|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK STK17B 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
TK LYN 247
CMGC MAPK14 24
Other PLK1 53
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCQ 380
CAMK PRKD1 583
AGC ROCK1 76
STE SLK 34
ILT---SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILH-EIAVLELAKSCPRVINLHEVYEN------TSEIILILEYAAGGEIFSLCLP-ELAE---MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK---IGHACELRE---IMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE---DNQETYLNISQVNVDYSEETFSSVS------------------------------QLATDFIQSLLVKNPEK--RPT-------AE-ICLSHSWL--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHL-RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQ--RPM-------LR-EVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHL-HHPNILRLYNYFYD------RRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GNPPFE-SA---SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSE--RLP-------LA-QVSAHPWV--------------
---YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHSNIVRLHDSISE------EGFHYLVFDLVTGGELFEDIV---ARE---YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKCKGAAVKLADFGLAIEV--QGDQQAWFG---FAGTPGYLSPEVLR-----KEAYGKPVDIWACGVILYILLV-GYPPFW-DE---DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAK--RIT-------AH-EALKHPWV--------------
---YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHPNIVRLHDSISE------EGFHYLVFDLVTGGELFEDIV---ARE---YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGAAVKLADFGLAIEV--QGDQQAWFG---FAGTPGYLSPEVLR-----KDPYGKPVDMWACGVILYILLV-GYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKDLINKMLTINPAK--RIT-------AS-EALKHPWI--------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIR-EISLLKEL-RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-------GK-MALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR-EISLLKEL-NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-------AK-AALAHPFF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK-EICINKML-NHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSA--RIT-------IP-DIKKDRW-Y-------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------EIKILENLRGGPNIITLADIVKDP----VSRTPALVFEHVNNTDFKQLY------Q---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-------AR-EAMEHPYF--------------
---IKLVKRLGAGQFGEVWMGYYN-NSTKVAVKTLK-PG-TM-SVQAFL-E-EANLMKTL-QHDKLVRLYAVVTR------EEPIYIITEYMAKGSLLDFLK----SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMC---KIADFGLARVI--E--DNEYTAREGAKFPIKWTAPEAIN-----FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GRTNADVMTALSQGYRMPRVENCP------------------------------------DELYDIMKMCWKEKAEE--RPT-------FD-YLQSV--L--------------
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYR-ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-------AA-QALAHAYF--------------
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQREKMSMEISIHRSL-AHQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV--EYDGERKKT---LCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---CLKETYLRIKKNEYSIPKHIN----------------------------------PVAASLIQKMLQTDPTA--RPT-------IN-ELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-VIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQT------MDRLYFVMEYVNGGDLMYHIQ---QVG---RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEN--IWDGVTTKT---FCGTPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLA-GQAPFE-GE---DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGK--RLG-------C----------GPEGERDIKEHAFF
-FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDV-VLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQT------KDHLFFVMEFLNGGDLMYHIQ---DKG---RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI---KIADFGMCKEN--IFGESRAST---FCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLI-GQSPFH-GD---DEDELFESIRVDTPHYPRWIT----------------------------------KESKDILEKLFEREPTK--RLG------VTG-NIKIHPFF--------------
--F-NFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDV-ILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQT------KDRLFFVMEYVNGGDLMFQIQ---RSR---KFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLD-AEGHC---KLADFGMCKEG--ILNGVTTTT---FCGTPDYIAPEILQ-----ELEYGPSVDWWALGVLMYEMMA-GQPPFE-AD---NEDDLFESILHDDVLYPVWLS----------------------------------KEAVSILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF------------
---FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV-ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQT------PDRLFFVMEFVNGGDLMFHIQ---KSR---RFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHC---KLADFGMCKEG--ICNGVTTAT---FCGTPDYIAPEILQ-----EMLYGPAVDWWAMGVLLYEMLC-GHAPFE-AE---NEDDLFEAILNDEVVYPTWLH----------------------------------EDATGILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-------------
-FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-VLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT------KENLFFVMEYLNGGDLMYHIQ---SCH---KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI---KIADFGMCKEN--MLGDAKTNT---FCGTPDYIAPEILL-----GQKYNHSVDWWSFGVLLYEMLI-GQSPFH-GQ---DEEELFHSIRMDNPFYPRWLE----------------------------------KEAKDLLVKLFVREPEK--RLG-------VRGDIRQHPLF--------------
-PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLR-FPTKQESQLRN-EVAILQNL-HHPGVVNLECMFET------PERVFVVMEKLHGDMLEMILS--SEKG---RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI---IGEKSFRRS---VVGTPAYLAPEVLR-----NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED-----EDIHDQIQNAAFMYPPNPWKEIS------------------------------HEAIDLINNLLQVKMRK--RYS-------VD-KTLSHPWL--------------
---YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFE-MIKRSDSAFFWEERDIMAFA-NSPWVVQLFYAFQD------DRYLYMVMEYMPGGDLVNLMS----NY---DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLD-KSGHL---KLADFGTCMKM-NKEGMVRCDT---AVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLV-GDTPFY-AD---SLVGTYSKIMNHKNSLTFPDDNDIS------------------------------KEAKNLICAFLTDREVRLGRNG-------VE-EIKRHLFF--------------
---WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS-EEELEDYM--V-EIDILASC-DHPNIVKLLDAFYY------ENNLWILIEFCAGGAVDAVML--ELER---PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI---KLADFGVSAKN--TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-ELNPMRVLLKIAKSEPPTLAQPSRWS----------------------------------SNFKDFLKKCLEKNVDA--RWT-------TS-QLLQHPFV--------------
|