KIDFamMap

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Kinase profiling results of kinases in KIF 2C6EA_HPM (AURKA, PDB code: 2C6E, chain A)
Template Kinase: AURKA Template inhibitor: HPM	44 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C	C	C	C	C	C	C	C
PRKCD	AGC
PRKCQ	AGC
RPS6KB1	AGC
MAPKAPK2	3
CHEK2	CAMK
CDK2	CMGC
CDC2L6	CMGC
CDK8	CMGC
CDC2L5	CMGC
CDK11A	CMGC
CDK11A	CMGC
CDKL2	CMGC
MAPK8	CMGC
MAPK9	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
AAK1	Other
PLK1	Other
PLK2	Other
PLK3	Other
PLK4	Other
TTK	Other
STK36	Other
STK10	STE
ABL1	TK
TNK1	TK
TNK2	TK
ALK	TK
CSK	TK
EGFR	TK
PTK2	TK
PTK2B	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
JAK2	TK
JAK3	TK
RET	TK
BLK	TK
LCK	TK
BTK	TK
TEK	TK
TIE1	TK
RAF1	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C
PRKCD	AGC
PRKCQ	AGC
RPS6KB1	AGC
CHEK2	CAMK
MAPKAPK2	CAMK
CDK2	CMGC
MAPK8	CMGC
MAPK9	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
PLK1	Other
PLK2	Other
PLK3	Other
TTK	Other
STK10	STE
ABL1	TK
ALK	TK
BLK	TK
BTK	TK
CSK	TK
EGFR	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
JAK2	TK
JAK3	TK
LCK	TK
PTK2	TK
PTK2B	TK
RET	TK
TEK	TK
TNK2	TK
RAF1	TKL