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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other STK16 203
CMGC CDK6 13
TK EPHB4 615
Other STK36 4
YL--FIQKLGEGGFSYVDLVEGL---HDGH-FYALKRILCHEQQDRE--EA--QREADMHRLFN---HPNILRLVAYCLRER-GAKHEAWLLLPFFKRGTLWNEIERLKDKGN--FLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHV---EGSRQALTLQDWAA---QRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMF-GEGPYDMV--FQKGDSVALAVQNQLSIPQSPR--HS--------------------SALRQLLNSMMTVDPHQRPHIPLLL-----SQL
--YECVAEIGEGAYGKVFKARDL---KNGGRFVALKRVRVQTGEEGM--PLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDK--VPEP--GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-------------YSFQMALTS---VVVTLWYRAPEV--LL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF---
-V-KIEEVIGAGEFGEVCRGRLKAPGKKES-CVAIKTLK-GGYT-ERQRREFL-SEASIMGQFE---HPNIIRLEGVVTN-----SMPVMILTEFMENGALDSFLR-----LNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLE---ENS-----S--DPTYTSSLGGKIPIRWTAPEA--IA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP--------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL-----
--YHVLEMIGEGSFGRVYKGRRK---YSAQ-VVALKFIPKLGRSEKE--LRNLQREIEIMRGLR---HPNIVHMLDSFET-----DKEVVVVTDYAEG-ELFQILE----DDG--KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAM------------STNTMVLTS---IKGTPLYMSPEL--VE-ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS------------------------PCFKNFLQGLLTKDPRQRLSWPDLLYHPFI---
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