Kinase profiling results of kinases in KIF 1PXPA_CK8 (CDK2, PDB code: 1PXP, chain A)
Template Kinase: CDK2
Template inhibitor: CK8

 14 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK2CMGC
CDK4CMGC
CDK7CMGC
CDK9CMGC
GSK3BCMGC
MAPK14CMGC
AURKAOther
AURKBOther
AURKCOther
PLK1Other
SRCTK
LCKTK
ZAP70TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK4CMGC
CDK7CMGC
CDK9CMGC
GSK3BCMGC
MAPK14CMGC
AURKAOther
AURKBOther
AURKCOther
PLK1Other
LCKTK
SRCTK
ZAP70TK