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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2D 14
CAMK CAMK2G 14
CMGC CDC2 4
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CMGC DYRK1A 150
CMGC DYRK1B 111
AGC GRK1 190
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CMGC ICK 4
TK JAK3 822
STE MAP2K1 68
STE MAP2K5 166
STE MAP3K2 356
STE MAP3K3 362
CMGC MAPK14 24
CAMK MARK2 53
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK3 268
CMGC PCTK1 165
AGC PDPK1 82
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PIM3 40
AGC PKN2 657
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCQ 380
CAMK PRKD2 551
CMGC PRPF4B 687
AGC RPS6KA1 62
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
STE STK10 36
CAMK STK11 49
STE YSK4 1162
----FELLKVLGQGSYGKV---FLVRK---V----K-G-SDAGQLYAMKVLKKAT-LKVRD-RV-RSKM-------ERDILAEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD--EEGHI--------------------KITDFGLSKEA--------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLP-------------FQ-GK-----DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVE-EIKRHPFF--------------
----FEIGRPLGKGKFGNV---YLARE---K----Q-S-KF---ILALKVLFKAQLEKAGV-EH-QLRR-------EVEIQSHL-R------HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS--KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGEL--------------------KIADFGWSV----------HAPSSRRTT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FE-AN-----TYQETYKRISRVEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-------LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNV---YLARE---K----K-S-HF---IVALKVLFKSQ-IEKEG-VE-HQLR------REIEIQAHL-H------HPN-----ILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ----KSC--TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL--------------------KIADFGWSV----------HAPSLRRKT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GNPP-------------FE-SA-----SHNETYRRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-------LA-QVSAHPWV--------------
----FEIGRPLGKGKFGNV---YLARL---K----E-S-HF---IVALKVLFKSQ-IEKEG-LE-HQLR------REIEIQAHL-Q------HPN-----ILRLYNYFH--D--------ARRVY--LILEYAPRG--ELYKELQ----KSE--KL---DEQRTATIIEELADALTYCHD--KKVIHRDIKPENLLLG--FRGEV--------------------KIADFGWSV----------HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FE-SA-----SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP-------LA-QILKHPWV--------------
----YQLFEELGKGAFSVV---RRCMK---I----P-T-GQ---EYAAKIINTKK-LSARD-HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGFHY--LVFDLVTGG--ELFEDIV----ARE--YY---SEADASHCIQQILESVNHCHL--NGIVHRDLKPENLLLA--SKSKGA-----------------AVKLADFGLAIEV--------QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPP-------------FW-DE-----DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-------AS-EALKHPWI--------------
----YQLFEELGKGAFSVV---RRCVK---K----T-S-TQ---EYAAKIINTKK-LSARD-HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGFHY--LVFDLVTGG--ELFEDIV----ARE--YY---SEADASHCIHQILESVNHIHQ--HDIVHRDLKPENLLLA--SKCKGA-----------------AVKLADFGLAIEV--------QGEQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDIWACGVILYILLV-GYPP-------------FW-DE-----DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-------AD-QALKHPWV--------------
----YTKIEKIGEGTYGVV---YKGRH---K----T-T-GQ---VVAMKKIRLES-EEEGV-PS-TAIR-------EISLLKEL-R------HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF--------GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPL-------------FH-GD--SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
--YL--NLEKLGEGSYATV---YKGIS---R----I-N-GQ---LVALKVISMNA-EEGVP--F-TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T--------KETLT--FVFEYMHT---DLAQYMS---QHPG--GL---HPHNVRLFMFQLLRGLAYIHH--QHVLHRDLKPQNLLIS--HLGEL--------------------KLADFGLARAK--------SIPSQTYSS---EVVTLWYRPPDALL-----GATEYSSELDIWGAGCIFIEMFQ-GQPL-------------FP-GV-SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS-------AQ-EALVHDYF--------------
----FQKVEKIGEGTYGVV---YKARN---K----L-T-GE---VVALKKIRLDT-ETEGV-PS-TAIR-------EISLLKEL-N------HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF--------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FP-GD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
----FQKVEKIGEGTYGVV---YKAKN---R----E-T-GQ---LVALKKIRLDL-EMEGV-PS-TAIR-------EISLLKEL-K------HPN-----IVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS--EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI--------------------KLADFGLARAF--------GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RKAL-------------FP-GD--SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
----YEKLEKIGEGTYGTV---FKAKN---R----E-T-HE---IVALKRVRLDD-DDEGV-PS-SALR-------EICLLKEL-K------HKN-----IVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG--DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL--------------------KLADFGLARAF--------GIPVRCYSA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGRPL-------------FP-GN--DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-------AE-EALQHPYF--------------
----YEKLAKIGQGTFGEV---FKARH---R----K-T-GQ---KVALKKVLMEN-EKEGF-PI-TALR-------EIKILQLL-K------HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV--KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL--------------------KLADFGLARAFSL----AKNSQPNRYTN---RVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RSPI-------------MQ-GN--TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-------SD-DALNHDFF--------------
----YENLGLVGEGSYGMV---MKCRN---K----D-T-GR---IVAIKKFLESD-DDKMV-KK-IAMR-------EIKLLKQL-R------HEN-----LVNLLEVCK--K--------KKRWY--LVFEFVDHT--ILDDLEL----FPN--GL---DYQVVQKYLFQIINGIGFCHS--HNIIHRDIKPENILVS--QSGVV--------------------KLCDFGFARTL--------AAPGEVYTD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GEPL-------------FP-GD--SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------
----FEILGVVGEGAYGVV---LKCRH---K----E-T-HE---IVAIKKFKDSE-ENEEV-KE-TTLR-------ELKMLRTL-K------QEN-----IVELKEAFR--R--------RGKLY--LVFEYVEK---NMLELLE---EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--NDIVHRDIKPENLLIS--HNDVL--------------------KLCDFGFARNL-------SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQPL-------------FP-GE--SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TE-QCLNHPTF--------------
---W-DLVQTLGEGAYGEV---QLAVN---R----V-T-EE---AVAVKIVDMKR-AVDCP-EN-I-KK-------EICINKML-N------HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI--GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL--------------------KISDFGLATVFR------YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELP-------------WD-QP----SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEV---KLAFE---R----K-T-CK---KVAIKIISKRK-FAIGS-AR-EADPALN-VETEIEILKKL-N------HPC-----IIKIKNFF---D--------AEDYY--IVLELMEGG--ELFDKVV----GNK--RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS--SQEEDC-----------------LIKITDFGHSKI---------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPP-------------FS-EH----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT-------TE-EALRHPWL--------------
----YEIVDTLGEGAFGKV---VECID---H----K-AGGR---HVAVKIVKNVD-RYCEA-AR-S----------EIQVLEHL-NT----TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG--FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA-----------TYDDEHHST---LVSTRHYRAPEVIL------ALGWSQPCDVWSIGCILIEYYL-GFTV-------------FP-TH--DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY----------------------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRIT-------LR-EALKHPFF--------------
----YEIVSTLGEGTFGRV---VQCVD---H----R-R-GG--ARVALKIIKNVE-KYKEA-AR----L-------EINVLEKI-NEK-DPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN--YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-----------FDHEHHST---IVSTRHYRAPEVIL------ELGWSQPCDVWSIGCIIFEYYV-GFTL-------------FQ-TH--DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-------LG-EALQHPFF--------------
----YEIVGNLGEGTFGKV---VECLD---H----A-R-GK--SQVALKIIRNVG-KYREA-AR----L-------EINVLKKI-KE---KDKENK--FLCVLMSDWFN--F--------HGHMC--IAFELLGK---NTFEFLK-----EN--NFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-----------FDHEHHTT---IVATRHYRPPEVIL------ELGWAQPCDVWSIGCILFEYYR-GFTL-------------FQ-TH--ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-------LA-EALLHPFF--------------
----YEIVDTLGEGAFGKV---VECID---H----GMD-GM---HVAVKIVKNVG-RYREA-AR-S----------EIQVLEHL-NS----TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS--FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-----------TYDDEHHST---LVSTRHYRAPEVIL------ALGWSQPCDVWSIGCILIEYYL-GFTV-------------FQ-TH--DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY----------------------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-------LD-EALQHPFF--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-N-NE---KVVVKILKPVK-KKKIK-R-------------EIKILENLRG------GPN-----IITLADIVK--DP------VSRTPA--LVFEHVNNT--DFKQLY-------Q--TL---TDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHNVMID-HEHRKL--------------------RLIDWGLAEF---------YHPGQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RKEP-------------FFHGH--DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AR-EAMEHPYF--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-N-NE---RVVVKILKPVK-KKKIK-R-------------EVKILENLRG------GTN-----IIKLIDTVK--DP------VSKTPA--LVFEYINNT--DFKQLY-------Q--IL---TDFDIRFYMYELLKALDYCHS--KGIMHRDVKPHNVMID-HQQKKL--------------------RLIDWGLAEF---------YHPAQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RREP-------------FFHGQ--DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-------AK-EAMEHPYF--------------
----YEIDSLIGKGSFGQV---VKAYD---R----V-E-QE---WVAIKIIKNKK-AFLNQ-AQ-I----------EVRLLELMNK------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT--NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-----------LGQRIYQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GEPL-------------FS-GA--NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-------PY-YALQHSFF--------------
----YEIDSLIGKGSFGQV---VKAYD---H----Q-T-QE---LVAIKIIKNKK-AFLNQ-AQ-I----------ELRLLELMNQ------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT--HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-----------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GEPL-------------FS-GS--NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-------PL-GALQHGFF--------------
FLDF----RVLGKGGFGEV---SACQM---K----A-T-GK---LYACKKLNKKR-LKKRK-GY-QGAM------VEKKILMKV-H------SRF-----IVSLAYAFE--T--------KADLC--LVMTIMNGG--DIRYHIYNVNEENP--GF---PEPRALFYTAQIICGLEHLHQ--RRIVYRDLKPENVLLD--NDGNV--------------------RISDLGLAVEL--------LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGP-------------FR-AR-GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF--
---F-TEFRVLGKGGFGEV---CAVQV---K----N-T-GK---MYACKKLDKKR-LKKKG-GE-KMAL------LEKEILEKV-S------SPF-----IVSLAYAFE--S--------KTHLC--LVMSLMNGG--DLKFHIYN--VGTR--GL---DMSRVIFYSAQIACGMLHLHE--LGIVYRDMKPENVLLD--DLGNC--------------------RLSDLGLAVE---------MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTP-------------FK-DY-KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-------SR-E-------KSDDPR--------
----YTDIKVIGNGSFGVV---YQARL---A----E-T-RE---LVAIKKVLQDK-RFKNR---------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKL--TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVL--------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FP-GD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVV---YQAKL---C----D-S-GE---LVAIKKVLQDK-RFKNR---------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL--------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FP-GD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-------PL-EACAHSFF--------------
----YEVLEFLGRGTFGQV---AKCWK---R----S-T-KE---IVAIKILKNHP-SYARQ-GQ-I----------EVSILSRL-S------SENADEYNFVRSYECFQ--H--------KNHTC--LVFEMLEQ---NLYDFLKQ--NKFS--PL---PLKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLV--DPVRQPY----------------RVKVIDFGSAS----------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA--SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-------PL-KTLNHQFV--------------
----YEVLEFLGRGTFGQV---VKCWK---R----G-T-NE---IVAIKILKNHP-SYARQ-GQ-I----------EVSILARL-STE-SADDYN-----FVRAYECFQ--H--------KNHTC--LVFEMLEQ---NLYDFLKQ--NKFS--PL---PLKYIRPVLQQVATALMKLKS--LGLIHADLKPENIMLV--DPSRQPY----------------RVKVIDFGSAS----------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA--SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQV---VKCWK---R----G-T-NE---IVAIKILKNHP-SYARQ-GQ-I----------EVSILARL-S------TENADEYNFVRAYECFQ--H--------RNHTC--LVFEMLEQ---NLYDFLKQ--NKFS--PL---PLKVIRPILQQVATALKKLKS--LGLIHADLKPENIMLV--DPVRQPY----------------RVKVIDFGSAS----------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA--LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-------PA-ETLNHPFV--------------
----YDIIEVLGKGTFGEV---AKGWR---R----S-T-GE---MVAIKILKNDA-YRNRI-IK-N----------ELKLLHCM-RGL-DPEEAH-----VIRFLEFFH--D--------ALKFY--LVFELLEQ---NLFEFQK-----EN--NFAPLPARHIRTVTLQVLTALARLKE--LAIIHADLKPENIMLV--DQTRCPF----------------RVKVIDFGSASIF--------SEVRYVKEP---YIQSRFYRAPEILL------GLPFCEKVDVWSLGCVMAELHL-GWPL-------------YP-GN--NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-------PS-AALRHPFV--------------
----YTTIRQLGDGTYGSV---LLGRS---I----E-S-GE---LIAIKKMKRKF-YSWEE-C--MNLR-------EVKSLKKL-N------HAN-----VVKLKEVIR--E--------NDHLY--FIFEYMKE---NLYQLIK---ERNK--LF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLLCM--GPELV--------------------KIADFGLARE---------IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LRPL-------------FP-GA--SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------AS-QALRYPYF--------------
---L-KYISQLGKGNFGSV---ELCRY---DPLGDN-T-GA---LVAVKQLQ-HS-GP-DQQRD-FQ-R-------EIQILKAL-H------SDF-----IVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ-----RHRARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV--------------------KIADFGLAKLL---PL---D--KDYYVVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCER-DVP-ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----FEKISELGAGNGGVV---FKVSH---K----P-S-GL----VMARKLIHLE-IKPAI-RN-QIIR-------ELQVLHEC-N------SPY-----IVGFYGAFY--S--------DGEIS--ICMEHMDGG--SLDQVLK----KAG--RI---PEQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN--SRGEI--------------------KLCDFGVSG----------QLIDSMANS---FVGTRSYMSPERLQ------GTHYSVQSDIWSMGLSLVEMAV-GRYP-------------IP-PP--DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-------LK-QLMVHAFI--------------
-IRY---RDTLGHGNGGTV---YKAYH---V----P-S-GK---ILAVKVILLDI-TLELQ-KQ-I-MS-------ELEILYKC-D------SSY-----IIGFYGAFF--V--------ENRIS--ICTEFMDGG--SLD--------VYR--KM---PEHVLGRIAVAVVKGLTYLWS--LKILHRDVKPSNMLVN--TRGQV--------------------KLCDFGVST----------QLVNSIAKT---YVGTNAYMAPERIS------GEQYGIHSDVWSLGISFMELAL-GRFP-------------YP-QI--QKNQGSLMPLQLLQCIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVHFITQCMRKQPKERPA-------PE-ELMGHPFI--------------
----WRLGKLLGQGAFGRV---YLCYD---V----D-T-GR---ELAVKQVQFDP-DSPET-SK-EVNAL----ECEIQLLKNL-L------HER-----IVQYYGCLR--DP------QEKTLS--IFMEYMPGG--SIKDQLK----AYG--AL---TENVTRKYTRQILEGVHYLHS--NMIVHRDIKGANILRD--STGNV--------------------KLGDFGASKRLQ-----TICLSGTGMKS---VTGTPYWMSPEVIS------GEGYGRKADIWSVACTVVEMLT-EKPP-------------WA-EF-----EAMAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS-------AD-ELLRHMF-V-------------
---W-RRGKLLGQGAFGRV---YLCYD---V----D-T-GR---ELASKQVQFDP-DSPET-SK-EVSAL----ECEIQLLKNL-Q------HER-----IVQYYGCLR--DR------AEKTLT--IFMEYMPGG--SVKDQLK----AYG--AL---TESVTRKYTRQILEGMSYLHS--NMIVHRDIKGANILRD--SAGNV--------------------KLGDFGASKRLQ-----TICMSGTGMRS---VTGTPYWMSPEVIS------GEGYGRKADVWSLGCTVVEMLT-EKPP-------------WA-EY-----EAMAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS-------AE-ELLTHHF-A-------------
----YQNLSPVGSGAYGSV---CAAFD---T----K-T-GL---RVAVKKLSRPF-QSIIH-AK-RTYR-------ELRLLKHM-K------HEN-----VIGLLDVFT--PARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ--KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL--------------------KILDFGLAR-----------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTL-------------FP-GT--DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-------AA-QALAHAYF--------------
----YRLLKTIGKGNFAKV---KLARH---I----L-T-GK---EVAVKIIDKTQ-LNSSS-LQ-KLFR-------EVRIMKVL-N------HPN-----IVKLFEVIE--T--------EKTLY--LVMEYASGG--EVFDYLV----AHG--RM---KEKEARAKFRQIVSAVQYCHQ--KFIVHRDLKAENLLLD--ADMNI--------------------KIADFGFSNE---------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLP-------------FD-GQ-----NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT-------LE-QIMKDRWM--------------
----YELQETLGKGTYGKV---KRATE---R----F-S-GR---VVAIKSIRKDK-IKDEQ-DM-VHIR------REIEIMSSL-N------HPH-----IISIYEVFE--N--------KDKIV--IIMEYASKG--ELYDYIS----ERR--RL---SERETRHFFRQIVSAVHYCHK--NGVVHRDLKLENILLD--DNCNI--------------------KIADFGLSNL---------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMP-------------FD-GF-----DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT-------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKV---KKARE---S----S-G-R----LVAIKSIRKDK-IKDEQ-DL-MHIR------REIEIMSSL-N------HPH-----IIAIHEVFE--N--------SSKIV--IVMEYASRG--DLYDYIS----ERQ--QL---SEREARHFFRQIVSAVHYCHQ--NRVVHRDLKLENILLD--ANGNI--------------------KIADFGLSNL---------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMP-------------FD-GH-----DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT-------LE-DVASHWW-V-------------
----YTRFEKIGQGASGTV---YTALD---I----A-T-GQ---EVAIKQMNLQQ-QPKKE-LI-I--N-------EILVMREN-K------NPN-----IVNYLDSYL--V--------GDELW--VVMEYLAGG--SLTDVVT-----ET--CM---DEGQIAAVCRECLQALDFLHS--NQVIHRDIKSDNILLG--MDGSV--------------------KLTDFGFCAQI--------TPEQSKRST---MVGTPYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMVE-GEPP-------------YL-NE--NPLRALYLIATNGTPELQNPERLS---------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS-------AK-ELLQHPFL--------------
---Y-IKLDKLGEGTYATV---YKGKS---K----L-T-DN---LVALKEIRLEH-EEGAP-C--TAIR-------EVSLLKDL-K------HAN-----IVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN--II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL--------------------KLADFGLARAK--------SIPTKTYSN---EVVTLWYRPPDILL-----GSTDYSTQIDMWGVGCIFYEMAT-GRPL-------------FP-GS--TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AE-DAMKHPFF--------------
---F-KFGKILGEGSFSTV---VLARE---L----A-T-SR---EYAIKILEKRH-IIKEN-KVPYVTR-------ERDVMSRL-D------HPF-----FVKLYFTFQ--D--------DEKLY--FGLSYAKNG--ELLKYIR----KIG--SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHI--------------------QITDFGTAKVLS------PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPP-------------FR-AG-----NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
----YEKLEKLGEGSYATV---YKGKS---K----V-N-GK---LVALKVIRLQE-EEGTP-F--TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T--------KETLT--LVFEYVHT---DLCQYMD---KHPG--GL---HPDNVKLFLFQLLRGLSYIHQ--RYILHRDLKPQNLLIS--DTGEL--------------------KLADFGLARAK--------SVPSHTYSN---EVVTLWYRPPDVLL-----GSTEYSTCLDMWGVGCIFVEMIQ-GVAA-------------FP-GM-KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS-------AQ-AALSHEYF--------------
----YEPKEILGRGVSSVV---RRCIH---K----P-T-SQ---EYAVKVIDVTG-GGSFS-PE-EVRELREATLKEVDILRKVSG------HPN-----IIQLKDTYE--T--------NTFFF--LVFDLMKRG--ELFDYLT----EKV--TL---SEKETRKIMRALLEVICTLHK--LNIVHRDLKPENILLD--DNMNI--------------------KLTDFGFSCQ---------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPP-------------FW-HR-----KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
----YQVGAVLGSGGFGTV---YAGSR---I----A-D-GL---PVAVKHVVKER-VTEWG-SL-GGATV----PLEVVLLRKV-GAA--GGARG-----VIRLLDWFE--R--------PDGFL--LVLERPEPA-QDLFDFIT----ERG--AL---DEPLARRFFAQVLAAVRHCHS--CGVVHRDIKDENLLVD-LRSGEL--------------------KLIDFGSGA----------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIP-------------FE-QD-----------EEILRGRLLFRRRVS---------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS-------LD-QIAAHPWM--------------
--FR--CCAVLGRGHFGKV---LLAEY---K----N-T-NE---MFAIKALKKGD-IVARD-EV-DSLM------CEKRIFETV-NS---VRHPF-----LVNLFACFQ--T--------KEHVC--FVMEYAAGG--DLMMHIH-----TD--VF---SEPRAVFYAACVVLGLQYLHE--HKIVYRDLKLDNLLLD--TEGFV--------------------KIADFGLCKEG--------MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESP-------------FP-GD-----DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKV---MLADR---K----G-T-EE---LYAIKILKKDV-VIQDD-DV-ECTM------VEKRVLALLDK------PPF-----LTQLHSCFQ--T--------VDRLY--FVMEYVNGG--DLMYHIQ----QVG--KF---KEPQAVFYAAEISIGLFFLHK--RGIIYRDLKLDNVMLD--SEGHI--------------------KIADFGMCKEH--------MMDGVTTRT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQPP-------------FD-GE-----DEDELFQSIMEHNVSYPKSLS---------------------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKV---LLGEL---K----G-R-GE---YFAIKALKKDV-VLIDD-DV-ECTM------VEKRVLTLAAE------NPF-----LTHLICTFQ--T--------KDHLF--FVMEFLNGG--DLMYHIQ----DKG--RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVLLD--RDGHI--------------------KIADFGMCKEN--------IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSP-------------FH-GD-----DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKV---MLAEL---K----G-K-DE---VYAVKVLKKDV-ILQDD-DV-DCTM------TEKRILALARK------HPY-----LTQLYCCFQ--T--------KDRLF--FVMEYVNGG--DLMFQIQ----RSR--KF---DEPRSRFYAAEVTSALMFLHQ--HGVIYRDLKLDNILLD--AEGHC--------------------KLADFGMCKEG--------ILNGVTTTT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQPP-------------FE-AD-----NEDDLFESILHDDVLYPVWLS---------------------------------------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
--FI--LHKMLGKGSFGKV---FLAEF---K----K-T-NQ---FFAIKALKKDV-VLMDD-DV-ECTM------VEKRVLSLAWE------HPF-----LTHMFCTFQ--T--------KENLF--FVMEYLNGG--DLMYHIQ----SCH--KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHI--------------------KIADFGMCKEN--------MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSP-------------FH-GQ-----DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
--PD----EVLGSGQFGVV---YGGKH---R----K-T-GR---DVAVKVIDKLR-FPTKQ-ES-QLRN-------EVAILQSL-R------HPG-----IVNLECMFE--T--------PEKVF--VVMEKLHGD--MLEMILS---SEKG--RL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVLLA--SADPFP-----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFP-------------FN-ED-------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
YNVY----GYTGQGVFSNV---VRARD---N----ARA-NQ---EVAVKIIRNNE-LMQKT-G----LK-------ELEFLKKL-NDADPDDKFH-----CLRLFRHFY--H--------KQHLC--LVFEPLSM---NLREVLKK-YGKDV--GL---HIKAVRSYSQQLFLALKLLKR--CNILHADIKPDNILVN--ESKTI-------------------LKLCDFGSAS----------HVADNDITP---YLVSRFYRAPEIII------GKSYDYGIDMWSVGCTLYELYT-GKIL-------------FP-GK--TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS-------IN-QALQHAFI--------------
----FELLKVLGQGSFGKVFLVRKVTR---P----D-S-GH---LYAMKVLKKAT-LKVRD-RV-RTKM-------ERDILADV-N------HPF-----VVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALGLDHLHS--LGIIYRDLKPENILLD--EEGHI--------------------KLTDFGLSKEA--------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLP-------------FQ-GK-----DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAE-EIKRHV--FY------------
----FELLKVLGQGSFGKV---FLVKK---I----S-G-SDARQLYAMKVLKKAT-LKVRD-RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD--EEGHI--------------------KLTDFGLSKES--------IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLP-------------FQ-GK-----DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVE-EIKRHSFF--------------
----FELLKVLGQGSFGKV---FLVRK---K----T-G-PDAGQLYAMKVLKKAS-LKVRD-RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DVFTRLS----KEV--LF---TEEDVKFYLAELALALDHLHQ--LGIVYRDLKPENILLD--EIGHI--------------------KLTDFGLSKES--------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLP-------------FQ-GK-----DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS----EGVE-EIKRHLFF--------------
----FELLRVLGKGGYGKV---FQVRKVTGA----N-T-GK---IFAMKVLKKAM-IVRNA-KD-TAHTK-----AERNILEEV-K------HPF-----IVDLIYAFQ--T--------GGKLY--LILEYLSGG--ELFMQLE----REG--IF---MEDTACFYLAEISMALGHLHQ--KGIIYRDLKPENIMLN--HQGHV--------------------KLTDFGLCKES--------IHDGTVTHT---FCGTIEYMAPEILM------RSGHNRAVDWWSLGALMYDMLT-GAPP-------------FT-GE-----NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF--------------
----WEIVGELGDGAFGKV---YKAKN---K----E-T-GA---LAAAKVIETKS-EEELE-DY-I--V-------EIEILATC-D------HPY-----IVKLLGAYY--H--------DGKLW--IMIEFCPGG--AVDAIML---ELDR--GL---TEPQIQVVCRQMLEALNFLHS--KRIIHRDLKAGNVLMT--LEGDI--------------------RLADFGVSAKN--------LKTLQKRDS---FIGTPYWMAPEVVMCE-TMKDTPYDYKADIWSLGITLIEMAQ-IEPP-------------HH-EL--NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS-------AA-QLLEHPFV--------------
-YLM---GDLLGEGSYGKV---KEVLD---S----E-T-LC---RRAVKILKKKK-LRRIP-NG-EANVK-----KEIQLLRRL-R------HKN-----VIQLVDVLY--NE------EKQKMY--MVMEYCVCGMQEMLDSVP-----EK--RF---PVCQAHGYFCQLIDGLEYLHS--QGIVHKDIKPGNLLLT--TGGTL--------------------KISDLGVAEALH------PFAADDTCRT---SQGSPAFQPPEIAN----GLDTFSGFKVDIWSAGVTLYNITT-GLYP-------------FE-GD-----NIYKLFENIGKGSYAIPGDCG---------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS-------IR-QIRQHSWF--------------
----WTKGEILGKGAYGTV---YCGLT---S----Q-G-Q----LIAVKQVALDT-SNKLA-AE-KEYRKL---QEEVDLLKAL-K------HVN-----IVAYLGTCL--Q--------ENTVS--IFMEFVPGG--SISSIIN----RFG--PL---PEMVFCKYTKQILQGVAYLHE--NCVVHRDIKGNNVMLM--PTGII--------------------KLIDFGCARRLAWA--GLNGTHSDMLKS---MHGTPYWMAPEVIN------ESGYGRKSDIWSIGCTVFEMAT-GKPP-------------LA-SM----DRMAAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS-------AL-QLLKHSFL--------------
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