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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK STK11 203
CAMK CHEK2 220
AGC GRK6 186
CMGC GSK3B 56
CAMK MAPKAPK2 64
AGC PDPK1 82
AGC PRKCI 245
YLM---GDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNG-EANVK----KEIQLLRRL-RHKNVIQLVDVLYNE--EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLT-TGGTL---KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGD---------NIYKLFENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF-----------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D----AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH--------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE-AMAL-----NEKQILEKV-NSRFVVSLAYAYET----KDALC--LVLTLMNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI---RISDLGLAVH---VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFPGD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------R------EVELHWRASQCPHIVRIVDVYENLYAGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD----DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVAGLPPFRAG---------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
--F-DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDI-DWVQ-----TEKHVFEQASNHPFLVGLHSCFQT----ESRLF--FVIEYVNGG--DLMFHMQ----RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD-SEGHI---KLTDYGMCKEG--LRPGDTTSTFCGTPNYIAPEILR---GEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
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