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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT3 203
AGC AKT1 150
CAMK DCLK3 356
AGC GRK7 191
STE MAP4K2 16
AGC ROCK1 76
AGC ROCK2 92
STE STK3 27
STE STK4 30
FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS--RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHI----KITDFGLCKEG-ITDAATMKTFCGTPEYLAPEV--LE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLS----SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF------
-F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS--RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI----KITDFGLCKEG-IKDGATMKTFCGTPEYLAPEV--LE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF------
--YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMV-DS-EILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAII--ESVKFPEPDAALMIMDLCKALVHMHD-KSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK----HVVRPIFTVCGTPTYVAPEI--LS----EKGYGLEVDMWAAGVILYILLCGFPPFRSP--ERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKK--RYT-----AHQVLQHPWI------
-F-TEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLDDLGNC----RLSDLGLAVE--MKGGKPITQRAGTNGYMAPEI--LM---EKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF---TEEAKDICRLFLAKKPEQ--RLG-----SRE-------KSDDPR
--FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSL--QQ-EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHS-QGKIHRDIKGANLLLTLQGDV----KLADFGVSGEL-TASVAKRRSFIGTPYWMAPEVAAVE---RKGGYNELCDVWALGITAIELGELQPPLFHL-HPMRALMLMSKSSFQPPKLRDKTR--WTQNFHHFLKLALTKNPKK--RPT-----AEKLLQHPF-T-----
--YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS---NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHL----KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEV--LKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD----SLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF------
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS---NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHL----KLADFGTCMKMDETGMVHCDTAVGTPDYISPEV--LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD----SLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF------
-F-DVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IK-EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIATILKSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEV--IQ----EIGYNCVADIWSLGITSIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWS----DDFTDFVKKCLVKNPEQ--RAT-----ATQLLQHPFI------
-F-DVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IK-EISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHA----KLADFGVAGQL-TDTMAKRNTVIGTPFWMAPEV--IQ----EIGYNCVADIWSLGITAIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWS----DNFTDFVKQCLVKSPEQ--RAT-----ATQLLQHPFV------
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