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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
AGC AKT1 150
Other AURKA 133
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
TK FYN 271
CMGC GSK3B 56
TK HCK 241
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CAMK MAPKAPK2 64
CAMK MARK2 53
AGC PRKCA 339
AGC PRKCB 342
AGC SGK1 98
TK SRC 270
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEK---EGVEHQLRREIEIQ-AHL-H---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGEL---KIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV--------------
--F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV-IVA---KDEVAHTLTENRVL-QNS-R---HPFLTALKYSFQT------HDRLC--FVMEYANGG--ELFFHLS----RER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI---KITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR-EVEIQ-SHL-R---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGEL---KIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIR-EISLL-KEL-N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--------------
--Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR-EVALL-RRL-EAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTV---KLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVD---CPENI-KK-EICIN-KML-N---HENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-------------
---LQLIKRLGNGQFGEVWMGTWN-GNTKVAIKTLK-PG-TM----SPESFL-E-EAQIM-KKL-K---HDKLVQLYAVVS-------EEPIY--IVTEYMNKG--SLLDFLK-----DGEGRALKLPNLVDMAAQVAAGMAYIER-MNYIHRDLRSANILVG-NGLIC---KIADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGM-NNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL----------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFK---NR-------ELQIM-RKL-D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF--------------
---LKLEKKLGAGQFGEVWMATYN-KHTKVAVKTMK-PG-SM----SVEAFL-A-EANVM-KTL-Q---HDKLVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK-----SDEGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVS-ASLVC---KIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L--------------
---YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQT---YCQRT-LR-EIKIL-LRF-R---HENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--------------
---YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQ---THAKRAYR-ELVLM-KCV-N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI--------------
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSI---IHAKRTYR-ELRLL-KHM-K---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF--------------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR----------R-EVELH-WRASQ---CPHIVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ---AFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE----TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--------------
---YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQ-LNS---SSLQKLFR-EVRIM-KVL-N---HPNIVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV----AHG---RMKEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLLLD-ADMNI---KIADFGFSNE----FTFGNKLDT---FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ----NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV-VIQ---DDDVECTMVEKRVL-ALLDK---PPFLTQLHSCFQT------VDRLY--FVMEYVNGG--DLMYHIQ----QVG---KFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH---MMDGVTTRT---FCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFDGE----DEDELFQSIMEHNVSYPKSLS---------------------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-VIQ---DDDVECTMVEKRVL-ALPGK---PPFLTQLHSCFQT------MDRLY--FVMEYVNGG--DLMYHIQ----QVG---RFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEN---IWDGVTTKT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE----DEDELFQSIMEHNVAYPKSMS---------------------------------------KEAVAICKGLMTKHPGKRLG-----C---------GPEGERDIKEHAFF
---FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA-ILK---KKEEKHIMSERNVLLKNV-K---HPFLVGLHFSFQT------ADKLY--FVLDYINGG--ELFYHLQ----RER---CFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLD-SQGHI---VLTDFGLCKEN---IEHNSTTST---FCGTPEYLAPEVLH-KQPYDRTVDWWCLGAVLYEMLY-GLPPFYSR----NTAEMYDNILNKPLQLKPNIT---------------------------------------NSARHLLEGLLQKDRTKRLGAK-DDFMEIKSHV--FF------------
--L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PG-TM----SPEAFL-Q-EAQVM-KKL-R---HEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVC---KVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--------------
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