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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ALK 1116
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
CMGC CSNK2A1 39
TK EGFR 712
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
STE MAP4K2 16
CAMK MAPKAPK2 64
TK NTRK1 510
STE PAK4 321
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
AGC PRKACA 44
AGC PRKCD 349
AGC PRKCQ 380
AGC PRKCZ 252
TK RET 724
TK TEK 824
TK TXK 271
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EH-QLRR-EVEIQSHL--R---HPNILRLYGYFH--D-----ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-S---AGEL---KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEM--IE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN-------TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI-----------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EE-FL-K-EAAVMKEI--K---HPNLVQLLGVCT--R-----EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHLV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPES--LA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI----DLSQVYELLEKDYRMERPEGCP------------------------------------EKVYELMRACWQWNPSDRPS------FA-EIHQA--F-----------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS----EQDELD-FL-M-EALIISKF--N---HQNIVRCIGVSL--Q-----SLPRF--ILLELMAGG--DLKSFLR-----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT-CPGPGRVA---KIGDFGMARDI--Y-R--ASYYRKGGCAMLPVKWMPPEA--FM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YP-SK----SNQEVLEFVTSGGRMDPPKNCP------------------------------------GPVYRIMTQCWQHQPEDRPN------FA-IILER--I-----------
----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEK---EG--VE-HQLRREIEIQAHL--H---HPNILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-L---KGEL---KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEM--IE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA-------SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV-----------
----FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKSQ-IEK---EG--LE-HQLRREIEIQAHL--Q---HPNILRLYNYFH--D-----ARRVY--LILEYAPRG--ELYKELQ----KSE-------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-F---RGEV---KIADFGWSV------HTPSLRRKT---MCGTLDYLPPEM--IE-GRTYDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA-------SHSETYRRILKVDVRFPLSMP----------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV-----------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PS-TAIR-EISLLKEL--R---HPNIVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-D---KGTI---KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEV--LLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD----SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF-----------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PS-TAIR-EISLLKEL--N---HPNIVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-T---EGAI---KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF-----------
---Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PI-STVR-EVALLRRL--EAFEHPNVVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-S---GGTV---KLADFGLARI-----YSYQMALTP---VVVTLWYRAPEV--LL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN----SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL-----------
----YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLDD-DDE---GV--PS-SALR-EICLLKEL--K---HKNIVRLHDVLH--S-----DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-R---NGEL---KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDV--LFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FP-GN----DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS------AE-EALQHPYF-----------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKR-AVD---CP--EN-I-KK-EICINKML--N---HENVVKFYGHRR--E-----GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-E---RDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPEL--LKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP------SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y----------
----YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPVK-KKK---IK--R-------EIKILENL-RG---GPNIITLADIVK--DP---VSRTPA--LVFEHVNNT--DFKQLY-------Q-------------------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE---HRKL---RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH----DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF-----------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS----PKANKE-IL-D-EAYVMASV--D---NPHVCRLLGICL--------TSTVQ--LITQLMPFG--CLLDYVR-----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-T---PQHV---KITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALES--IL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI----PASEISSILEKGERLPQPPICT------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF---------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT----EKDLSD-LI-S-EMEMMKMIG-K---HKNIINLLGACT--Q-----DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-E---DNVM---KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEA--LF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV----PVEELFKLLKEGHRMDKPSNCT------------------------------------NELYMMMRDCWHAVPSQRPT------FK-QLVEDL-------------
----YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDK-RFK---NR----------ELQIMRKL--D---HCNIVRLRYFFY--SSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPD---TAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPEL--IFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF-----------
----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFK---NR----------ELQIMRKL--D---HCNIVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD---TAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPEL--IFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF-----------
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EG-AM----SE--ED-FI-E-EAEVMMKL--S---HPKLVQLYGVCL--E-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-E---NQVI---KVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEV--FS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR----SNSEVVEDISTGFRLYKPRLAS------------------------------------THVYQIMNHCWKERPEDRPA------FS-RLLRQL-------------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE-----EHLRD-FE-R-EIEILKSL--Q---HDNIVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-N---ENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPES--LT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM----IVFHLIELLKNNGRLPRPDGCP------------------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV---------
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP----DQ-QRD-FQ-R-EIQILKAL--H---SDFIVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-S---EAHV---KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPES--LS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P--ALCRLLELLEEGQRLPAPPACP------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL----------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM----SP--DA-FL-A-EANLMKQL--Q---HQRLVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-D---TLSC---KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEA--IN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM----TNPEVIQNLERGYRMVRPDNCP------------------------------------EELYQLMRLCWKERPEDRPT------FD-YLRSV--L-----------
----FELLQRVGAGTYGDVYKARDT-------VTSELAAVKIVKLDP-GDD---IS--SL---QQ-EITILREC--R---HPNVVAYIGSYL--R-----NDRLW--ICMEFCGGG--SLQEIYH----ATG-------------------------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLT-L---QGDV---KLADFGVSGEL----TASVAKRRS---FIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGE-LQPP---------------LF-HL----HPMRALMLMSKSSFQPPKLRDKTR--WT------------------------------QNFHHFLKLALTKNPKKRPT------AE-KLLQHPF-T----------
-KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDCP-KAR-------------R-EVELHWRA-SQ---CPHIVRIVDVYE--NLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-S---KRPNAILKLTDFGFAKE-----TTSHNSLTT---PCYTPYYVAPEV--LG-PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FY-SN---HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT------IT-EFMNHPWI-----------
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EA-SE----SA-RQD-FQ-R-EAELLTML--Q---HQHIVRFFGVCT--E-----GRPLL--MVFEYMRHG--DLNRFLR-----SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-Q---GLVV---KIGDFGMSRDI--Y-S--TDYYRVGGRTMLPIRWMPPES--IL-YRKFTTESDVWSFGVVLWEIFTYGKQP---------------WY-QL----SNTEAIDCITQGRELERPRACP------------------------------------PEVYAIMRGCWQREPQQRHS------IK-DVHARL-------------
DNFI-----KIGEGSTGIVCIATVR-------SSGKLVAVKKMDLRK-QQR---RE--L---LFN-EVVIMRDY--Q---HENVVEMYNSYL--V-----GDELW--VVMEFLEGG--ALTDIVT-----HT-------------------------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT-H---DGRV---KLSDFGFCAQV----SKEVPRRKS---LVGTPYWMAPEL--IS-RLPYGPEVDIWSLGIMVIEMVD-GEPP---------------YF-NE----PPLKAMKMIRDNLPPRLKNLHKVS----------------------------------PSLKGFLDRLLVRDPAQRAT------AA-ELLKHPFL-----------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRH-IIK---EN--KVPYVTR-ERDVMSRL--D---HPFFVKLYFTFQ--D-----DEKLY--FGLSYAKNG--ELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-E---DMHI---QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPEL--LT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG-------NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLK---PH--QR-EKMSMEISIHRSL--A---HQHVVGFHGFFE--D-----NDFVF--VVLELCRRR--SLLELHK----RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-E---DLEV---KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEV--LS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS-------CLKETYLRIKKNEYSIPKHIN----------------------------------PVAASLIQKMLQTDPTARPT------IN-ELLNDEFF-----------
--YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSR-VAK---PH--QR-EKILNEIELHRDL--Q---HRHIVRFSHHFE--D-----ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-E---NMEL---KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEV--LL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA-------DLKETYRCIKQVHYTLPASLS----------------------------------LPARQLLAAILRASPRDRPS------ID-QILRHDFF-----------
---F-ERIKTLGTGSFGRVMLVKHK-------ETGNHYAMKILDKQK-VVK---LK--QI-EHTLNEKRILQAV--N---FPFLVKLEFSFK--D-----NSNLY--MVMEYVPGG--EMFSHLR----RIG-------------------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-Q---QGYI---QVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEI--IL-SKGYNKAVDWWALGVLIYEMAA-GYPP---------------FF-AD-------QPIQIYEKIVSGKVRFPSHFS----------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVN-DIKNHKWF-----------
--FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKALKKDV-VLI---DD--DV-ECTMVEKRVLTLA-AE---NPFLTHLICTFQ--T-----KDHLF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-R---DGHI---KIADFGMCKEN----IFGESRAST---FCGTPDYIAPEI--LQ-GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD-------DEDELFESIRVDTPHYPRWIT----------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF-----------
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKALKKDV-VLM---DD--DV-ECTMVEKRVLSLA-WE---HPFLTHMFCTFQ--T-----KENLF--FVMEYLNGG--DLMYHIQ----SCH-------------------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-K---DGHI---KIADFGMCKEN----MLGDAKTNT---FCGTPDYIAPEI--LL-GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ-------DEEELFHSIRMDNPFYPRWLE----------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF-----------
---F-DLIRVIGRGSYAKVLLVRLK-------KNDQIYAMKVVKKEL-VHD---DE--DI-DWVQTEKHVFEQA-SS---NPFLVGLHSCFQ--T-----TSRLF--LVIEYVNGG--DLMFHMQ----RQR-------------------------KLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLD-A---DGHI---KLTDYGMCKEG----LGPGDTTST---FCGTPNYIAPEI--LR-GEEYGFSVDWWALGVLMFEMMA-GRSP---------------FD-IITDNPDMNTEDYLFQVILEKPIRIPRFLS----------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF--
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS----PSELRD-LL-S-EFNVLKQV--N---HPHVIKLYGACS--Q-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-E---GRKM---KISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIES--LF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI----PPERLFNLLKTGHRMERPDNCS------------------------------------EEMYRLMLQCWKQEPDKRPV------FA-DISKDL-------------
----IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-EY-AS----KDDHRD-FA-G-ELEVLCKLG-H---HPNIINLLGACE--H-----RGYLY--LAIEYAPHG--NLLDFLR-----KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-E---NYVA---KIADFGLSRGQ--------EVYVKKTMGRLPVRWMAIES--LN-YSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YC-GM----TCAELYEKLPQGYRLEKPLNCD------------------------------------DEVYDLMRQCWREKPYERPS------FA-QILV---SL----------
---L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-EG-SM----SE--ED-FI-E-EAKVMMKL--S---HSKLVQLYGVCI--Q-----RKPLY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-S---TCIV---KISDFGMTRYV----L--DDEYVSSFGAKFPIKWSPPEV--FL-FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FE-NK----SNLQVVEAISEGFRLYRPHLAP------------------------------------MSIYEVMYSCWHEKPEGRPT------FA-ELLR---AV----------
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