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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE STK24 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CAMK DAPK1 13
TK EGFR 712
Other EIF2AK2 267
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
AGC GRK6 186
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK LCK 245
STE MAP2K1 68
CMGC MAPK12 27
CAMK MAPKAPK2 64
TK MET 1078
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCI 245
TK PTK2 422
TK RET 724
TK SRC 270
STE STRADA 69
TK TNK2 150
Other TTK 525
TK ZAP70 338
----FTKLEKIGKG--SFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q------EITVLSQC--D-SPY--VTKYYGSYL-K-----------------------------DTKLWIIMEYLGGG-SAL-DLLE----PG-------------------------PLDETQIATILREILKGLDYLHS-EKKIHRDIKAANVLLS-E---HGEV----KLADFGVAGQL-----------TDTQIKR--NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PPHSEL------HPMKVLFLI-PKNNPPTLEGNYS------------------------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI-----------
----ITMKHKLGGG--QYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K------EAAVMKEI--K-HPN--LVQLLGVCT-R-----------------------------EPPFYIITEFMTYG-NLL-DYLR----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG-E---NHLV----KVADFGLSRLM-----------T--GDTY--TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYPGI------DLSQVYELL-EKDYRMERPEGCP------------------------------------------------EKVYELMRACWQWNPSDRPS------FAEIHQA--F-----------
---I-TLIRGLGHG--AFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-D-FL-M------EALIISKF--N-HQN--IVRCIGVSL-Q-----------------------------SLPRFILLELMAGG-DLK-SFLR----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEE-NHFIHRDIAARNCLLT-CPGPGRVA----KIGDFGMARDI-----Y-----R--ASYY--RKGGCAMLPVKWMPPEAFM-----------EGIFTSKTDTWSFGVLLWEIFSLGY-MPYPSK------SNQEVLEFV-TSGGRMDPPKNCP------------------------------------------------GPVYRIMTQCWQHQPEDRPN------FAIILER--I-----------
----FEIGRPLGKG--KFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR------EVEIQSHL--R-HPN--ILRLYGYFH-D-----------------------------ATRVYLILEYAPLG-TVY-RELQ---KLS-------------------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-S---AGEL----KIADFGWSV-------------HAPSSRR--TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN---------TYQETY-KRISRVEFTFPDFVT----------------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
----YELCEVIGKG--PFSVVRRCINR-------ETGQQFAVKIVDVA--K-FTSSP--G-L-STEDL---KREASICHML--K-HPH--IVELLETYS-S-----------------------------DGMLYMVFEFMDGA-DLCFEIVKRADAGF-------------------------VYSEAVASHYMRQILEALRYCHD-NNIIHRDVKPHCVLLA-S---KENSA-PVKLGGFGVAIQL-----------GESGLVA--GG---RVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLS-GC-LPFYGT----------KERLF-EGIIKGKYKMNPRQWSHIS------------------------------------------ESAKDLVRRMLMLDPAERIT------VYEALNHPWL-----------
----FQKVEKIGEG--TYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR------EISLLKEL--N-HPN--IVKLLDVIH-T-----------------------------ENKLYLVFEFLHQ--DLK-KFMDA-SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-T---EGAI----KLADFGLARAF-----------GVPVRTY--TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
----YEKLAKIGQG--TFGEVFKARHR-------KTGQKVALKKVLME--N-EKEGF--P-I-TALR------EIKILQLL--K-HEN--VVNLIEICR-TKASP---------------------YNRCKGSIYLVFDFCEH--DLA-GLLS--NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLIT-R---DGVL----KLADFGLARAFSL-------AKNSQPNRY--TN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQGN------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK-----------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID------SDDALNHDFF-----------
--YI--MSKTLGSG--ACGEVKLAFER-------KTCKKVAIKIISKR--K-FAIGS--A-R-EADPALNVETEIEILKKL--N-HPC--IIKIKNFF--D-----------------------------AEDYYIVLELMEGG-ELF-DKVV---GNK-------------------------RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-S---QEEDC-LIKITDFGHSKI------------LGETSLM--RT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GY-PPFSEH--------RTQVSLK-DQITSGKYNFIPEVWAEVS------------------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
----YDTGEELGSG--QFAVVKKCREK-------STGLQYAAKFIKKR--R-TKSSR--R-G-VSREDI--EREVSILKEI--Q-HPN--VITLHEVYE-N-----------------------------KTDVILILELVAGG-ELF-DFLA---EKE-------------------------SLTEEEATEFLKQILNGVYYLHS-LQIAHFDLKPENIMLL-D---RNVPKPRIKIIDFGLAHK------------IDFGNEF--KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SPFLGD---------TKQETL-ANVSAVNYEFEDEYFSNTS------------------------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
---F-KKIKVLGSG--AFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-E-IL-D------EAYVMASV--D-NPH--VCRLLGICL-------------------------------TSTVQLITQLMPFG-CLL-DYVR----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVK-T---PQHV----KITDFGLAKLL-----G-----A--EEKE--YHAEGGKVPIKWMALESIL-----------HRIYTHQSDVWSYGVTVWELMTFGS-KPYDGI------PASEISSIL-EKGERLPQPPICT------------------------------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF---------
---F-KEIELIGSG--GFGQVFKAKHR-------IDGKTYVIKRVKYN--N-EKAER----------------EVKALAKL--D-HVN--IVHYNGCWD-GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKG-TLE-QWIEK-RRGE-------------------------KLDKVLALELFEQITKGVDYIHS-KKLIHRDLKPSNIFLV-D---TKQV----KIGDFGLVTS------------LKNDGKR--TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFET-------------SKF-FTDLRDGIISDIFDK-----------------------------------------------KEKTLLQKLLSKKPEDRPN------TSEILR----TLT--------
---L-RKLKVLGSG--VFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-A-VT-D------HMLAIGSL--D-HAH--IVRLLGLCP-------------------------------GSSLQLVTQYLPLG-SLL-DHVR----QH-----------------------RGALGPQLLLNWGVQIAKGMYYLEE-HGMVHRNLAARNVLLK-S---PSQV----QVADFGVADLL-----P-----P--DDKQ--LLYSEAKTPIKWMALESIH-----------FGKYTHQSDVWSYGVTVWELMTFGA-EPYAGL------RLAEVPDLL-EKGERLAQPQICT------------------------------------------------IDVYMVMVKCWMIDENIRPT------FKELANE--F-----------
---L-VLGKPLGEG--CFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S------EMEMMKMIG-K-HKN--IINLLGACT-Q-----------------------------DGPLYVIVEYASKG-NLR-EYLQ----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-KKCIHRDLAARNVLVT-E---DNVM----KIADFGLARDI-----H-----H--IDYY--KKTTNGRLPVKWMAPEALF-----------DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPGV------PVEELFKLL-KEGHRMDKPSNCT------------------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
----LTLGKPLGEG--CFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S------EMEMMKMIG-K-HKN--IINLLGACT-Q-----------------------------DGPLYVIVEYASKG-NLR-EYLR----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-QKCIHRDLAARNVLVT-E---NNVM----KIADFGLARDI-----N-----N--IDYY--KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SPYPGI------PVEELFKLL-KEGHRMDKPANCT------------------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
---F-RQYRVLGKG--GFGEVCACQVR-------ATGKMYACKKLEKK--R-IKKRK--G-E-AMAL-----NEKQILEKV--N-SRF--VVSLAYAYE-T-----------------------------KDALCLVLTLMNGG-DLK-FHIYH-MGQA-------------------------GFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLD-D---HGHI----RISDLGLAVH------------VPEGQTI--KG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQ-SPFQQR------KKKIKREEV-ERLVK-EVPEEYSER--FS------------------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
----LKLEKKLGAG--QFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A------EANVMKTL--Q-HDK--LVKLHAVVT-------------------------------KEPIYIITEFMAKG-SLL-DFLK----SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVS-A---SLVC----KIADFGLARVI-----------E--DNEY--TAREGAKFPIKWTAPEAIN-----------FGSFTIKSDVWSFGILLMEIVTYGR-IPYPGM------SNPEVIRAL-ERGYRMPRPENCP------------------------------------------------EELYNIMMRCWKNRPEERPT------FEYIQSV--L-----------
----ITMSRELGQG--SFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-E-FL-N------EASVMKEF--N-CHH--VVRLLGVVS-Q-----------------------------GQPTLVIMELMTRG-DLK-SYLR----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-NKFVHRDLAARNCMVA-E---DFTV----KIGDFGMTRDI-----Y-----E--TDYY--RKGGKGLLPVRWMSPESLK-----------DGVFTTYSDVWSFGVVLWEIATLAE-QPYQGL------SNEQVLRFV-MEGGLLDKPDNCP------------------------------------------------DMLFELMRMCWQYNPKMRPS------FLEIISS--I-----------
----ITLLRELGQG--SFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-E-FL-N------EASVMKGF--T-CHH--VVRLLGVVS-K-----------------------------GQPTLVVMELMAHG-DLK-SYLR----SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-KKFVHRDLAARNCMVA-H---DFTV----KIGDFGMTRDI-----Y-----E--TDYY--RKGGKGLLPVRWMAPESLK-----------DGVFTTSSDMWSFGVVLWEITSLAE-QPYQGL------SNEQVLKFV-MDGGYLDQPDNCP------------------------------------------------ERVTDLMRMCWQFNPKMRPT------FLEIVNLL-------------
-VGG----NKMGEG--GFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-----QEIKVMAKC--Q-HEN--LVELLGFSS-D-----------------------------GDDLCLVYVYMPNG-SLL-DRLSCLDGTP-------------------------PLSWHMRCKIAQGAANGINFLHE-NHHIHRDIKSANILLD-E---AFTA----KISDFGLARASE---------KFAQTVMT--SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PAVDEH------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD----------------------------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ--------
----LKLVERLGAG--QFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A------EANLMKQL--Q-HQR--LVRLYAVVT-------------------------------QEPIYIITEYMENG-SLV-DFLK----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS-D---TLSC----KIADFGLARLI-----------E--DNEY--TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IPYPGM------TNPEVIQNL-ERGYRMVRPDNCP------------------------------------------------EELYQLMRLCWKERPEDRPT------FDYLRSV--L-----------
----FEKISELGAG--NGGVVFKVSHK-------PSGL-VMARKLIHL--E-IKPAI--R-N-QIIR------ELQVLHEC--N-SPY--IVGFYGAFY-S-----------------------------DGEISICMEHMDGG-SLD-QVLK---KAG-------------------------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-S---RGEI----KLCDFGVSG-------------QLIDSMA--NS---FVGTRSYMSPERLQ-----------GTHYSVQSDIWSMGLSLVEMAV-GR-YPIPPP------DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD------LKQLMVHAFI-----------
----YRDLQPVGSG--AYGAVCSAVDG-------RTGAKVAIKKLYRP--F-QSELF--A-K-RAYR------ELRLLKHM--R-HEN--VIGLLDVFT-PDET-----------------------LDDFTDFYLVMPFMGT--DLG-KLMK----HE-------------------------KLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVN-E---DCEL----KILDFGLAR--------------QADSEM--TG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFKGS------DHLDQLKEI-MKVTGTPPAEFVQRLQSDEAKNYMKGLPELE------------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AGEALAHPYF-----------
-KVT---SQVLGLG--INGKVLQIFNK-------RTQEKFALKMLQDC--P-KAR-----------R------EVELHWRA-SQ-CPH--IVRIVDVYE-NLY-------------------------AGRKCLLIVMECLDGG-ELF-SRIQD-RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-S---KRPNA-ILKLTDFGFAKE------------TTSHNSL--TT---PCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLC-GY-PPFYSN-----HGLAISPGMK-TRIRMGQYEFPNPEWSEVS------------------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
----VHFNEVIGRG--HFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T------EGIIMKDF--S-HPN--VLSLLGICLRS-----------------------------EGSPLVVLPYMKHG-DLR-NFIR----NE-----------------------THNPTVKDLIGFGLQVAKGMKYLAS-KKFVHRDLAARNCMLD-E---KFTV----KVADFGLARDM-----Y-----D--KEYYSVHNKTGAKLPVKWMALESLQ-----------TQKFTTKSDVWSFGVLLWELMTRGA-PPYPDV------NTFDITVYL-LQGRRLLQPEYCP------------------------------------------------DPLYEVMLKCWHPKAEMRPS------FSELVSR--I-----------
---F-KFGKILGEG--SFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR------ERDVMSRL--D-HPF--FVKLYFTFQ-D-----------------------------DEKLYFGLSYAKNG-ELL-KYIR---KIG-------------------------SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-E---DMHI----QITDFGTAKVLS---------PESKQARA--NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG---------NEYLIF-QKIIKLEYDFPEKFF----------------------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
----YQVGPLLGSG--GFGSVYSGIRV-------SDNLPVAIKHVEKD--R-ISDWG--E-L-PNGTRV--PMEVVLLKKV--S-SGFSGVIRLLDWFE-R-----------------------------PDSFVLILERPEPVQDLF-DFIT---ERG-------------------------ALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLN---RGEL----KLIDFGSGA-------------LLKDTVY--TD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GD-IPFEHD----------------EEIIRGQVFFRQRVS----------------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM-----------
--YV--RGRFLGKG--GFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-----MEISIHRSL--A-HQH--VVGFHGFFE-D-----------------------------NDFVFVVLELCRRR-SLL-ELHK---RRK-------------------------ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-E---DLEV----KIGDFGLATKV-----------EYDGERK--KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PPFETS---------CLKETY-LRIKKNEYSIPKHIN----------------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
---F-DLLRVIGRG--SYAKVLLVRLK-------KTDRIYAMKVVKKE--L-VNDDE--D-I-DWVQ-----TEKHVFEQA-SN-HPF--LVGLHSCFQ-T-----------------------------ESRLFFVIEYVNGG-DLM-FHMQ---RQR-------------------------KLPEEHARFYSAEISLALNYLHE-RGIIYRDLKLDNVLLD-S---EGHI----KLTDYGMCKEG-----------LRPGDTT--ST---FCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMA-GR-SPFDIVGSSDNPDQNTEDYLF-QVILEKQIRIPRSLS----------------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
----IELGRCIGEG--QFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q------EALTMRQF--D-HPH--IVKLIGVIT-------------------------------ENPVWIIMELCTLG-ELR-SFLQ----VR-----------------------KYSLDLASLILYAYQLSTALAYLES-KRFVHRDIAARNVLVS-S---NDCV----KLGDFGLSRYM-----------E--DSTY--YKASKGKLPIKWMAPESIN-----------FRRFTSASDVWMFGVCMWEILMHGV-KPFQGV------KNNDVIGRI-ENGERLPMPPNCP------------------------------------------------PTLYSLMTKCWAYDPSRRPR------FTELKAQL-------------
---L-VLGKTLGEG--EFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S------EFNVLKQV--N-HPH--VIKLYGACS-Q-----------------------------DGPLLLIVEYAKYG-SLR-GFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVA-E---GRKM----KISDFGLSRDV-----Y-----E--EDSY--VKRSQGRIPVKWMAIESLF-----------DHIYTTQSDVWSFGVLLWEIVTLGG-NPYPGI------PPERLFNLL-KTGHRMERPDNCS------------------------------------------------EEMYRLMLQCWKQEPDKRPV------FADISKDL-------------
---L-RLEVKLGQG--CFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q------EAQVMKKL--R-HEK--LVQLYAVVS-------------------------------EEPIYIVTEYMSKG-SLL-DFLK----GE----------------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-E---NLVC----KVADFGLARLI-----------E--DNEY--TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGR-VPYPGM------VNREVLDQV-ERGYRMPCPPECP------------------------------------------------ESLHDLMCQCWRKEPEERPT------FEYLQAF--L-----------
----YELLTVIGKGFEDLMTVNLARYK-------PTGEYVTVRRINLE--A-CSNEM--V-T-FLQG------ELHVSKLF--N-HPN--IVPYRATFI-A-----------------------------DNELWVVTSFMAYG-SAK-DLICT-HFMD-------------------------GMNELAIAYILQGVLKALDYIHH-MGYVHRSVKASHILIS-V---DGKV----YLSGLRSN--LSMIS--HGQRQRVVHDFP--KY---SVKVLPWLSPEVLQ---------QNLQGYDAKSDIYSVGITACELAN-GH-VPFKDM---------PATQML-LEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPS------ASTLLNHSFF-----------
---L-RLLEKLGDG--SFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R------EVNAMHSL--D-HRN--LIRLYGVVL-------------------------------TPPMKMVTELAPLG-SLL-DRLR----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLA-T---RDLV----KIGDFGLMRAL----PQ-----N--DDHY--VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EPWIGL------NGSQILHKIDKEGERLPRPEDCP------------------------------------------------QDIYNVMVQCWAHKPEDRPT------FVALRDF--L-----------
----YSILKQIGSG--GSSKVFQVLNE-------KKQ-IYAIKYVNLE--E-ADNQT--L-D-SYRN------EIAYLNKL-QQHSDK--IIRLYDYEI-T-----------------------------DQYIYMVMECGNI--DLN-SWLK---KKK-------------------------SIDPWERKSYWKNMLEAVHTIHQ-HGIVHSDLKPANFLIV-----DGML----KLIDFGIANQMQ---------PDTTSVVK--DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQQI--------INQISKL-HAIIDPNHEIEFPDIPE--------------------------------------------KDLQDVLKCCLKRDPKQRIS------IPELLAHPYV-----------
LIAD----IELGCG--NFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R------EAQIMHQL--D-NPY--IVRLIGVCQ-------------------------------AEALMLVMEMAGGG-PLH-KFLV----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEE-KNFVHRDLAARNVLLV-N---RHYA----KISDFGLSKAL----GA-----D--DSYY--TARSAGKWPLKWYAPECIN-----------FRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKM------KGPEVMAFI-EQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPD------FLTVEQR--M-----------
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