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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK EGFR 712
CMGC GSK3B 56
TK IGF1R 999
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK LCK 245
TK NTRK1 510
TK PDGFRB 600
TK PTK2 422
TK SRC 270
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQIEK---EG--V-EHQLRREIEIQAHL-H---HPNILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV---
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM----EV--E-EFL-K-EAAVMKEI-K---HPNLVQLLGVCT--R-----EPPFY--IITEFMTYG--NLLDYLR-----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEE---GV--P-STAIR-EISLLKEL-R---HPNIVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETE---GV--P-STAIR-EISLLKEL-N---HPNIVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
--Y-EPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGL--P-ISTVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP----------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS----PKANK-EIL-D-EAYVMASV-D---NPHVCRLLGICL--------TSTVQ--LITQLMPFG--CLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFK---NR----------ELQIMRKL-D---HCNIVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ----------------------------------------------------------------------------------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---
---ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAAS----MRERI-EFL-N-EASVMKEF-N---CHHVVRLLGVVS--Q-----GQPTL--VIMELMTRG--DLKSYLR-----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFTVKIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I---
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAMVDIT---TE--ELKQQFDQEIKVMAKC-Q---HENLVELLGFSS--D-----GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTAKISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HSTE-----EHLR-DFE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HSGP----DQ-QR-DFQ-R-EIQILKAL-H---SDFIVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL--
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QGSM----SP--D-AFL-A-EANLMKQL-Q---HQRLVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
-IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASE----SA-RQ-DFQ-R-EAELLTML-Q---HQHIVRFFGVCT--E-----GRPLL--MVFEYMRHG--DLNRFLR-----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVVKIGDFGMSRDI--Y-S--TDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCITQGRELERPRACP----------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----
--L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK-STAR----SSEKQ-ALM-S-ELKIMSHLGP---HLNVVNLLGACT--K-----GGPIY--IITEYCRYG--DLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLIC-EGKLVKICDFGLARDI--M-R--DSNYISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--
---IELGRCIGEGQFGDVHQGIYM--SPENPALAVAIKTCK-NCTS----DSVRE-KFL-Q-EALTMRQF-D---HPHIVKLIGVIT--------ENPVW--IIMELCTLG--ELRSFLQ-----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-----
--L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PGTM----SP--E-AFL-Q-EAQVMKKL-R---HEKLVQLYAVVS--------EEPIY--IVTEYMSKG--SLLDFLK-----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
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