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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
Other AURKA 133
Other AURKC 43
TK LCK 245
FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV--HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV--HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQ-IEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSE---KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSV--HTPSLRRKT---MCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV
LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QG-SM-SPDAFL-A-EANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK-TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L
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