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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
TK ALK 1116
TK CSF1R 582
TK FGFR1 478
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK KIT 589
TKL LRRK2 1886
TK LTK 510
TKL MAP3K11 117
TKL MAP3K9 144
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PDGFRB 600
AGC PDPK1 82
TK PTK2 422
TKL RAF1 349
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA6 73
TK SRC 270
---FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKA--TLKVRD-----R-V-RSKM-ERDILAEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLS---KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL---G---IIYRDLKPENILLDE--------EGHI--------KITDFGLSKEA----IDHDKRA--------------YS---FCGTIEYMAPEVVN-RRG---HTQSADWWSFGVLMFEMLT-GSLP---------------FQGK-------DRKETM-ALILK----AKLGMPQFLS------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
--I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPL---QVAVKTLP-E--VCS-EQD---EL-D-FL-M-EALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN---H---FIHRDIAARNCLLTCP-----GPGRVA--------KIGDFGMARDI--Y-R--ASYY--------------RKGGCAMLPVKWMPPEAFM-EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK----SNQEVLEFV-TSGGR----MDPPKNCP--------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I-----------
---LQFGKTLGAGAFGKV---VEATAFG--LGKEDAVL---KVAVKMLK-S--TAH-ADE---KE-A-LM-S-ELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK---N---CIHRDVAARNVLLTN--------GHVA--------KIGDFGLARDI--M-N--DSNY--------------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGLNP---------------YPGI-L--VNSKFYKLV-KDGYQ----MAQPAFAP--------------KNIYSIMQACWALEPTHRPT-----FQQICSFL-------------
--L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVT---KVAVKMLK-S--DAT-EKD---LS-D-LI-S-EMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK---K---CIHRDLAARNVLVTE--------DNVM--------KIADFGLARDI--H-H--IDYY--------------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV----PVEELFKLL-KEGHR----MDKPSNCT--------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
VGG----NKMGEGGFGVV---YKGYVN-------NTT-----VAVKKLAAM--VDITTE-----ELK-QQFDQEIKVMAKC-QHENLVELLGFSS--DGDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---H---HIHRDIKSANILLDE--------AFTA--------KISDFGLARASE--KFAQTVMT--------------SR---IVGTTAYMAPEALR--GE---ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH----REPQLLLDI-KEEIE----DEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ--------
---LKFLQQLGKGNFGSV---EMCRYDP---LQDNTGE---VVAVKKLQ-H--STE--EH---LR-D-FE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK---R---YIHRDLATRNILVEN--------ENRV--------KIGDFGLTKVL-PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM----IVFHLIELL-KNNGR----LPRPDGCP--------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
--L-KYISQLGKGNFGSV---ELCRYDP---LGDNTGA---LVAVKQLQ-H--SGP-DQ----QR-D-FQ-R-EIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR---R---CVHRDLAARNILVES--------EAHV--------KIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P--ALCRLLELL-EEGQR----LPAPPACP--------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL----------
---LSFGKTLGAGAFGKV---VEATAYG--LIKSDAAM---TVAVKMLK-P--SAH-LTE---RE-A-LM-S-ELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK---N---CIHRDLAARNILLTH--------GRIT--------KICDFGLARDI--K-N--DSNY--------------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGSSP---------------YPGM-P--VDSKFYKMI-KEGFR----MLSPEHAP--------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I-----------
EFL------LGDGSFGSV---YRAAYE-------GEE-----VAVKIFNKH--TSLRLL-----R-Q------ELVVLCHL-HHPSLISLLAAGI--RP--RMLVMELASKGSLDRLLQ--QDKA----------------------------------------------------------------------------------------------------SLTRTLQHRIALHVADGLRYLHSA---M---IIYRDLKPHNVLLFT--------LY-PNAA--IIAKIADYGIAQ------YCCRMGI--------------KT---SEGTPGFRAPEVARGNVI---YNQQADVYSFGLLLYDILTTGGRI---------------VEGLK-FPNEFDELEIQ-GKLPD----PVKEYGCAPW------------PMVEKLIKQCLKENPQERPT-----SAQVF-----DIL--------
--V-TLLRALGHGAFGEV---YEGLVIG--LPGDSSPL---QVAIKTLP-E--LCS-PQD---EL-D-FL-M-EALIISKF-RHQNIVRCVGLSL--RATPRLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN---H---FIHRDIAARNCLLSCA-----GPSRVA--------KIGDFGMARDI--Y-R--ASYY--------------RRGDRALLPVKWMPPEAFL-EGI---FTSKTDSWSFGVLLWEIFSLGYMP---------------YPGR----TNQEVLDFV-VGGGR----MDPPRGCP--------------GPVYRIMTQCWQHEPELRPS-----FASILERL-------------
---LRLEEVIGIGGFGKV---YRGSWR---------GE---LVAVKAAR-Q--DPD-EDISVTAE-S-VR-Q-EARLFAML-AHPNIIALKAVCL--EEPNLCLVMEYAAGGPLSRALA----GR----------------------------------------------------------------------------------------------------RVPPHVLVNWAVQIARGMHYLHCE---ALVPVIHRDLKSNNILLLQPIESDDMEHKTL--------KITDFGLAREW---------HK--------------TTQMSAAGTYAWMAPEVIK-AST---FSKGSDVWSFGVLLWELLT-GEVP---------------YRGI----DCLAVAYGVAVNKLT----LPIPSTCP--------------EPFAQLMADCWAQDPHRRPD-----FASILQQL-------------
--L-TLEEIIGIGGFGKV---YRAFWI-------GDE-----VAVKAARHDP-DEDISQ-----T-I-ENVRQEAKLFAML-KHPNIIALRGVCL--KEPNLCLVMEFARGGPLNRVLS----GK----------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHDEAIVP---IIHRDLKSSNILILQ--------KVENGDLSNKILKITDFGLAR------EWHRTTK--------------MS---AAGTYAWMAPEVIR-ASM---FSKGSDVWSYGVLLWELLT-GEVP---------------FRGI-------DGLAVA-YGVAM----NKLALPIPSTCP----------EPFAKLMEDCWNPDPHSRPS-----FTNILDQ---LT---------
-IV--LKWELGEGAFGKV---FLAECHN--LLPEQDKM---LVAVKALK-E--ASE-SA----RQ-D-FQ-R-EAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL---H---FVHRDLATRNCLVGQ--------GLVV--------KIGDFGMSRDI--Y-S--TDYY--------------RVGGRTMLPIRWMPPESIL-YRK---FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL----SNTEAIDCI-TQGRE----LERPRACP--------------PEVYAIMRGCWQREPQQRHS-----IKDVHARL-------------
--I-VLKRELGEGAFGKV---FLAECYN--LCPEQDKI---LVAVKTLK-D--ASD-NA----RK-D-FH-R-EAELLTNL-QHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ---H---FVHRDLATRNCLVGE--------NLLV--------KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSLGVVLWEIFTYGKQP---------------WYQL----SNNEVIECI-TQGRV----LQRPRTCP--------------QEVYELMLGCWQREPHMRKN-----IKGIHTL--L-----------
--I-VLKRELGEGAFGKV---FLAECYN--LSPTKDKM---LVAVKALK-D--PTL-AA----RK-D-FQ-R-EAELLTNL-QHEHIVKFYGVCG--DGDPLIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ---H---FVHRDLATRNCLVGA--------NLLV--------KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRK---FTTESDVWSFGVILWEIFTYGKQP---------------WFQL----SNTEVIECI-TQGRV----LERPRVCP--------------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL-------------
--L-VLGRTLGSGAFGQV---VEATAHG--LSHSQATM---KVAVKMLK-S--TAR-SSE---KQ-A-LM-S-ELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK---N---CVHRDLAARNVLICE--------GKLV--------KICDFGLARDI--M-R--DSNY--------------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGGTP---------------YPEL-P--MNEQFYNAI-KRGYR----MAQPAHAS--------------DEIYEIMQKCWEEKFEIRPP-----FSQLVL---LL----------
--F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKR--HIIKEN-----K-VPYVTR-ERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR---KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGK---G---IIHRDLKPENILLNE--------DMHI--------QITDFGTAKVLS--PESKQARA--------------NS---FVGTAQYVSPELLT-EKS---ACKSSDLWALGCIIYQLVA-GLPP---------------FRAG-------NEYLIF-QKIIK----LEYDFPEKFF------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---IELGRCIGEGQFGDV---HQGIYM----SPENPAL---AVAIKTCK-N--CTS-DSV---RE-K-FL-Q-EALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK---R---FVHRDIAARNVLVSS--------NDCV--------KLGDFGLSRYM----E--DSTY--------------YKASKGKLPIKWMAPESIN-FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV----KNNDVIGRI-ENGER----LPMPPNCP--------------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL-------------
-VM--LSTRIGSGSFGTV---YKGKWH----------G---DVAVKILK-V-VDPT-PEQ---FQ-A-FR-N-EVAVLRKT-RHVNILLFMGYMT---KDNLAIVTQWCEGSSLYKHLH----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK---N---IIHRDMKSNNIFLHE--------GLTV--------KIGDFGLATVK--S-R--WSGS--------------QQVEQPTGSVLWMAPEVIR-MQDNNPFSFQSDVYSYGIVLYELMT-GELP---------------YSHI-N--NRDQIIFMV-GRGYASPDLSKLYKNCP--------------KAMKRLVADCVKKVKEERPL-----FPQILSS--I-----------
--L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYT---TVAVKMLK-E--NAS-PSE---LR-D-LL-S-EFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM---K---LVHRDLAARNILVAE--------GRKM--------KISDFGLSRDV--Y-E--EDSY--------------VKRSQGRIPVKWMAIESLF-DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI----PPERLFNLL-KTGHR----MERPDNCS--------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
---FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKA--TLKVRD-----R-V-RTKM-ERDILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLS---KEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL---G---IIYRDLKPENILLDE--------EGHI--------KLTDFGLSKEA----IDHEKKA--------------YS---FCGTVEYMAPEVVN-RQG---HSHSADWWSYGVLMFEMLT-GSLP---------------FQGK-------DRKETM-TLILK----AKLGMPQFLS------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKA--SLKVRD-----R-V-RTKM-ERDILVEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDVFTRLS---KEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL---G---IVYRDLKPENILLDE--------IGHI--------KLTDFGLSKES----VDQEKKA--------------YS---FCGTVEYMAPEVVN-RRG---HSQSADWWSYGVLMFEMLT-GTLP---------------FQGK-------DRNETM-NMILK----AKLGMPQFLS------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTT---RVAIKTLK-P--GTM-SP-----E-A-FL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM---N---YVHRDLRAANILVGE--------NLVC--------KVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM----VNREVLDQV-ERGYR----MPCPPECP--------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
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