N------------------G-NT---KVAIKTLK-P--GTM-----SP-----E-S-FL-E-------------------------EAQIM-KKL--K------HDK-----LVQLYAVVS----------------------------------------EEP------IYIVTEYMNKG---SLLDFLK------------------------DG----------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M-----N---YIHRDLRSANILVG---N--------GL-IC-------------------KIADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELVTKGR--VP---------------YP-GM-----------NNREV-LEQV-ER----GYR---MPCPQDCP-----------------------------------------------------------------------------ISLHE-LMIHCWKKDPEE--RPT-----FE-YLQSFL--------------
-FLDF----RVLGKGGFGEV---SACQM---K----------------A-T-GK---LYACKKLNKK--RLK-K---RK-----G-Y-QGAM------------------------VEKKIL-MKV--H------SRF-----IVSLAYAFE--T-------------------------------------KAD------LCLVMTIMNGG---DIRYHIYNV-------------------NEENP--------------------------GF---PEPRALFYTAQIICGLEHLHQ--R-----R---IVYRDLKPENVLLD---N--------DG-NV-------------------RISDLGLAVEL--------------------LDGQSKT--------------KG---YAGTPGFMAPELLQ-----------GEE--YDFSVDYFALGVTLYEMIA-AR--GP---------------FR-AR----------GEKVEN-KELK-HR----IIS---EPVKYPDKFS---------------------------------------------------------------------------QASKD-FCEALLEKDPEK--RLG-----FR-D-------ETCDKLRAHPLF
---FR--HYRVLGKGGFGEV---CACQV---R----------------A-T-GK---MYACKKLQKK--RIK-K---RK-----G-E-AMAL------------------------NEKRIL-EKV--Q------SRF-----VVSLAYAYE--T-------------------------------------KDA------LCLVLTIMNGG---DLKFHIYN---------------------LGNP--------------------------GF---DEQRAVFYAAELCCGLEDLQR--E-----R---IVYRDLKPENILLD---D--------RG-HI-------------------RISDLGLATE---------------------IPEGQRV--------------RG---RVGTVGYMAPEVVN-----------NEK--YTFSPDWWGLGCLIYEMIQ-GH--SP---------------FK-KY-----------KEKVK-WEEV-DQ----RIK---NDTEEYSE---KFS-----------------------------------------------------------------------EDAKS-ICRMLLTKNPSK--RLGCRGEGAA-GVKQHPV-F-----------
----F-TEFRVLGKGGFGEV---CAVQV---K----------------N-T-GK---MYACKKLDKK--RLK-K---KG-----G-E-KMAL------------------------LEKEIL-EKV--S------SPF-----IVSLAYAFE--S-------------------------------------KTH------LCLVMSLMNGG---DLKFHIYN---------------------VGTR--------------------------GL---DMSRVIFYSAQIACGMLHLHE--L-----G---IVYRDMKPENVLLD---D--------LG-NC-------------------RLSDLGLAVE---------------------MKGGKPI--------------TQ---RAGTNGYMAPEILM----------EKVS--YSYPVDWFAMGCSIYEMVA-GR--TP---------------FK-DY----------KEKVSK-EDLK-QR----TLQ---DEVKFQHDNF---T-----------------------------------------------------------------------EEAKD-ICRLFLAKKPEQ--RLG-----SR-E-------KSDDPR------
-----LKLEKKLGAGQFGEV---WMATY---N------------------K-HT---KVAVKTMK-P--GSM-----SV-----E-A-FL-A-------------------------EANVM-KTL--Q------HDK-----LVKLHAVVT----------------------------------------KEP------IYIITEFMAKG---SLLDFLK------------------------SD----------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R-----N---YIHRDLRAANILVS---A--------SL-VC-------------------KIADFGLARVI--------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGS--FTIKSDVWSFGILLMEIVTYGR--IP---------------YP-GM-----------SNPEV-IRAL-ER----GYR---MPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEE--RPT-----FE-YIQSV--L------------
-----YEVLEFLGRGTFGQV---AKCWK---R----------------S-T-KE---IVAIKILKNH--PSY-A---RQ-----G-Q-I----------------------------EVSIL-SRL--S------SENADEYNFVRSYECFQ--H-------------------------------------KNH------TCLVFEMLEQ----NLYDFLKQ---------------------NKFS--------------------------PL---PLKYIRPILQQVATALMKLKS--L-----G---LIHADLKPENIMLV---D--------PV-RQPY---------------RVKVIDFGSAS----------------------HVSKAVC--------------ST---YLQSRYYRAPEIIL-----------GLP--FCEAIDMWSLGCVIAELFL-GW--PL---------------YP-GA-----------SEYDQ-IRYI-SQ----TQG---LPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID-LLKKMLTIDADK--RIT-----PL-KTLNHQFV------------
-----YEVLEFLGRGTFGQV---VKCWK---R----------------G-T-NE---IVAIKILKNH--PSY-A---RQ-----G-Q-I----------------------------EVSIL-ARL--STE-SADDYN-----FVRAYECFQ--H-------------------------------------KNH------TCLVFEMLEQ----NLYDFLKQ---------------------NKFS--------------------------PL---PLKYIRPVLQQVATALMKLKS--L-----G---LIHADLKPENIMLV---D--------PS-RQPY---------------RVKVIDFGSAS----------------------HVSKAVC--------------ST---YLQSRYYRAPEIIL-----------GLP--FCEAIDMWSLGCVIAELFL-GW--PL---------------YP-GA-----------SEYDQ-IRYI-SQ----TQG---LPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID-LLKKMLTIDADK--RIT-----PI-ETLNHPFV------------
-----YEVLDFLGRGTFGQV---VKCWK---R----------------G-T-NE---IVAIKILKNH--PSY-A---RQ-----G-Q-I----------------------------EVSIL-ARL--S------TENADEYNFVRAYECFQ--H-------------------------------------RNH------TCLVFEMLEQ----NLYDFLKQ---------------------NKFS--------------------------PL---PLKVIRPILQQVATALKKLKS--L-----G---LIHADLKPENIMLV---D--------PV-RQPY---------------RVKVIDFGSAS----------------------HVSKTVC--------------ST---YLQSRYYRAPEIIL-----------GLP--FCEAIDMWSLGCVIAELFL-GW--PL---------------YP-GA-----------LEYDQ-IRYI-SQ----TQG---LPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVS-LLKKMLLIDADL--RIT-----PA-ETLNHPFV------------
-----YDIIEVLGKGTFGEV---AKGWR---R----------------S-T-GE---MVAIKILKND--AYR-N---RI-----I-K-N----------------------------ELKLL-HCM--RGL-DPEEAH-----VIRFLEFFH--D-------------------------------------ALK------FYLVFELLEQ----NLFEFQK------------------------EN--------------------------NFAPLPARHIRTVTLQVLTALARLKE--L-----A---IIHADLKPENIMLV---D--------QT-RCPF---------------RVKVIDFGSASIF--------------------SEVRYVK--------------EP---YIQSRFYRAPEILL-----------GLP--FCEKVDVWSLGCVMAELHL-GW--PL---------------YP-GN-----------NEYDQ-VRYI-CE----TQG---LPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHE--RIS-----PS-AALRHPFV------------
--IGS----RKLGEGSFAKV---REGLH---V----------------L-T-GE---KVAIKVIDKK--RAK-K---DT-----Y-V-TKNLR-----------------------REGQIQ-QMI--R------HPN-----ITQLLDILE--T-------------------------------------ENS------YYLVMELCPGG---NLMHKIY-----------------------EKK--------------------------RL---EESEARRYIRQLISAVEHLHR--A-----G---VVHRDLKIENLLLD---E--------DN-NI-------------------KLIDFGLSNCAG------------------ILGYSDPF--------------ST---QCGSPAYAAPELLA-----------RKK--YGPKIDVWSIGVNMYAMLT-GT--LP---------------FT-VE------------PFSL-RALY-QK----MVD----KEMNPLPTQ--LS-----------------------------------------------------------------------TGAIS-FLRSLLEPDPVK--RPN-----IQ-QALANRWL------------
-----YTTIRQLGDGTYGSV---LLGRS---I----------------E-S-GE---LIAIKKMKRK--FYS-W---EE-----C---MNLR-------------------------EVKSL-KKL--N------HAN-----VVKLKEVIR--E-------------------------------------NDH------LYFIFEYMKE----NLYQLIK----------------------ERNK--------------------------LF---PESAIRNIMYQILQGLAFIHK--H-----G---FFHRDLKPENLLCM---G--------PE-LV-------------------KIADFGLARE---------------------IRSKPPY--------------TD---YVSTRWYRAPEVLL----------RSTN--YSSPIDVWAVGCIMAEVYT-LR--PL---------------FP-GA-----------SEIDT-IFKI-CQ----VLG---TPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKK--RPT-----AS-QALRYPYF------------
--VGG----NKMGEGGFGVV---YKGYV---N----------------N-T-T-----VAVKKLAAM--VDI-T---TE-----ELK-QQFD------------------------QEIKVM-AKC--Q------HEN-----LVELLGFSS--D-------------------------------------GDD------LCLVYVYMPNG---SLLDRLSC--------------------LDGTP--------------------------PL---SWHMRCKIAQGAANGINFLHE--N-----H---HIHRDIKSANILLD---E--------AF-TA-------------------KISDFGLARASE------------------KFAQTVMT--------------SR---IVGTTAYMAPEALR------------GE--ITPKSDIYSFGVVLLEIIT-GL--PA---------------VD-EH-----------REPQL-LLDI-KE----EIE---DEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYS-VASQCLHEKKNK--RPD-----IK-KVQQ----LLQ---------
-----LTFVQEIGSGQFGLV---HLGYW---L------------------N-KD---KVAIKTIR-E--GAM-----SE-----E-D-FI-E-------------------------EAEVM-MKL--S------HPK-----LVQLYGVCL--E-------------------------------------QAP------ICLVFEFMEHG---CLSDYLR------------------------TQ-----------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A-----C---VIHRDLAARNCLVG---E--------NQ-VI-------------------KVSDFGMTRFV--------------------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----------FSR--YSSKSDVWSFGVLMWEVFSEGK--IP---------------YE-NR-----------SNSEV-VEDI-ST----GFR---LYKPRLAS-----------------------------------------------------------------------------THVYQ-IMNHCWKERPED--RPA-----FS-RLLRQL--------------
----L-KRIRDLGEGHFGKV---ELCRY---DP------------EGDN-T-GE---QVAVKSLK-P--ESG-----GNH---IA-D-LK-K-------------------------EIEIL-RNL--Y------HEN-----IVKYKGICT-ED--------------------------------------GGN----GIKLIMEFLPSG---SLKEYLP------------------------KN-----------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R-----Q---YVHRDLAARNVLVE---S--------EH-QV-------------------KIGDFGLTKAI---------ET---------D--KEYY--------------TVKDDRDSPVFWYAPECLM-----------QSK--FYIASDVWSFGVTLHELLTYCD--SDSSPMALF-LKMIGPTHG-QM-----------TVTRL-VNTL-KE----GKR---LPCPPNCP-----------------------------------------------------------------------------DEVYQ-LMRKCWEFQPSN--RTS-----FQ-NLIE---GF-----------
-----LKFLQQLGKGNFGSV---EMCRY---DP------------LQDN-T-GE---VVAVKKLQ-H--STE------EH---LR-D-FE-R-------------------------EIEIL-KSL--Q------HDN-----IVKYKGVCYSAG-------------------------------------RRN------LKLIMEYLPYG---SLRDYLQ------------------------KH-----------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K-----R---YIHRDLATRNILVE---N--------EN-RV-------------------KIGDFGLTKVL---------PQ---------D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESK--FSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQG-QM-----------IVFHL-IELL-KN----NGR---LPRPDGCP-----------------------------------------------------------------------------DEIYM-IMTECWNNNVNQ--RPS-----FR-DLA----LRV----------
----L-KYISQLGKGNFGSV---ELCRY---DP------------LGDN-T-GA---LVAVKQLQ-H--SGP-----DQ----QR-D-FQ-R-------------------------EIQIL-KAL--H------SDF-----IVKYRGVSYGPG-------------------------------------RQS------LRLVMEYLPSG---CLRDFLQ------------------------RH-----------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R-----R---CVHRDLAARNILVE---S--------EA-HV-------------------KIADFGLAKLL---------PL---------D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNI--FSRQSDVWSFGVVLYELFTYCD--KSCSPSAE--FLRMMGCER-DV-P---------ALCRL-LELL-EE----GQR---LPAPPACP-----------------------------------------------------------------------------AEVHE-LMKLCWAPSPQD--RPS-----FS-ALGP---QL-----------
-----LKLVERLGAGQFGEV---WMGYY---N------------------G-HT---KVAVKSLK-Q--GSM-----SP-----D-A-FL-A-------------------------EANLM-KQL--Q------HQR-----LVRLYAVVT----------------------------------------QEP------IYIITEYMENG---SLVDFLK------------------------TP----------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R-----N---YIHRDLRAANILVS---D--------TL-SC-------------------KIADFGLARLI--------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGT--FTIKSDVWSFGILLTEIVTHGR--IP---------------YP-GM-----------TNPEV-IQNL-ER----GYR---MVRPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPED--RPT-----FD-YLRSV--L------------
-----IKLVKRLGAGQFGEV---WMGYY---N------------------N-ST---KVAVKTLK-P--GTM-----SV-----Q-A-FL-E-------------------------EANLM-KTL--Q------HDK-----LVRLYAVVT--R-------------------------------------EEP------IYIITEYMAKG---SLLDFLK------------------------SD----------------------EG-GKV---LLPKLIDFSAQIAEGMAYIER--K-----N---YIHRDLRAANVLVS---E--------SL-MC-------------------KIADFGLARVI--------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGC--FTIKSDVWSFGILLYEIVTYGK--IP---------------YP-GR-----------TNADV-MTAL-SQ----GYR---MPRVENCP-----------------------------------------------------------------------------DELYD-IMKMCWKEKAEE--RPT-----FD-YLQSV--L------------
-----FEKISELGAGNGGVV---FKVSH---K----------------P-S-GL----VMARKLIHL--EIK-P---AI-----R-N-QIIR-------------------------ELQVL-HEC--N------SPY-----IVGFYGAFY--S-------------------------------------DGE------ISICMEHMDGG---SLDQVLK-----------------------KAG--------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH-----K---IMHRDVKPSNILVN---S--------RG-EI-------------------KLCDFGVSG----------------------QLIDSMA--------------NS---FVGTRSYMSPERLQ-----------GTH--YSVQSDIWSMGLSLVEMAV-GR--YP---------------IP-PP-----------DAKEL-ELMF-GC----QVE---GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAE--RAD-----LK-QLMVHAFI------------
---LV--TISELGRGAYGVV---EKVRH---A----------------Q-S-GT---IMAVKRIRAT--VNS-Q---EQ-----K-R-L-LM-------------------------DLDIN-MRT-VD------CFY-----TVTFYGALF--R-------------------------------------EGD------VWICMELMDTS----LDKFYRKV-------------------LDKNM--------------------------TI---PEDILGEIAVSIVRALEHLHS--K----LS---VIHRDVKPSNVLIN---K--------EG-HV-------------------KMCDFGISGY---------------------LVDSVAK--------------TM---DAGCKPYMAPERINP-------ELNQKG--YNVKSDVWSLGITMIEMAI-LR--FP---------------YE-SW----------GTPFQQ-LKQV-VE----EPS---PQLPADRF-----S-----------------------------------------------------------------------PEFVD-FTAQCLRKNPAE--RMS-----YL-ELMEHPFF------------
--IRY---RDTLGHGNGGTV---YKAYH---V----------------P-S-GK---ILAVKVILLD--ITL-E---LQ-----K-Q-I-MS-------------------------ELEIL-YKC--D------SSY-----IIGFYGAFF--V-------------------------------------ENR------ISICTEFMDGG---SLD---------------------------VYR--------------------------KM---PEHVLGRIAVAVVKGLTYLWS--L-----K---ILHRDVKPSNMLVN---T--------RG-QV-------------------KLCDFGVST----------------------QLVNSIA--------------KT---YVGTNAYMAPERIS-----------GEQ--YGIHSDVWSLGISFMELAL-GR--FP---------------YP-QI-----------QKNQG-SLMP-LQ----LLQ---CIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVH-FITQCMRKQPKE--RPA-----PE-ELMGHPFI------------
-LEPI----MELGRGAYGVV---EKMRH---V----------------P-S-GQ---IMAVKRIRAT--VNS-Q---EQ-----K-R-L-LM-------------------------DLDIS-MRT-VD------CPF-----TVTFYGALF--R-------------------------------------EGD------VWICMELMDTSLDKFYKQVID-----------------------KGQ--------------------------TI---PEDILGKIAVSIVKALEHLHS--K----LS---VIHRDVKPSNVLIN---A--------LG-QV-------------------KMCDFGISGY---------------------LVDSVAK--------------TI---DAGCKPYMAPERINP-------ELNQKG--YSVKSDIWSLGITMIELAI-LR--FP---------------YD-SW----------GTPFQQ-LKQV-VE----EPS---PQLPADKF-----S-----------------------------------------------------------------------AEFVD-FTSQCLKKNSKE--RPT-----YP-ELMQHPFF------------
-----LRLEEVIGIGGFGKV---YRGSW---R--------------------GE---LVAVKAAR-Q--DPD-----EDISVTAE-S-VR-Q-------------------------EARLF-AML--A------HPN-----IIALKAVCL--E-------------------------------------EPN------LCLVMEYAAGG---PLSRALA------------------------GR--------------------------RV---PPHVLVNWAVQIARGMHYLHC--E-----ALVPVIHRDLKSNNILLL---QPIESDDMEHK-TL-------------------KITDFGLAREW-------------------------HK--------------TTQMSAAGTYAWMAPEVIK-----------AST--FSKGSDVWSFGVLLWELLT-GE--VP---------------YR-GI-----------DCLAV-AYGVAVN----KLT---LPIPSTCP-----------------------------------------------------------------------------EPFAQ-LMADCWAQDPHR--RPD-----FA-SILQQL--------------
LDLQW------VGSGAQGAV---FLGRF---H--------------------GE---EVAVKKVR-D--LKE-----T---------------------------------------DIKHL-RKL--K------HPN-----IITFKGVCT--Q-------------------------------------APC------YCILMEFCAQG---QLYEVLR------------------------AG-------------------------RPV---TPSLLVDWSMGIAGGMNYLHL--H-----K---IIHRDLKSPNMLIT---Y--------DD-VV-------------------KISDFGTSKEL------------------------SDK--------------STKMSFAGTVAWMAPEVIR-----------NEP--VSEKVDIWSFGVVLWELLT-GE--IP---------------YK-DV-----------DSSAI-IWGVGSN----SLH---LPVPSSCP-----------------------------------------------------------------------------DGFKI-LLRQCWNSKPRN--RPS-----FR-QILLH--L------------
-ISEL----QWLGSGAQGAV---FLGKF---R--------------------AE---EVAIKKVR-E--QNE-----TD---------------------------------------IKHL-RKL--K------HPN-----IIAFKGVCT--Q-------------------------------------APC------YCIIMEYCAHG---QLYEVLR------------------------AG-------------------------RKI---TPRLLVDWSTGIASGMNYLHL--H-----K---IIHRDLKSPNVLVT---H--------TD-AV-------------------KISDFGTSKEL------------------------SDK--------------STKMSFAGTVAWMAPEVIR-----------NEP--VSEKVDIWSFGVVLWELLT-GE--IP---------------YK-DV-----------DSSAI-IWGVGSN----SLH---LPVPSTCP-----------------------------------------------------------------------------DGFKI-LMKQTWQSKPRN--RPS-----FR-QTLMH--L------------
-----IEVEEVVGRGAFGVV---CKAKW---R--------------------AK---DVAIKQIE------S-----ESE---RK-A-FI-V-------------------------ELRQL-SRV--N------HPN-----IVKLYGACL-----------------------------------------NP------VCLVMEYAEGG---SLYNVLH------------------------GA----------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M-----QPKALIHRDLKPPNLLLV---A--------GGTVL-------------------KICDFGTACDI--------------------------Q--------------THMTNNKGSAAWMAPEVFE-----------GSN--YSEKCDVFSWGIILWEVITR-R--KP---------------FD-EIGG---------PAFRI-MWAV-HN----GTR---PPLIKNLP-----------------------------------------------------------------------------KPIES-LMTRCWSKDPSQ--RPS-----ME-EIVKI--M------------
----L-TLEEIIGIGGFGKV---YRAFW---I----------------G-D-E-----VAVKAARHDP-DED-I---SQ-----T-I-ENVR------------------------QEAKLF-AML--K------HPN-----IIALRGVCL--K-------------------------------------EPN------LCLVMEFARGG---PLNRVLS------------------------GK--------------------------RI---PPDILVNWAVQIARGMNYLHD--EA--IVP---IIHRDLKSSNILIL---Q--------KV-ENGDLS-----------NKILKITDFGLAR----------------------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----------ASM--FSKGSDVWSYGVLLWELLT-GE--VP---------------FR-GI--------------DG-LAVA-YG----VAM---NKLALPIPSTCP-------------------------------------------------------------------------EPFAK-LMEDCWNPDPHS--RPS-----FT-NILDQ---LT----------
-----YQNLKPIGSGAQGIV---CAAYD---A----------------V-L-DR---NVAIKKLSRP--FQN-Q---TH-----A-K-RAYR-------------------------ELVLM-KCV--N------HKN-----IISLLNVFT--PQKT-------------------------------LEEFQD------VYLVMELMDA----NLCQVIQ-------------------------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----G---IIHRDLKPSNIVVK---S--------DC-TL-------------------KILDFGLART---------------------AGTSFMM--------------TP---YVVTRYYRAPEVIL-----------GMG--YKENVDIWSVGCIMGEMVR-HK--IL---------------FP-GR-----------DYIDQ-WNKV-IE----QLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RIS-----VD-DALQHPYI------------
-----YQQLKPIGSGAQGIV---CAAFD---T----------------V-L-GI---NVAVKKLSRP--FQN-Q---TH-----A-K-RAYR-------------------------ELVLL-KCV--N------HKN-----IISLLNVFT--PQKT-------------------------------LEEFQD------VYLVMELMDA----NLCQVIH-------------------------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--A-----G---IIHRDLKPSNIVVK---S--------DC-TL-------------------KILDFGLART---------------------ACTNFMM--------------TP---YVVTRYYRAPEVIL-----------GMG--YKENVDIWSVGCIMGELVK-GC--VI---------------FQ-GT-----------DHIDQ-WNKV-IE----QLG---TPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDK--RIS-----VD-EALRHPYI------------
-----YRLQKTIGKGNFAKV---KLARH---V----------------L-T-GR---EVAVKIIDKT--QLN-P---TS-----L-Q-KLFR-------------------------EVRIM-KIL--N------HPN-----IVKLFEVIE--T-------------------------------------EKT------LYLVMEYASGG---EVFDYLV-----------------------AHG--------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----Y---IVHRDLKAENLLLD---G--------DM-NI-------------------KIADFGFSNE---------------------FTVGNKL--------------DT---FCGSPPYAAPELFQ----------GKKY--DGPEVDVWSLGVILYTLVS-GS--LP---------------FD-GQ--------------NL-KELR-ER----VLR---GKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKKLLVLNPIK--RGS-----LE-QIMKDRWM------------
-----YRLLKTIGKGNFAKV---KLARH---I----------------L-T-GK---EVAVKIIDKT--QLN-S---SS-----L-Q-KLFR-------------------------EVRIM-KVL--N------HPN-----IVKLFEVIE--T-------------------------------------EKT------LYLVMEYASGG---EVFDYLV-----------------------AHG--------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K-----F---IVHRDLKAENLLLD---A--------DM-NI-------------------KIADFGFSNE---------------------FTFGNKL--------------DT---FCGSPPYAAPELFQ----------GKKY--DGPEVDVWSLGVILYTLVS-GS--LP---------------FD-GQ--------------NL-KELR-ER----VLR---GKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKKFLILNPSK--RGT-----LE-QIMKDRWM------------
-----YRLLKTIGKGNFAKV---KLARH---I----------------L-T-GR---EVAIKIIDKT--QLN-P---TS-----L-Q-KLFR-------------------------EVRIM-KIL--N------HPN-----IVKLFEVIE--T-------------------------------------EKT------LYLIMEYASGG---EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV--------------------------QV---SFDLLSLMFTFIVSAVQYCHQ--K-----R---IVHRDLKAENLLLD---A--------DM-NI-------------------KIADFGFSNE---------------------FTVGGKL--------------DT---FCGSPPYAAPELFQ----------GKKY--DGPEVDVWSLGVILYTLVS-GS--LP---------------FD-GQ--------------NL-KELR-ER----VLR---GKYRIPFYMS---------------------------------------------------------------------------TDCEN-LLKRFLVLNPIK--RGT-----LE-QIMKDRWI------------
-----YRLLRTIGKGNFAKV---KLARH---I----------------L-T-GR---EVAIKIIDKT--QLN-P---SS-----L-Q-KLFR-------------------------EVRIM-KGL--N------HPN-----IVKLFEVIE--T-------------------------------------EKT------LYLVMEYASAG---EVFDYLV-----------------------SHG--------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K-----N---IVHRDLKAENLLLD---A--------EA-NI-------------------KIADFGFSNE---------------------FTLGSKL--------------DT---FCGSPPYAAPELFQ----------GKKY--DGPEVDIWSLGVILYTLVS-GS--LP---------------FD-GH--------------NL-KELR-ER----VLR---GKYRVPFYMS---------------------------------------------------------------------------TDCES-ILRRFLVLNPAK--RCT-----LE-QIMKDKWI------------
---FD--TIKLISNGAYGAV---YLVRH---R----------------D-T-RQ---RFAMKKINKQ--NLILR---NQ-----I-Q-QAFV-------------------------ERDIL-TFA--E------NPF-----VVGMFCSFE--T-------------------------------------RRH------LCMVMEYVEGG---DCATLLK-----------------------NIG--------------------------AL---PVEMARMYFAETVLALEYLHN--Y-----G---IVHRDLKPDNLLIT---S--------MG-HI-------------------KLTDFGLSKMGLMSLTTN-----LYEGHIEKDAREFLD--------------KQ---VCGTPEYIAPEVIL-----------RQG--YGKPVDWWAMGIILYEFLV-GC--VP---------------FF-GD--------------TP-EELF-GQ----VIS---DDILWPEGDE-ALP-----------------------------------------------------------------------TEAQL-LISSLLQTNPLV--RLGA--GGAF-EVKQHSFF------------
-----LTLGAQIGEGEFGAV---LQGEY---L--------------------GQ---KVAVKNIK-C--DVT-----AQ-------A-FL-D-------------------------ETAVM-TKM--Q------HEN-----LVRLLGVIL----------------------------------------HQG------LYIVMEHVSKG---NLVNFLR------------------------TR----------------------GR-ALV---NTAQLLQFSLHVAEGMEYLES--K-----K---LVHRDLAARNILVS---E--------DL-VA-------------------KVSDFGLAKAE--------------------------R--------------KGLDSSRLPVKWTAPEALK-----------HGK--FTSKSDVWSFGVLLWEVFSYGR--AP---------------YP-KM-----------SLKEV-SEAV-EK----GYR---MEPPEGCP-----------------------------------------------------------------------------GPVHV-LMSSCWEAEPAR--RPP-----FR-KLAEKL--------------
-----VHFNEVIGRGHFGCV---YHGTL---L-------------DNDG-K-KI---HCAVKSLN-R--ITD-----IGE---VS-Q-FL-T-------------------------EGIIM-KDF--S------HPN-----VLSLLGICL-RS-------------------------------------EGS------PLVVLPYMKHG---DLRNFIR------------------------NE-----------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K-----K---FVHRDLAARNCMLD---E--------KF-TV-------------------KVADFGLARDM----------Y---------D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----------TQK--FTTKSDVWSFGVLLWELMTRGA--PP---------------YP-DV-----------NTFDI-TVYL-LQ----GRR---LLQPEYCP-----------------------------------------------------------------------------DPLYE-VMLKCWHPKAEM--RPS-----FS-ELVSR--I------------
-----YRIRGEIGSGNFSQV---KLGIH---S----------------L-T-KE---KVAIKILDKT--KLD-Q---KT-----Q-R-LLSR-------------------------EISSM-EKL--H------HPN-----IIRLYEVVE--T-------------------------------------LSK------LHLVMEYAGGG---ELFGKIS-----------------------TEG--------------------------KL---SEPESKLIFSQIVSAVKHMHE--N-----Q---IIHRDLKAENVFYT---S--------NT-CV-------------------KVGDFGFSTV---------------------SKKGEML--------------NT---FCGSPPYAAPELFR----------DEHY--IGIYVDIWALGVLLYFMVT-GT--MP---------------FR-AE--------------TV-AKLK-KS----ILE---GTYSVPPHV----S-----------------------------------------------------------------------EPCHR-LIRGVLQQIPTE--RYG-----ID-CIMNDEWM------------
----I-EYVRDIGEGAFGRV---FQARA---PG-----------LLPYE-P-FT---MVAVKMLK-E--EAS-----ADM---QA-D-FQ-R-------------------------EAALM-AEF--D------NPN-----IVKLLGVCA--V-------------------------------------GKP------MCLLFEYMAYG---DLNEFLR------------------------SMSPHTVCSLSHSDLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R-----K---FVHRDLATRNCLVG---E--------NM-VV-------------------KIADFGLSRNI----------Y---------S--ADYY--------------KANENDAIPIRWMPPESIF-----------YNR--YTTESDVWAYGVVLWEIFSYGL--QP---------------YY-GM-----------AHEEV-IYYV-RD----GNI---LSCPENCP-----------------------------------------------------------------------------VELYN-LMRLCWSKLPAD--RPS-----FT-SIHRIL--------------
-----YEVLYTIGTGSYGRC---QKIRR---K----------------S-D-GK---ILVWKELDYG--SMT-E---AE-----K-Q-MLVS-------------------------EVNLL-REL--K------HPN-----IVRYYDRII--DR-----------------------------------TNTT------LYIVMEYCEGG---DLASVITKG-------------------TKERQ--------------------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHT---VLHRDLKPANVFLD---G--------KQ-NV-------------------KLGDFGLARIL--------------------NHDTSFA--------------KT---FVGTPYYMSPEQMN-----------RMS--YNEKSDIWSLGCLLYELCA-LM--PP---------------FT-AF--------------SQ-KELA-GK----IRE---GKFRRIPYRY---S-----------------------------------------------------------------------DELNE-IITRMLNLKDYH--RPS-----VE-EILENPL-I-----------
----I-VLKRELGEGAFGKV---FLAEC---YN-----------LCPEQ-D-KI---LVAVKTLK-D--ASD-----NA----RK-D-FH-R-------------------------EAELL-TNL--Q------HEH-----IVKFYGVCV--E-------------------------------------GDP------LIMVFEYMKHG---DLNKFLR------------------------AHGPDAV-----------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q-----H---FVHRDLATRNCLVG---E--------NL-LV-------------------KIGDFGMSRDV----------Y---------S--TDYY--------------RVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSLGVVLWEIFTYGK--QP---------------WY-QL-----------SNNEV-IECI-TQ----GRV---LQRPRTCP-----------------------------------------------------------------------------QEVYE-LMLGCWQREPHM--RKN-----IK-GIHTL--L------------
----I-VLKRELGEGAFGKV---FLAEC---YN-----------LSPTK-D-KM---LVAVKALK-D--PTL-----AA----RK-D-FQ-R-------------------------EAELL-TNL--Q------HEH-----IVKFYGVCG--D-------------------------------------GDP------LIMVFEYMKHG---DLNKFLR------------------------AHGPDAMIL--------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q-----H---FVHRDLATRNCLVG---A--------NL-LV-------------------KIGDFGMSRDV----------Y---------S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSFGVILWEIFTYGK--QP---------------WF-QL-----------SNTEV-IECI-TQ----GRV---LERPRVCP-----------------------------------------------------------------------------KEVYD-VMLGCWQREPQQ--RLN-----IK-EIYKIL--------------
-----YELQETLGKGTYGKV---KRATE---R----------------F-S-GR---VVAIKSIRKD--KIK-D---EQ-----D-M-VHIR------------------------REIEIM-SSL--N------HPH-----IISIYEVFE--N-------------------------------------KDK------IVIIMEYASKG---ELYDYIS-----------------------ERR--------------------------RL---SERETRHFFRQIVSAVHYCHK--N-----G---VVHRDLKLENILLD---D--------NC-NI-------------------KIADFGLSNL---------------------YQKDKFL--------------QT---FCGSPLYASPEIVN----------GRPY--RGPEVDSWALGVLLYTLVY-GT--MP---------------FD-GF--------------DH-KNLI-RQ----ISS---GEYREPTQP----------------------------------------------------------------------------SDARG-LIRWMLMVNPDR--RAT-----IE-DIANHWW-V-----------
-----YEFLETLGKGTYGKV---KKARE---S----------------S-G-R----LVAIKSIRKD--KIK-D---EQ-----D-L-MHIR------------------------REIEIM-SSL--N------HPH-----IIAIHEVFE--N-------------------------------------SSK------IVIVMEYASRG---DLYDYIS-----------------------ERQ--------------------------QL---SEREARHFFRQIVSAVHYCHQ--N-----R---VVHRDLKLENILLD---A--------NG-NI-------------------KIADFGLSNL---------------------YHQGKFL--------------QT---FCGSPLYASPEIVN----------GKPY--TGPEVDSWSLGVLLYILVH-GT--MP---------------FD-GH--------------DH-KILV-KQ----ISN---GAYREPPK-----P-----------------------------------------------------------------------SDACG-LIRWLLMVNPTR--RAT-----LE-DVASHWW-V-----------
-----YTRFEKIGQGASGTV---YTALD---I----------------A-T-GQ---EVAIKQMNLQ--QQP-K---KE-----L-I-I--N-------------------------EILVM-REN--K------NPN-----IVNYLDSYL--V-------------------------------------GDE------LWVVMEYLAGG---SLTDVVT------------------------ET--------------------------CM---DEGQIAAVCRECLQALDFLHS--N-----Q---VIHRDIKSDNILLG---M--------DG-SV-------------------KLTDFGFCAQI--------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----------RKA--YGPKVDIWSLGIMAIEMVE-GE--PP---------------YL-NE-----------NPLRA-LYLI-AT----NGT---PELQNPERLS---------------------------------------------------------------------------AVFRD-FLNRCLEMDVDR--RGS-----AK-ELLQHPFL------------
----Y-IKLDKLGEGTYATV---YKGKS---K----------------L-T-DN---LVALKEIRLE--HEE-G---AP-----C---TAIR-------------------------EVSLL-KDL--K------HAN-----IVTLHDIIH--T-------------------------------------EKS------LTLVFEYLDK----DLKQYLD----------------------DCGN--------------------------II---NMHNVKLFLFQLLRGLAYCHR--Q-----K---VLHRDLKPQNLLIN---E--------RG-EL-------------------KLADFGLARAK--------------------SIPTKTY--------------SN---EVVTLWYRPPDILL----------GSTD--YSTQIDMWGVGCIFYEMAT-GR--PL---------------FP-GS-----------TVEEQ-LHFI-FR----ILG---TPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGAD-LLTKLLQFEGRN--RIS-----AE-DAMKHPFF------------
-----YVKLDKLGEGTYATV---FKGRS---K----------------L-T-EN---LVALKEIRLE--HEE-G---AP-----C---TAIR-------------------------EVSLL-KNL--K------HAN-----IVTLHDLIH--T-------------------------------------DRS------LTLVFEYLDS----DLKQYLD-----------------------HCG--------------------------NL--MSMHNVKIFMFQLLRGLAYCHH--R-----K---ILHRDLKPQNLLIN---E--------RG-EL-------------------KLADFGLARAK--------------------SVPTKTY--------------SN---EVVTLWYRPPDVLL----------GSTE--YSTPIDMWGVGCIHYEMAT-GR--PL---------------FP-GS-----------TVKEE-LHLI-FR----LLG---TPTEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIH-LLSSLLLYESKS--RMS-----AE-AALSHSYF------------
----F-KFGKILGEGSFSTV---VLARE---L----------------A-T-SR---EYAIKILEKR--HII-K---EN-----K-VPYVTR-------------------------ERDVM-SRL--D------HPF-----FVKLYFTFQ--D-------------------------------------DEK------LYFGLSYAKNG---ELLKYIR-----------------------KIG--------------------------SF---DETCTRFYTAEIVSALEYLHG--K-----G---IIHRDLKPENILLN---E--------DM-HI-------------------QITDFGTAKVLS------------------PESKQARA--------------NS---FVGTAQYVSPELLT-----------EKS--ACKSSDLWALGCIIYQLVA-GL--PP---------------FR-AG--------------NE-YLIF-QK----IIK---LEYDFPEKFF---------------------------------------------------------------------------PKARD-LVEKLLVLDATK--RLG-----CE-EM------EGYGPLKAHPF-
-----YEKLEKLGEGSYATV---YKGKS---K----------------V-N-GK---LVALKVIRLQ--EEE-G---TP-----F---TAIR-------------------------EASLL-KGL--K------HAN-----IVLLHDIIH--T-------------------------------------KET------LTLVFEYVHT----DLCQYMD----------------------KHPG--------------------------GL---HPDNVKLFLFQLLRGLSYIHQ--R-----Y---ILHRDLKPQNLLIS---D--------TG-EL-------------------KLADFGLARAK--------------------SVPSHTY--------------SN---EVVTLWYRPPDVLL----------GSTE--YSTCLDMWGVGCIFVEMIQ-GV--AA---------------FP-GM----------KDIQDQ-LERI-FL----VLG---TPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAED-LASKLLQCSPKN--RLS-----AQ-AALSHEYF------------
-----YEPKEILGRGVSSVV---RRCIH---K----------------P-T-SQ---EYAVKVIDVT--GGG-S---FS-----P-E-EVRELRE------------------ATLKEVDIL-RKV-SG------HPN-----IIQLKDTYE--T-------------------------------------NTF------FFLVFDLMKRG---ELFDYLT-----------------------EKV--------------------------TL---SEKETRKIMRALLEVICTLHK--L-----N---IVHRDLKPENILLD---D--------NM-NI-------------------KLTDFGFSCQ---------------------LEPGERL--------------RE---VCGTPSYLAPEIIECS-----MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS--PP---------------FW-HR--------------KQ-MLML-RM----IMS---GNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKD-LVSRFLVVQPQN--RYT-----AE-EALAHPFF------------
--YDP---KDVIGRGVSSVV---RRCVH---R----------------A-T-GH---EFAVKIMEVT--AER-L---SP-----E-Q-LEEVREA-------------------TRRETHIL-RQV-AG------HPH-----IITLIDSYE--S-------------------------------------SSF------MFLVFDLMRKG---ELFDYLT-----------------------EKV--------------------------AL---SEKETRSIMRSLLEAVSFLHA--N-----N---IVHRDLKPENILLD---D--------NM-QI-------------------RLSDFGFSCH---------------------LEPGEKL--------------RE---LCGTPGYLAPEILKCS-----MDETHPG--YGKEVDLWACGVILFTLLA-GS--PP---------------FW-HR--------------RQ-ILML-RM----IME---GQYQFSSPEWDDRS-----------------------------------------------------------------------STVKD-LISRLLQVDPEA--RLT-----AE-QALQHPFF------------
-----YQVGAVLGSGGFGTV---YAGSR---I----------------A-D-GL---PVAVKHVVKE--RVT-E---WG-----S-L-GGATV----------------------PLEVVLL-RKV--GAA--GGARG-----VIRLLDWFE--R-------------------------------------PDG------FLLVLERPEPA--QDLFDFIT-----------------------ERG--------------------------AL---DEPLARRFFAQVLAAVRHCHS--C-----G---VVHRDIKDENLLVD--LR--------SG-EL-------------------KLIDFGSGA----------------------LLKDTVY--------------TD---FDGTRVYSPPEWIR----------YHRY--HGRSATVWSLGVLLYDMVC-GD--IP---------------FE-QD----------------------EE----ILR---GRLLFRRRVS---------------------------------------------------------------------------PECQQ-LIRWCLSLRPSE--RPS-----LD-QIAAHPWM------------
----F-KFLAVLGRGHFGKV---LLSEF---R----------------P-S-GE---LFAIKALKKG--DIV-A---RD-----E-V-ESLM------------------------CEKRIL-AAV--TS---AGHPF-----LVNLFGCFQ--T-------------------------------------PEH------VCFVMEYSAGG---DLMLHIH------------------------SD--------------------------VF---SEPRAIFYSACVVLGLQFLHE--H-----K---IVYRDLKLDNLLLD---T--------EG-YV-------------------KIADFGLCKEG--------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----------DTS--YTRAVDWWGLGVLLYEMLV-GE--SP---------------FP-GD--------------DE-EEVF-DS----IVN---DEVRYPRFLS---------------------------------------------------------------------------AEAIG-IMRRLLRRNPER--RLGSSERDAE-DVKKQPFF------------
---FR--CCAVLGRGHFGKV---LLAEY---K----------------N-T-NE---MFAIKALKKG--DIV-A---RD-----E-V-DSLM------------------------CEKRIF-ETV--NS---VRHPF-----LVNLFACFQ--T-------------------------------------KEH------VCFVMEYAAGG---DLMMHIH------------------------TD--------------------------VF---SEPRAVFYAACVVLGLQYLHE--H-----K---IVYRDLKLDNLLLD---T--------EG-FV-------------------KIADFGLCKEG--------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----------ETS--YTRAVDWWGLGVLIYEMLV-GE--SP---------------FP-GD--------------DE-EEVF-DS----IVN---DEVRYPRFLS---------------------------------------------------------------------------TEAIS-IMRRLLRRNPER--RLGASEKDAE-DVKKHPFF------------
---FI--LHKMLGKGSFGKV---FLAEF---K----------------K-T-NQ---FFAIKALKKD--VVL-M---DD-----D-V-ECTM------------------------VEKRVL-SLA-WE------HPF-----LTHMFCTFQ--T-------------------------------------KEN------LFFVMEYLNGG---DLMYHIQ-----------------------SCH--------------------------KF---DLSRATFYAAEIILGLQFLHS--K-----G---IVYRDLKLDNILLD---K--------DG-HI-------------------KIADFGMCKEN--------------------MLGDAKT--------------NT---FCGTPDYIAPEILL-----------GQK--YNHSVDWWSFGVLLYEMLI-GQ--SP---------------FH-GQ--------------DE-EELF-HS----IRM---DNPFYPRWLE---------------------------------------------------------------------------KEAKD-LLVKLFVREPEK--RLG-----VRGDIRQHPLF------------
---PD----EVLGSGQFGIV---YGGKH---R----------------K-T-GR---DVAIKIIDKL--RFP-T---KQ-----E-S-QLRN-------------------------EVAIL-QNL--H------HPG-----VVNLECMFE--T-------------------------------------PER------VFVVMEKLHGD---MLEMILS----------------------SEKG--------------------------RL---PEHITKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLA---S--------AD-PFP----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----------NKG--YNRSLDMWSVGVIIYVSLS-GT--FP---------------FN-ED-----------------EDIH-DQ----IQN---AAFMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRK--RYS-----VD-KTLSHPWL------------
---PD----EVLGSGQFGVV---YGGKH---R----------------K-T-GR---DVAVKVIDKL--RFP-T---KQ-----E-S-QLRN-------------------------EVAIL-QSL--R------HPG-----IVNLECMFE--T-------------------------------------PEK------VFVVMEKLHGD---MLEMILS----------------------SEKG--------------------------RL---PERLTKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLA---S--------AD-PFP----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLL-----------NQG--YNRSLDMWSVGVIMYVSLS-GT--FP---------------FN-ED-----------------EDIN-DQ----IQN---AAFMYPASPWSHIS-----------------------------------------------------------------------AGAID-LINNLLQVKMRK--RYS-----VD-KSLSHPWL------------
--FAD----EVLGSGQFGIV---YGGKH---R----------------K-T-GR---DVAIKVIDKM--RFP-T---KQ-----E-S-QLRN-------------------------EVAIL-QNL--H------HPG-----IVNLECMFE--T-------------------------------------PER------VFVVMEKLHGD---MLEMILS----------------------SEKS--------------------------RL---PERITKFMVTQILVALRNLHF--K-----N---IVHCDLKPENVLLA---S--------AE-PFP----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR-----------SKG--YNRSLDMWSVGVIIYVSLS-GT--FP---------------FN-ED-----------------EDIN-DQ----IQN---AAFMYPPNPWREIS-----------------------------------------------------------------------GEAID-LINNLLQVKMRK--RYS-----VD-KSLSHPWL------------
-YNVY----GYTGQGVFSNV---VRARD---N----------------ARA-NQ---EVAVKIIRNN--ELM-Q---KT-----G-----LK-------------------------ELEFL-KKL--NDADPDDKFH-----CLRLFRHFY--H-------------------------------------KQH------LCLVFEPLSM----NLREVLKK--------------------YGKDV--------------------------GL---HIKAVRSYSQQLFLALKLLKR--C-----N---ILHADIKPDNILVN---E--------SK-TI------------------LKLCDFGSAS----------------------HVADNDI--------------TP---YLVSRFYRAPEIII-----------GKS--YDYGIDMWSVGCTLYELYT-GK--IL---------------FP-GK-----------TNNHM-LKLA-MD----LKG---KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAK--RIS-----IN-QALQHAFI------------
-----YEVVKVIGRGAFGEV---QLVRH---K----------------S-T-RK---VYAMKLLSKF--EMI-K---RS-----D-S-AFFW------------------------EERDIM-AFA--N------SPW-----VVQLFYAFQ--D-------------------------------------DRY------LYMVMEYMPGG---DLVNLMS------------------------NY--------------------------DV---PEKWARFYTAEVVLALDAIHS--M-----G---FIHRDVKPDNMLLD---K--------SG-HL-------------------KLADFGTCMKM-------------------NKEGMVRC--------------DT---AVGTPDYISPEVLKS-------QGGDGY--YGRECDWWSVGVFLYEMLV-GD--TP---------------FY-AD--------------SL-VGTY-SK----IMN---HKNSLTFPDDNDIS-----------------------------------------------------------------------KEAKN-LICAFLTDREVRLGRNG-----VE-EIKRHLFF------------
-----YDVVKVIGRGAFGEV---QLVRH---K----------------A-S-QK---VYAMKLLSKF--EMI-K---RS-----D-S-AFFW------------------------EERDIM-AFA--N------SPW-----VVQLFYAFQ--D-------------------------------------DRY------LYMVMEYMPGG---DLVNLMS------------------------NY--------------------------DV---PEKWAKFYTAEVVLALDAIHS--M-----G---LIHRDVKPDNMLLD---K--------HG-HL-------------------KLADFGTCMKM-------------------DETGMVHC--------------DT---AVGTPDYISPEVLKS-------QGGDGF--YGRECDWWSVGVFLYEMLV-GD--TP---------------FY-AD--------------SL-VGTY-SK----IMD---HKNSLCFPEDAEIS-----------------------------------------------------------------------KHAKN-LICAFLTDREVRLGRNG-----VE-EIRQHPFF------------
-----FELLKVLGQGSFGKVFLVRKVTR---P----------------D-S-GH---LYAMKVLKKA--TLK-V---RD-----R-V-RTKM-------------------------ERDIL-ADV--N------HPF-----VVKLHYAFQ--T-------------------------------------EGK------LYLILDFLRGG---DLFTRLS-----------------------KEV--------------------------MF---TEEDVKFYLAELALGLDHLHS--L-----G---IIYRDLKPENILLD---E--------EG-HI-------------------KLTDFGLSKEA--------------------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RQG--HSHSADWWSYGVLMFEMLT-GS--LP---------------FQ-GK--------------DR-KETM-TL----ILK---AKLGMPQFLS---------------------------------------------------------------------------TEAQS-LLRALFKRNPAN--RLGSGPDGAE-EIKRHV--FY----------
-----FELLKVLGQGSFGKV---FLVKK---I----------------S-G-SDARQLYAMKVLKKA--TLK-V---RD-----R-V-RTKM-------------------------ERDIL-VEV--N------HPF-----IVKLHYAFQ--T-------------------------------------EGK------LYLILDFLRGG---DLFTRLS-----------------------KEV--------------------------MF---TEEDVKFYLAELALALDHLHS--L-----G---IIYRDLKPENILLD---E--------EG-HI-------------------KLTDFGLSKES--------------------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RRG--HTQSADWWSFGVLMFEMLT-GT--LP---------------FQ-GK--------------DR-KETM-TM----ILK---AKLGMPQFLS---------------------------------------------------------------------------PEAQS-LLRMLFKRNPAN--RLGAGPDGVE-EIKRHSFF------------
--REP-----ALGQGSFSVC---RRCRQ---R----------------Q-S-GQ---EFAVKILSRR--LEA-N---TQ-----R--------------------------------EVAAL-RLC-QS------HPN-----VVNLHEVHH--D-------------------------------------QLH------TYLVLELLRGG---ELLEHIR-----------------------KKR--------------------------HF---SESEASQILRSLVSAVSFMHE-EA-----G---VVHRDLKPENILYA---D--------DT--PGA---------------PVKIIDFGFARLR-------------------PQSPGVPM--------------QT---PCFTLQYAAPELLA-----------QQG--YDESCDLWSLGVILYMMLS-GQ--VP---------------FQ-GASG-------QGGQSQA-AEIM-CK----IRE---GRFSLDGEAWQGVS-----------------------------------------------------------------------EEAKE-LVRGLLTVDPAK--RLK-----LE-GLRGSSW-L-----------
-----FELLKVLGTGAYGKV---FLVRKISGH----------------D-T-GK---LYAMKVLKKA--TIV-Q---KA-----K-T-TEHTR-----------------------TERQVL-EHI-RQ------SPF-----LVTLHYAFQ--T-------------------------------------ETK------LHLILDYINGG---ELFTHLS-----------------------QRE--------------------------RF---TEHEVQIYVGEIVLALEHLHK--L-----G---IIYRDIKLENILLD---S--------NG-HV-------------------VLTDFGLSKEF-------------------VADETERA--------------YS---FCGTIEYMAPDIVR---------GGDSG--HDKAVDWWSLGVLMYELLT-GA--SP---------------FT-VD----------GEKNSQ-AEIS-RR----ILK---SEPPYPQEMS---------------------------------------------------------------------------ALAKD-LIQRLLMKDPKK--RLGCGPRDAD-EIKEHLFF------------
-----FELLKVLGQGSFGKV---FLVRK---K----------------T-G-PDAGQLYAMKVLKKA--SLK-V---RD-----R-V-RTKM-------------------------ERDIL-VEV--N------HPF-----IVKLHYAFQ--T-------------------------------------EGK------LYLILDFLRGG---DVFTRLS-----------------------KEV--------------------------LF---TEEDVKFYLAELALALDHLHQ--L-----G---IVYRDLKPENILLD---E--------IG-HI-------------------KLTDFGLSKES--------------------VDQEKKA--------------YS---FCGTVEYMAPEVVN-----------RRG--HSQSADWWSYGVLMFEMLT-GT--LP---------------FQ-GK--------------DR-NETM-NM----ILK---AKLGMPQFLS---------------------------------------------------------------------------AEAQS-LLRMLFKRNPAN--RLGS--EGVE-EIKRHLFF------------
-----FELLRVLGKGGYGKV---FQVRKVTGA----------------N-T-GK---IFAMKVLKKA--MIV-R---NA-----K-D-TAHTK-----------------------AERNIL-EEV--K------HPF-----IVDLIYAFQ--T-------------------------------------GGK------LYLILEYLSGG---ELFMQLE-----------------------REG--------------------------IF---MEDTACFYLAEISMALGHLHQ--K-----G---IIYRDLKPENIMLN---H--------QG-HV-------------------KLTDFGLCKES--------------------IHDGTVT--------------HT---FCGTIEYMAPEILM-----------RSG--HNRAVDWWSLGALMYDMLT-GA--PP---------------FT-GE--------------NR-KKTI-DK----ILK---CKLNLPPYLT---------------------------------------------------------------------------QEARD-LLKKLLKRNAAS--RLGAGPGDAG-EVQAHPFF------------
-----YELVRELGKGTYGKV---DLVVY---K----------------G-T-GT---KMALKFVNKS--KTK-L---KN-----F-----LR-------------------------EVSIT-NSL-SS------SPF-----IIKVFDVVF--E------------------------------------TEDC------YVFAQEYAPAG---DLFDIIP-----------------------PQV--------------------------GL---PEDTVKRCVQQLGLALDFMHG--R-----Q---LVHRDIKPENVLLFD-RE--------CR-RV-------------------KLADFGMTR-----------------------RVGCRV--------------KR---VSGTIPYTAPEVCQAG------RADGLA--VDTGVDVWAFGVLIFCVLT-GN--FP---------------WE-AA-----------SGADAFFEEF-VR----WQR---GRLPGLPSQWRRFT-----------------------------------------------------------------------EPALR-MFQRLLALEPER--RGP-----AK-EVF-----RFLKH-------
----F-DFLKVIGKGSFGKV---LLAKR---K----------------L-D-GK---FYAVKVLQKK--IVL-N---RK-----E-Q-KHIM------------------------AERNVLLKNV--K------HPF-----LVGLHYSFQ--T-------------------------------------TEK------LYFVLDFVNGG---ELFFHLQ-----------------------RER--------------------------SF---PEHRARFYAAEIASALGYLHS--I-----K---IVYRDLKPENILLD---S--------VG-HV-------------------VLTDFGLCKEG--------------------IAISDTT--------------TT---FCGTPEYLAPEVIR-----------KQP--YDNTVDWWCLGAVLYEMLY-GL--PP---------------FY-CR--------------DV-AEMY-DN----ILH---KPLSLRPGVS---------------------------------------------------------------------------LTAWS-ILEELLEKDRQN--RLGAK-EDFL-EIQNHPFF------------
-----YDIERTLGKGNFAVV---KLARH---R----------------V-T-KT---QVAIKIIDKT--RLD-S---SN-----L-E-KIYR-------------------------EVQLM-KLL--N------HPH-----IIKLYQVME--T-------------------------------------KDM------LYIVTEFAKNG---EMFDYLT-----------------------SNG--------------------------HL---SENEARKKFWQILSAVEYCHD--H-----H---IVHRDLKTENLLLD---G--------NM-DI-------------------KLADFGFGNF---------------------YKSGEPL--------------ST---WCGSPPYAAPEVFE----------GKEY--EGPQLDIWSLGVVLYVLVC-GS--LP---------------FD-GP--------------NL-PTLR-QR----VLE---GRFRIPFFMS---------------------------------------------------------------------------QDCES-LIRRMLVVDPAR--RIT-----IA-QIRQHRWM------------
-----YDIEGTLGKGNFAVV---KLGRH---R----------------I-T-KT---EVAIKIIDKS--QLD-A---VN-----L-E-KIYR-------------------------EVQIM-KML--D------HPH-----IIKLYQVME--T-------------------------------------KSM------LYLVTEYAKNG---EIFDYLA-----------------------NHG--------------------------RL---NESEARRKFWQILSAVDYCHG--R-----K---IVHRDLKAENLLLD---N--------NM-NI-------------------KIADFGFGNF---------------------FKSGELL--------------AT---WCGSPPYAAPEVFE----------GQQY--EGPQLDIWSMGVVLYVLVC-GA--LP---------------FD-GP--------------TL-PILR-QR----VLE---GRFRIPYFMS---------------------------------------------------------------------------EDCEH-LIRRMLVLDPSK--RLT-----IA-QIKEHKWM------------
-----WEIIGELGDGAFGKV---YKAQN---K----------------E-T-SV---LAAAKVIDTK--SEE-E---LE-----D-Y-M--V-------------------------EIDIL-ASC--D------HPN-----IVKLLDAFY--Y-------------------------------------ENN------LWILIEFCAGG---AVDAVML----------------------ELER--------------------------PL---TESQIQVVCKQTLDALNYLHD--N-----K---IIHRDLKAGNILFT---L--------DG-DI-------------------KLADFGVSAKN--------------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE------TSKDRP--YDYKADVWSLGITLIEMAE-IE--PP---------------HH-EL-----------NPMRV-LLKI-AK----SEP---PTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDA--RWT-----TS-QLLQHPFV------------
-----YDLDKTLGRGHFAVV---KLARH---V----------------F-T-GE---KVAVKVIDKT--KLD-T---LA-----T-G-HLFQ-------------------------EVRCM-KLV--Q------HPN-----IVRLYEVID--T-------------------------------------QTK------LYLILELGDGG---DMFDYIM----------------------KHEE--------------------------GL---NEDLAKKYFAQIVHAISYCHK--L-----H---VVHRDLKPENVVFF--EK--------QG-LV-------------------KLTDFGFSNK---------------------FQPGKKL--------------TT---SCGSLAYSAPEILL----------GDEY--DAPAVDIWSLGVILFMLVC-GQ--PP---------------FQ-EA--------------ND-SETL-TM----IMD---CKYTVPSHVS---------------------------------------------------------------------------KECKD-LITRMLQRDPKR--RAS-----LE-EIENHPWL------------
----L-RLEVKLGQGCFGEV---WMGTW---N------------------G-TT---RVAIKTLK-P--GTM-----SP-----E-A-FL-Q-------------------------EAQVM-KKL--R------HEK-----LVQLYAVVS----------------------------------------EEP------IYIVTEYMSKG---SLLDFLK------------------------GE----------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M-----N---YVHRDLRAANILVG---E--------NL-VC-------------------KVADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELTTKGR--VP---------------YP-GM-----------VNREV-LDQV-ER----GYR---MPCPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEE--RPT-----FE-YLQAF--L------------
---FA--LGRKLGEGYFGEV---WEGLW---L------------------G-SL---PVAIKVIK-S--ANM-----K-----LT-D-LA-K-------------------------EIQTL-KGL--R------HER-----LIRLHAVCS--G-------------------------------------GEP------VYIVTELMRKG---NLQAFLG------------------------TP----------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q-----R---VVHRDLAARNVLVD---D--------GL-AC-------------------KVADFGLARLL--------------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----------YRV--FSQKSDVWSFGVLLHEVFTYGQ--CP---------------YE-GM-----------TNHET-LQQI-MR----GYR---LPRPAACP-----------------------------------------------------------------------------AEVYV-LMLECWRSSPEE--RPS-----FA-TLREKL--------------
-----WEIVGELGDGAFGKV---YKAKN---K----------------E-T-GA---LAAAKVIETK--SEE-E---LE-----D-Y-I--V-------------------------EIEIL-ATC--D------HPY-----IVKLLGAYY--H-------------------------------------DGK------LWIMIEFCPGG---AVDAIML----------------------ELDR--------------------------GL---TEPQIQVVCRQMLEALNFLHS--K-----R---IIHRDLKAGNVLMT---L--------EG-DI-------------------RLADFGVSAKN--------------------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE------TMKDTP--YDYKADIWSLGITLIEMAQ-IE--PP---------------HH-EL-----------NPMRV-LLKI-AK----SDP---PTLLTPSKWS---------------------------------------------------------------------------VEFRD-FLKIALDKNPET--RPS-----AA-QLLEHPFV------------
--LCP---GRELGRGKFAVV---RKCIK---K----------------D-S-GK---EFAAKFMRKR--RKG-Q---DC-----R-M-EIIH-------------------------EIAVL-ELA-QD------NPW-----VINLHEVYE--T-------------------------------------ASE------MILVLEYAAGG---EIFDQCVA---------------------DREE--------------------------AF---KEKDVQRLMRQILEGVHFLHT--R-----D---VVHLDLKPQNILLT---S--------ES-PLG----------------DIKIVDFGLSRI---------------------LKNSEEL--------------RE---IMGTPEYVAPEILS-----------YDP--ISMATDMWSIGVLTYVMLT-GI--SP---------------FL-GN--------------DK-QETF-LN----ISQ---MNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVD-FIRTLLVKKPED--RAT-----AE-ECLKHPWL------------
--ILT---SKELGRGKFAVV---RQCIS---K----------------S-T-GQ---EYAAKFLKKR--RRG-Q---DC-----R-A-EILH-------------------------EIAVL-ELA-KS------CPR-----VINLHEVYE--N-------------------------------------TSE------IILILEYAAGG---EIFSLCLP---------------------ELAE--------------------------MV---SENDVIRLIKQILEGVYYLHQ--N-----N---IVHLDLKPQNILLS---S--------IY-PLG----------------DIKIVDFGMSRK---------------------IGHACEL--------------RE---IMGTPEYLAPEILN-----------YDP--ITTATDMWNIGIIAYMLLT-HT--SP---------------FV-GE--------------DN-QETY-LN----ISQ---VNVDYSEETFSSVS-----------------------------------------------------------------------QLATD-FIQSLLVKNPEK--RPT-----AE-ICLSHSWL------------
-----FTKLEKIGKGSFGEV---FKGID---N----------------R-T-QK---VVAIKIIDLE--EAE-D---EI-----E-D-IQ-Q-------------------------EITVL-SQC--D------SPY-----VTKYYGSYL--K-------------------------------------DTK------LWIIMEYLGGG---SALDLLE------------------------PG--------------------------PL---DETQIATILREILKGLDYLHS--E-----K---KIHRDIKAANVLLS---E--------HG-EV-------------------KLADFGVAGQL--------------------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----------QSA--YDSKADIWSLGITAIELAR-GE--PP---------------HS-EL-----------HPMKV-LFLI-PK----NNP---PTLEGNYS-----------------------------------------------------------------------------KPLKE-FVEACLNKEPSF--RPT-----AK-ELLKHKFI------------
----F-TKLDRIGKGSFGEV---YKGID---N----------------H-T-KE---VVAIKIIDLE--EAE-D---EI-----E-D-IQ-Q-------------------------EITVL-SQC--D------SPY-----ITRYFGSYL--K-------------------------------------STK------LWIIMEYLGGG---SALDLLK------------------------PG--------------------------PL---EETYIATILREILKGLDYLHS--E-----R---KIHRDIKAANVLLS---E--------QG-DV-------------------KLADFGVAGQL--------------------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----------QSA--YDFKADIWSLGITAIELAK-GE--PP---------------NS-DL-----------HPMRV-LFLI-PK----NSP---PTLEGQHS-----------------------------------------------------------------------------KPFKE-FVEACLNKDPRF--RPT-----AK-ELLKHKFI------------
-----YTFGRILGKGSFGIV---IEATD---K----------------E-T-ET---KWAIKKVNKE--KAG-S---SA-----V-K-LLER-------------------------EVNIL-KSV--K------HEH-----IIHLEQVFE--T-------------------------------------PKK------MYLVMELCEDG---ELKEILD-----------------------RKG--------------------------HF---SENETRWIIQSLASAIAYLHN--N-----D---IVHRDLKLENIMVK---S--------SL-IDDNNE----------INLNIKVTDFGLAVKK-------------------QSRSEAML--------------QA---TCGTPIYMAPEVIS-----------AHD--YSQQCDIWSIGVVMYMLLR-GE--PP---------------FL-AS--------------SE-EKLF-EL----IRK---GELHFENAVWNSIS-----------------------------------------------------------------------DCAKS-VLKQLMKVDPAH--RIT-----AK-ELLDNQWL------------
-----YSLLAEIGRGSYGVV---YEAVA---G----------------R-S-GA---RVAVKKIRCD--APE-N---VE-----L----ALA-------------------------EFWAL-TSLKRR------HQN-----VVQFEECVL--QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY------LWFVMEFCEGG---DLNQYVL------------------------SR--------------------------RP---DPATNKSFMLQLTSAIAFLHK--N-----H---IVHRDLKPDNILIT---E--------RS-GTP----------------ILKVADFGLSKVCAGLAPRGK---EGNQDNKNVNVNKYWL--------------SS---ACGSDFYMAPEVWE------------GH--YTAKADIFALGIIIWAMIE-RI--TF---------------ID-SE-----------TKKEL-LGTY-IK----QGT---EIVPVGEALLENPKMELHIPQ---------------------------------------------------------KRRTSMSEGIKQ-LLKDMLAANPQD--RPD-----AF-EL------ETRM--------
---YL--LLHLLGRGGFSEV---YKAFD---L----------------T-E-QR---YVAVKIHQLN--KNW-R---DE-----K-K-ENYHKH--------------------ACREYRIH-KEL--D------HPR-----IVKLYDYFS--L------------------------------------DTDS------FCTVLEYCEGN---DLDFYLK-----------------------QHK--------------------------LM---SEKEARSIIMQIVNALKYLNE--IK---PP---IIHYDLKPGNILLV---N--------GT-ACG----------------EIKITDFGLSKIMDDD-------------SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVV-------GKEPPK--ISNKVDVWSVGVIFYQCLY-GR--KP---------------FG-HN------------QSQQ-DILQ-EN----TIL---KATEVQFPPKPVVT-----------------------------------------------------------------------PEAKA-FIRRCLAYRKED--RID-----VQ-QLACDPYL------------
----L-RLLEKLGDGSFGVV---RRGEW---D-------------APSG-K-TV---SVAVKCLK-PDVLSQ-----PEA---MD-D-FI-R-------------------------EVNAM-HSL--D------HRN-----LIRLYGVVL----------------------------------------TPP------MKMVTELAPLG---SLLDRLR------------------------KH-----------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K-----R---FIHRDLAARNLLLA---T--------RD-LV-------------------KIGDFGLMRAL---------PQ---------N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRT--FSHASDTWMFGVTLWEMFTYGQ--EP---------------WI-GL-----------NGSQI-LHKIDKE----GER---LPRPEDCP-----------------------------------------------------------------------------QDIYN-VMVQCWAHKPED--RPT-----FV-ALRDF--L------------
-----YSILKQIGSGGSSKV---FQVLN---E----------------K-K-Q----IYAIKYVNLE--EAD-N---QT-----L-D-SYRN-------------------------EIAYL-NKL-QQ-----HSDK-----IIRLYDYEI--T-------------------------------------DQY------IYMVMECGNI----DLNSWLK-----------------------KKK--------------------------SI---DPWERKSYWKNMLEAVHTIHQ--H-----G---IVHSDLKPANFLIV------------DG-ML-------------------KLIDFGIANQMQ------------------PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK--ISPKSDVWSLGCILYYMTY-GK--TP---------------FQ-QI-------------INQ-ISKL-HA----IID---PNHEIEFPDIPE-------------------------------------------------------------------------KDLQD-VLKCCLKRDPKQ--RIS-----IP-ELLAHPYV------------
---FI--LTERLGSGTYATV---YKAYA---KK---------------D-T-RE---VVAIKCVAKK--SLN-K---AS-----V-E-NLLT-------------------------EIEIL-KGI--R------HPH-----IVQLKDFQW--D-------------------------------------SDN------IYLIMEFCAGG---DLSRFIH-----------------------TRR--------------------------IL---PEKVARVFMQQLASALQFLHE--R-----N---ISHLDLKPQNILLSS-LE--------KP-HL-------------------KLADFGFAQH---------------------MSPWDEK--------------HV---LRGSPLYMAPEMVC-----------QRQ--YDARVDLWSMGVILYEALF-GQ--PP---------------FA-SR-----------SFSEL-EEKI-RS----NRV---IELPLRPLLS---------------------------------------------------------------------------RDCRD-LLQRLLERDPSR--RIS-----FQ-DFFAHPWV------------
----L-RLEVKLGQGCFGEV---WMGTW---N------------------G-TT---KVAIKTLK-P--GTM-----MP-----E-A-FL-Q-------------------------EAQIM-KKL--R------HDK-----LVPLYAVVS----------------------------------------EEP------IYIVTEFMSKG---SLLDFLK------------------------EG----------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M-----N---YIHRDLRAANILVG---E--------NL-VC-------------------KIADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILQTELVTKGR--VP---------------YP-GM-----------VNREV-LEQV-ER----GYR---MPCPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDE--RPT-----FE-YIQSFL--------------
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