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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL TGFBR1 203
TK ABL1 261
TK ABL2 288
TK BMX 422
TK FYN 271
TK LCK 245
TKL RAF1 349
TK SRC 270
IV--LQESIGKGRFGEVWRGKWRGEE--VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK---TL
--ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCTR----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F--
--ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCTL----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHVVKVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----DLSQVYDLLEKGYR----MEQPEGCP------PKVYELMRACWKWSPADRPSFAETHQA-F--
--ITLLKELGSGQFGVVQLGKWK-GQYDVAVKMIK-E-GSM-SE--DEFFQEAQTMMKLSHPKLVKFYGVCSK----EYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDRDLCVKVSDFGMTRYV-----L--DDQYVSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK----------QPYDLY-----DNSQVVLKVSQGHR----LYRPHLAS------DTIYQIMYSCWHELPEKRPTFQQLLSS-I--
--LQLIKRLGNGQFGEVWMGTWN-GNTKVAIKTLK-P-GTM-SP--ESFLEEAQIMKKLKHDKLVQLYAVVS-----EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR----------VPYPGM-----NNREVLEQVERGYR----MPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL---
--LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT-----QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L--
VM--LSTRIGSGSFGTVYKGKWH---GDVAVKILK-VVDPT-PEQFQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMDYLHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK--S--R--WSGSQQVEQPTGSVLWMAPEVIR------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LPYSHI-N---NRDQIIFMVGRGYASPDLSKLYKNCP------KAMKRLVADCVKKVKEERPLFPQILSS-I--
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-P-GTM-SP--EAFLQEAQVMKKLRHEKLVQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VPYPGM-----VNREVLDQVERGYR----MPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L--
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