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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ABL1 203
TK ABL2 288
TKL BRAF 456
TK CSF1R 582
TK DDR1 572
TK EPHA3 621
TK FGFR1 478
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK2 331
CMGC MAPK14 24
TK PDGFRA 593
TK PDGFRB 600
TK TEK 824
--ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------------T--GDTY---------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
--ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-L------EPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------------T--GDTY---------TAHAGAKFPIKWTAPESLA-YNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----MEQPEGCP------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F-
--ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KMLN-VTAPT-PQQLQAFK-NEVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------------SR--WSGS---------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
--LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KMLK-S-TAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------------MN--DSNY---------IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGL-NPYPGILVNSKFYKLV----KDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
--LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KILR-P-DAT-KNARNDFL-KEVKIMSRL-KDPNIIRLLGVCV-Q------DDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------------YA--GDYY---------RVQGRAVLPIRWMAWECIL-MGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL---
-I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLRKH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-------------ED--DPEA--------AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGE-RPYWEM-SNQDVIKAV----DEGYR----LPPPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
-L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KMLK-S-DAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------------HH--IDYY---------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
--ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAV-KTVN-E-SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------------YE--TDYY---------RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
--LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KMLK-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------------YK--DPDY---------VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
--LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KMLK-P-SAH-LTEREALM-SELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------------KN--DSNY---------VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
--LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSLK-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------------E--DNEY---------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL--I-RCD-EETQKTFL-TEVKVMRSL-DHPNVLKFIGVLY-K------DKKLNLLTEYIEGGTLKDFLRSM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT------KKRTLRKNDRKKRYTVVGNPYWMAPEMLN-GKS---YDETVDIFSFGIVLCEIIGQVY-ADPDCLPRTLDFGLNV----KLFWE----KFVPTDCP------------------------------PAFFPLAAICCRLEPESRPAFSKLED---SF
--YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKLSRP-FQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVKCQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----------------HTDDEM---------TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GR-TLFPGT-DHIDQLKLI----LRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KMLK-P-TAR-SSEKQALM-SELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------------MH--DSNY---------VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
-L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KMLK-S-TAR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------------MR--DSNY---------ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
--IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAI-KRMK-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------------------EVY---------VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
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