Kinase profiling results of kinases in KIF 3C1XA_CKK (MET, PDB code: 3C1X, chain A)
Template Kinase: MET
Template inhibitor: AZD_1152HQPA

 19 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
MYO3ASTE  
DDR1TK  
DDR2TK  
PTK2BTK  
IGF1RTK  
INSRTK  
INSRRTK  
METTK  
MUSKTK  
LCKTK  
TEKTK  
TIE1TK  
NTRK1TK  
NTRK2TK  
NTRK3TK  
FLT1TK  
FLT4TK  
KDRTK  
RIPK1TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
DDR2TK
FLT1TK
FLT4TK
IGF1RTK
INSRTK
INSRRTK
KDRTK
LCKTK
METTK
MUSKTK
NTRK1TK
NTRK2TK
NTRK3TK
PTK2BTK
TEKTK