Summary of query kinase
Query kinase FYN (P06241)
Kinase group TK
Number of inhibitors 162
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 FYN BMS-354825 2-Heteroarylamino-thiazole Analog 12m BD00013268 n/a 1 n/a n/a n/a BindingDB BindingDB
1 FYN SKI-606 BD00004552 n/a 1.8 n/a n/a n/a BindingDB BindingDB
2 FYN CHEMBL90976 BD50118660 n/a 100 n/a n/a n/a BindingDB BindingDB
3 FYN CHEMBL56109 BD50137583 n/a 100 n/a n/a n/a BindingDB BindingDB
4 FYN CHEMBL416353 BD50290382 n/a 1000 n/a n/a n/a BindingDB BindingDB
5 FYN CHEMBL16028 BD50290385 n/a 1000 n/a n/a n/a BindingDB BindingDB
6 FYN CHEMBL573578 BD50298225 n/a 1000 n/a n/a n/a BindingDB BindingDB
7 FYN CHEMBL100551 BD50132153 n/a 10000 n/a n/a n/a BindingDB BindingDB
8 FYN CHEMBL15285 BD50290377 n/a 10000 n/a n/a n/a BindingDB BindingDB
9 FYN CHEMBL277743 BD50290378 n/a 10000 n/a n/a n/a BindingDB BindingDB
10 FYN CHEMBL416166 BD50290380 n/a 10000 n/a n/a n/a BindingDB BindingDB
11 FYN CHEMBL277347 BD50290384 n/a 10000 n/a n/a n/a BindingDB BindingDB
12 FYN CHEMBL371295 BD50175200 n/a 1070 n/a n/a n/a BindingDB BindingDB
13 FYN CHEMBL328907 BD50118657 n/a 1100 n/a n/a n/a BindingDB BindingDB
14 FYN CHEMBL209148 BD50186460 n/a 1100 n/a n/a n/a BindingDB BindingDB
15 FYN CHEMBL54283 BD50137572 n/a 1200 n/a n/a n/a BindingDB BindingDB
16 FYN CHEMBL47940 BD50092228 n/a 126 n/a n/a n/a BindingDB BindingDB
17 FYN CHEMBL1813790 BD50349878 n/a 1300 n/a n/a n/a BindingDB BindingDB
18 FYN CHEMBL1080994 BD50311953 n/a 140 n/a n/a n/a BindingDB BindingDB
19 FYN CHEMBL55594 BD50137585 n/a 1400 n/a n/a n/a BindingDB BindingDB
20 FYN CHEMBL1834657 BD50355393 n/a 1900 n/a n/a n/a BindingDB BindingDB
21 FYN CHEMBL1087650 BD50311985 n/a 1940 n/a n/a n/a BindingDB BindingDB
22 FYN CHEMBL162 BD50059889 n/a 2 33 n/a n/a BindingDB BindingDB
23 FYN CHEMBL301271 BD50137569 n/a 200 n/a n/a n/a BindingDB BindingDB
24 FYN CHEMBL55496 BD50137576 n/a 200 n/a n/a n/a BindingDB BindingDB
25 FYN Pyrrolo[2,3-d]pyrimidine 1 BD00008793 n/a 2030 n/a n/a n/a BindingDB BindingDB
26 FYN CHEMBL436137 BD50193874 n/a 23 n/a n/a n/a BindingDB BindingDB
27 FYN CHEMBL477817 BD50263132 n/a 25 n/a n/a n/a BindingDB BindingDB
28 FYN CHEMBL59042 BD50137584 n/a 300 n/a n/a n/a BindingDB BindingDB
29 FYN CHEMBL1221699 BD50324687 n/a 3700 n/a n/a n/a BindingDB BindingDB
30 FYN CHEMBL120077 BD50179207 n/a 378 n/a n/a n/a BindingDB BindingDB
31 FYN CHEMBL88009 BD50131117 n/a 4 n/a n/a n/a BindingDB BindingDB
32 FYN CHEMBL300853 BD50137578 n/a 400 n/a n/a n/a BindingDB BindingDB
33 FYN CHEMBL292930 BD50137582 n/a 400 n/a n/a n/a BindingDB BindingDB
34 FYN CHEMBL301143 BD50137587 n/a 400 n/a n/a n/a BindingDB BindingDB
35 FYN CHEMBL57143 BD50137591 n/a 400 n/a n/a n/a BindingDB BindingDB
36 FYN CHEBI:444181 BD50182212 n/a 466 n/a n/a n/a BindingDB BindingDB
37 FYN CHEMBL569078 BD50303802 n/a 5 n/a n/a n/a BindingDB BindingDB
38 FYN CHEMBL56569 BD50137573 n/a 50 n/a n/a n/a BindingDB BindingDB
39 FYN Tetracyclic Pyridone, 1 BD00026198 n/a 500 n/a n/a n/a BindingDB BindingDB
40 FYN CHEMBL291759 BD50137570 n/a 500 n/a n/a n/a BindingDB BindingDB
41 FYN CHEMBL47203 BD50114585 n/a 59 n/a n/a n/a BindingDB BindingDB
42 FYN PP1 BD00025116 n/a 6 n/a n/a n/a BindingDB BindingDB
43 FYN CHEMBL52513 BD50137571 n/a 60 n/a n/a n/a BindingDB BindingDB
44 FYN CHEMBL298566 BD50137581 n/a 600 n/a n/a n/a BindingDB BindingDB
45 FYN CHEMBL264406 BD50229961 n/a 600 n/a n/a n/a BindingDB BindingDB
46 FYN CHEMBL296185 BD50137580 n/a 700 n/a n/a n/a BindingDB BindingDB
47 FYN BMS-354825 2-Carboxamido-4-hydrido-thiazole Analog 7n BD00013246 n/a 71 n/a n/a n/a BindingDB BindingDB
48 FYN CHEMBL293712 BD50137574 n/a 800 n/a n/a n/a BindingDB BindingDB
49 FYN CHEMBL432649 BD50118655 n/a 84 n/a n/a n/a BindingDB BindingDB
50 FYN 2,4-dianilino pyrimidine, 2 BD00026145 n/a n/a 0.4 n/a n/a BindingDB BindingDB
51 FYN BMS-354825 BD00013216 n/a n/a 0.79 n/a n/a BindingDB BindingDB
52 FYN Dasatinib Dasatinib n/a n/a 0.79 n/a n/a NB2008 NB2008
53 FYN Dasatinib Dasatinib n/a n/a 0.79 n/a n/a NB2011DRx NB2011DRx
54 FYN SKI_606 SKI_606 n/a n/a 11 n/a n/a NB2011DRx NB2011DRx
55 FYN CP_690550 CP_690550 n/a n/a 1100 n/a n/a NB2011DRx NB2011DRx
56 FYN AZD_2171 AZD_2171 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
57 FYN cid_11712649 BD00031093 n/a n/a 1300 n/a n/a BindingDB BindingDB
58 FYN Crizotinib Crizotinib n/a n/a 1300 n/a n/a NB2011DRx NB2011DRx
59 FYN MLN_8054 MLN_8054 n/a n/a 1300 n/a n/a NB2008 NB2008
60 FYN MLN_8054 MLN_8054 n/a n/a 1300 n/a n/a NB2011DRx NB2011DRx
61 FYN AB_1010 AB_1010 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
62 FYN TAE_684 TAE_684 n/a n/a 1400 n/a n/a NB2011DRx NB2011DRx
63 FYN CHEMBL12253 BD50022182 n/a n/a 150 n/a n/a BindingDB BindingDB
64 FYN cid_6445562 BD00031090 n/a n/a 1600 n/a n/a BindingDB BindingDB
65 FYN CHEBI:259924 BD50119072 n/a n/a 1600 n/a n/a BindingDB BindingDB
66 FYN Nilotinib Nilotinib n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
67 FYN VX-745 BD00015244 n/a n/a 2100 n/a n/a BindingDB BindingDB
68 FYN cid_11656518 BD00031088 n/a n/a 2100 n/a n/a BindingDB BindingDB
69 FYN CHEBI:668343 BD50298227 n/a n/a 2100 n/a n/a BindingDB BindingDB
70 FYN CHEMBL608533 BD50326053 n/a n/a 2100 n/a n/a BindingDB BindingDB
71 FYN CHIR_265 CHIR_265 n/a n/a 2100 n/a n/a NB2008 NB2008
72 FYN CHIR_265 CHIR_265 n/a n/a 2100 n/a n/a NB2011DRx NB2011DRx
73 FYN PKC_412 PKC_412 n/a n/a 2100 n/a n/a NB2008 NB2008
74 FYN PKC_412 PKC_412 n/a n/a 2100 n/a n/a NB2011DRx NB2011DRx
75 FYN VX_745 VX_745 n/a n/a 2100 n/a n/a NB2008 NB2008
76 FYN VX_745 VX_745 n/a n/a 2100 n/a n/a NB2011DRx NB2011DRx
77 FYN PLX_4720 PLX_4720 n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
78 FYN CHEMBL8682 BD50016603 n/a n/a 240 n/a n/a BindingDB BindingDB
79 FYN EKB_569 EKB_569 n/a n/a 2400 n/a n/a NB2008 NB2008
80 FYN cid_10138259 BD00031095 n/a n/a 2600 n/a n/a BindingDB BindingDB
81 FYN SU_14813 SU_14813 n/a n/a 2600 n/a n/a NB2008 NB2008
82 FYN SU_14813 SU_14813 n/a n/a 2600 n/a n/a NB2011DRx NB2011DRx
83 FYN Pazopanib BD00026474 n/a n/a 2700 n/a n/a BindingDB BindingDB
84 FYN GW_786034 GW_786034 n/a n/a 2700 n/a n/a NB2008 NB2008
85 FYN Pazopanib Pazopanib n/a n/a 2700 n/a n/a NB2011DRx NB2011DRx
86 FYN R406 R406 n/a n/a 28 n/a n/a NB2011DRx NB2011DRx
87 FYN AMG 706 BD00024773 n/a n/a 2800 n/a n/a BindingDB BindingDB
88 FYN AMG_706 AMG_706 n/a n/a 2800 n/a n/a NB2008 NB2008
89 FYN AMG_706 AMG_706 n/a n/a 2800 n/a n/a NB2011DRx NB2011DRx
90 FYN PP_242 PP_242 n/a n/a 300 n/a n/a NB2011DRx NB2011DRx
91 FYN Imatinib BD00013530 n/a n/a 3100 n/a n/a BindingDB BindingDB
92 FYN Imatinib Imatinib n/a n/a 3100 n/a n/a NB2008 NB2008
93 FYN Imatinib Imatinib n/a n/a 3100 n/a n/a NB2011DRx NB2011DRx
94 FYN Staurosporine Staurosporine n/a n/a 33 n/a n/a NB2008 NB2008
95 FYN Staurosporine Staurosporine n/a n/a 33 n/a n/a NB2011DRx NB2011DRx
96 FYN JNJ_28312141 JNJ_28312141 n/a n/a 340 n/a n/a NB2011DRx NB2011DRx
97 FYN ZD6474 BD00004655 n/a n/a 360 n/a n/a BindingDB BindingDB
98 FYN Vandetanib Vandetanib n/a n/a 360 n/a n/a NB2011DRx NB2011DRx
99 FYN ZD_6474 ZD_6474 n/a n/a 360 n/a n/a NB2008 NB2008
100 FYN TG_101348 TG_101348 n/a n/a 38 n/a n/a NB2011DRx NB2011DRx
101 FYN PD_173955 PD_173955 n/a n/a 4.9 n/a n/a NB2011DRx NB2011DRx
102 FYN CHEMBL522892 BD50265677 n/a n/a 440 n/a n/a BindingDB BindingDB
103 FYN CHIR_258 CHIR_258 n/a n/a 440 n/a n/a NB2008 NB2008
104 FYN CHIR_258 CHIR_258 n/a n/a 440 n/a n/a NB2011DRx NB2011DRx
105 FYN cid_11409972 BD00031085 n/a n/a 50 n/a n/a BindingDB BindingDB
106 FYN AST_487 AST_487 n/a n/a 50 n/a n/a NB2008 NB2008
107 FYN AST_487 AST_487 n/a n/a 50 n/a n/a NB2011DRx NB2011DRx
108 FYN CHEMBL349371 BD50074327 n/a n/a 500 n/a n/a BindingDB BindingDB
109 FYN Staurosporine BD00002579 n/a n/a 51 n/a n/a BindingDB BindingDB
110 FYN SU11248 BD00004814 n/a n/a 520 n/a n/a BindingDB BindingDB
111 FYN Sunitinib Sunitinib n/a n/a 520 n/a n/a NB2008 NB2008
112 FYN Sunitinib Sunitinib n/a n/a 520 n/a n/a NB2011DRx NB2011DRx
113 FYN VX-680 BD00013534 n/a n/a 530 n/a n/a BindingDB BindingDB
114 FYN VX_680 VX_680 n/a n/a 530 n/a n/a NB2008 NB2008
115 FYN VX_680 VX_680 n/a n/a 530 n/a n/a NB2011DRx NB2011DRx
116 FYN CI_1033 CI_1033 n/a n/a 5300 n/a n/a NB2011DRx NB2011DRx
117 FYN CHEMBL165399 BD50074326 n/a n/a 60 n/a n/a BindingDB BindingDB
118 FYN BIBF_1120der BIBF_1120der n/a n/a 630 n/a n/a NB2011DRx NB2011DRx
119 FYN HKI_272 HKI_272 n/a n/a 6400 n/a n/a NB2011DRx NB2011DRx
120 FYN KW_2449 KW_2449 n/a n/a 660 n/a n/a NB2011DRx NB2011DRx
121 FYN CHEMBL164585 BD50074328 n/a n/a 700 n/a n/a BindingDB BindingDB
122 FYN Ki_20227 Ki_20227 n/a n/a 7100 n/a n/a NB2011DRx NB2011DRx
123 FYN CHEMBL603469 BD50308060 n/a n/a 84 n/a n/a BindingDB BindingDB
124 FYN CEP_701 CEP_701 n/a n/a 84 n/a n/a NB2011DRx NB2011DRx
125 FYN Sorafenib Sorafenib n/a n/a 8400 n/a n/a NB2011DRx NB2011DRx
126 FYN EXEL_2880 EXEL_2880 n/a n/a 88 n/a n/a NB2011DRx NB2011DRx
127 FYN CHEMBL539 BD50074329 n/a n/a 900 n/a n/a BindingDB BindingDB
128 FYN CHEMBL1240703 BD50326054 n/a n/a 940 n/a n/a BindingDB BindingDB
129 FYN CHEMBL432189 BD50131114 1.1 n/a n/a n/a n/a BindingDB BindingDB
130 FYN CHEMBL67237 BD50129307 100 n/a n/a n/a n/a BindingDB BindingDB
131 FYN benzothiazole analog 13a BD00013357 2.4 n/a n/a n/a n/a BindingDB BindingDB
132 FYN CHEMBL1778662 BD50343938 28 n/a n/a n/a n/a BindingDB BindingDB
133 FYN CHEMBL90002 BD50131131 8.8 n/a n/a n/a n/a BindingDB BindingDB
134 FYN CAS120685_11_2 CAS120685_11_2 n/a n/a n/a n/a 33.96 NB2011RBC NB2011RBC
135 FYN CAS160807_49_8 CAS160807_49_8 n/a n/a n/a n/a 43.29 NB2011RBC NB2011RBC
136 FYN CAS179248_59_0 CAS179248_59_0 n/a n/a n/a n/a 26.9 NB2011RBC NB2011RBC
137 FYN CAS190654_01_4 CAS190654_01_4 n/a n/a n/a n/a 48.64 NB2011RBC NB2011RBC
138 FYN CAS212844_53_6 CAS212844_53_6 n/a n/a n/a n/a 48.85 NB2011RBC NB2011RBC
139 FYN CAS213743_31_8 CAS213743_31_8 n/a n/a n/a n/a 3.51 NB2011RBC NB2011RBC
140 FYN CAS220792_57_4 CAS220792_57_4 n/a n/a n/a n/a 18.92 NB2011RBC NB2011RBC
141 FYN CAS221244_14_0 CAS221244_14_0 n/a n/a n/a n/a 44.71 NB2011RBC NB2011RBC
142 FYN CAS302962_49_8 CAS302962_49_8 n/a n/a n/a n/a 1.96 NB2011RBC NB2011RBC
143 FYN CAS326914_10_7 CAS326914_10_7 n/a n/a n/a n/a 28.39 NB2011RBC NB2011RBC
144 FYN CAS330161_87_0 CAS330161_87_0 n/a n/a n/a n/a 33.13 NB2011RBC NB2011RBC
145 FYN CAS380843_75_4 CAS380843_75_4 n/a n/a n/a n/a 29.42 NB2011RBC NB2011RBC
146 FYN CAS404828_08_6 CAS404828_08_6 n/a n/a n/a n/a 40.04 NB2011RBC NB2011RBC
147 FYN CAS405169_16_6 CAS405169_16_6 n/a n/a n/a n/a 22.51 NB2011RBC NB2011RBC
148 FYN CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 24.77 NB2011RBC NB2011RBC
149 FYN CAS443913_73_3 CAS443913_73_3 n/a n/a n/a n/a 48.24 NB2011RBC NB2011RBC
150 FYN CAS601514_19_6 CAS601514_19_6 n/a n/a n/a n/a 7.92 NB2011RBC NB2011RBC
151 FYN CAS622387_85_3 CAS622387_85_3 n/a n/a n/a n/a 45.66 NB2011RBC NB2011RBC
152 FYN CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 3.59 NB2011RBC NB2011RBC
153 FYN CAS667463_62_9 CAS667463_62_9 n/a n/a n/a n/a 5.05 NB2011RBC NB2011RBC
154 FYN CAS740841_15_0 CAS740841_15_0 n/a n/a n/a n/a 20.88 NB2011RBC NB2011RBC
155 FYN CAS790299_79_5 CAS790299_79_5 n/a n/a n/a n/a 37.32 NB2011RBC NB2011RBC
156 FYN CAS854171_35_0 CAS854171_35_0 n/a n/a n/a n/a 12.97 NB2011RBC NB2011RBC
157 FYN CAS856436_16_3 CAS856436_16_3 n/a n/a n/a n/a 32.67 NB2011RBC NB2011RBC
158 FYN CAS866405_64_3 CAS866405_64_3 n/a n/a n/a n/a 20.87 NB2011RBC NB2011RBC
159 FYN CAS896138_40_2 CAS896138_40_2 n/a n/a n/a n/a 28.82 NB2011RBC NB2011RBC
160 FYN CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a 22.94 NB2011RBC NB2011RBC
161 FYN STU STU n/a n/a n/a n/a n/a PDB PDB