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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2D 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK2 163
CMGC CLK4 159
AGC GRK4 187
AGC GRK6 186
AGC GRK7 191
CAMK MARK2 53
CAMK MARK4 59
CAMK NUAK1 55
AGC PDPK1 82
CAMK PHKG1 20
AGC RPS6KA1 62
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
STE SLK 34
STE STK10 36
CAMK TSSK1B 12
-----FELLKVLGQGSYGKV---FLVRK---VK-GSDAGQLYAMKVLKKAT-LKVRDRV-RSKM-------------------------ERDILAEV-N-----HPF----IVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS---KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI-------------------KITDFGLSKEA----IDHDKRAYSFCGTIEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGSLPFQGK----DRKETMALILKAKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FEIGRPLGKGKFGNV---YLARE---KQ-SKF---ILALKVLFKAQLEKAGVEH-QLRR-------------------------EVEIQSHL-R-----HPN----ILRLYGYFHD--ATRVYLILEYAPLGTVYRELQ---KLSKF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL-------------------KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLVGKPPFEAN----TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
-----FEIGRPLGKGKFGNV---YLARE---KK-SHF---IVALKVLFKSQ-IEKEGVE-HQLR------------------------REIEIQAHL-H-----HPN----ILRLYNYFYD--RRRIYLILEYAPRGELYKELQ---KSCTF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL-------------------KIADFGWSV------HAPSLRRKTMCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLVGNPPFESA----SHNETYRRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
-----FEIGRPLGKGKFGNV---YLARL---KE-SHF---IVALKVLFKSQ-IEKEGLE-HQLR------------------------REIEIQAHL-Q-----HPN----ILRLYNYFHD--ARRVYLILEYAPRGELYKELQ---KSEKL--DEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV-------------------KIADFGWSV------HTPSLRRKTMCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLVGYPPFESA----SHSETYRRILKVDVRFPLSMP-----------------------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV-----------
-----YRLEKTLGKGQTGLV---KLGVH---CI-TGQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAILKLI-E-----HPH----VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLV---KKGRL--TPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNI-------------------RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIK-----GEKY--DGRRADMWSCGVILFALLVGALPFDDD----NLRQLLEKVKRGVFHMPHFIP-----------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLV---KLGVH---CV-TCQ---KVAIKIVNREK-LSESVLM-KVER-------------------------EIAILKLI-E-----HPH----VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLV---KKGRL--TPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNI-------------------RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIR-----GEKY--DGRKADVWSCGVILFALLVGALPFDDD----NLRQLLEKVKRGVFHMPHFIP-----------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----YQLFEELGKGAFSVV---RRCMK---IP-TGQ---EYAAKIINTKK-LSARDHQ-KLER-------------------------EARICRLL-K-----HPN----IVRLHDSISE--EGFHYLVFDLVTGGELFEDIV---AREYY--SEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGA----------------AVKLADFGLAIEV----QGDQQAWFGFAGTPGYLSPEVLR------KDP--YGKPVDMWACGVILYILLVGYPPFWDE----DQHRLYQQIKAGAYDFPSPEWDTVT-------------------------------------PEAKDLINKMLTINPAKRIT-----ASEALKHPWI-----------
-----YKLQSEIGKGAYGVV---RLAYN---ES-EDR---HYAMKVLSKKK-LLKQYGF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL-D-----HVN----VVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPC----DKPF--SEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHV-------------------KIADFGVSNQF----EGNDAQLSSTAGTPAFMAPEAISD---SGQSF--SGKALDVWATGVTLYCFVYGKCPFIDD----FILALHRKIKNEPVVFPEEPEIS---------------------------------------EELKDLILKMLDKNPETRIG-----VPDIKLHPWV-----------
-----YTLKDEIGKGSYGVV---KLAYN---EN-DNT---YYAMKVLSKKK-LIRQAGF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D-----HPN----VVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPT----LKPL--SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI-------------------KIADFGVSNEF----KGSDALLSNTVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE----RIMCLHSKIKSQALEFPDQPDIA---------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV-----------
-----YTKIEKIGEGTYGVV---YKGRH---KT-TGQ---VVAMKKIRLES-EEEGVPS-TAIR-------------------------EISLLKEL-R-----HPN----IVSLQDVLMQ--DSRLYLIFEFLSM-DLKKYLDSIPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELATKKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
-----FQKVEKIGEGTYGVV---YKARN---KL-TGE---VVALKKIRLDT-ETEGVPS-TAIR-------------------------EISLLKEL-N-----HPN----IVKLLDVIHT--ENKLYLVFEFLHQ-DLKKFMDA-SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVTRRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
----W-DLVQTLGEGAYGEV---QLAVN---RV-TEE---AVAVKIVDMKR-AVDCPEN-I-KK-------------------------EICINKML-N-----HEN----VVKFYGHRRE--GNIQYLFLEYCSGGELFDRIE---PDIGM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL-------------------KISDFGLATVFR--YNNRERLLNKMCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLAGELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEV---KLAFE---RK-TCK---KVAIKIISKRK-FAIGSAR-EADPALN-------------------VETEIEILKKL-N-----HPC----IIKIKNFF-D--AEDYYIVLELMEGGELFDKVV---GNKRL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC----------------LIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVS---VGTAG--YNRAVDCWSLGVILFICLSGYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
-----YEIVSTLGEGTFGRV---VQCVD---HR-RGG--ARVALKIIKNVE-KYKEAAR----L-------------------------EINVLEKI-NEKDPDNKN---LCVQMFDWFDY--HGHMCISFELLGL-STFDFLK---DNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL------ELG--WSQPCDVWSIGCIIFEYYVGFTLFQTH-DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF-----------
-----YEIVDTLGEGAFGKV---VECID---HGMDGM---HVAVKIVKNVG-RYREAAR-S----------------------------EIQVLEHL-NS---TDPNSVFRCVQMLEWFDH--HGHVCIVFELLGL-STYDFIK---ENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL------ALG--WSQPCDVWSIGCILIEYYLGFTVFQTH-DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-----LDEALQHPFF-----------
---FR--HYRVLGKGGFGEV---CACQV---RA-TGK---MYACKKLQKKR-IKKRKGE-AMAL------------------------NEKRILEKV-Q-----SRF----VVSLAYAYET--KDALCLVLTIMNGGDLKFHIYN-LGNPGF--DEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHI-------------------RISDLGLATE-----IPEGQRVRGRVGTVGYMAPEVVN------NEK--YTFSPDWWGLGCLIYEMIQGHSPFKKY-KEKVKWEEVDQRIKNDTEEYSE---KFS-------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPV-F----------
----F-RQYRVLGKGGFGEV---CACQV---RA-TGK---MYACKKLEKKR-IKKRKGE-AMAL------------------------NEKQILEKV-N-----SRF----VVSLAYAYET--KDALCLVLTLMNGGDLKFHIYH-MGQAGF--PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-------------------RISDLGLAVH-----VPEGQTIKGRVGTVGYMAPEVVK------NER--YTFSPDWWALGCLLYEMIAGQSPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS-------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
----F-TEFRVLGKGGFGEV---CAVQV---KN-TGK---MYACKKLDKKR-LKKKGGE-KMAL------------------------LEKEILEKV-S-----SPF----IVSLAYAFES--KTHLCLVMSLMNGGDLKFHIYN-VGTRGL--DMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNC-------------------RLSDLGLAVE-----MKGGKPITQRAGTNGYMAPEILM-----EKVS--YSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF---T-------------------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR-----
-----YRLLKTIGKGNFAKV---KLARH---IL-TGK---EVAVKIIDKTQ-LNSSSLQ-KLFR-------------------------EVRIMKVL-N-----HPN----IVKLFEVIET--EKTLYLVMEYASGGEVFDYLV---AHGRM--KEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNI-------------------KIADFGFSNE-----FTFGNKLDTFCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVSGSLPFDGQ----NLKELRERVLRGKYRIPFYMS-----------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLRTIGKGNFAKV---KLARH---IL-TGR---EVAIKIIDKTQ-LNPSSLQ-KLFR-------------------------EVRIMKGL-N-----HPN----IVKLFEVIET--EKTLYLVMEYASAGEVFDYLV---SHGRM--KEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANI-------------------KIADFGFSNE-----FTLGSKLDTFCGSPPYAAPELFQ-----GKKY--DGPEVDIWSLGVILYTLVSGSLPFDGH----NLKELRERVLRGKYRVPFYMS-----------------------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
-----YELQETLGKGTYGKV---KRATE---RF-SGR---VVAIKSIRKDK-IKDEQDM-VHIR------------------------REIEIMSSL-N-----HPH----IISIYEVFEN--KDKIVIIMEYASKGELYDYIS---ERRRL--SERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI-------------------KIADFGLSNL-----YQKDKFLQTFCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVYGTMPFDGF----DHKNLIRQISSGEYREPTQP------------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
----F-KFGKILGEGSFSTV---VLARE---LA-TSR---EYAIKILEKRH-IIKENKVPYVTR-------------------------ERDVMSRL-D-----HPF----FVKLYFTFQD--DEKLYFGLSYAKNGELLKYIR---KIGSF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI-------------------QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT------EKS--ACKSSDLWALGCIIYQLVAGLPPFRAG----NEYLIFQKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIH---KP-TSQ---EYAVKVIDVTG-GGSFSPE-EVRELRE------------------ATLKEVDILRKVSG-----HPN----IIQLKDTYET--NTFFFLVFDLMKRGELFDYLT---EKVTL--SEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNI-------------------KLTDFGFSCQ-----LEPGERLREVCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLAGSPPFWHR----KQMLMLRMIMSGNYQFGSPEWDDYS-------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
-----FELLKVLGQGSFGKVFLVRKVTR---PD-SGH---LYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDILADV-N-----HPF----VVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS---KEVMF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI-------------------KLTDFGLSKEA----IDHEKKAYSFCGTVEYMAPEVVN------RQG--HSHSADWWSYGVLMFEMLTGSLPFQGK----DRKETMTLILKAKLGMPQFLS-----------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSFGKV---FLVKK---IS-GSDARQLYAMKVLKKAT-LKVRDRV-RTKM-------------------------ERDILVEV-N-----HPF----IVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS---KEVMF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI-------------------KLTDFGLSKES----IDHEKKAYSFCGTVEYMAPEVVN------RRG--HTQSADWWSFGVLMFEMLTGTLPFQGK----DRKETMTMILKAKLGMPQFLS-----------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRK---KT-GPDAGQLYAMKVLKKAS-LKVRDRV-RTKM-------------------------ERDILVEV-N-----HPF----IVKLHYAFQT--EGKLYLILDFLRGGDVFTRLS---KEVLF--TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI-------------------KLTDFGLSKES----VDQEKKAYSFCGTVEYMAPEVVN------RRG--HSQSADWWSYGVLMFEMLTGTLPFQGK----DRNETMNMILKAKLGMPQFLS-----------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
-----FELLRVLGKGGYGKV---FQVRKVTGAN-TGK---IFAMKVLKKAM-IVRNAKD-TAHTK-----------------------AERNILEEV-K-----HPF----IVDLIYAFQT--GGKLYLILEYLSGGELFMQLE---REGIF--MEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHV-------------------KLTDFGLCKES----IHDGTVTHTFCGTIEYMAPEILM------RSG--HNRAVDWWSLGALMYDMLTGAPPFTGE----NRKKTIDKILKCKLNLPPYLT-----------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF-----------
-----WEIIGELGDGAFGKV---YKAQN---KE-TSV---LAAAKVIDTKS-EEELEDY-M--V-------------------------EIDILASC-D-----HPN----IVKLLDAFYY--ENNLWILIEFCAGGAVDAVML--ELERPL--TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI-------------------KLADFGVSAKN----TRTIQRRDSFIGTPYWMAPEVVMCE-TSKDRP--YDYKADVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS-----------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV-----------
-----WEIVGELGDGAFGKV---YKAKN---KE-TGA---LAAAKVIETKS-EEELEDY-I--V-------------------------EIEILATC-D-----HPY----IVKLLGAYYH--DGKLWIMIEFCPGGAVDAIML--ELDRGL--TEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDI-------------------RLADFGVSAKN----LKTLQKRDSFIGTPYWMAPEVVMCE-TMKDTP--YDYKADIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIAKSDPPTLLTPSKWS-----------------------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV-----------
YLLGI-----NLGEGSYAKV---KSAYS---ER-LKF---NVAIKIIDRKK-APADFLE-KFLP------------------------REIEILAML-N-----HCS----IIKTYEIFET-SHGKVYIVMELAVQGDLLELIK---TRGAL--HEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNI-------------------KLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQ-----GIPY--QPKVYDIWSLGVILYIMVCGSMPYDDS----NIKKMLRIQKEHRVNFPRSKHLT---------------------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM-----------
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