Summary of query kinase
Query kinase MAP4K4 (O95819)
Kinase group STE
Number of inhibitors 112
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 MAP4K4 PLX4720 BD00025617 n/a 2800 n/a n/a n/a BindingDB BindingDB
1 MAP4K4 CHEMBL576620 BD50302943 n/a 4200 n/a n/a n/a BindingDB BindingDB
2 MAP4K4 cid_11656518 BD00031088 n/a n/a 1300 n/a n/a BindingDB BindingDB
3 MAP4K4 CHIR_265 CHIR_265 n/a n/a 1300 n/a n/a NB2008 NB2008
4 MAP4K4 CHIR_265 CHIR_265 n/a n/a 1300 n/a n/a NB2011DRx NB2011DRx
5 MAP4K4 PP_242 PP_242 n/a n/a 1300 n/a n/a NB2011DRx NB2011DRx
6 MAP4K4 SU11248 BD00004814 n/a n/a 140 n/a n/a BindingDB BindingDB
7 MAP4K4 A_674563 A_674563 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
8 MAP4K4 JNJ_28312141 JNJ_28312141 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
9 MAP4K4 Sunitinib Sunitinib n/a n/a 140 n/a n/a NB2008 NB2008
10 MAP4K4 Sunitinib Sunitinib n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
11 MAP4K4 ZD6474 BD00004655 n/a n/a 1400 n/a n/a BindingDB BindingDB
12 MAP4K4 Vandetanib Vandetanib n/a n/a 1400 n/a n/a NB2011DRx NB2011DRx
13 MAP4K4 ZD_6474 ZD_6474 n/a n/a 1400 n/a n/a NB2008 NB2008
14 MAP4K4 cid_11409972 BD00031085 n/a n/a 15 n/a n/a BindingDB BindingDB
15 MAP4K4 AST_487 AST_487 n/a n/a 15 n/a n/a NB2008 NB2008
16 MAP4K4 AST_487 AST_487 n/a n/a 15 n/a n/a NB2011DRx NB2011DRx
17 MAP4K4 BIBF_1120der BIBF_1120der n/a n/a 150 n/a n/a NB2011DRx NB2011DRx
18 MAP4K4 CHEMBL522892 BD50265677 n/a n/a 160 n/a n/a BindingDB BindingDB
19 MAP4K4 CHIR_258 CHIR_258 n/a n/a 160 n/a n/a NB2008 NB2008
20 MAP4K4 CHIR_258 CHIR_258 n/a n/a 160 n/a n/a NB2011DRx NB2011DRx
21 MAP4K4 EXEL_2880 EXEL_2880 n/a n/a 190 n/a n/a NB2011DRx NB2011DRx
22 MAP4K4 AZD_2171 AZD_2171 n/a n/a 2000 n/a n/a NB2011DRx NB2011DRx
23 MAP4K4 Pazopanib Pazopanib n/a n/a 2200 n/a n/a NB2011DRx NB2011DRx
24 MAP4K4 CHEMBL603469 BD50308060 n/a n/a 23 n/a n/a BindingDB BindingDB
25 MAP4K4 CEP_701 CEP_701 n/a n/a 23 n/a n/a NB2011DRx NB2011DRx
26 MAP4K4 GDC_0879 GDC_0879 n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
27 MAP4K4 CHEMBL162 BD50059889 n/a n/a 24 n/a n/a BindingDB BindingDB
28 MAP4K4 Staurosporine Staurosporine n/a n/a 24 n/a n/a NB2008 NB2008
29 MAP4K4 Staurosporine Staurosporine n/a n/a 24 n/a n/a NB2011DRx NB2011DRx
30 MAP4K4 VX-680 BD00013534 n/a n/a 2400 n/a n/a BindingDB BindingDB
31 MAP4K4 VX_680 VX_680 n/a n/a 2400 n/a n/a NB2008 NB2008
32 MAP4K4 VX_680 VX_680 n/a n/a 2400 n/a n/a NB2011DRx NB2011DRx
33 MAP4K4 CHEMBL576982 BD50300690 n/a n/a 2500 n/a n/a BindingDB BindingDB
34 MAP4K4 AC220 AC220 n/a n/a 2500 n/a n/a NB2011DRx NB2011DRx
35 MAP4K4 cid_10138259 BD00031095 n/a n/a 260 n/a n/a BindingDB BindingDB
36 MAP4K4 SU_14813 SU_14813 n/a n/a 260 n/a n/a NB2008 NB2008
37 MAP4K4 SU_14813 SU_14813 n/a n/a 260 n/a n/a NB2011DRx NB2011DRx
38 MAP4K4 PHA_665752 PHA_665752 n/a n/a 280 n/a n/a NB2011DRx NB2011DRx
39 MAP4K4 BMS-354825 BD00013216 n/a n/a 3100 n/a n/a BindingDB BindingDB
40 MAP4K4 Dasatinib Dasatinib n/a n/a 3100 n/a n/a NB2008 NB2008
41 MAP4K4 Dasatinib Dasatinib n/a n/a 3100 n/a n/a NB2011DRx NB2011DRx
42 MAP4K4 KW_2449 KW_2449 n/a n/a 33 n/a n/a NB2011DRx NB2011DRx
43 MAP4K4 CHEBI:259924 BD50119072 n/a n/a 330 n/a n/a BindingDB BindingDB
44 MAP4K4 EKB_569 EKB_569 n/a n/a 330 n/a n/a NB2008 NB2008
45 MAP4K4 HKI_272 HKI_272 n/a n/a 330 n/a n/a NB2011DRx NB2011DRx
46 MAP4K4 AG_013736 AG_013736 n/a n/a 350 n/a n/a NB2011DRx NB2011DRx
47 MAP4K4 CHEBI:668344 BD50298226 n/a n/a 3700 n/a n/a BindingDB BindingDB
48 MAP4K4 SB_203580 SB_203580 n/a n/a 3700 n/a n/a NB2008 NB2008
49 MAP4K4 SB_203580 SB_203580 n/a n/a 3700 n/a n/a NB2011DRx NB2011DRx
50 MAP4K4 BAY 439006 BD00016673 n/a n/a 4800 n/a n/a BindingDB BindingDB
51 MAP4K4 Sorafenib Sorafenib n/a n/a 4800 n/a n/a NB2008 NB2008
52 MAP4K4 Sorafenib Sorafenib n/a n/a 4800 n/a n/a NB2011DRx NB2011DRx
53 MAP4K4 AMG_706 AMG_706 n/a n/a 5800 n/a n/a NB2011DRx NB2011DRx
54 MAP4K4 BMS_540215 BMS_540215 n/a n/a 590 n/a n/a NB2011DRx NB2011DRx
55 MAP4K4 CHEBI:668343 BD50298227 n/a n/a 650 n/a n/a BindingDB BindingDB
56 MAP4K4 CHEMBL608533 BD50326053 n/a n/a 650 n/a n/a BindingDB BindingDB
57 MAP4K4 PKC_412 PKC_412 n/a n/a 650 n/a n/a NB2008 NB2008
58 MAP4K4 PKC_412 PKC_412 n/a n/a 650 n/a n/a NB2011DRx NB2011DRx
59 MAP4K4 SKI_606 SKI_606 n/a n/a 8.2 n/a n/a NB2011DRx NB2011DRx
60 MAP4K4 PD_173955 PD_173955 n/a n/a 880 n/a n/a NB2011DRx NB2011DRx
61 MAP4K4 BIRB-796 BD00013533 n/a n/a 90 n/a n/a BindingDB BindingDB
62 MAP4K4 BIRB_796 BIRB_796 n/a n/a 90 n/a n/a NB2008 NB2008
63 MAP4K4 BIRB_796 BIRB_796 n/a n/a 90 n/a n/a NB2011DRx NB2011DRx
64 MAP4K4 TAE_684 TAE_684 n/a n/a 970 n/a n/a NB2011DRx NB2011DRx
65 MAP4K4 CAS103745_39_7 CAS103745_39_7 n/a n/a n/a n/a 44.11 NB2011RBC NB2011RBC
66 MAP4K4 CAS120685_11_2 CAS120685_11_2 n/a n/a n/a n/a 7.25 NB2011RBC NB2011RBC
67 MAP4K4 CAS127243_85_0 CAS127243_85_0 n/a n/a n/a n/a 43.85 NB2011RBC NB2011RBC
68 MAP4K4 CAS133053_19_7 CAS133053_19_7 n/a n/a n/a n/a 37.75 NB2011RBC NB2011RBC
69 MAP4K4 CAS135897_06_2 CAS135897_06_2 n/a n/a n/a n/a 0.99 NB2011RBC NB2011RBC
70 MAP4K4 CAS136194_77_9 CAS136194_77_9 n/a n/a n/a n/a 0.43 NB2011RBC NB2011RBC
71 MAP4K4 CAS142273_20_9 CAS142273_20_9 n/a n/a n/a n/a 6.61 NB2011RBC NB2011RBC
72 MAP4K4 CAS152121_53_4 CAS152121_53_4 n/a n/a n/a n/a 44.94 NB2011RBC NB2011RBC
73 MAP4K4 CAS160807_49_8 CAS160807_49_8 n/a n/a n/a n/a 41.97 NB2011RBC NB2011RBC
74 MAP4K4 CAS204005_46_9 CAS204005_46_9 n/a n/a n/a n/a 48.78 NB2011RBC NB2011RBC
75 MAP4K4 CAS216661_57_3 CAS216661_57_3 n/a n/a n/a n/a 28.4 NB2011RBC NB2011RBC
76 MAP4K4 CAS221244_14_0 CAS221244_14_0 n/a n/a n/a n/a 43.46 NB2011RBC NB2011RBC
77 MAP4K4 CAS227449_73_2 CAS227449_73_2 n/a n/a n/a n/a 48.41 NB2011RBC NB2011RBC
78 MAP4K4 CAS237430_03_4 CAS237430_03_4 n/a n/a n/a n/a 4.47 NB2011RBC NB2011RBC
79 MAP4K4 CAS244148_46_7 CAS244148_46_7 n/a n/a n/a n/a 21.23 NB2011RBC NB2011RBC
80 MAP4K4 CAS288144_20_7 CAS288144_20_7 n/a n/a n/a n/a 6.84 NB2011RBC NB2011RBC
81 MAP4K4 CAS302962_49_8 CAS302962_49_8 n/a n/a n/a n/a 49.2 NB2011RBC NB2011RBC
82 MAP4K4 CAS326914_10_7 CAS326914_10_7 n/a n/a n/a n/a 4.33 NB2011RBC NB2011RBC
83 MAP4K4 CAS330161_87_0 CAS330161_87_0 n/a n/a n/a n/a 46.15 NB2011RBC NB2011RBC
84 MAP4K4 CAS34823_86_4 CAS34823_86_4 n/a n/a n/a n/a 36.09 NB2011RBC NB2011RBC
85 MAP4K4 CAS380843_75_4 CAS380843_75_4 n/a n/a n/a n/a 1.03 NB2011RBC NB2011RBC
86 MAP4K4 CAS396129_53_6 CAS396129_53_6 n/a n/a n/a n/a 48.31 NB2011RBC NB2011RBC
87 MAP4K4 CAS404828_08_6 CAS404828_08_6 n/a n/a n/a n/a 25.68 NB2011RBC NB2011RBC
88 MAP4K4 CAS405169_16_6 CAS405169_16_6 n/a n/a n/a n/a 2.96 NB2011RBC NB2011RBC
89 MAP4K4 CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 4.46 NB2011RBC NB2011RBC
90 MAP4K4 CAS457081_03_7 CAS457081_03_7 n/a n/a n/a n/a 38.41 NB2011RBC NB2011RBC
91 MAP4K4 CAS52029_86_4 CAS52029_86_4 n/a n/a n/a n/a 43.41 NB2011RBC NB2011RBC
92 MAP4K4 CAS546102_60_7 CAS546102_60_7 n/a n/a n/a n/a 29.26 NB2011RBC NB2011RBC
93 MAP4K4 CAS557795_19_4 CAS557795_19_4 n/a n/a n/a n/a 12.44 NB2011RBC NB2011RBC
94 MAP4K4 CAS601514_19_6 CAS601514_19_6 n/a n/a n/a n/a 12.46 NB2011RBC NB2011RBC
95 MAP4K4 CAS608512_97_6 CAS608512_97_6 n/a n/a n/a n/a 5.36 NB2011RBC NB2011RBC
96 MAP4K4 CAS622387_85_3 CAS622387_85_3 n/a n/a n/a n/a 22.51 NB2011RBC NB2011RBC
97 MAP4K4 CAS626604_39_5 CAS626604_39_5 n/a n/a n/a n/a 36.44 NB2011RBC NB2011RBC
98 MAP4K4 CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 1.91 NB2011RBC NB2011RBC
99 MAP4K4 CAS658084_23_2 CAS658084_23_2 n/a n/a n/a n/a 40.9 NB2011RBC NB2011RBC
100 MAP4K4 CAS666837_93_0 CAS666837_93_0 n/a n/a n/a n/a 19.36 NB2011RBC NB2011RBC
101 MAP4K4 CAS667463_62_9 CAS667463_62_9 n/a n/a n/a n/a 28.64 NB2011RBC NB2011RBC
102 MAP4K4 CAS740841_15_0 CAS740841_15_0 n/a n/a n/a n/a 30.16 NB2011RBC NB2011RBC
103 MAP4K4 CAS852045_46_6 CAS852045_46_6 n/a n/a n/a n/a 35.5 NB2011RBC NB2011RBC
104 MAP4K4 CAS852527_97_0 CAS852527_97_0 n/a n/a n/a n/a 6.82 NB2011RBC NB2011RBC
105 MAP4K4 CAS852547_30_9 CAS852547_30_9 n/a n/a n/a n/a 4.48 NB2011RBC NB2011RBC
106 MAP4K4 CAS854171_35_0 CAS854171_35_0 n/a n/a n/a n/a 11.58 NB2011RBC NB2011RBC
107 MAP4K4 CAS856436_16_3 CAS856436_16_3 n/a n/a n/a n/a 0.63 NB2011RBC NB2011RBC
108 MAP4K4 CAS866405_64_3 CAS866405_64_3 n/a n/a n/a n/a 28.98 NB2011RBC NB2011RBC
109 MAP4K4 CAS871307_18_5 CAS871307_18_5 n/a n/a n/a n/a 44.43 NB2011RBC NB2011RBC
110 MAP4K4 CAS896138_40_2 CAS896138_40_2 n/a n/a n/a n/a 6.63 NB2011RBC NB2011RBC
111 MAP4K4 CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a 0.12 NB2011RBC NB2011RBC