KIDFamMap

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Kinase profiling results of kinases in KIF 3AMAA_SKE (PRKACA, PDB code: 3AMA, chain A)
Template Kinase: PRKACA Template inhibitor: JNJ-7706621	46 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group
ROCK1	AGC
ROCK2	AGC
PDPK1	AGC
PRKACA	AGC
CAMK2A	CAMK
CAMK2B	CAMK
BRSK1	CAMK
BRSK2	CAMK
MARK2	CAMK
MARK4	CAMK
NUAK1	CAMK
NUAK2	CAMK
SIK1	CAMK
SIK2	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
CHEK2	CAMK
TSSK1B	CAMK
CDK2	CMGC
CDK3	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK10	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
NEK1	Other
NEK3	Other
EIF2AK2	Other
PLK1	Other
PLK3	Other
PLK4	Other
TLK1	Other
TLK2	Other
ULK1	Other
ULK2	Other
PAK7	STE
SLK	STE
STK10	STE
ABL1	TK
FER	TK
FES	TK
MAP3K7	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C
PDPK1	AGC
PRKACA	AGC
ROCK1	AGC
ROCK2	AGC
BRSK1	CAMK
BRSK2	CAMK
CAMK2A	CAMK
CAMK2B	CAMK
CHEK2	CAMK
MARK2	CAMK
MARK4	CAMK
NUAK1	CAMK
NUAK2	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
SIK2	CAMK
TSSK1B	CAMK
CDC2	CMGC
CDC2	CMGC
CDK2	CMGC
CDK3	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK10	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
NEK1	Other
NEK3	Other
NEK8	Other
PLK1	Other
PLK3	Other
TLK2	Other
ULK1	Other
ULK2	Other
PAK7	STE
SLK	STE
STK10	STE
ABL1	TK
FER	TK
FES	TK
MAP3K7	TKL