Kinase profiling results of kinases in KIF 3D0EA_G93 (AKT2, PDB code: 3D0E, chain A)
Template Kinase: AKT2
Template inhibitor: 9-N-ethyl-8-ethoxy-manzamine A

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
CITAGC 
ROCK1AGC 
ROCK2AGC 
GRK1AGC 
GRK7AGC 
PRKACAAGC 
PRKACBAGC 
PRKXAGC 
PRKCDAGC 
PRKCQAGC 
PRKCEAGC 
PRKCHAGC 
PRKG1AGC 
PRKG2AGC 
PKN1AGC 
PKN2AGC 
CHEK1CAMK 
DAPK3CAMK 
PIM1CAMK 
PIM3CAMK 
PRKD1CAMK 
PRKD3CAMK 
CHEK2CAMK 
CDK2CMGC 
GSK3ACMGC 
RETTK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
AKT1AGC 
AKT2AGC 
AKT3AGC 
GRK7AGC 
PKN1AGC 
PKN2AGC 
PRKACAAGC 
PRKCDAGC 
PRKCEAGC 
PRKCHAGC 
PRKCQAGC 
PRKG1AGC 
PRKG2AGC 
PRKXAGC 
ROCK1AGC 
ROCK2AGC 
CHEK1CAMK 
CHEK2CAMK 
DAPK3CAMK 
PIM1CAMK 
PIM3CAMK 
PRKD1CAMK 
PRKD3CAMK 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
GSK3ACMGC 
RETTK