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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
TKL BRAF 456
TK JAK3 822
AGC PRKACA 44
AGC ROCK2 92
F-EYLKLLGKGTFGKVILVKEK----ATGRYYAMKILKKE-V-IVAKD--EVAHTLTENRVLQNSRHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLE----DND---YGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ----DHEKLFELILM----EEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF-
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE----GRM---HDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN----TYQETYKRISR----VEFTFPDFVT----EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI-
-FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKS-Q-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLGLKGELKIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE----GRM---HNEKVDLWCIGVLCYELLV-GNPP-------------FESA----SHNETYRRIVK----VDLKFPASVP----MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV-
-ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKTRHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH-IIETKFEMIKLIDIARQTAQGMDYLHA-KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-S-R--WSGSHQFEQLSGSILWMAPEVIR----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP-------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDE--RPL-----FPQILA---SI
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-H-S-GP-DQ-QRDFQ-R-EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEAHVKIADFGLAKLLPL-D--KDYYVVREPGQSPIFWYAPESLS----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQR----LPAPPACP------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL
F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQ-K-VVKLK--QIEHTLNEKRILQAVNFPFLVKLEFSFK--DNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK------RVKGRTWT---LCGTPEYLAPEIIL----SKG---YNKAVDWWALGVLIYEMAA-GYPP-------------FFAD----QPIQIYEKIVS----GKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF-
-YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKF-E-MIKRS--DSAFFWEERDIMAFANSPWVVQLFYAFQ--DDRYLYMVMEYMPGGDLVNLMS-NY--DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM--DETGMVHCDT---AVGTPDYISPEVLKSQGGDGF---YGRECDWWSVGVFLYEMLV-GDTP-------------FYAD----SLVGTYSKIMD----HKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
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