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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
Other AURKC 43
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK EGFR 712
TK FGFR2 481
TKL IRAK4 186
TK JAK2 849
TK LCK 245
CMGC MAPK10 64
CMGC MAPK9 26
TK RET 724
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKA---GV--E-HQLRR-EVEIQSHL-R---HPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM----EV--E-EFL-K-EAAVMKEI-K---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKS-Q-IEK---EG--L-EHQLRREIEIQAHL-Q---HPNILRLYNYFH--D------ARRVYLILEYAPRGELYKELQ---KSE-------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSV------HTPSLRRKT---MCGTLDYLPPEMIE-GRT---YDEKVDLWCIGVLCYELLV-GYPP---------------FESA----SHSETYRRILK----VDVRFPLSMP---------------------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV---
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTA-PT----PQQLQ-AFK-N-EVGVLRKT-R---HVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH----II-----------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK--S-R--WSGSHQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP-----------------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE-S-EEE---GV--P-STAIR-EISLLKEL-R---HPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD-T-ETE---GV--P-STAIR-EISLLKEL-N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVP-N-GGGGGGGL--P-ISTVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QST---YATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIG----LPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-A-TS----PKANK-EIL-D-EAYVMASV-D---NPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL-HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D-D-AT----EKDLS-DLV-S-EMEMMKMIGK---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI--N-N--IDYYKKTTNGRLPVKWMAPEALF-DRV---YTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHR----MDKPANCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM-V-DIT---TE--ELKQQFDQEIKVMAKC-Q---HENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSCLDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--GE---ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-REPQLLLDIKEEIE----DEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-S-TE-----EHLR-DFE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-G-SM----SP--D-AFL-A-EANLMKQL-Q---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP-F-QNQ---TH--A-KRAYR-ELVLMKCV-N---HKNIISLLNVFT--PQKTLEEFQDVYLVMELMDA-NLCQVIQ-----M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMG---YKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRP-F-QNQ---TH--A-KRAYR-ELVLLKCV-N---HKNIISLLNVFT--PQKTLEEFQDVYLVMELMDA-NLCQVIH-----M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL-GMG---YKENVDIWSVGCIMGELVK-GCVI---------------FQGT-DHIDQWNKVIEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI---
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E-N-AS----PSELR-DLL-S-EFNVLKQV-N---HPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIESLF-DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHR----MERPDNCS-----------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
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