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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TNK2 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
TK EGFR 712
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK INSR 1023
TKL IRAK4 186
TK KIT 589
TK LCK 245
TK MET 1078
TK RET 724
TK SRC 270
STE STK24 24
TK ZAP70 338
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL--TPPMKMVTELAPLGSLLDRLR----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLR----EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLR----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-HQLRR-EVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQ---KLS-----------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-STAIR-EISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRR-DFL-G-EASIMGQF-DHPNIIRLEGVVT-KSKPVMIVTEYMENGSLDSFLR----KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL--E-D--DPEA-AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP----------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL-----
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-AVT-D-HMLAIGSL-DHAHIVRLLGLCP--GSSLQLVTQYLPLGSLLDHVR----QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL--P-P--DDKQ--LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT----------------------------IDVYMVMVKCWMIDENIRPTFKELANE--F---
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-DLI-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQ----ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLR----ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-AFL-A-EANVMKTL-QHDKLVKLHAVVT--KEPIYIITEFMAKGSLLDFLK----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSS-DGDDLCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTERE-ALM-S-ELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY--VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLK----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-QFL-T-EGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR----NE---------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYL-LQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I---
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK----GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYL-KDTKLWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI---
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ--AEALMLVMEMAGGGPLHKFLV----GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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