Statistics

Summary

KIDFamMap contains

  • 1,208 kinase-inhibitor families

    6 conformation types
    1. Type A structures: 669 structures
    2. Type B structures: 381 structures
    3. Type C structures: 34 structures
    4. Type D structures: 16 structures
    5. Type E structures: 80 structures
    6. Type F structures: 28 structures

  • 962 kinase-inhibitor-disease relationships

  • 399 human protein kinases
  • 35,788 kinase inhibitors
  • 186,985 kinase-inhibitor interactions
  • 55,603 kinase-inhibitor interactions (<=10uM)
  • 339 diseases
  • 638 disease allelic variants

Data sources

  • Kinases

    518 human protein kinases from Kinase.Com
    339 human protein kinase available in KIDFamMap.

  • Inhibitors

    872 kinase inhibitors from Protein Data Bank
    38 kinase inhibitors from Karaman, M.W. et al. [1]
    72 kinase inhibitors from Davis et al. [2]
    178 kinase inhibitors from Anastassiadis et al. [3]
    36,324 kinase inhibitors from BindingDB

  • Kinase-inhibitor interactions

    1,208 kinase inhibitors from Protein Data Bank
    11,894 kinase-inhibitor interactions from Karaman, M.W. et al. [1]
    30,168 kinase-inhibitor interactions from Davis, M.I. et al. [2]
    53,400 kinase-inhibitor interactions from Anastassiadis, T. et al. [3]
    90,315 kinase-inhibitor interactions from BindingDB

  • Kinase-inhibitor-disease relationships

    730 diseases from KEGG
    232 diseases from OMIM

  • Diseases

    124 diseases from KEGG
    215 diseases from OMIM

  • Disease allelic variants

    638 disease allelic variants from OMIM
Reference
  1. Nat Biotechnol. 2008 Jan;26(1):127-32. Karaman, M.W., Herrgard, S., Treiber, D.K., Gallant, P., Atteridge, C.E., Campbell, B.T., Chan, K.W., Ciceri, P., Davis, M.I., Edeen, P.T., Faraoni, R., Floyd, M., Hunt, J.P., Lockhart, D.J., Milanov, Z.V., Morrison, M.J., Pallares, G., Patel, H.K., Pritchard, S., Wodicka, L.M., Zarrinkar, P.P.. (2008) A quantitative analysis of kinase inhibitor selectivity. Nature Biotechnology.26, 127-32.
  2. Davis, M.I., Hunt, J.P., Herrgard, S., Ciceri, P., Wodicka, L.M., Pallares, G., Hocker, M., Treiber, D.K. and Zarrinkar, P.P. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nature Biotechnology.29, 1046-51. doi: 10.1038/nbt.1990.
  3. Anastassiadis, T., Deacon, S.W., Devarajan, K., Ma, H.C. and Peterson, J.R. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nature Biotechnology.29, 1039-45. doi: 10.1038/nbt.2017.