Kinase profiling results of kinases in KIF 3FQEA_P5C (SYK, PDB code: 3FQE, chain A)
Template Kinase: SYK
Template inhibitor: AMG_706

24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
CHEK2CAMK   
ABL1TK   
ALKTK   
DDR1TK   
EGFRTK   
PTK2TK   
PTK2BTK   
FERTK   
FGFR1TK   
FGFR4TK   
JAK1TK   
JAK2TK   
JAK3TK   
RETTK   
FGRTK   
FYNTK   
PTK6TK   
SYKTK   
ZAP70TK   
ITKTK   
TNNI3KTKL   
MAP3K7TKL   
BRAFTKL   
RIPK2TKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
CHEK2CAMK   
ABL1TK   
ALKTK   
EGFRTK   
FERTK   
FGFR1TK   
FGFR4TK   
FGRTK   
FYNTK   
ITKTK   
JAK1TK   
JAK2TK   
JAK3TK   
PTK2TK   
PTK2BTK   
PTK6TK   
RETTK   
SYKTK   
ZAP70TK   
BRAFTKL   
MAP3K7TKL   
RIPK2TKL