Kinase profiling results of kinases in KIF 2RFNA_AM7 (MET, PDB code: 2RFN, chain A)
Template Kinase: MET
Template inhibitor: pyrimidone, 22

 10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C
MYO3ASTE     
MST4STE     
DDR2TK     
PTK2BTK     
IGF1RTK     
INSRRTK     
METTK     
NTRK1TK     
FLT4TK     
KDRTK     

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
MST4STE 
DDR2TK 
FLT4TK 
IGF1RTK 
INSRRTK 
KDRTK 
METTK 
NTRK1TK 
PTK2BTK