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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CSNK2A1 39
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PRKCA 339
-FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKAT-LKVRDRVRSKM----ERDILAEV-N----HPF--IVKLHYAFQT--EGKLYLILDF-LRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GSLPFQ-GK---DRKETMALILKAKLGMPQFLS----------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF--------------
-FEIGRPLGKGKFGNVYLAREKQSKF---ILALKVLFKAQLEKAGVEHQLRR----EVEIQSHL-R----HPN--ILRLYGYFHD--ATRVYLILEY-APLG-TVYRELQ--KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--------------
-FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDT-ETEGVPSTAIR----EISLLKEL-N----HPN--IVKLLDVIHT--ENKLYLVFEF-LHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--------------
-FQKVEKIGEGTYGVVYKAKNRETGQ---LVALKKIRLDL-EMEGVPSTAIR----EISLLKEL-K----HPN--IVRLLDVVHN--ERKLYLVFEF-LSQ--DLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFP-GDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR--------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF--------------
-YEKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDD-DDEGVPSSALR----EICLLKEL-K----HKN--IVRLHDVLHS--DKKLTLVFEF-CDQ--DLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF--------------
-YQLVRKLGRGKYSEVFEAINITNNE---KVVVKILKPVK-KKKIKR---------EIKILENLRG----GPN--IITLADIVKDPVSRTPALVFEH-VNNT-DFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF--------------
-YQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKV-S----SGFSGVIRLLDWFER--PDSFVLILER-PEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--------------
-YRLGPLLGKGGFGTVFAGHRLTDRL---QVAIKVIPRNR-VLGWSPLSDSVTCPLEVALLWKV-GAGGGHPG--VIRLLDWFET--QEGFMLVLERPLPAQ-DLFDYIT--EKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGA--LLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPFE-RD---------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPS-----LEEILLDPWM--------------
-YQVGAVLGSGGFGTVYAGSRIADGL---PVAVKHVVKER-VTEWGSLGGATV-PLEVVLLRKV-GAAGGARG--VIRLLDWFER--PDGFLLVLER-PEPAQDLFDFIT--ERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC-GDIPFE-QD---------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM--------------
F-NFLMVLGKGSFGKVMLADRKGTEE---LYAIKILKKDV-VIQDDDVECTM---VEKRVLALLDK----PPF--LTQLHSCFQT--VDRLYFVMEY-VNGG-DLMYHIQ--QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFD-GE---DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
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