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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other TTK 203
CAMK CAMK1G 23
CMGC CDK2 4
CMGC CDK5 4
CMGC CDKL5 13
CAMK DAPK1 13
CAMK DAPK3 13
Other NEK1 4
Other NEK2 8
Other NEK3 4
Other NEK4 6
Other NEK5 4
CAMK PHKG1 20
CAMK PHKG2 24
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
STE STK24 24
CAMK STK33 116
Other ULK3 14
---YSILKQIGSGGSSKV---FQVLNE-KKQ----IYAIKYVNLEEADNQTLDSYRN-------EIAYLNKLQQHSDKIIRLYDYEIT--DQYIYMVMECGNI-DLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV----DGML---------KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE---------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV----
-FI--FMEVLGSGAFSEV---FLVKQR-LTGK---LFALKCIKKSPAFRDSSLE--N-------EIAVLKKI-K-HENIVTLEDIYES--TTHYYLVMQLVSGGELFDRIL----ERGVYTEKDASLVIQQVLSAVKYLHEN-----GIVHRDLKPENLLYLTPEENSKI---------MITDFGLSK----MEQNGIMSTACGTPGYVAPEVLA-----------QKPYSKAVDCWSIGVITYILLC-GYPPFYEE---TESKLFEKIKEGYYEFESPFWDDIS-------------------------ESAKDFICHLLEKDPNERYT-----CEKALSHPWI----
---FQKVEKIGEGTYGVV---YKARNK-LTGE---VVALKKIRLDTETEGVPSTAIR-------EISLLKEL-N-HPNIVKLLDVIHT--ENKLYLVFEFLHQ-DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN---TEGAI---------KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF----
---YEKLEKIGEGTYGTV---FKAKNR-ETHE---IVALKRVRLDDDDEGVPSSALR-------EICLLKEL-K-HKNIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN---RNGEL---------KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF----
---FEILGVVGEGAYGVV---LKCRHK-ETHE---IVAIKKFKDSEENEEVKETTLR-------ELKMLRTL-K-QENIVELKEAFRR--RGKLYLVFEYVEK-NMLELLE---EMPNGVPPEKVKSYIYQLIKAIHWCHKN-----DIVHRDIKPENLLIS---HNDVL---------KLCDFGFARNL-SEGNNANYTEYVATRWYRSPELLL-----------GAPYGKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-----TEQCLNHPTF----
---YDTGEELGSGQFAVV---KKCREK-STGL---QYAAKFIKKRRTKSSRRGVSREDI---EREVSILKEI-Q-HPNVITLHEVYEN--KTDVILILELVAGGELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL---DRNVPKP-----RIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS-------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI----
---YEMGEELGSGQFAIV---RKCRQK-GTGK---EYAAKFIKKRRLSSSRRGVSREEI---EREVNILREI-R-HPNIITLHDIFEN--KTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL---DKNVPNP-----RIKLIDFGIAHK---IEAGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS-------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI----
--Y-VRLQKIGEGSFGKA---ILVKST-EDGR---QYVIKEINISRMSSKEREESRR-------EVAVLANM-K-HPNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLT---KDGTV---------QLGDFGIARVL--NSTVELARTCIGTPYYLSPEICE-----------NKPYNNKSDIWALGCVLYELCT-LKHAFEAG---SMKNLVLKIISGSFPPVSLHYS----------------------------YDLRSLVSQLFKRNPRDRPS-----VNSILEKGF-I---
---YEVLYTIGTGSYGRC---QKIRRK-SDGK---ILVWKELDYGSMTEAEKQMLVS-------EVNLLREL-K-HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD---GKQNV---------KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---SQKELAGKIREGKFRRIPYRY---S-------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I---
--Y-MVLRMIGEGSFGRA---LLVQHE-SSNQ---MFAMKEIRLPKSFSNTQN-SRK-------EAVLLAKM-K-HPNIVAFKESFEA--EGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLT---QNGKV---------KLGDFGSARLL--SNPMAFACTYVGTPYYVPPEIWE-----------NLPYNNKSDIWSLGCILYELCT-LKHPFQANSWKNLILKVCQGCISPLPSHYS-------------------------------YELQFLVKQMFKRNPSHRPS-----ATTLLS----RGIV
--Y-CYLRVVGKGSYGEV---TLVKHR-RDGK---QYVIKKLNLRNASSRERRAAEQ-------EAQLLSQL-K-HPNIVTYKESWEG-GDGLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYLHEK-----HILHRDLKTQNVFLT---RTNII---------KVGDLGIARVL--ENHCDMASTLIGTPYYMSPELFS-----------NKPYNYKSDVWALGCCVYEMAT-LKHAFNAK---DMNSLVYRIIEGKLPPMPRDY---S-------------------------PELAELIRTMLSKRPEERPS-----VRSILRQPYI----
---YDVIKAIGQGAFGKA---YLAKGK-SDSK---HCVIKEINFEKMPIQEKEASKK-------EVILLEKM-K-HPNIVAFFNSFQE--NGRLFIVMEYCDGGDLMKRINR--QRGVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIFLS---KNGMV--------AKLGDFGIARVL--NNSMELARTCIGTPYYLSPEICQ-----------NKPYNNKTDIWSLGCVLYELCT-LKHPFEGN---NLQQLVLKICQAHFAPISPGF---S-------------------------RELHSLISQLFQVSPRDRPS-----INSILKRPFL----
---YEPKEILGRGVSSVV---RRCIHK-PTSQ---EYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSG-HPNIIQLKDTYET--NTFFFLVFDLMKRGELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLD---DNMNI---------KLTDFGFSCQ---LEPGERLREVCGTPSYLAPEIIECS-----MNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS-------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF----
YDP---KDVIGRGVSSVV---RRCVHR-ATGH---EFAVKIMEVTAERLSPEQLEEVREA-TRRETHILRQVAG-HPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLT----EKVALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD---DNMQI---------RLSDFGFSCH---LEPGEKLRELCGTPGYLAPEILKCS-----MDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHR---RQILMLRMIMEGQYQFSSPEWDDRS-------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF----
---FELLKVLGQGSFGKVFLVRKVTRP-DSGH---LYAMKVLKKATLKVRDRVRTKM-------ERDILADV-N-HPFVVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS-----------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
---FELLKVLGQGSYGKV---FLVRKV-KGSDAGQLYAMKVLKKATLKVRDRVRSKM-------ERDILAEV-N-HPFIVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KITDFGLSKEA--IDHDKRAYSFCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS-----------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF----
---FELLKVLGQGSFGKV---FLVKKI-SGSDARQLYAMKVLKKATLKVRDRVRTKM-------ERDILVEV-N-HPFIVKLHYAFQT--EGKLYLILDFLRGGDLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD---EEGHI---------KLTDFGLSKES--IDHEKKAYSFCGTVEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS-----------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF----
---FELLKVLGQGSFGKV---FLVRKK-TGPDAGQLYAMKVLKKASLKVRDRVRTKM-------ERDILVEV-N-HPFIVKLHYAFQT--EGKLYLILDFLRGGDVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLD---EIGHI---------KLTDFGLSKES--VDQEKKAYSFCGTVEYMAPEVVN-----------RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS-----------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---FTKLEKIGKGSFGEV---FKGIDN-RTQK---VVAIKIIDLEEAEDEIEDIQ-Q-------EITVLSQC-D-SPYVTKYYGSYLK--DTKLWIIMEYLGGGSALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS---EHGEV---------KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS-------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI----
---YTFGRILGKGSFGIV---IEATDK-ETET---KWAIKKVNKEKAGSSAVKLLER-------EVNILKSV-K-HEHIIHLEQVFET--PKKMYLVMELCEDGELKEILD----RKGHFSENETRWIIQSLASAIAYLHNN-----DIVHRDLKLENIMVK---SSLIDDNNEINLNIKVTDFGLAVKK-QSRSEAMLQATCGTPIYMAPEVIS-----------AHDYSQQCDIWSIGVVMYMLLR-GEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS-------------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL----
-FI--LTERLGSGTYATV---YKAYAKKDTRE---VVAIKCVAKKSLNKASVENLLT-------EIEILKGI-R-HPHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIH----TRRILPEKVARVFMQQLASALQFLHER-----NISHLDLKPQNILLSS-LEKPHL---------KLADFGFAQH---MSPWDEKHVLRGSPLYMAPEMVC-----------QRQYDARVDLWSMGVILYEALF-GQPPFASRSFSELEEKIRSNRVIELPLRPLLS-----------------------------RDCRDLLQRLLERDPSRRIS-----FQDFFAHPWV----
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