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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT3 203
AGC AKT1 150
TK JAK3 822
AGC ROCK1 76
AGC ROCK2 92
FD--YLKLLGKGTFGKVILVREK----ASGKYYAMKILKKEVIIAKD-EVAHTLTESRVLKNTRHPFLTSLKYSFQ--TKDRLCFVMEYVNGGELFFHLSRER--VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHIKITDFGLCKEG---ITDAATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ----DHEKLFELILMEDIKFPRTLS----SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF-
-F-EYLKLLGKGTFGKVILVKEK----ATGRYYAMKILKKEVIVAKD-EVAHTLTENRVLQNSRHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ----DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF-
-L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQQRDFQ-R-EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEAHVKIADFGLAKLLPL-D--KDYYVVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL
--YEVVKVIGRGAFGEVQLVRHK----STRKVYAMKLLSKFEMIKRS-DSAFFWEERDIMAFANSPWVVQLFYAFQ--DDRYLYMVMEYMPGGDLVNLMS-NY--DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM--NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTP-------------FYAD----SLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF-
--YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIKRS-DSAFFWEERDIMAFANSPWVVQLFYAFQ--DDRYLYMVMEYMPGGDLVNLMS-NY--DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKM--DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP-------------FYAD----SLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
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