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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ABL2 288
Other AURKB 77
CMGC CDC2 4
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
TK EGFR 712
TK FGFR1 478
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK LCK 245
CMGC MAPK10 64
CMGC MAPK9 26
AGC PDPK1 82
CAMK PIM1 38
AGC PRKG2 453
TKL RAF1 349
Other WNK2 195
-----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKAGV--EH-QLRR------EVEIQSHL-RHPN--ILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK--RVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE---GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
-----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EE-FL-K------EAAVMKEI-KHPN--LVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA---YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
-----ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EE-FL-K------EAAVMKEI-KHPN--LVQLLGVCT--L------EPPFY--IVTEYMPYG--NLLDYLR-----EC--------------NREEVTAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-ENHVV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA---YNT---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYDLLEKGYR----MEQPEGCP-----------------------------------------PKVYELMRACWKWSPADRPS-----FAETHQA--F-----------
-----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKS-Q-IEKEG--VE-HQLR-----REIEIQAHL-HHPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLG-LKGEL---KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE---GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVK----VDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
-----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE-S-EEEGV--PS-TAIR------EISLLKEL-RHPN--IVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLID-DKGTI---KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL--GSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
-----YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLD-D-DDEGV--PS-SALR------EICLLKEL-KHKN--IVRLHDVLH--S------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSR--NVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF--GAKL---YSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLG----TPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
----W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMK-R-AVDCP--EN-I-KK------EICINKML-NHEN--VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK--RREF---HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKE----KKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKR-K-FAIGS--AR-EADPALNVETEIEILKKL-NHPC--IIKIKNFF---D------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAG---YNRAVDCWSLGVILFICLS-GYPP---------------FSEH---RTQVSLKDQITS----GKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
----F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-A-TS-PKANKE-IL-D------EAYVMASV-DNPH--VCRLLGICL---------TSTVQ--LITQLMPFG--CLLDYVR-----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVK-TPQHV---KITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL---HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF---------
----L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-D-AT-EKDLSD-LI-S------EMEMMKMIGKHKN--IINLLGACT--Q------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT-EDNVM---KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF---DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHR----MDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQD-K-RFKNR---------------ELQIMRKL-DHCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF--GATD---YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLG----TPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E-G-AM-SE--ED-FI-E------EAEVMMKL-SHPK--LVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVG-ENQVI---KVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEVFS---FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFR----LYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPA-----FSRLLRQL-------------
-----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-S-TE--EHLRD-FE-R------EIEILKSL-QHDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE-NENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT---ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
-----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-G-SM-SP--DA-FL-A------EANLMKQL-QHQR--LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVS-DTLSC---KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN---YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
-----YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP-F-QNQTH--AK-RAYR------ELVLMKCV-NHKN--IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL---GMG---YKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-----YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRP-F-QNQTH--AK-RAYR------ELVLLKCV-NHKN--IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------ELDHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL---GMG---YKENVDIWSVGCIMGELVK-GCVI---------------FQGT-DHIDQWNKVIEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
----F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR-H-IIKEN--KVPYVTR------ERDVMSRL-DHPF--FVKLYFTFQ--D------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGK--GIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT---EKS---ACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIK----LEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YQVGPLLGSGGFGSVYSGIRV-------SDNLPVAIKHVEKD-R-ISDWG--EL-PNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG-----------------ALQEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENILIDLNRGEL---KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR--YHRY---HGRSAAVWSLGILLYDMVC-GDIP---------------FEHD----------EEIIR----GQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM-----------
----L-EIIATLGVGGFGRVELVKVK-------NENVAFAMKCIRKK-H-IVDTK--QQ-EHVY-----SEKRILEEL-CSPF--IVKLYRTFK--D------NKYVY--MLLEACLGG--ELWSILR----DRG-----------------SFDEPTSKFCVACVTEAFDYLHRL--GIIYRDLKPENLILD-AEGYL---KLVDFGFAKK-----IGSGQKTWT---FCGTPEYVAPEVIL---NKG---HDFSVDFWSLGILVYELLT-GNPP---------------FSGV----DQMMTYNLILK----GIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
---VM--LSTRIGSGSFGTVYKGKWH----------GDVAVKILK-VVD-PT-PEQFQA-FR-N------EVAVLRKT-RHVN--ILLFMGYMT---------KDNLA--IVTQWCEGS--SLYKHLH-----VQ---------------ETKFQMFQLIDIARQTAQGMDYLHAK--NIIHRDMKSNNIFLH-EGLTV---KIGDFGLATVK--S-R--WSGSQQVEQPTGSVLWMAPEVIR---MQDNNPFSFQSDVYSYGIVLYELMT-GELP---------------YSHINNRDQIIFMVGRGYASPDLSKLYKNCP-----------------------------------------KAMKRLVADCVKKVKEERPL-----FPQILSS--I-----------
LKFDI-----ELGRGSFKTVYKGLDT-------ETWVEVAWCELQDR-K-LTKLE--RQ-RFKE------EAEMLKGL-QHPN--IVRFYDFWE--SSA--KGKRCIV--LVTELMTSG--TLKTYLK----RFK-----------------VMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSV---KIGDLGLAT------LKRASFAKS---VIGTPEFMAPEMYE----EH---YDESVDVYAFGMCMLEMAT-SEYP---------------YSEC---QNAAQIYRKVTC----GIKPASFEKVHD-------------------------------------PEIKEIIGECICKNKEERYE-----IKDLLSHAFF-----------
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