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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TNK2 203
CMGC CDC2 4
CMGC CDK2 4
TKL RAF1 349
-L-RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK-PDVLSQ-PEAMDDFI-REVNAMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLR----KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHYVMQEHRKVPFAWCAPESLK-TRT---FSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGER----LPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L
--YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLE--SEEEGV--PSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSAR---YSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRI-FRALG----TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
--FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLD--TETEGV--PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKY---YSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
VM--LSTRIGSGSFGTVYKGKWH------GDVAVKILK-V-VDPT-PEQFQAFR-NEVAVLRKTRHVNILLFMGYMT-KDNLAIVTQWCEGSSLYKHLH----VQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-SR--WSGSQQVEQPTGSVLWMAPEVIR-MQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMV-GRGYASPDLSKLYKNCP----------------------------KAMKRLVADCVKKVKEERPLFPQILSS--I
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